GREMLIN Database
Q9HRX2 - GTP-binding protein homolog
UniProt: Q9HRX2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (384)
Sequences: 373 (253)
Seq/√Len: 12.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_V221_V5.6621.00
352_Y359_G5.6031.00
345_S349_D5.3521.00
83_G86_E4.5171.00
317_T338_A4.3221.00
17_F21_A3.9270.99
307_Y311_D3.5880.99
36_I78_A3.4260.99
221_V246_A3.3580.98
96_D99_S3.2670.98
293_M298_G3.2150.98
115_N119_E3.1670.98
106_N131_D3.1560.97
257_G282_Q3.1010.97
329_D333_T2.9270.96
271_D290_R2.9260.96
341_L345_S2.7450.94
352_Y360_D2.6450.93
314_E343_A2.5550.92
10_P31_Y2.5540.92
5_A16_T2.5190.91
200_S203_D2.5030.91
105_V246_A2.4470.90
10_P15_S2.4440.90
45_V305_L2.3800.88
272_F286_L2.3710.88
148_E201_G2.3710.88
19_T256_R2.3290.87
364_H373_E2.3100.87
8_G14_K2.2830.86
8_G13_G2.2830.86
26_V39_N2.2820.86
350_L380_L2.2220.85
31_Y34_T2.1920.84
126_H131_D2.1860.84
77_V98_L2.1440.82
140_D212_R2.0710.80
5_A347_P2.0690.80
287_E290_R1.9770.77
229_P232_N1.9560.76
20_A41_G1.9170.74
358_I390_S1.9150.74
207_L360_D1.8670.72
316_V380_L1.8620.72
367_N378_D1.8480.71
88_R311_D1.8350.71
52_L385_V1.8280.71
140_D209_R1.8180.70
97_E104_I1.8160.70
5_A18_Y1.8120.70
169_I183_V1.7890.69
107_V246_A1.7820.69
8_G15_S1.7660.68
63_C68_R1.7540.67
4_I103_V1.7540.67
103_V308_A1.7470.67
49_C63_C1.7440.67
7_A12_A1.7280.66
347_P362_Y1.6830.64
108_V147_V1.6810.64
363_L373_E1.6780.64
361_G390_S1.6680.63
189_E214_R1.6480.62
362_Y365_A1.6460.62
265_Y268_G1.6460.62
110_A368_A1.6410.62
7_A104_I1.6400.62
263_L293_M1.6270.61
21_A74_L1.6200.61
55_E58_C1.5940.60
201_G357_D1.5930.60
107_V221_V1.5800.59
80_L92_N1.5310.56
54_R368_A1.5220.56
108_V372_R1.5030.55
378_D384_D1.5020.55
262_F285_A1.5020.55
230_E295_E1.5010.55
367_N370_T1.4980.55
70_V385_V1.4940.54
256_R315_M1.4880.54
356_S359_G1.4840.54
316_V344_G1.4780.54
372_R381_G1.4530.52
341_L349_D1.4320.51
67_K305_L1.4050.50
5_A385_V1.4050.50
10_P51_C1.3930.49
150_N172_M1.3650.48
282_Q286_L1.3640.48
132_I221_V1.3620.48
225_V233_V1.3470.47
10_P14_K1.3310.46
10_P13_G1.3310.46
332_G335_L1.3300.46
202_E311_D1.3290.46
279_G282_Q1.3240.46
378_D386_V1.3220.46
26_V107_V1.3050.45
78_A82_P1.2980.44
34_T66_G1.2920.44
307_Y312_L1.2880.44
37_D284_E1.2850.44
116_E304_A1.2810.43
329_D336_P1.2710.43
317_T382_E1.2610.42
203_D231_E1.2610.42
78_A97_E1.2600.42
306_D319_F1.2590.42
19_T104_I1.2500.42
82_P135_V1.2480.42
37_D145_G1.2470.42
104_I192_Y1.2400.41
264_D273_D1.2400.41
46_R269_D1.2350.41
12_A174_T1.2310.41
54_R327_W1.2230.41
271_D287_E1.2220.40
305_L364_H1.2190.40
16_T20_A1.2150.40
53_T378_D1.2050.40
135_V172_M1.2020.39
341_L353_A1.2010.39
170_T183_V1.2000.39
10_P34_T1.1950.39
347_P376_E1.1890.39
8_G11_N1.1880.39
11_N14_K1.1880.39
369_K389_V1.1840.39
265_Y272_F1.1740.38
82_P134_F1.1680.38
69_Y266_D1.1650.38
36_I77_V1.1620.37
196_P212_R1.1510.37
74_L85_H1.1470.37
132_I345_S1.1420.37
257_G324_Q1.1200.35
306_D373_E1.1190.35
107_V289_L1.1180.35
221_V304_A1.1180.35
249_Q257_G1.1100.35
51_C154_V1.1030.35
178_A216_K1.1010.35
329_D335_L1.0830.34
263_L334_V1.0720.33
165_I191_D1.0690.33
17_F304_A1.0690.33
201_G366_V1.0600.33
43_T390_S1.0580.33
44_H180_E1.0520.32
61_E232_N1.0480.32
261_G265_Y1.0450.32
7_A135_V1.0420.32
19_T25_E1.0410.32
47_T382_E1.0410.32
93_Q177_G1.0370.32
48_A52_L1.0350.32
175_G300_G1.0340.31
173_M329_D1.0330.31
91_G94_F1.0280.31
21_A45_V1.0280.31
13_G35_T1.0260.31
14_K35_T1.0260.31
8_G35_T1.0260.31
19_T28_V1.0160.31
7_A19_T1.0160.31
88_R117_E1.0120.30
7_A10_P1.0110.30
271_D276_G1.0080.30
78_A98_L1.0080.30
61_E68_R1.0010.30
173_M183_V0.9950.30
332_G365_A0.9950.30
92_N138_E0.9930.30
90_L106_N0.9930.30
8_G16_T0.9930.30
13_G16_T0.9930.30
109_D226_D0.9920.30
89_G138_E0.9910.30
30_N120_P0.9870.29
232_N235_R0.9850.29
380_L389_V0.9800.29
93_Q97_E0.9740.29
58_C102_D0.9710.29
169_I186_V0.9660.28
338_A387_K0.9660.28
212_R375_G0.9620.28
165_I279_G0.9620.28
40_R73_E0.9620.28
53_T122_E0.9590.28
347_P359_G0.9560.28
176_F215_T0.9550.28
343_A381_G0.9510.28
34_T224_K0.9490.28
5_A13_G0.9470.28
5_A8_G0.9470.28
5_A14_K0.9470.28
58_C63_C0.9460.28
378_D381_G0.9440.28
268_G272_F0.9400.27
189_E210_G0.9380.27
212_R385_V0.9330.27
148_E204_R0.9330.27
141_L205_E0.9330.27
254_V265_Y0.9320.27
121_V125_D0.9260.27
313_L337_D0.9240.27
143_L212_R0.9220.27
270_E280_D0.9210.27
125_D210_G0.9180.27
108_V347_P0.9120.26
20_A26_V0.9120.26
33_F38_A0.9070.26
203_D319_F0.9060.26
246_A293_M0.9040.26
272_F275_T0.9020.26
17_F103_V0.9020.26
144_A327_W0.9010.26
61_E285_A0.9010.26
247_T250_G0.9000.26
49_C58_C0.8990.26
103_V219_V0.8920.25
280_D283_R0.8920.25
6_L16_T0.8900.25
72_V202_E0.8900.25
19_T229_P0.8890.25
380_L384_D0.8810.25
10_P135_V0.8790.25
133_D291_E0.8760.25
58_C93_Q0.8750.25
146_I324_Q0.8740.25
10_P29_A0.8740.25
6_L390_S0.8730.25
27_D43_T0.8700.25
23_R29_A0.8680.25
6_L17_F0.8670.24
10_P81_V0.8600.24
179_S185_A0.8590.24
365_A386_V0.8520.24
106_N115_N0.8520.24
70_V319_F0.8500.24
348_V386_V0.8480.24
279_G374_I0.8480.24
155_E197_I0.8450.24
7_A229_P0.8420.24
159_R172_M0.8410.23
106_N135_V0.8390.23
37_D155_E0.8380.23
148_E284_E0.8380.23
234_Q343_A0.8370.23
87_G138_E0.8370.23
105_V304_A0.8350.23
351_A365_A0.8320.23
78_A81_V0.8320.23
6_L43_T0.8320.23
48_A67_K0.8310.23
191_D314_E0.8300.23
81_V154_V0.8290.23
216_K345_S0.8260.23
347_P352_Y0.8240.23
93_Q174_T0.8240.23
271_D275_T0.8230.23
84_A89_G0.8210.23
7_A228_A0.8190.23
257_G367_N0.8190.23
81_V145_G0.8170.23
45_V246_A0.8150.23
5_A28_V0.8140.22
135_V295_E0.8120.22
321_V350_L0.8100.22
56_E61_E0.8080.22
234_Q237_L0.8070.22
341_L363_L0.8060.22
81_V228_A0.8060.22
341_L348_V0.8060.22
37_D73_E0.8050.22
60_H104_I0.8040.22
19_T65_D0.8040.22
81_V156_R0.8040.22
118_G142_W0.8010.22
29_A113_A0.8010.22
6_L110_A0.7990.22
249_Q288_A0.7980.22
86_E357_D0.7980.22
29_A288_A0.7980.22
180_E212_R0.7970.22
374_I380_L0.7970.22
96_D156_R0.7900.22
34_T50_P0.7890.22
34_T51_C0.7830.21
19_T24_S0.7830.21
231_E234_Q0.7820.21
108_V244_I0.7810.21
98_L134_F0.7800.21
80_L84_A0.7800.21
287_E339_V0.7790.21
80_L89_G0.7780.21
165_I289_L0.7770.21
102_D361_G0.7770.21
141_L154_V0.7750.21
233_V252_L0.7750.21
367_N383_G0.7750.21
74_L90_L0.7740.21
344_G379_E0.7730.21
67_K266_D0.7720.21
84_A138_E0.7700.21
332_G336_P0.7650.21
221_V238_D0.7620.21
102_D139_M0.7610.21
375_G378_D0.7600.21
12_A97_E0.7590.21
19_T135_V0.7590.21
50_P53_T0.7590.21
359_G365_A0.7580.21
262_F383_G0.7570.20
183_V293_M0.7540.20
34_T49_C0.7530.20
28_V375_G0.7530.20
81_V107_V0.7530.20
93_Q104_I0.7510.20
43_T361_G0.7500.20
270_E273_D0.7490.20
113_A354_V0.7490.20
18_Y40_R0.7390.20
97_E131_D0.7390.20
49_C68_R0.7370.20
327_W385_V0.7360.20
152_E385_V0.7360.20
106_N126_H0.7340.20
36_I98_L0.7310.20
219_V258_A0.7310.20
279_G283_R0.7280.20
36_I97_E0.7270.19
359_G362_Y0.7230.19
132_I243_V0.7210.19
144_A204_R0.7210.19
82_P117_E0.7160.19
38_A50_P0.7160.19
131_D141_L0.7150.19
255_R265_Y0.7130.19
230_E287_E0.7110.19
26_V148_E0.7080.19
175_G299_T0.7060.19
142_W226_D0.7050.19
102_D177_G0.7050.19
38_A160_S0.7050.19
28_V328_T0.7050.19
33_F91_G0.7040.19
250_G342_D0.7040.19
129_V235_R0.7040.19
195_D386_V0.7040.19
289_L356_S0.7040.19
380_L386_V0.7030.19
112_G118_G0.6990.19
146_I176_F0.6970.19
80_L138_E0.6970.19
112_G128_P0.6970.19
210_G214_R0.6970.19
105_V133_D0.6960.19
178_A192_Y0.6960.19
10_P98_L0.6950.18
101_A199_W0.6910.18
9_K299_T0.6890.18
118_G175_G0.6880.18
212_R221_V0.6860.18
12_A104_I0.6850.18
43_T47_T0.6840.18
216_K222_A0.6840.18
116_E325_S0.6840.18
49_C66_G0.6840.18
61_E64_H0.6830.18
50_P199_W0.6800.18
29_A292_T0.6780.18
200_S318_A0.6780.18
364_H389_V0.6760.18
167_T303_R0.6750.18
323_D326_K0.6720.18
118_G299_T0.6720.18
205_E305_L0.6720.18
179_S353_A0.6710.18
65_D280_D0.6700.18
127_D348_V0.6700.18
88_R325_S0.6690.18
16_T22_T0.6690.18
78_A134_F0.6660.18
109_D224_K0.6640.18
355_H365_A0.6610.17
263_L275_T0.6610.17
225_V240_D0.6600.17
76_D79_G0.6570.17
96_D151_W0.6560.17
74_L250_G0.6530.17
77_V80_L0.6520.17
117_E135_V0.6510.17
303_R307_Y0.6490.17
64_H157_A0.6490.17
90_L96_D0.6450.17
167_T180_E0.6440.17
47_T185_A0.6430.17
39_N77_V0.6430.17
62_H104_I0.6420.17
70_V277_D0.6410.17
206_A209_R0.6400.17
151_W156_R0.6400.17
84_A87_G0.6380.17
41_G215_T0.6380.17
7_A24_S0.6380.17
348_V376_E0.6350.17
327_W368_A0.6310.17
201_G262_F0.6290.16
126_H232_N0.6280.16
114_T118_G0.6270.16
265_Y308_A0.6250.16
43_T286_L0.6250.16
45_V90_L0.6250.16
43_T147_V0.6230.16
6_L273_D0.6230.16
178_A270_E0.6220.16
189_E385_V0.6210.16
45_V302_Q0.6210.16
87_G142_W0.6210.16
7_A376_E0.6190.16
29_A108_V0.6180.16
36_I39_N0.6160.16
75_L126_H0.6140.16
120_P383_G0.6130.16
206_A269_D0.6120.16
42_V47_T0.6120.16
62_H69_Y0.6120.16
206_A210_G0.6110.16
29_A34_T0.6100.16
33_F39_N0.6100.16
196_P222_A0.6090.16
15_S35_T0.6090.16
335_L365_A0.6090.16
199_W375_G0.6070.16
195_D198_Q0.6070.16
72_V186_V0.6060.16
358_I364_H0.6060.16
81_V289_L0.6050.16
186_V358_I0.6040.16
306_D364_H0.6010.16
80_L87_G0.6010.16
213_E307_Y0.5980.16
89_G92_N0.5980.16
51_C358_I0.5980.16
19_T26_V0.5970.16
4_I298_G0.5950.16
11_N15_S0.5950.16
213_E311_D0.5940.16
16_T385_V0.5940.16
179_S314_E0.5930.15
4_I244_I0.5910.15
269_D272_F0.5900.15
139_M273_D0.5900.15
63_C66_G0.5890.15
341_L370_T0.5880.15
230_E233_V0.5870.15
68_R226_D0.5870.15
326_K387_K0.5870.15
218_I231_E0.5870.15
129_V278_V0.5860.15
70_V327_W0.5860.15
45_V105_V0.5850.15
75_L158_S0.5850.15
189_E283_R0.5820.15
374_I378_D0.5820.15
336_P354_V0.5800.15
149_D385_V0.5800.15
178_A215_T0.5800.15
376_E387_K0.5790.15
138_E142_W0.5780.15
182_Q215_T0.5780.15
265_Y299_T0.5780.15
134_F253_A0.5760.15
89_G142_W0.5750.15
17_F116_E0.5740.15
122_E238_D0.5730.15
128_P131_D0.5730.15
66_G194_D0.5720.15
90_L309_V0.5690.15
93_Q155_E0.5680.15
210_G213_E0.5680.15
41_G325_S0.5680.15
11_N338_A0.5670.15
4_I20_A0.5660.15
370_T375_G0.5660.15
51_C81_V0.5640.15
212_R245_P0.5630.15
15_S36_I0.5620.15
137_E244_I0.5620.15
31_Y150_N0.5590.15
207_L211_V0.5580.15
279_G286_L0.5580.15
68_R142_W0.5570.15
61_E247_T0.5570.15
249_Q262_F0.5570.15
52_L57_R0.5570.15
113_A121_V0.5560.14
33_F36_I0.5560.14
221_V375_G0.5560.14
146_I208_A0.5550.14
354_V357_D0.5540.14
91_G95_L0.5540.14
5_A150_N0.5530.14
182_Q193_P0.5520.14
5_A22_T0.5500.14
251_E265_Y0.5490.14
370_T374_I0.5490.14
103_V119_E0.5480.14
159_R195_D0.5450.14
84_A91_G0.5440.14
151_W321_V0.5440.14
288_A386_V0.5430.14
151_W199_W0.5430.14
325_S371_N0.5420.14
251_E300_G0.5390.14
333_T336_P0.5380.14
136_E304_A0.5380.14
174_T190_F0.5380.14
257_G279_G0.5370.14
54_R60_H0.5370.14
68_R109_D0.5370.14
10_P172_M0.5360.14
68_R337_D0.5340.14
39_N309_V0.5330.14
155_E353_A0.5320.14
238_D383_G0.5320.14
118_G226_D0.5310.14
77_V82_P0.5310.14
253_A257_G0.5310.14
109_D118_G0.5310.14
35_T76_D0.5310.14
66_G177_G0.5310.14
201_G290_R0.5300.14
186_V190_F0.5290.14
50_P56_E0.5270.14
330_A362_Y0.5270.14
83_G176_F0.5260.14
143_L208_A0.5250.14
355_H360_D0.5250.14
164_D261_G0.5250.14
58_C174_T0.5250.14
167_T276_G0.5200.14
8_G76_D0.5200.14
14_K76_D0.5200.14
13_G76_D0.5200.14
82_P151_W0.5170.14
70_V183_V0.5160.13
243_V326_K0.5150.13
10_P50_P0.5140.13
30_N85_H0.5140.13
13_G19_T0.5130.13
14_K19_T0.5130.13
8_G19_T0.5130.13
281_D339_V0.5130.13
4_I8_G0.5120.13
4_I14_K0.5120.13
4_I13_G0.5120.13
32_P94_F0.5120.13
47_T61_E0.5120.13
257_G323_D0.5100.13
330_A374_I0.5080.13
72_V340_L0.5070.13
282_Q285_A0.5060.13
77_V199_W0.5050.13
94_F138_E0.5050.13
32_P91_G0.5040.13
350_L386_V0.5040.13
37_D117_E0.5040.13
34_T226_D0.5040.13
11_N19_T0.5020.13
304_A309_V0.5020.13
23_R298_G0.5020.13
305_L348_V0.5010.13
86_E260_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wxqA 1 0.8575 100 0.391 Contact Map
1jalA 1 0.8193 100 0.561 Contact Map
2dbyA 1 0.8321 100 0.564 Contact Map
1ni3A 1 0.8601 100 0.587 Contact Map
2ohfA 1 0.7379 100 0.651 Contact Map
4a9aA 1 0.7379 100 0.678 Contact Map
1lnzA 1 0.4606 100 0.789 Contact Map
4csu9 1 0.4351 100 0.8 Contact Map
3ievA 1 0.7125 100 0.802 Contact Map
1egaA 2 0.6972 100 0.812 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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