Q9HRX3 - HALSA - GREMLIN Contacts

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Q9HRX3 - Uncharacterized protein

UniProt:	Q9HRX3	Sequences: MTDWQADDVVAAQYADGGLLAARRALDARFGTGERSHYEWLFDHLDLGPDAAVLSLGAGHGAFWGANADRVPDGWDVTVTDAFQGVTADAMDALADAPHEFTFDVVDARDIPYPADTFDAVTAHHVLAHLGDADRRQALAEIARVLTPTGELHAATSGDDALTELWAVARDHGDVPDERPFTLQNGAAQLRDRFAAVERRRLDAPLVVDAPEPLVAYVLSLPGFDPEAGPALERAFRARFVDGTLTVTGDRGVLIARHPDTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	262 (218)
Sequences:	13829 (10653)
Seq/√Len:	721.5

ECOLI - BIOC TAM YJHP UBIE SMTA UBIG CMOA TEHB YAFE RLMA CMOB
BACSU - YCGJ YODH YBAJ MENG YXBB YQEM YRRT YXJB YRHH YDAC
HALSA - Q9HRX3 Q9HR63 ARSM Q9HMT2 Q9HND6 Q9HR81 Q9HSK6 Q9HQ85
SULSO - Q97WH3 Q97XD7 Q7LXN7 Q97ZU8 Q97WT7 Q97X57 Q97WN4 Q97YX4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
52_A	76_D	3.550	1.00
76_D	102_T	2.887	1.00
141_E	144_R	2.755	1.00
142_I	152_L	2.638	1.00
84_Q	105_V	2.636	1.00
143_A	194_F	2.606	1.00
90_A	103_F	2.356	1.00
78_T	118_F	2.338	1.00
64_W	77_V	2.329	1.00
80_T	106_V	2.324	1.00
87_T	103_F	2.323	1.00
119_D	147_T	2.318	1.00
54_L	118_F	2.301	1.00
146_L	150_G	2.290	1.00
113_Y	118_F	2.280	1.00
84_Q	88_A	2.251	1.00
58_A	79_V	2.237	1.00
87_T	105_V	2.189	1.00
121_V	142_I	2.185	1.00
78_T	104_D	2.139	1.00
51_A	120_A	2.074	1.00
69_D	97_A	2.045	1.00
187_A	191_R	1.953	1.00
89_D	92_D	1.949	1.00
225_D	229_G	1.931	1.00
121_V	146_L	1.930	1.00
58_A	64_W	1.907	1.00
52_A	78_T	1.822	1.00
53_V	67_N	1.814	1.00
87_T	91_M	1.807	1.00
65_G	93_A	1.806	1.00
57_G	126_V	1.798	1.00
132_D	137_Q	1.781	1.00
123_A	126_V	1.760	1.00
146_L	152_L	1.742	1.00
108_A	130_L	1.723	1.00
232_L	236_F	1.660	1.00
65_G	94_L	1.650	1.00
141_E	145_V	1.634	1.00
134_D	192_D	1.581	1.00
48_G	51_A	1.575	1.00
210_A	213_P	1.552	1.00
56_L	108_A	1.536	1.00
188_A	192_D	1.533	1.00
24_R	27_D	1.517	1.00
55_S	79_V	1.506	1.00
39_E	66_A	1.506	1.00
81_D	87_T	1.488	1.00
130_L	138_A	1.434	1.00
233_E	237_R	1.429	1.00
237_R	241_V	1.420	1.00
52_A	147_T	1.413	1.00
39_E	43_D	1.385	1.00
94_L	103_F	1.374	1.00
115_A	144_R	1.373	1.00
78_T	102_T	1.364	1.00
40_W	44_H	1.361	1.00
114_P	117_T	1.354	1.00
53_V	120_A	1.316	1.00
92_D	96_D	1.312	1.00
58_A	90_A	1.308	1.00
224_F	229_G	1.306	1.00
88_A	91_M	1.303	1.00
56_L	142_I	1.297	1.00
40_W	43_D	1.294	1.00
51_A	75_W	1.285	1.00
68_A	100_E	1.263	1.00
188_A	191_R	1.258	1.00
168_V	173_G	1.247	1.00
79_V	103_F	1.245	1.00
138_A	142_I	1.241	1.00
236_F	240_F	1.239	1.00
225_D	228_A	1.237	1.00
182_T	185_N	1.222	1.00
214_L	217_Y	1.220	1.00
168_V	172_H	1.218	1.00
106_V	112_P	1.218	1.00
72_P	75_W	1.217	1.00
44_H	200_R	1.208	1.00
166_W	170_R	1.203	1.00
52_A	118_F	1.193	1.00
169_A	173_G	1.175	1.00
66_A	69_D	1.173	1.00
63_F	124_H	1.164	1.00
23_R	26_L	1.155	1.00
65_G	69_D	1.150	1.00
214_L	218_V	1.147	1.00
107_D	110_D	1.146	1.00
137_Q	140_A	1.139	1.00
63_F	122_T	1.138	1.00
88_A	92_D	1.132	1.00
64_W	79_V	1.129	1.00
121_V	145_V	1.123	1.00
220_S	223_G	1.115	1.00
233_E	236_F	1.108	1.00
134_D	189_Q	1.104	1.00
54_L	121_V	1.102	1.00
226_P	229_G	1.096	1.00
126_V	130_L	1.086	1.00
66_A	70_R	1.081	1.00
41_L	153_H	1.075	1.00
57_G	123_A	1.074	1.00
65_G	97_A	1.073	1.00
111_I	145_V	1.067	1.00
165_L	168_V	1.055	1.00
94_L	101_F	1.048	1.00
213_P	216_A	1.048	1.00
82_A	107_D	1.037	1.00
165_L	169_A	1.034	1.00
234_R	238_A	1.031	1.00
43_D	70_R	1.028	1.00
235_A	239_R	1.025	1.00
140_A	193_R	1.022	1.00
124_H	155_A	1.022	1.00
142_I	146_L	1.021	1.00
165_L	172_H	1.020	1.00
187_A	199_R	1.012	1.00
52_A	117_T	1.011	1.00
137_Q	141_E	1.009	1.00
85_G	88_A	1.007	1.00
134_D	140_A	1.006	1.00
224_F	228_A	0.994	1.00
134_D	137_Q	0.992	1.00
111_I	141_E	0.978	1.00
211_P	214_L	0.977	1.00
79_V	90_A	0.972	1.00
68_A	101_F	0.965	1.00
44_H	198_E	0.955	1.00
231_A	235_A	0.954	1.00
146_L	194_F	0.950	1.00
41_L	124_H	0.945	1.00
217_Y	221_L	0.944	1.00
167_A	170_R	0.940	1.00
28_A	60_H	0.935	1.00
36_S	39_E	0.935	1.00
108_A	126_V	0.928	1.00
47_L	51_A	0.914	1.00
89_D	93_A	0.909	1.00
237_R	240_F	0.903	1.00
236_F	239_R	0.902	1.00
224_F	227_E	0.894	1.00
163_T	166_W	0.885	1.00
210_A	214_L	0.883	1.00
117_T	147_T	0.882	1.00
92_D	95_A	0.879	1.00
217_Y	220_S	0.874	1.00
170_R	173_G	0.867	1.00
34_E	37_H	0.866	1.00
112_P	141_E	0.864	1.00
166_W	169_A	0.863	1.00
53_V	122_T	0.862	1.00
213_P	217_Y	0.860	1.00
67_N	122_T	0.860	1.00
167_A	171_D	0.859	1.00
29_R	32_T	0.855	1.00
211_P	215_V	0.855	1.00
232_L	240_F	0.854	1.00
125_H	157_S	0.852	1.00
234_R	237_R	0.847	1.00
23_R	27_D	0.847	1.00
238_A	241_V	0.845	1.00
25_A	89_D	0.844	1.00
215_V	219_L	0.843	1.00
127_L	154_A	0.835	1.00
164_E	168_V	0.826	1.00
35_R	39_E	0.825	1.00
45_L	153_H	0.824	1.00
168_V	171_D	0.823	1.00
38_Y	63_F	0.822	1.00
209_D	213_P	0.819	1.00
164_E	167_A	0.815	1.00
51_A	147_T	0.815	1.00
39_E	70_R	0.814	1.00
93_A	97_A	0.814	1.00
216_A	219_L	0.810	1.00
93_A	96_D	0.803	1.00
221_L	224_F	0.802	1.00
60_H	86_V	0.802	1.00
51_A	119_D	0.799	1.00
162_L	165_L	0.794	1.00
226_P	230_P	0.793	1.00
80_T	111_I	0.785	1.00
106_V	111_I	0.779	1.00
50_D	53_V	0.775	1.00
235_A	238_A	0.775	1.00
40_W	202_L	0.769	1.00
183_L	187_A	0.765	1.00
115_A	141_E	0.763	1.00
109_R	137_Q	0.761	1.00
123_A	138_A	0.761	1.00
140_A	144_R	0.758	1.00
47_L	50_D	0.757	1.00
52_A	119_D	0.756	1.00
55_S	122_T	0.755	1.00
127_L	156_T	0.749	1.00
163_T	167_A	0.741	1.00
104_D	113_Y	0.741	1.00
165_L	173_G	0.734	1.00
165_L	171_D	0.734	1.00
139_L	190_L	0.732	1.00
232_L	235_A	0.726	1.00
225_D	230_P	0.723	1.00
185_N	189_Q	0.718	1.00
113_Y	117_T	0.717	1.00
80_T	104_D	0.713	1.00
232_L	237_R	0.712	1.00
109_R	131_G	0.712	1.00
31_G	34_E	0.712	1.00
211_P	217_Y	0.711	1.00
162_L	168_V	0.704	1.00
185_N	188_A	0.698	1.00
171_D	174_D	0.698	1.00
58_A	81_D	0.697	1.00
143_A	193_R	0.692	1.00
53_V	77_V	0.691	1.00
212_E	217_Y	0.690	1.00
42_F	70_R	0.689	1.00
211_P	218_V	0.685	1.00
166_W	173_G	0.680	1.00
94_L	97_A	0.677	1.00
133_A	189_Q	0.676	1.00
40_W	200_R	0.674	1.00
222_P	225_D	0.673	1.00
54_L	145_V	0.673	1.00
81_D	86_V	0.670	1.00
55_S	77_V	0.670	1.00
21_A	24_R	0.667	1.00
218_V	222_P	0.665	1.00
117_T	145_V	0.664	1.00
83_F	86_V	0.659	1.00
118_F	145_V	0.659	1.00
24_R	28_A	0.657	1.00
163_T	172_H	0.656	1.00
64_W	103_F	0.655	1.00
81_D	105_V	0.655	1.00
184_Q	187_A	0.654	1.00
175_V	178_E	0.650	1.00
27_D	31_G	0.650	1.00
169_A	172_H	0.649	1.00
210_A	216_A	0.649	1.00
178_E	181_F	0.648	1.00
36_S	40_W	0.645	1.00
38_Y	66_A	0.644	1.00
76_D	100_E	0.643	1.00
164_E	173_G	0.642	1.00
217_Y	222_P	0.638	1.00
120_A	151_E	0.636	1.00
110_D	137_Q	0.635	1.00
166_W	171_D	0.635	1.00
54_L	80_T	0.631	1.00
27_D	30_F	0.629	1.00
177_D	181_F	0.626	1.00
232_L	239_R	0.626	1.00
64_W	101_F	0.624	1.00
125_H	128_A	0.623	1.00
162_L	166_W	0.623	1.00
219_L	223_G	0.620	1.00
65_G	68_A	0.617	1.00
144_R	147_T	0.617	1.00
26_L	29_R	0.617	1.00
110_D	141_E	0.616	1.00
24_R	31_G	0.615	1.00
28_A	93_A	0.615	1.00
61_G	90_A	0.611	1.00
164_E	172_H	0.605	1.00
91_M	95_A	0.601	1.00
108_A	138_A	0.600	1.00
229_G	232_L	0.598	1.00
50_D	75_W	0.598	1.00
162_L	169_A	0.595	1.00
210_A	219_L	0.590	1.00
42_F	66_A	0.587	1.00
229_G	233_E	0.583	1.00
55_S	80_T	0.582	1.00
123_A	130_L	0.582	1.00
162_L	172_H	0.581	1.00
117_T	144_R	0.578	1.00
49_P	74_G	0.576	1.00
233_E	239_R	0.570	1.00
228_A	232_L	0.569	1.00
21_A	85_G	0.567	1.00
190_L	193_R	0.566	1.00
164_E	171_D	0.565	1.00
23_R	31_G	0.564	1.00
212_E	216_A	0.564	1.00
186_G	189_Q	0.562	1.00
57_G	130_L	0.561	1.00
50_D	74_G	0.560	1.00
78_T	113_Y	0.556	1.00
58_A	80_T	0.555	1.00
210_A	217_Y	0.554	1.00
113_Y	145_V	0.553	1.00
177_D	180_P	0.546	1.00
87_T	90_A	0.544	1.00
221_L	225_D	0.543	1.00
38_Y	42_F	0.541	1.00
224_F	230_P	0.539	1.00
152_L	190_L	0.538	1.00
33_G	38_Y	0.537	1.00
109_R	132_D	0.536	1.00
216_A	220_S	0.532	1.00
183_L	201_R	0.527	1.00
91_M	102_T	0.527	1.00
176_P	179_R	0.525	1.00
236_F	241_V	0.524	1.00
123_A	154_A	0.524	1.00
63_F	66_A	0.522	1.00
163_T	169_A	0.522	1.00
208_V	217_Y	0.521	1.00
84_Q	91_M	0.521	1.00
26_L	30_F	0.519	1.00
190_L	194_F	0.517	1.00
42_F	67_N	0.516	1.00
162_L	167_A	0.513	1.00
170_R	174_D	0.513	1.00
23_R	28_A	0.510	1.00
56_L	138_A	0.510	1.00
214_L	221_L	0.510	1.00
109_R	130_L	0.509	1.00
233_E	240_F	0.508	1.00
207_V	210_A	0.507	1.00
183_L	186_G	0.506	0.99
42_F	45_L	0.505	0.99
205_P	209_D	0.504	0.99
63_F	67_N	0.501	0.99
21_A	83_F	0.500	0.99
184_Q	188_A	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2p35A	2	0.8588	100	0.421	Contact Map
1vl5A	1	0.8435	100	0.429	Contact Map
3ccfA	1	0.8435	100	0.433	Contact Map
2yqzA	1	0.9008	100	0.434	Contact Map
3g5tA	1	0.9237	100	0.448	Contact Map
2o57A	2	0.9656	100	0.451	Contact Map
4pneA	2	0.9275	100	0.457	Contact Map
3ujcA	1	0.9275	100	0.459	Contact Map
1xxlA	1	0.8511	100	0.461	Contact Map
4kriA	1	0.9504	100	0.467	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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