GREMLIN Database
Q9HRX6 - 3-isopropylmalate dehydratase
UniProt: Q9HRX6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 248 (223)
Sequences: 1285 (906)
Seq/√Len: 60.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_A220_R4.5531.00
17_L109_V4.4291.00
17_L104_I4.0011.00
102_G170_R3.6481.00
51_A90_R3.4581.00
28_G116_G2.9781.00
90_R95_E2.8131.00
96_F159_P2.7331.00
220_R224_E2.6061.00
114_L194_L2.5601.00
30_I191_A2.5271.00
71_I82_L2.4011.00
80_L107_H2.3641.00
136_G173_D2.2531.00
105_D170_R2.2481.00
131_F180_E2.2231.00
166_A169_Q2.1571.00
43_C70_R2.1011.00
179_V194_L2.0981.00
45_G103_W2.0981.00
167_A174_A2.0541.00
214_D217_A2.0191.00
27_V194_L1.9601.00
21_L159_P1.9561.00
34_H38_V1.8951.00
17_L82_L1.8851.00
102_G106_H1.8671.00
192_R213_V1.8341.00
196_D206_S1.8101.00
111_P173_D1.8101.00
104_I172_L1.7700.99
101_T170_R1.7130.99
135_S174_A1.6980.99
132_G147_I1.6450.99
128_P193_R1.6360.99
130_V198_A1.6280.99
72_Y83_Q1.6140.99
41_M74_D1.6070.99
31_A114_L1.5770.99
20_G23_G1.5630.99
112_V167_A1.5530.99
19_E113_Y1.5430.98
14_D110_T1.5270.98
196_D213_V1.5260.98
80_L109_V1.5090.98
35_I81_A1.4960.98
44_V80_L1.4670.98
113_Y174_A1.4630.98
104_I109_V1.4460.98
44_V73_A1.4350.98
237_E240_Q1.4140.97
194_L199_I1.4040.97
17_L23_G1.3970.97
43_C72_Y1.3960.97
192_R216_A1.3840.97
67_P74_D1.3650.97
15_P78_G1.3630.97
18_I205_V1.3560.97
134_G139_P1.3130.96
38_V208_P1.3130.96
32_T81_A1.3110.96
227_A230_M1.3070.96
218_D222_Q1.3070.96
64_A67_P1.2980.96
128_P179_V1.2790.95
142_I177_L1.2740.95
12_I15_P1.2700.95
191_A195_I1.2620.95
32_T132_G1.2540.95
75_E78_G1.2400.94
185_F227_A1.2390.94
86_V124_L1.2330.94
39_F79_L1.2170.94
210_D213_V1.2000.93
38_V211_D1.1910.93
41_M81_A1.1890.93
15_P107_H1.1850.93
157_G161_G1.1750.92
209_T213_V1.1650.92
124_L182_D1.1550.92
101_T167_A1.1500.92
14_D77_R1.1450.91
86_V182_D1.1340.91
122_H126_D1.1330.91
70_R74_D1.1280.91
142_I175_A1.1270.91
133_I164_M1.1210.91
20_G28_G1.1100.90
15_P80_L1.1060.90
111_P175_A1.1020.90
101_T105_D1.0990.90
65_A74_D1.0940.89
177_L199_I1.0910.89
200_E206_S1.0860.89
226_L230_M1.0850.89
111_P141_R1.0840.89
18_I23_G1.0840.89
59_T62_S1.0800.89
12_I78_G1.0790.89
82_L96_F1.0710.88
20_G114_L1.0680.88
36_I72_Y1.0590.88
165_T169_Q1.0580.88
50_A95_E1.0560.88
81_A130_V1.0530.88
214_D218_D1.0510.88
17_L112_V1.0420.87
56_T165_T1.0390.87
115_S178_V1.0340.87
42_S199_I1.0320.87
216_A220_R1.0280.86
233_A236_H1.0250.86
177_L202_L1.0230.86
31_A212_L1.0120.85
225_Q228_E1.0030.85
189_A216_A0.9930.84
182_D223_K0.9920.84
82_L100_V0.9800.84
218_D221_S0.9780.83
54_Q188_P0.9720.83
49_C160_T0.9710.83
94_T166_A0.9650.83
43_C46_S0.9650.83
74_D79_L0.9550.82
181_S190_G0.9410.81
129_T180_E0.9400.81
69_V73_A0.9400.81
16_V203_V0.9360.81
111_P138_L0.9350.81
21_L32_T0.9280.80
23_G188_P0.9180.79
166_A170_R0.9160.79
21_L82_L0.9100.79
215_R218_D0.9070.79
222_Q226_L0.9060.78
48_S51_A0.9050.78
192_R215_R0.9010.78
70_R229_Q0.9000.78
210_D214_D0.8970.78
52_I99_C0.8950.78
196_D209_T0.8940.78
186_P215_R0.8830.77
221_S225_Q0.8780.76
86_V91_N0.8780.76
53_P187_D0.8750.76
39_F208_P0.8730.76
28_G187_D0.8650.75
41_M79_L0.8630.75
237_E241_A0.8630.75
44_V235_E0.8540.74
19_E163_L0.8500.74
91_N125_G0.8490.74
158_G162_A0.8480.74
201_P210_D0.8470.74
116_G203_V0.8470.74
43_C61_D0.8420.73
69_V74_D0.8350.73
231_Q234_D0.8290.72
200_E203_V0.8290.72
233_A237_E0.8270.72
46_S68_P0.8250.72
158_G161_G0.8170.71
102_G105_D0.8130.71
45_G71_I0.8130.71
20_G32_T0.8080.70
52_I226_L0.8080.70
51_A95_E0.8050.70
105_D172_L0.8050.70
58_Y223_K0.8020.69
134_G138_L0.8000.69
188_P215_R0.7980.69
31_A195_I0.7980.69
18_I199_I0.7960.69
195_I208_P0.7940.69
76_S108_D0.7940.69
28_G115_S0.7940.69
17_L21_L0.7930.69
137_A196_D0.7920.69
41_M72_Y0.7900.68
128_P180_E0.7890.68
125_G182_D0.7890.68
183_P240_Q0.7710.66
195_I200_E0.7700.66
91_N182_D0.7670.66
16_V19_E0.7650.66
97_A234_D0.7580.65
138_L141_R0.7550.65
101_T158_G0.7520.64
40_D231_Q0.7400.63
112_V238_S0.7370.63
215_R222_Q0.7350.63
176_A203_V0.7340.63
130_V194_L0.7340.63
31_A192_R0.7270.62
225_Q229_Q0.7210.61
232_H235_E0.7200.61
120_D183_P0.7160.61
44_V47_V0.7120.60
234_D238_S0.7090.60
108_D172_L0.7090.60
23_G158_G0.7080.60
193_R198_A0.7070.60
96_F100_V0.7070.60
27_V190_G0.7060.60
142_I147_I0.7060.60
110_T224_E0.7050.59
134_G196_D0.7020.59
99_C104_I0.7000.59
135_S168_T0.6960.59
65_A72_Y0.6940.58
211_D215_R0.6930.58
116_G135_S0.6910.58
26_L97_A0.6860.57
28_G161_G0.6850.57
52_I71_I0.6810.57
33_D146_D0.6800.57
61_D72_Y0.6790.57
163_L179_V0.6770.56
103_W107_H0.6770.56
24_V87_P0.6740.56
86_V184_Q0.6730.56
98_D235_E0.6720.56
67_P71_I0.6710.56
91_N184_Q0.6710.56
81_A116_G0.6710.56
47_V187_D0.6700.56
51_A216_A0.6700.56
186_P219_I0.6690.56
91_N126_D0.6670.55
122_H182_D0.6660.55
21_L29_K0.6630.55
18_I228_E0.6610.55
59_T152_E0.6600.55
105_D152_E0.6600.55
36_I83_Q0.6540.54
35_I74_D0.6510.54
124_L184_Q0.6490.53
19_E160_T0.6470.53
23_G159_P0.6470.53
67_P182_D0.6450.53
30_I34_H0.6430.53
105_D171_Q0.6420.52
190_G232_H0.6400.52
58_Y173_D0.6370.52
235_E239_T0.6340.52
54_Q126_D0.6310.51
95_E99_C0.6290.51
65_A70_R0.6290.51
25_G187_D0.6270.51
21_L103_W0.6270.51
18_I171_Q0.6270.51
124_L241_A0.6260.51
224_E228_E0.6250.51
115_S155_V0.6220.50
24_V182_D0.6140.49
104_I167_A0.6090.49
168_T174_A0.6090.49
58_Y62_S0.6070.49
27_V142_I0.6050.48
42_S73_A0.6040.48
53_P69_V0.6000.48
88_I100_V0.5960.47
39_F235_E0.5940.47
114_L120_D0.5910.47
24_V156_I0.5890.47
230_M236_H0.5880.46
20_G25_G0.5860.46
138_L163_L0.5840.46
24_V176_A0.5800.46
91_N124_L0.5800.46
23_G115_S0.5780.45
101_T104_I0.5780.45
161_G180_E0.5770.45
12_I48_S0.5750.45
171_Q216_A0.5710.45
62_S172_L0.5700.44
87_P167_A0.5700.44
102_G228_E0.5700.44
13_E228_E0.5690.44
63_H214_D0.5690.44
121_D124_L0.5660.44
112_V172_L0.5660.44
48_S87_P0.5630.44
162_A214_D0.5590.43
38_V207_V0.5570.43
135_S138_L0.5560.43
204_E208_P0.5550.43
134_G239_T0.5540.43
116_G161_G0.5500.42
95_E130_V0.5490.42
24_V54_Q0.5470.42
84_G184_Q0.5460.42
69_V84_G0.5460.42
189_A192_R0.5460.42
155_V184_Q0.5460.42
88_I121_D0.5450.42
42_S130_V0.5440.42
13_E105_D0.5440.42
206_S229_Q0.5430.41
148_G175_A0.5380.41
235_E238_S0.5370.41
57_V65_A0.5370.41
140_E201_P0.5350.41
141_R217_A0.5280.40
24_V27_V0.5230.39
115_S157_G0.5220.39
97_A101_T0.5200.39
77_R204_E0.5200.39
39_F205_V0.5200.39
54_Q120_D0.5190.39
40_D218_D0.5190.39
222_Q225_Q0.5180.39
188_P219_I0.5150.38
46_S70_R0.5150.38
121_D182_D0.5130.38
154_G187_D0.5130.38
20_G218_D0.5120.38
96_F163_L0.5110.38
15_P23_G0.5110.38
83_Q232_H0.5110.38
204_E233_A0.5100.38
137_A146_D0.5090.38
130_V188_P0.5080.38
177_L194_L0.5070.38
76_S204_E0.5050.37
19_E109_V0.5050.37
130_V193_R0.5040.37
221_S228_E0.5020.37
165_T204_E0.5020.37
26_L230_M0.5010.37
40_D76_S0.5010.37
17_L71_I0.5010.37
36_I81_A0.5000.37
84_G88_I0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wamA 4 0.9677 100 0.221 Contact Map
2p90A 3 0.9637 100 0.228 Contact Map
3e35A 3 0.9476 100 0.232 Contact Map
3mnfA 4 0.8669 100 0.245 Contact Map
3gaaA 5 0.9315 100 0.249 Contact Map
3wz2A 3 0.9032 100 0.256 Contact Map
3vr0A 3 0.8992 100 0.271 Contact Map
4g4sP 1 0.6653 99.9 0.637 Contact Map
4d2uA 3 0.8629 61.8 0.937 Contact Map
1qvrA 3 0.8387 59.1 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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