GREMLIN Database
Q9HRX3 - Uncharacterized protein
UniProt: Q9HRX3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (218)
Sequences: 13829 (10653)
Seq/√Len: 721.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_A76_D3.5501.00
76_D102_T2.8871.00
141_E144_R2.7551.00
142_I152_L2.6381.00
84_Q105_V2.6361.00
143_A194_F2.6061.00
90_A103_F2.3561.00
78_T118_F2.3381.00
64_W77_V2.3291.00
80_T106_V2.3241.00
87_T103_F2.3231.00
119_D147_T2.3181.00
54_L118_F2.3011.00
146_L150_G2.2901.00
113_Y118_F2.2801.00
84_Q88_A2.2511.00
58_A79_V2.2371.00
87_T105_V2.1891.00
121_V142_I2.1851.00
78_T104_D2.1391.00
51_A120_A2.0741.00
69_D97_A2.0451.00
187_A191_R1.9531.00
89_D92_D1.9491.00
225_D229_G1.9311.00
121_V146_L1.9301.00
58_A64_W1.9071.00
52_A78_T1.8221.00
53_V67_N1.8141.00
87_T91_M1.8071.00
65_G93_A1.8061.00
57_G126_V1.7981.00
132_D137_Q1.7811.00
123_A126_V1.7601.00
146_L152_L1.7421.00
108_A130_L1.7231.00
232_L236_F1.6601.00
65_G94_L1.6501.00
141_E145_V1.6341.00
134_D192_D1.5811.00
48_G51_A1.5751.00
210_A213_P1.5521.00
56_L108_A1.5361.00
188_A192_D1.5331.00
24_R27_D1.5171.00
55_S79_V1.5061.00
39_E66_A1.5061.00
81_D87_T1.4881.00
130_L138_A1.4341.00
233_E237_R1.4291.00
237_R241_V1.4201.00
52_A147_T1.4131.00
39_E43_D1.3851.00
94_L103_F1.3741.00
115_A144_R1.3731.00
78_T102_T1.3641.00
40_W44_H1.3611.00
114_P117_T1.3541.00
53_V120_A1.3161.00
92_D96_D1.3121.00
58_A90_A1.3081.00
224_F229_G1.3061.00
88_A91_M1.3031.00
56_L142_I1.2971.00
40_W43_D1.2941.00
51_A75_W1.2851.00
68_A100_E1.2631.00
188_A191_R1.2581.00
168_V173_G1.2471.00
79_V103_F1.2451.00
138_A142_I1.2411.00
236_F240_F1.2391.00
225_D228_A1.2371.00
182_T185_N1.2221.00
214_L217_Y1.2201.00
168_V172_H1.2181.00
106_V112_P1.2181.00
72_P75_W1.2171.00
44_H200_R1.2081.00
166_W170_R1.2031.00
52_A118_F1.1931.00
169_A173_G1.1751.00
66_A69_D1.1731.00
63_F124_H1.1641.00
23_R26_L1.1551.00
65_G69_D1.1501.00
214_L218_V1.1471.00
107_D110_D1.1461.00
137_Q140_A1.1391.00
63_F122_T1.1381.00
88_A92_D1.1321.00
64_W79_V1.1291.00
121_V145_V1.1231.00
220_S223_G1.1151.00
233_E236_F1.1081.00
134_D189_Q1.1041.00
54_L121_V1.1021.00
226_P229_G1.0961.00
126_V130_L1.0861.00
66_A70_R1.0811.00
41_L153_H1.0751.00
57_G123_A1.0741.00
65_G97_A1.0731.00
111_I145_V1.0671.00
165_L168_V1.0551.00
94_L101_F1.0481.00
213_P216_A1.0481.00
82_A107_D1.0371.00
165_L169_A1.0341.00
234_R238_A1.0311.00
43_D70_R1.0281.00
235_A239_R1.0251.00
140_A193_R1.0221.00
124_H155_A1.0221.00
142_I146_L1.0211.00
165_L172_H1.0201.00
187_A199_R1.0121.00
52_A117_T1.0111.00
137_Q141_E1.0091.00
85_G88_A1.0071.00
134_D140_A1.0061.00
224_F228_A0.9941.00
134_D137_Q0.9921.00
111_I141_E0.9781.00
211_P214_L0.9771.00
79_V90_A0.9721.00
68_A101_F0.9651.00
44_H198_E0.9551.00
231_A235_A0.9541.00
146_L194_F0.9501.00
41_L124_H0.9451.00
217_Y221_L0.9441.00
167_A170_R0.9401.00
28_A60_H0.9351.00
36_S39_E0.9351.00
108_A126_V0.9281.00
47_L51_A0.9141.00
89_D93_A0.9091.00
237_R240_F0.9031.00
236_F239_R0.9021.00
224_F227_E0.8941.00
163_T166_W0.8851.00
210_A214_L0.8831.00
117_T147_T0.8821.00
92_D95_A0.8791.00
217_Y220_S0.8741.00
170_R173_G0.8671.00
34_E37_H0.8661.00
112_P141_E0.8641.00
166_W169_A0.8631.00
53_V122_T0.8621.00
213_P217_Y0.8601.00
67_N122_T0.8601.00
167_A171_D0.8591.00
29_R32_T0.8551.00
211_P215_V0.8551.00
232_L240_F0.8541.00
125_H157_S0.8521.00
234_R237_R0.8471.00
23_R27_D0.8471.00
238_A241_V0.8451.00
25_A89_D0.8441.00
215_V219_L0.8431.00
127_L154_A0.8351.00
164_E168_V0.8261.00
35_R39_E0.8251.00
45_L153_H0.8241.00
168_V171_D0.8231.00
38_Y63_F0.8221.00
209_D213_P0.8191.00
164_E167_A0.8151.00
51_A147_T0.8151.00
39_E70_R0.8141.00
93_A97_A0.8141.00
216_A219_L0.8101.00
93_A96_D0.8031.00
221_L224_F0.8021.00
60_H86_V0.8021.00
51_A119_D0.7991.00
162_L165_L0.7941.00
226_P230_P0.7931.00
80_T111_I0.7851.00
106_V111_I0.7791.00
50_D53_V0.7751.00
235_A238_A0.7751.00
40_W202_L0.7691.00
183_L187_A0.7651.00
115_A141_E0.7631.00
109_R137_Q0.7611.00
123_A138_A0.7611.00
140_A144_R0.7581.00
47_L50_D0.7571.00
52_A119_D0.7561.00
55_S122_T0.7551.00
127_L156_T0.7491.00
163_T167_A0.7411.00
104_D113_Y0.7411.00
165_L173_G0.7341.00
165_L171_D0.7341.00
139_L190_L0.7321.00
232_L235_A0.7261.00
225_D230_P0.7231.00
185_N189_Q0.7181.00
113_Y117_T0.7171.00
80_T104_D0.7131.00
232_L237_R0.7121.00
109_R131_G0.7121.00
31_G34_E0.7121.00
211_P217_Y0.7111.00
162_L168_V0.7041.00
185_N188_A0.6981.00
171_D174_D0.6981.00
58_A81_D0.6971.00
143_A193_R0.6921.00
53_V77_V0.6911.00
212_E217_Y0.6901.00
42_F70_R0.6891.00
211_P218_V0.6851.00
166_W173_G0.6801.00
94_L97_A0.6771.00
133_A189_Q0.6761.00
40_W200_R0.6741.00
222_P225_D0.6731.00
54_L145_V0.6731.00
81_D86_V0.6701.00
55_S77_V0.6701.00
21_A24_R0.6671.00
218_V222_P0.6651.00
117_T145_V0.6641.00
83_F86_V0.6591.00
118_F145_V0.6591.00
24_R28_A0.6571.00
163_T172_H0.6561.00
64_W103_F0.6551.00
81_D105_V0.6551.00
184_Q187_A0.6541.00
175_V178_E0.6501.00
27_D31_G0.6501.00
169_A172_H0.6491.00
210_A216_A0.6491.00
178_E181_F0.6481.00
36_S40_W0.6451.00
38_Y66_A0.6441.00
76_D100_E0.6431.00
164_E173_G0.6421.00
217_Y222_P0.6381.00
120_A151_E0.6361.00
110_D137_Q0.6351.00
166_W171_D0.6351.00
54_L80_T0.6311.00
27_D30_F0.6291.00
177_D181_F0.6261.00
232_L239_R0.6261.00
64_W101_F0.6241.00
125_H128_A0.6231.00
162_L166_W0.6231.00
219_L223_G0.6201.00
65_G68_A0.6171.00
144_R147_T0.6171.00
26_L29_R0.6171.00
110_D141_E0.6161.00
24_R31_G0.6151.00
28_A93_A0.6151.00
61_G90_A0.6111.00
164_E172_H0.6051.00
91_M95_A0.6011.00
108_A138_A0.6001.00
229_G232_L0.5981.00
50_D75_W0.5981.00
162_L169_A0.5951.00
210_A219_L0.5901.00
42_F66_A0.5871.00
229_G233_E0.5831.00
55_S80_T0.5821.00
123_A130_L0.5821.00
162_L172_H0.5811.00
117_T144_R0.5781.00
49_P74_G0.5761.00
233_E239_R0.5701.00
228_A232_L0.5691.00
21_A85_G0.5671.00
190_L193_R0.5661.00
164_E171_D0.5651.00
23_R31_G0.5641.00
212_E216_A0.5641.00
186_G189_Q0.5621.00
57_G130_L0.5611.00
50_D74_G0.5601.00
78_T113_Y0.5561.00
58_A80_T0.5551.00
210_A217_Y0.5541.00
113_Y145_V0.5531.00
177_D180_P0.5461.00
87_T90_A0.5441.00
221_L225_D0.5431.00
38_Y42_F0.5411.00
224_F230_P0.5391.00
152_L190_L0.5381.00
33_G38_Y0.5371.00
109_R132_D0.5361.00
216_A220_S0.5321.00
183_L201_R0.5271.00
91_M102_T0.5271.00
176_P179_R0.5251.00
236_F241_V0.5241.00
123_A154_A0.5241.00
63_F66_A0.5221.00
163_T169_A0.5221.00
208_V217_Y0.5211.00
84_Q91_M0.5211.00
26_L30_F0.5191.00
190_L194_F0.5171.00
42_F67_N0.5161.00
162_L167_A0.5131.00
170_R174_D0.5131.00
23_R28_A0.5101.00
56_L138_A0.5101.00
214_L221_L0.5101.00
109_R130_L0.5091.00
233_E240_F0.5081.00
207_V210_A0.5071.00
183_L186_G0.5060.99
42_F45_L0.5050.99
205_P209_D0.5040.99
63_F67_N0.5010.99
21_A83_F0.5000.99
184_Q188_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p35A 2 0.8588 100 0.421 Contact Map
1vl5A 1 0.8435 100 0.429 Contact Map
3ccfA 1 0.8435 100 0.433 Contact Map
2yqzA 1 0.9008 100 0.434 Contact Map
3g5tA 1 0.9237 100 0.448 Contact Map
2o57A 2 0.9656 100 0.451 Contact Map
4pneA 2 0.9275 100 0.457 Contact Map
3ujcA 1 0.9275 100 0.459 Contact Map
1xxlA 1 0.8511 100 0.461 Contact Map
4kriA 1 0.9504 100 0.467 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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