Q9HRX6 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HRX6 - 3-isopropylmalate dehydratase

UniProt:	Q9HRX6	Sequences: MGSVTTHTAFDIEDPVLIEGLPGVGLVGKIATDHIIDVFDMSCVGSVSCAAIPQVTVYTEDSHAATPPVRIYADESRGLLALQGDVPISRNNGTEFADCVTGWIDHHDVTPVYLSGLPSDDHELGDLPTVFGIGSGALPERIAALDIGTPPERGVIGGPTGALMTAATQRQLDAAALVVESDPQFPDPAGARRLIDHAIEPLVEVSVPTDDLVDRAADIRSQKEQLAEQMQHADEHESTQAKPLRMFQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	248 (223)
Sequences:	1285 (906)
Seq/√Len:	60.6

HALSA - Q9HRX6 Q9HRU0
SULSO - Q97ZI5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
189_A	220_R	4.553	1.00
17_L	109_V	4.429	1.00
17_L	104_I	4.001	1.00
102_G	170_R	3.648	1.00
51_A	90_R	3.458	1.00
28_G	116_G	2.978	1.00
90_R	95_E	2.813	1.00
96_F	159_P	2.733	1.00
220_R	224_E	2.606	1.00
114_L	194_L	2.560	1.00
30_I	191_A	2.527	1.00
71_I	82_L	2.401	1.00
80_L	107_H	2.364	1.00
136_G	173_D	2.253	1.00
105_D	170_R	2.248	1.00
131_F	180_E	2.223	1.00
166_A	169_Q	2.157	1.00
43_C	70_R	2.101	1.00
179_V	194_L	2.098	1.00
45_G	103_W	2.098	1.00
167_A	174_A	2.054	1.00
214_D	217_A	2.019	1.00
27_V	194_L	1.960	1.00
21_L	159_P	1.956	1.00
34_H	38_V	1.895	1.00
17_L	82_L	1.885	1.00
102_G	106_H	1.867	1.00
192_R	213_V	1.834	1.00
196_D	206_S	1.810	1.00
111_P	173_D	1.810	1.00
104_I	172_L	1.770	0.99
101_T	170_R	1.713	0.99
135_S	174_A	1.698	0.99
132_G	147_I	1.645	0.99
128_P	193_R	1.636	0.99
130_V	198_A	1.628	0.99
72_Y	83_Q	1.614	0.99
41_M	74_D	1.607	0.99
31_A	114_L	1.577	0.99
20_G	23_G	1.563	0.99
112_V	167_A	1.553	0.99
19_E	113_Y	1.543	0.98
14_D	110_T	1.527	0.98
196_D	213_V	1.526	0.98
80_L	109_V	1.509	0.98
35_I	81_A	1.496	0.98
44_V	80_L	1.467	0.98
113_Y	174_A	1.463	0.98
104_I	109_V	1.446	0.98
44_V	73_A	1.435	0.98
237_E	240_Q	1.414	0.97
194_L	199_I	1.404	0.97
17_L	23_G	1.397	0.97
43_C	72_Y	1.396	0.97
192_R	216_A	1.384	0.97
67_P	74_D	1.365	0.97
15_P	78_G	1.363	0.97
18_I	205_V	1.356	0.97
134_G	139_P	1.313	0.96
38_V	208_P	1.313	0.96
32_T	81_A	1.311	0.96
227_A	230_M	1.307	0.96
218_D	222_Q	1.307	0.96
64_A	67_P	1.298	0.96
128_P	179_V	1.279	0.95
142_I	177_L	1.274	0.95
12_I	15_P	1.270	0.95
191_A	195_I	1.262	0.95
32_T	132_G	1.254	0.95
75_E	78_G	1.240	0.94
185_F	227_A	1.239	0.94
86_V	124_L	1.233	0.94
39_F	79_L	1.217	0.94
210_D	213_V	1.200	0.93
38_V	211_D	1.191	0.93
41_M	81_A	1.189	0.93
15_P	107_H	1.185	0.93
157_G	161_G	1.175	0.92
209_T	213_V	1.165	0.92
124_L	182_D	1.155	0.92
101_T	167_A	1.150	0.92
14_D	77_R	1.145	0.91
86_V	182_D	1.134	0.91
122_H	126_D	1.133	0.91
70_R	74_D	1.128	0.91
142_I	175_A	1.127	0.91
133_I	164_M	1.121	0.91
20_G	28_G	1.110	0.90
15_P	80_L	1.106	0.90
111_P	175_A	1.102	0.90
101_T	105_D	1.099	0.90
65_A	74_D	1.094	0.89
177_L	199_I	1.091	0.89
200_E	206_S	1.086	0.89
226_L	230_M	1.085	0.89
111_P	141_R	1.084	0.89
18_I	23_G	1.084	0.89
59_T	62_S	1.080	0.89
12_I	78_G	1.079	0.89
82_L	96_F	1.071	0.88
20_G	114_L	1.068	0.88
36_I	72_Y	1.059	0.88
165_T	169_Q	1.058	0.88
50_A	95_E	1.056	0.88
81_A	130_V	1.053	0.88
214_D	218_D	1.051	0.88
17_L	112_V	1.042	0.87
56_T	165_T	1.039	0.87
115_S	178_V	1.034	0.87
42_S	199_I	1.032	0.87
216_A	220_R	1.028	0.86
233_A	236_H	1.025	0.86
177_L	202_L	1.023	0.86
31_A	212_L	1.012	0.85
225_Q	228_E	1.003	0.85
189_A	216_A	0.993	0.84
182_D	223_K	0.992	0.84
82_L	100_V	0.980	0.84
218_D	221_S	0.978	0.83
54_Q	188_P	0.972	0.83
49_C	160_T	0.971	0.83
94_T	166_A	0.965	0.83
43_C	46_S	0.965	0.83
74_D	79_L	0.955	0.82
181_S	190_G	0.941	0.81
129_T	180_E	0.940	0.81
69_V	73_A	0.940	0.81
16_V	203_V	0.936	0.81
111_P	138_L	0.935	0.81
21_L	32_T	0.928	0.80
23_G	188_P	0.918	0.79
166_A	170_R	0.916	0.79
21_L	82_L	0.910	0.79
215_R	218_D	0.907	0.79
222_Q	226_L	0.906	0.78
48_S	51_A	0.905	0.78
192_R	215_R	0.901	0.78
70_R	229_Q	0.900	0.78
210_D	214_D	0.897	0.78
52_I	99_C	0.895	0.78
196_D	209_T	0.894	0.78
186_P	215_R	0.883	0.77
221_S	225_Q	0.878	0.76
86_V	91_N	0.878	0.76
53_P	187_D	0.875	0.76
39_F	208_P	0.873	0.76
28_G	187_D	0.865	0.75
41_M	79_L	0.863	0.75
237_E	241_A	0.863	0.75
44_V	235_E	0.854	0.74
19_E	163_L	0.850	0.74
91_N	125_G	0.849	0.74
158_G	162_A	0.848	0.74
201_P	210_D	0.847	0.74
116_G	203_V	0.847	0.74
43_C	61_D	0.842	0.73
69_V	74_D	0.835	0.73
231_Q	234_D	0.829	0.72
200_E	203_V	0.829	0.72
233_A	237_E	0.827	0.72
46_S	68_P	0.825	0.72
158_G	161_G	0.817	0.71
102_G	105_D	0.813	0.71
45_G	71_I	0.813	0.71
20_G	32_T	0.808	0.70
52_I	226_L	0.808	0.70
51_A	95_E	0.805	0.70
105_D	172_L	0.805	0.70
58_Y	223_K	0.802	0.69
134_G	138_L	0.800	0.69
188_P	215_R	0.798	0.69
31_A	195_I	0.798	0.69
18_I	199_I	0.796	0.69
195_I	208_P	0.794	0.69
76_S	108_D	0.794	0.69
28_G	115_S	0.794	0.69
17_L	21_L	0.793	0.69
137_A	196_D	0.792	0.69
41_M	72_Y	0.790	0.68
128_P	180_E	0.789	0.68
125_G	182_D	0.789	0.68
183_P	240_Q	0.771	0.66
195_I	200_E	0.770	0.66
91_N	182_D	0.767	0.66
16_V	19_E	0.765	0.66
97_A	234_D	0.758	0.65
138_L	141_R	0.755	0.65
101_T	158_G	0.752	0.64
40_D	231_Q	0.740	0.63
112_V	238_S	0.737	0.63
215_R	222_Q	0.735	0.63
176_A	203_V	0.734	0.63
130_V	194_L	0.734	0.63
31_A	192_R	0.727	0.62
225_Q	229_Q	0.721	0.61
232_H	235_E	0.720	0.61
120_D	183_P	0.716	0.61
44_V	47_V	0.712	0.60
234_D	238_S	0.709	0.60
108_D	172_L	0.709	0.60
23_G	158_G	0.708	0.60
193_R	198_A	0.707	0.60
96_F	100_V	0.707	0.60
27_V	190_G	0.706	0.60
142_I	147_I	0.706	0.60
110_T	224_E	0.705	0.59
134_G	196_D	0.702	0.59
99_C	104_I	0.700	0.59
135_S	168_T	0.696	0.59
65_A	72_Y	0.694	0.58
211_D	215_R	0.693	0.58
116_G	135_S	0.691	0.58
26_L	97_A	0.686	0.57
28_G	161_G	0.685	0.57
52_I	71_I	0.681	0.57
33_D	146_D	0.680	0.57
61_D	72_Y	0.679	0.57
163_L	179_V	0.677	0.56
103_W	107_H	0.677	0.56
24_V	87_P	0.674	0.56
86_V	184_Q	0.673	0.56
98_D	235_E	0.672	0.56
67_P	71_I	0.671	0.56
91_N	184_Q	0.671	0.56
81_A	116_G	0.671	0.56
47_V	187_D	0.670	0.56
51_A	216_A	0.670	0.56
186_P	219_I	0.669	0.56
91_N	126_D	0.667	0.55
122_H	182_D	0.666	0.55
21_L	29_K	0.663	0.55
18_I	228_E	0.661	0.55
59_T	152_E	0.660	0.55
105_D	152_E	0.660	0.55
36_I	83_Q	0.654	0.54
35_I	74_D	0.651	0.54
124_L	184_Q	0.649	0.53
19_E	160_T	0.647	0.53
23_G	159_P	0.647	0.53
67_P	182_D	0.645	0.53
30_I	34_H	0.643	0.53
105_D	171_Q	0.642	0.52
190_G	232_H	0.640	0.52
58_Y	173_D	0.637	0.52
235_E	239_T	0.634	0.52
54_Q	126_D	0.631	0.51
95_E	99_C	0.629	0.51
65_A	70_R	0.629	0.51
25_G	187_D	0.627	0.51
21_L	103_W	0.627	0.51
18_I	171_Q	0.627	0.51
124_L	241_A	0.626	0.51
224_E	228_E	0.625	0.51
115_S	155_V	0.622	0.50
24_V	182_D	0.614	0.49
104_I	167_A	0.609	0.49
168_T	174_A	0.609	0.49
58_Y	62_S	0.607	0.49
27_V	142_I	0.605	0.48
42_S	73_A	0.604	0.48
53_P	69_V	0.600	0.48
88_I	100_V	0.596	0.47
39_F	235_E	0.594	0.47
114_L	120_D	0.591	0.47
24_V	156_I	0.589	0.47
230_M	236_H	0.588	0.46
20_G	25_G	0.586	0.46
138_L	163_L	0.584	0.46
24_V	176_A	0.580	0.46
91_N	124_L	0.580	0.46
23_G	115_S	0.578	0.45
101_T	104_I	0.578	0.45
161_G	180_E	0.577	0.45
12_I	48_S	0.575	0.45
171_Q	216_A	0.571	0.45
62_S	172_L	0.570	0.44
87_P	167_A	0.570	0.44
102_G	228_E	0.570	0.44
13_E	228_E	0.569	0.44
63_H	214_D	0.569	0.44
121_D	124_L	0.566	0.44
112_V	172_L	0.566	0.44
48_S	87_P	0.563	0.44
162_A	214_D	0.559	0.43
38_V	207_V	0.557	0.43
135_S	138_L	0.556	0.43
204_E	208_P	0.555	0.43
134_G	239_T	0.554	0.43
116_G	161_G	0.550	0.42
95_E	130_V	0.549	0.42
24_V	54_Q	0.547	0.42
84_G	184_Q	0.546	0.42
69_V	84_G	0.546	0.42
189_A	192_R	0.546	0.42
155_V	184_Q	0.546	0.42
88_I	121_D	0.545	0.42
42_S	130_V	0.544	0.42
13_E	105_D	0.544	0.42
206_S	229_Q	0.543	0.41
148_G	175_A	0.538	0.41
235_E	238_S	0.537	0.41
57_V	65_A	0.537	0.41
140_E	201_P	0.535	0.41
141_R	217_A	0.528	0.40
24_V	27_V	0.523	0.39
115_S	157_G	0.522	0.39
97_A	101_T	0.520	0.39
77_R	204_E	0.520	0.39
39_F	205_V	0.520	0.39
54_Q	120_D	0.519	0.39
40_D	218_D	0.519	0.39
222_Q	225_Q	0.518	0.39
188_P	219_I	0.515	0.38
46_S	70_R	0.515	0.38
121_D	182_D	0.513	0.38
154_G	187_D	0.513	0.38
20_G	218_D	0.512	0.38
96_F	163_L	0.511	0.38
15_P	23_G	0.511	0.38
83_Q	232_H	0.511	0.38
204_E	233_A	0.510	0.38
137_A	146_D	0.509	0.38
130_V	188_P	0.508	0.38
177_L	194_L	0.507	0.38
76_S	204_E	0.505	0.37
19_E	109_V	0.505	0.37
130_V	193_R	0.504	0.37
221_S	228_E	0.502	0.37
165_T	204_E	0.502	0.37
26_L	230_M	0.501	0.37
40_D	76_S	0.501	0.37
17_L	71_I	0.501	0.37
36_I	81_A	0.500	0.37
84_G	88_I	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wamA	4	0.9677	100	0.221	Contact Map
2p90A	3	0.9637	100	0.228	Contact Map
3e35A	3	0.9476	100	0.232	Contact Map
3mnfA	4	0.8669	100	0.245	Contact Map
3gaaA	5	0.9315	100	0.249	Contact Map
3wz2A	3	0.9032	100	0.256	Contact Map
3vr0A	3	0.8992	100	0.271	Contact Map
4g4sP	1	0.6653	99.9	0.637	Contact Map
4d2uA	3	0.8629	61.8	0.937	Contact Map
1qvrA	3	0.8387	59.1	0.938	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.