GREMLIN Database
Q9HRX1 - Uncharacterized protein
UniProt: Q9HRX1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (326)
Sequences: 8626 (5580)
Seq/√Len: 309.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
238_V339_M4.2111.00
266_G271_D3.3281.00
305_F314_A3.3071.00
246_D249_T3.1301.00
280_E300_H3.0581.00
240_A265_V3.0291.00
294_A297_D2.9131.00
243_T266_G2.8991.00
245_D249_T2.8951.00
160_R164_R2.8801.00
149_Y153_R2.7451.00
228_V314_A2.7121.00
136_R139_T2.6871.00
266_G296_E2.6341.00
264_L299_A2.4651.00
309_M317_R2.4511.00
240_A269_M2.3581.00
24_N76_S2.3521.00
238_V336_V2.3271.00
119_V165_I2.2831.00
53_R149_Y2.2651.00
168_A172_L2.2501.00
63_I156_S2.2131.00
275_V302_P2.1781.00
327_F339_M2.1461.00
243_T273_R2.1431.00
243_T296_E2.1411.00
26_F147_L2.1181.00
241_V250_N2.1051.00
53_R146_P2.0981.00
231_E311_V2.0391.00
41_D138_K2.0181.00
327_F336_V2.0071.00
241_V264_L1.9751.00
231_E340_V1.9461.00
343_T347_E1.9261.00
143_Y147_L1.9081.00
56_E149_Y1.8881.00
265_V272_F1.8871.00
45_F142_H1.8841.00
260_V277_Y1.8701.00
42_E54_A1.8661.00
252_D256_D1.8571.00
88_A92_T1.8141.00
48_T142_H1.8081.00
242_S245_D1.7811.00
314_A340_V1.7811.00
226_I230_D1.7571.00
239_V253_R1.7561.00
245_D250_N1.7441.00
164_R168_A1.7401.00
216_E220_A1.7361.00
220_A349_I1.7041.00
30_T144_C1.6641.00
139_T143_Y1.6481.00
325_L339_M1.6301.00
307_A337_V1.6261.00
244_T266_G1.6051.00
200_M217_V1.6021.00
311_V345_V1.5951.00
239_V259_H1.5801.00
293_L297_D1.5671.00
111_L115_A1.5651.00
268_S271_D1.5501.00
236_D335_G1.5311.00
266_G273_R1.5281.00
16_G82_V1.5261.00
24_N72_I1.5241.00
239_V262_Y1.5101.00
67_G151_W1.5001.00
153_R156_S1.4971.00
53_R145_A1.4841.00
23_G75_C1.4601.00
309_M314_A1.4591.00
48_T51_L1.4411.00
43_S55_W1.4281.00
27_F71_G1.4161.00
235_V270_D1.4111.00
87_L90_L1.4071.00
144_C147_L1.4061.00
77_V80_G1.4021.00
261_R324_E1.4011.00
284_D298_V1.3841.00
54_A145_A1.3811.00
156_S160_R1.3801.00
249_T252_D1.3661.00
15_F19_A1.3611.00
316_D319_Q1.3551.00
45_F48_T1.3441.00
146_P150_W1.3401.00
228_V328_V1.3381.00
52_R56_E1.3271.00
55_W59_D1.3271.00
275_V325_L1.3261.00
92_T96_E1.3201.00
317_R321_E1.3171.00
229_G307_A1.3161.00
50_G142_H1.3161.00
330_D333_T1.3121.00
14_I18_I1.3091.00
346_L350_T1.3081.00
47_E51_L1.3061.00
54_A141_A1.3001.00
91_F94_V1.2991.00
164_R167_K1.2971.00
12_L16_G1.2941.00
107_T111_L1.2941.00
235_V335_G1.2651.00
17_G79_L1.2501.00
272_F327_F1.2491.00
29_A140_V1.2481.00
50_G146_P1.2441.00
270_D335_G1.2411.00
147_L150_W1.2401.00
67_G159_I1.2361.00
239_V257_S1.2321.00
257_S262_Y1.2311.00
325_L341_T1.2301.00
228_V305_F1.2251.00
49_A52_R1.2201.00
302_P327_F1.2191.00
245_D253_R1.2161.00
306_D309_M1.1851.00
32_F35_T1.1851.00
270_D336_V1.1741.00
168_A171_S1.1721.00
204_L214_R1.1681.00
216_E349_I1.1621.00
305_F326_A1.1521.00
150_W153_R1.1461.00
26_F144_C1.1451.00
29_A133_G1.1441.00
21_L120_A1.1441.00
27_F151_W1.1431.00
330_D335_G1.1271.00
242_S267_E1.1181.00
19_A23_G1.1151.00
330_D334_G1.1091.00
56_E60_R1.1071.00
318_F326_A1.0851.00
143_Y146_P1.0841.00
128_A169_I1.0831.00
276_V298_V1.0821.00
306_D332_D1.0781.00
203_L207_T1.0681.00
12_L15_F1.0661.00
191_D199_R1.0621.00
31_E130_T1.0551.00
42_E55_W1.0541.00
261_R343_T1.0521.00
76_S121_H1.0511.00
196_L203_L1.0491.00
109_S113_A1.0481.00
69_Q72_I1.0341.00
293_L298_V1.0311.00
273_R299_A1.0291.00
251_L255_A1.0271.00
170_L175_V1.0241.00
72_I76_S1.0231.00
67_G152_T1.0211.00
60_R63_I1.0171.00
132_L175_V1.0171.00
248_E252_D1.0131.00
223_I312_S1.0121.00
157_P161_A1.0121.00
235_V330_D1.0121.00
305_F328_V1.0041.00
244_T296_E1.0001.00
252_D255_A0.9901.00
17_G117_M0.9891.00
240_A336_V0.9881.00
309_M313_D0.9841.00
254_M262_Y0.9801.00
90_L93_P0.9781.00
243_T299_A0.9771.00
53_R56_E0.9701.00
161_A164_R0.9701.00
192_G196_L0.9691.00
192_G195_D0.9681.00
57_M145_A0.9631.00
42_E58_T0.9621.00
303_L317_R0.9571.00
81_V114_L0.9561.00
304_V329_T0.9531.00
57_M64_Y0.9521.00
235_V333_T0.9501.00
223_I315_I0.9421.00
227_P230_D0.9361.00
50_G54_A0.9361.00
343_T353_V0.9331.00
241_V295_L0.9331.00
48_T52_R0.9261.00
242_S265_V0.9171.00
263_P272_F0.9161.00
201_G218_I0.9161.00
68_C148_H0.9161.00
63_I152_T0.9141.00
332_D335_G0.9111.00
28_V32_F0.9071.00
261_R277_Y0.9061.00
314_A345_V0.9031.00
25_G29_A0.9021.00
39_Q59_D0.9011.00
37_V137_A0.8971.00
267_E271_D0.8911.00
238_V269_M0.8881.00
20_L78_G0.8881.00
291_G294_A0.8761.00
62_E167_K0.8741.00
214_R218_I0.8741.00
296_E299_A0.8651.00
329_T336_V0.8631.00
219_G349_I0.8621.00
89_V92_T0.8621.00
290_D293_L0.8621.00
223_I345_V0.8571.00
280_E357_Y0.8561.00
30_T148_H0.8551.00
231_E345_V0.8541.00
303_L326_A0.8501.00
73_T130_T0.8471.00
243_T250_N0.8461.00
252_D286_D0.8451.00
115_A119_V0.8431.00
228_V340_V0.8421.00
70_L158_I0.8381.00
167_K177_M0.8371.00
52_R55_W0.8351.00
317_R320_A0.8331.00
316_D320_A0.8311.00
51_L142_H0.8301.00
171_S176_E0.8281.00
197_R222_D0.8201.00
24_N28_V0.8191.00
265_V268_S0.8171.00
96_E105_I0.8171.00
235_V334_G0.8151.00
16_G19_A0.8141.00
247_L250_N0.8131.00
154_T157_P0.8131.00
260_V279_P0.8131.00
353_V358_D0.8111.00
170_L174_G0.8081.00
254_M278_L0.8071.00
152_T156_S0.8061.00
92_T106_A0.8011.00
247_L293_L0.7981.00
110_V114_L0.7981.00
263_P327_F0.7941.00
263_P275_V0.7931.00
193_R225_R0.7931.00
79_L117_M0.7901.00
277_Y280_E0.7881.00
105_I109_S0.7881.00
72_I126_E0.7871.00
91_F95_F0.7851.00
32_F133_G0.7841.00
324_E343_T0.7800.99
79_L121_H0.7790.99
347_E352_E0.7780.99
272_F336_V0.7740.99
22_A25_G0.7690.99
41_D44_A0.7680.99
167_K171_S0.7670.99
37_V42_E0.7660.99
314_A318_F0.7630.99
125_A130_T0.7620.99
140_V144_C0.7620.99
343_T348_A0.7590.99
226_I348_A0.7560.99
343_T352_E0.7540.99
303_L321_E0.7480.99
324_E346_L0.7470.99
72_I121_H0.7470.99
87_L91_F0.7430.99
196_L209_V0.7420.99
289_R292_T0.7400.99
241_V253_R0.7390.99
241_V245_D0.7390.99
329_T332_D0.7370.99
255_A283_R0.7370.99
91_F109_S0.7350.99
233_V354_E0.7330.99
126_E130_T0.7320.99
229_G337_V0.7280.99
50_G53_R0.7280.99
305_F309_M0.7280.99
277_Y324_E0.7270.99
249_T253_R0.7270.99
254_M281_A0.7260.99
241_V262_Y0.7240.99
307_A332_D0.7230.99
342_I353_V0.7230.99
37_V138_K0.7180.99
304_V327_F0.7170.99
330_D337_V0.7170.99
29_A33_A0.7170.99
146_P149_Y0.7160.99
37_V54_A0.7160.99
261_R325_L0.7130.99
253_R256_D0.7130.99
193_R221_L0.7130.99
80_G118_N0.7110.99
61_L64_Y0.7110.99
72_I75_C0.7110.99
26_F71_G0.7090.99
135_E175_V0.7050.99
277_Y300_H0.7030.99
127_Q162_G0.7010.99
151_W155_M0.7010.99
139_T142_H0.6960.99
306_D333_T0.6960.99
315_I318_F0.6950.99
248_E292_T0.6940.99
72_I125_A0.6930.99
77_V118_N0.6920.99
62_E131_Y0.6910.99
324_E353_V0.6890.99
215_E219_G0.6890.99
242_S271_D0.6880.99
88_A109_S0.6880.99
197_R218_I0.6850.99
73_T118_N0.6850.99
77_V114_L0.6850.99
93_P96_E0.6830.99
348_A352_E0.6820.99
39_Q55_W0.6810.99
217_V221_L0.6790.99
232_A338_G0.6760.99
20_L75_C0.6740.99
260_V355_D0.6720.99
193_R224_D0.6720.99
228_V309_M0.6710.98
193_R197_R0.6690.98
41_D45_F0.6680.98
250_N254_M0.6680.98
81_V110_V0.6670.98
24_N121_H0.6650.98
69_Q121_H0.6640.98
241_V254_M0.6640.98
289_R293_L0.6620.98
224_D312_S0.6620.98
108_L112_V0.6600.98
286_D293_L0.6600.98
315_I345_V0.6590.98
60_R152_T0.6590.98
265_V271_D0.6560.98
235_V337_V0.6530.98
243_T246_D0.6500.98
23_G27_F0.6490.98
47_E52_R0.6470.98
21_L79_L0.6460.98
24_N75_C0.6430.98
69_Q76_S0.6430.98
306_D329_T0.6430.98
347_E355_D0.6410.98
303_L323_Q0.6390.98
306_D334_G0.6380.98
92_T105_I0.6360.98
16_G20_L0.6360.98
132_L140_V0.6350.98
163_D167_K0.6320.98
72_I127_Q0.6310.98
235_V332_D0.6310.98
13_R17_G0.6300.98
250_N295_L0.6240.98
343_T355_D0.6230.98
28_V126_E0.6210.98
54_A58_T0.6210.98
33_A141_A0.6190.97
297_D301_P0.6190.97
73_T114_L0.6180.97
51_L55_W0.6180.97
300_H323_Q0.6170.97
65_L69_Q0.6120.97
69_Q80_G0.6100.97
170_L177_M0.6070.97
89_V93_P0.6050.97
234_P237_E0.6040.97
88_A106_A0.6030.97
28_V72_I0.6020.97
191_D196_L0.6020.97
73_T121_H0.6010.97
302_P325_L0.5990.97
261_R275_V0.5980.97
158_I162_G0.5970.97
250_N294_A0.5970.97
77_V81_V0.5960.97
273_R296_E0.5950.97
343_T356_P0.5940.97
235_V238_V0.5940.97
21_L125_A0.5930.97
77_V113_A0.5920.97
232_A337_V0.5910.97
20_L25_G0.5900.97
28_V121_H0.5900.97
253_R257_S0.5890.97
307_A334_G0.5880.97
169_I173_V0.5880.97
88_A91_F0.5870.97
236_D333_T0.5870.97
284_D293_L0.5870.97
88_A94_V0.5840.96
347_E351_G0.5840.96
32_F36_R0.5830.96
45_F51_L0.5800.96
29_A144_C0.5790.96
141_A145_A0.5780.96
28_V68_C0.5770.96
285_L290_D0.5760.96
269_M336_V0.5730.96
162_G166_A0.5720.96
265_V269_M0.5710.96
353_V356_P0.5690.96
57_M152_T0.5680.96
324_E342_I0.5680.96
324_E347_E0.5610.95
34_L141_A0.5600.95
283_R286_D0.5590.95
159_I163_D0.5580.95
73_T76_S0.5580.95
239_V256_D0.5570.95
37_V64_Y0.5570.95
50_G143_Y0.5560.95
63_I160_R0.5560.95
315_I342_I0.5560.95
33_A140_V0.5550.95
248_E291_G0.5550.95
58_T61_L0.5520.95
222_D225_R0.5510.95
65_L125_A0.5490.95
37_V142_H0.5480.95
78_G82_V0.5480.95
307_A330_D0.5480.95
315_I350_T0.5470.95
132_L136_R0.5450.95
75_C79_L0.5450.95
248_E251_L0.5430.95
153_R157_P0.5430.95
24_N73_T0.5400.94
197_R217_V0.5400.94
343_T358_D0.5390.94
51_L141_A0.5390.94
21_L24_N0.5390.94
118_N122_L0.5380.94
71_G118_N0.5380.94
49_A53_R0.5350.94
62_E163_D0.5350.94
114_L117_M0.5340.94
31_E73_T0.5340.94
251_L286_D0.5330.94
284_D290_D0.5330.94
236_D337_V0.5310.94
313_D316_D0.5310.94
339_M344_D0.5310.94
342_I357_Y0.5300.94
223_I310_S0.5280.94
352_E356_P0.5260.94
70_L73_T0.5260.94
280_E283_R0.5250.94
204_L211_D0.5240.94
198_S202_D0.5240.94
110_V121_H0.5210.93
68_C114_L0.5200.93
18_I22_A0.5190.93
216_E223_I0.5180.93
346_L355_D0.5170.93
227_P308_D0.5160.93
78_G81_V0.5150.93
57_M61_L0.5130.93
90_L94_V0.5130.93
292_T297_D0.5110.93
200_M209_V0.5100.93
265_V273_R0.5090.93
270_D332_D0.5090.93
342_I350_T0.5080.93
91_F116_V0.5080.93
21_L25_G0.5070.92
69_Q73_T0.5060.92
35_T134_V0.5060.92
329_T333_T0.5050.92
32_F61_L0.5040.92
36_R134_V0.5040.92
121_H127_Q0.5030.92
78_G110_V0.5020.92
50_G145_A0.5020.92
73_T77_V0.5020.92
295_L299_A0.5000.92
202_D205_S0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hg0A 2 0.4235 100 0.591 Contact Map
3lhhA 1 0.3415 100 0.697 Contact Map
3ocoA 2 0.3689 99.9 0.716 Contact Map
3oi8A 2 0.4262 99.9 0.723 Contact Map
3ocmA 5 0.4071 99.9 0.725 Contact Map
3kxrA 3 0.4399 99.9 0.732 Contact Map
2v8qE 1 0.4153 99.9 0.739 Contact Map
3lv9A 2 0.3552 99.9 0.74 Contact Map
4iysA 2 0.388 99.9 0.745 Contact Map
3lfrA 2 0.3552 99.9 0.76 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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