GREMLIN Database
Q9HRX4 - Aspartate aminotransferase
UniProt: Q9HRX4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (344)
Sequences: 43499 (30138)
Seq/√Len: 1624.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_V52_E3.2221.00
112_E133_N2.9981.00
71_A274_S2.9141.00
92_T98_A2.7281.00
293_V359_R2.7221.00
288_E292_D2.6471.00
107_V132_G2.6171.00
77_A83_D2.5431.00
176_P180_R2.4761.00
304_D317_T2.4491.00
289_A355_M2.4301.00
151_E188_E2.3351.00
111_D159_A2.3161.00
67_A270_E2.3141.00
242_A247_A2.2741.00
360_D364_V2.2331.00
112_E135_V2.2321.00
41_D45_Q2.1371.00
295_L299_E2.1281.00
175_S178_D2.0931.00
295_L307_T2.0701.00
100_H104_E2.0641.00
117_D136_G2.0011.00
297_G300_A1.9921.00
70_D86_P1.9671.00
71_A74_E1.9531.00
325_E329_R1.9001.00
297_G362_I1.8641.00
297_G301_M1.8291.00
293_V297_G1.7961.00
237_L269_A1.7911.00
297_G366_R1.7701.00
149_T153_H1.7631.00
180_R184_R1.7611.00
66_A70_D1.7541.00
144_T178_D1.7471.00
78_R277_Q1.7431.00
74_E274_S1.7351.00
45_Q49_D1.7341.00
194_I223_V1.7341.00
73_V86_P1.7091.00
146_A149_T1.7081.00
124_D128_R1.6871.00
325_E368_A1.6801.00
151_E181_A1.6801.00
360_D363_D1.6701.00
88_G244_E1.6561.00
71_A270_E1.6481.00
324_D328_D1.6481.00
149_T152_D1.6441.00
44_R48_V1.6401.00
293_V355_M1.6331.00
70_D74_E1.6321.00
127_T132_G1.6231.00
297_G363_D1.6131.00
186_A193_C1.6111.00
262_S265_A1.6061.00
190_D219_N1.6031.00
102_A221_V1.5961.00
124_D136_G1.5901.00
354_D357_T1.5901.00
301_M366_R1.5701.00
49_D271_A1.5671.00
112_E157_D1.5641.00
296_D300_A1.5541.00
198_V225_A1.5481.00
113_V127_T1.5471.00
147_P181_A1.5421.00
299_E305_V1.5381.00
117_D138_P1.5371.00
103_M127_T1.5321.00
102_A194_I1.5161.00
292_D296_D1.5091.00
30_L361_A1.5051.00
181_A184_R1.4981.00
72_I239_W1.4971.00
112_E155_T1.4901.00
45_Q48_V1.4881.00
63_R251_L1.4571.00
240_V250_M1.4551.00
65_T267_Y1.4451.00
295_L305_V1.4401.00
95_G223_V1.4291.00
148_E181_A1.4211.00
178_D181_A1.4141.00
66_A86_P1.4061.00
115_F134_P1.4011.00
176_P209_R1.4001.00
294_L314_A1.3981.00
84_V241_A1.3791.00
297_G359_R1.3761.00
109_P131_G1.3711.00
74_E78_R1.3711.00
300_A366_R1.3711.00
46_A49_D1.3701.00
76_H241_A1.3691.00
226_C269_A1.3681.00
333_V347_A1.3651.00
270_E274_S1.3641.00
46_A271_A1.3591.00
353_T357_T1.3491.00
44_R52_E1.3471.00
281_D285_A1.3411.00
299_E307_T1.3411.00
286_A289_A1.3391.00
295_L314_A1.3141.00
286_A355_M1.3141.00
112_E158_T1.3091.00
317_T346_T1.3021.00
25_E330_G1.3001.00
140_R178_D1.2981.00
317_T345_G1.2971.00
320_D337_S1.2861.00
294_L362_I1.2831.00
47_A268_A1.2761.00
184_R188_E1.2711.00
114_L158_T1.2701.00
47_A51_I1.2681.00
154_I185_I1.2671.00
151_E155_T1.2641.00
104_E130_A1.2641.00
138_P149_T1.2631.00
249_R252_R1.2591.00
186_A191_V1.2581.00
325_E328_D1.2551.00
224_N239_W1.2531.00
85_A88_G1.2531.00
315_M336_G1.2401.00
176_P213_E1.2371.00
329_R367_A1.2341.00
147_P185_I1.2341.00
151_E189_H1.2331.00
67_A274_S1.2321.00
87_A244_E1.2231.00
140_R149_T1.2151.00
357_T360_D1.2091.00
98_A240_V1.2051.00
316_P349_I1.2031.00
185_I189_H1.2011.00
355_M359_R1.2011.00
151_E185_I1.2001.00
301_M363_D1.1941.00
63_R69_V1.1891.00
177_A180_R1.1861.00
67_A267_Y1.1821.00
286_A290_R1.1721.00
103_M107_V1.1711.00
177_A181_A1.1701.00
184_R187_D1.1681.00
359_R363_D1.1631.00
93_A97_E1.1611.00
75_K277_Q1.1561.00
185_I191_V1.1541.00
210_S213_E1.1531.00
271_A274_S1.1511.00
69_V73_V1.1491.00
187_D217_T1.1451.00
108_D111_D1.1451.00
218_D243_S1.1451.00
281_D284_V1.1441.00
321_G325_E1.1431.00
90_I247_A1.1431.00
49_D53_S1.1371.00
291_R351_Y1.1361.00
205_E309_G1.1331.00
271_A275_G1.1321.00
248_E252_R1.1321.00
363_D367_A1.1261.00
293_V296_D1.1081.00
321_G324_D1.1081.00
140_R146_A1.1071.00
114_L137_L1.1071.00
285_A288_E1.1061.00
41_D44_R1.1061.00
329_R364_V1.1031.00
290_R293_V1.1011.00
49_D52_E1.0991.00
187_D216_D1.0971.00
192_L221_V1.0961.00
160_A194_I1.0931.00
103_M162_V1.0901.00
267_Y270_E1.0811.00
221_V242_A1.0801.00
180_R214_F1.0801.00
277_Q281_D1.0761.00
291_R295_L1.0711.00
152_D156_D1.0711.00
42_H45_Q1.0641.00
285_A289_A1.0631.00
105_A253_V1.0531.00
282_E286_A1.0431.00
97_E254_H1.0391.00
72_I91_A1.0341.00
211_P214_F1.0341.00
67_A70_D1.0301.00
326_V333_V1.0281.00
204_F288_E1.0161.00
107_V113_V1.0111.00
68_L91_A1.0071.00
154_I191_V1.0061.00
176_P214_F1.0011.00
26_D330_G0.9991.00
278_G282_E0.9951.00
42_H275_G0.9891.00
254_H258_Q0.9811.00
147_P151_E0.9801.00
37_F286_A0.9791.00
296_D299_E0.9791.00
76_H239_W0.9771.00
187_D218_D0.9751.00
183_A220_V0.9741.00
292_D307_T0.9741.00
85_A244_E0.9721.00
304_D319_P0.9711.00
192_L219_N0.9701.00
155_T158_T0.9641.00
279_V282_E0.9631.00
221_V240_V0.9621.00
323_I333_V0.9621.00
72_I89_V0.9561.00
155_T189_H0.9551.00
187_D219_N0.9551.00
127_T134_P0.9471.00
322_W326_V0.9451.00
137_L153_H0.9421.00
319_P345_G0.9401.00
88_G247_A0.9311.00
148_E152_D0.9301.00
74_E77_A0.9241.00
128_R134_P0.9241.00
73_V89_V0.9221.00
89_V241_A0.9181.00
45_Q52_E0.9181.00
24_G330_G0.9141.00
98_A223_V0.9141.00
101_L254_H0.9131.00
26_D360_D0.9101.00
303_L318_V0.9021.00
73_V85_A0.9001.00
192_L246_R0.8991.00
326_V365_M0.8981.00
318_V347_A0.8941.00
90_I250_M0.8911.00
116_P145_L0.8901.00
289_A293_V0.8861.00
282_E285_A0.8831.00
65_T270_E0.8831.00
106_H192_L0.8821.00
221_V246_R0.8811.00
320_D335_P0.8771.00
278_G281_D0.8761.00
38_P44_R0.8671.00
223_V240_V0.8671.00
247_A251_L0.8671.00
95_G225_A0.8651.00
244_E248_E0.8601.00
148_E151_E0.8581.00
320_D324_D0.8561.00
42_H271_A0.8541.00
56_A267_Y0.8531.00
237_L261_A0.8501.00
242_A250_M0.8451.00
237_L265_A0.8451.00
93_A262_S0.8451.00
114_L153_H0.8441.00
75_K201_H0.8401.00
125_A128_R0.8401.00
290_R354_D0.8391.00
364_V367_A0.8371.00
119_G164_N0.8371.00
147_P182_F0.8341.00
203_V208_H0.8301.00
291_R308_P0.8271.00
292_D295_L0.8241.00
294_L297_G0.8221.00
333_V349_I0.8191.00
279_V283_M0.8191.00
105_A250_M0.8181.00
117_D342_H0.8161.00
66_A69_V0.8101.00
135_V153_H0.8041.00
65_T266_Q0.8031.00
211_P220_V0.8011.00
88_G217_T0.7981.00
114_L150_V0.7981.00
147_P178_D0.7961.00
301_M362_I0.7921.00
212_M215_A0.7901.00
183_A193_C0.7881.00
46_A50_A0.7881.00
116_P137_L0.7791.00
69_V86_P0.7731.00
96_S122_S0.7711.00
203_V206_G0.7711.00
44_R51_I0.7711.00
324_D327_V0.7651.00
323_I335_P0.7651.00
42_H279_V0.7621.00
201_H229_T0.7591.00
296_D359_R0.7581.00
167_A170_T0.7581.00
50_A53_S0.7551.00
294_L351_Y0.7541.00
95_G198_V0.7521.00
100_H130_A0.7511.00
315_M346_T0.7511.00
90_I240_V0.7501.00
139_L167_A0.7471.00
280_V284_V0.7461.00
289_A292_D0.7461.00
97_E258_Q0.7411.00
104_E253_V0.7381.00
144_T175_S0.7371.00
303_L316_P0.7341.00
208_H212_M0.7331.00
322_W347_A0.7321.00
336_G339_F0.7321.00
97_E101_L0.7321.00
26_D357_T0.7291.00
331_V365_M0.7291.00
327_V332_V0.7271.00
75_K80_Q0.7261.00
349_I361_A0.7221.00
363_D366_R0.7221.00
212_M222_V0.7211.00
101_L250_M0.7211.00
154_I189_H0.7161.00
158_T191_V0.7131.00
137_L149_T0.7101.00
193_C211_P0.7091.00
291_R307_T0.7081.00
251_L254_H0.7081.00
117_D340_G0.7081.00
140_R144_T0.7041.00
263_A267_Y0.7041.00
100_H257_V0.7011.00
288_E291_R0.6961.00
47_A264_P0.6951.00
331_V364_V0.6941.00
267_Y271_A0.6941.00
73_V84_V0.6931.00
284_V288_E0.6921.00
195_S211_P0.6921.00
71_A273_L0.6881.00
248_E251_L0.6871.00
245_R248_E0.6861.00
102_A250_M0.6861.00
229_T280_V0.6851.00
61_S66_A0.6801.00
356_A359_R0.6791.00
283_M287_F0.6771.00
208_H213_E0.6771.00
326_V368_A0.6711.00
174_Q178_D0.6711.00
150_V185_I0.6681.00
141_D304_D0.6661.00
145_L178_D0.6661.00
107_V111_D0.6661.00
154_I158_T0.6641.00
161_F191_V0.6641.00
209_R214_F0.6631.00
50_A271_A0.6601.00
302_G319_P0.6601.00
39_T42_H0.6591.00
205_E288_E0.6571.00
113_V132_G0.6531.00
106_H160_A0.6531.00
186_A190_D0.6511.00
290_R355_M0.6511.00
209_R213_E0.6501.00
242_A246_R0.6481.00
322_W368_A0.6471.00
323_I327_V0.6461.00
163_V179_M0.6441.00
211_P215_A0.6441.00
197_E222_V0.6421.00
115_F127_T0.6421.00
35_P287_F0.6391.00
200_E224_N0.6371.00
107_V160_A0.6371.00
176_P207_E0.6371.00
110_G133_N0.6331.00
30_L358_L0.6301.00
27_A332_V0.6301.00
44_R47_A0.6281.00
174_Q179_M0.6261.00
268_A271_A0.6261.00
152_D155_T0.6251.00
226_C239_W0.6241.00
68_L269_A0.6241.00
115_F136_G0.6231.00
116_P167_A0.6231.00
298_L316_P0.6211.00
135_V155_T0.6211.00
39_T43_A0.6211.00
70_D73_V0.6201.00
75_K230_Y0.6191.00
80_Q200_E0.6181.00
92_T240_V0.6181.00
294_L358_L0.6171.00
202_I287_F0.6161.00
172_A309_G0.6161.00
100_H126_L0.6161.00
64_G69_V0.6151.00
316_P346_T0.6151.00
90_I251_L0.6111.00
39_T44_R0.6111.00
60_T65_T0.6101.00
112_E159_A0.6081.00
141_D317_T0.6081.00
155_T188_E0.6061.00
293_V362_I0.6051.00
243_S246_R0.6021.00
144_T172_A0.6021.00
165_S197_E0.6001.00
204_F291_R0.6001.00
90_I242_A0.5991.00
48_V51_I0.5971.00
173_V203_V0.5971.00
283_M286_A0.5961.00
105_A249_R0.5951.00
181_A185_I0.5941.00
94_G236_R0.5921.00
50_A267_Y0.5921.00
226_C273_L0.5901.00
99_L126_L0.5901.00
28_I360_D0.5891.00
103_M130_A0.5891.00
69_V251_L0.5891.00
266_Q270_E0.5891.00
50_A268_A0.5891.00
76_H222_V0.5861.00
138_P153_H0.5861.00
300_A359_R0.5861.00
197_E200_E0.5851.00
218_D245_R0.5851.00
41_D52_E0.5851.00
103_M132_G0.5831.00
123_Y127_T0.5821.00
91_A237_L0.5821.00
67_A71_A0.5801.00
141_D306_P0.5781.00
153_H156_D0.5761.00
138_P146_A0.5761.00
145_L150_V0.5741.00
42_H278_G0.5731.00
24_G27_A0.5731.00
217_T220_V0.5731.00
331_V361_A0.5721.00
354_D359_R0.5721.00
103_M126_L0.5661.00
113_V160_A0.5631.00
360_D367_A0.5621.00
166_P310_G0.5611.00
101_L253_V0.5601.00
93_A261_A0.5591.00
123_Y161_F0.5581.00
53_S56_A0.5571.00
322_W327_V0.5561.00
230_Y277_Q0.5551.00
71_A75_K0.5531.00
82_V212_M0.5531.00
329_R368_A0.5511.00
323_I347_A0.5511.00
136_G341_D0.5491.00
121_V338_A0.5491.00
135_V158_T0.5481.00
96_S120_F0.5481.00
37_F40_P0.5481.00
305_V314_A0.5471.00
68_L270_E0.5451.00
358_L361_A0.5451.00
60_T263_A0.5431.00
36_D290_R0.5421.00
337_S344_A0.5421.00
165_S173_V0.5411.00
68_L72_I0.5411.00
40_P43_A0.5411.00
162_V194_I0.5401.00
197_E210_S0.5391.00
210_S214_F0.5391.00
336_G346_T0.5381.00
364_V368_A0.5381.00
151_E154_I0.5331.00
137_L145_L0.5311.00
65_T263_A0.5301.00
98_A238_G0.5281.00
46_A268_A0.5281.00
29_N34_Q0.5281.00
261_A266_Q0.5281.00
205_E291_R0.5271.00
199_Y313_Y0.5271.00
183_A187_D0.5271.00
43_A272_A0.5261.00
186_A219_N0.5261.00
277_Q280_V0.5261.00
254_H261_A0.5251.00
115_F124_D0.5251.00
43_A232_M0.5201.00
306_P317_T0.5201.00
117_D124_D0.5181.00
84_V88_G0.5171.00
77_A82_V0.5151.00
72_I226_C0.5151.00
31_G332_V0.5141.00
245_R249_R0.5131.00
116_P139_L0.5111.00
34_Q58_G0.5101.00
47_A50_A0.5081.00
204_F287_F0.5081.00
215_A218_D0.5061.00
265_A268_A0.5051.00
75_K200_E0.5051.00
294_L349_I0.5041.00
202_I284_V0.5031.00
102_A223_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x5dA 3 0.9625 100 0.283 Contact Map
2douA 2 0.9786 100 0.284 Contact Map
1gd9A 2 0.992 100 0.287 Contact Map
2o1bA 2 0.9759 100 0.289 Contact Map
3dydA 2 0.9517 100 0.291 Contact Map
1yizA 2 0.9893 100 0.291 Contact Map
1vp4A 2 0.9946 100 0.292 Contact Map
4my5A 2 0.9946 100 0.292 Contact Map
1b5pA 2 0.9786 100 0.293 Contact Map
3e2yA 2 0.9812 100 0.295 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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