Q9HRX1 - HALSA - GREMLIN Contacts

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Q9HRX1 - Uncharacterized protein

UniProt:	Q9HRX1	Sequences: MSAGEITPVTALRIFGGIALLAGNGFFVATEFALTRVRQFDESAFQETAGLRRAWEMTDRLEIYLTGCQLGITVCSVGLGVVAEPALAVLFTPVFEFVGFGAGSIATLSVLVALAVMNVAHLVLAEQAPTYLGVERAKTVAHYCAPLHYWWTRTMSPIIRAGDRIAKAILSLVGVEMTRSWTEEGAEDPIDGRSDLRSRMGDLLSGTGVPDERREEVIGALDIDRIPVGDEAVPVDEVVAVSTTDDLETNLDRMADSPHVRYPLVGESMDDFRGVVYLPEAFRDLDDLRDGTLALEDVAHPPLVFDADMSVSDAIDRFQAERQELAFVTDADTGGVVGMVTITDVLEAITGEVEDPYDEAAEKSQS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	366 (326)
Sequences:	8626 (5580)
Seq/√Len:	309.1

ECOLI - YTFL YFJD YEGH YOAE CORC
BACSU - YHDT YQHB YUGS YHDP YRKA
HALSA - Q9HRX1 Q9HHN9 Q9HN02

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
238_V	339_M	4.211	1.00
266_G	271_D	3.328	1.00
305_F	314_A	3.307	1.00
246_D	249_T	3.130	1.00
280_E	300_H	3.058	1.00
240_A	265_V	3.029	1.00
294_A	297_D	2.913	1.00
243_T	266_G	2.899	1.00
245_D	249_T	2.895	1.00
160_R	164_R	2.880	1.00
149_Y	153_R	2.745	1.00
228_V	314_A	2.712	1.00
136_R	139_T	2.687	1.00
266_G	296_E	2.634	1.00
264_L	299_A	2.465	1.00
309_M	317_R	2.451	1.00
240_A	269_M	2.358	1.00
24_N	76_S	2.352	1.00
238_V	336_V	2.327	1.00
119_V	165_I	2.283	1.00
53_R	149_Y	2.265	1.00
168_A	172_L	2.250	1.00
63_I	156_S	2.213	1.00
275_V	302_P	2.178	1.00
327_F	339_M	2.146	1.00
243_T	273_R	2.143	1.00
243_T	296_E	2.141	1.00
26_F	147_L	2.118	1.00
241_V	250_N	2.105	1.00
53_R	146_P	2.098	1.00
231_E	311_V	2.039	1.00
41_D	138_K	2.018	1.00
327_F	336_V	2.007	1.00
241_V	264_L	1.975	1.00
231_E	340_V	1.946	1.00
343_T	347_E	1.926	1.00
143_Y	147_L	1.908	1.00
56_E	149_Y	1.888	1.00
265_V	272_F	1.887	1.00
45_F	142_H	1.884	1.00
260_V	277_Y	1.870	1.00
42_E	54_A	1.866	1.00
252_D	256_D	1.857	1.00
88_A	92_T	1.814	1.00
48_T	142_H	1.808	1.00
242_S	245_D	1.781	1.00
314_A	340_V	1.781	1.00
226_I	230_D	1.757	1.00
239_V	253_R	1.756	1.00
245_D	250_N	1.744	1.00
164_R	168_A	1.740	1.00
216_E	220_A	1.736	1.00
220_A	349_I	1.704	1.00
30_T	144_C	1.664	1.00
139_T	143_Y	1.648	1.00
325_L	339_M	1.630	1.00
307_A	337_V	1.626	1.00
244_T	266_G	1.605	1.00
200_M	217_V	1.602	1.00
311_V	345_V	1.595	1.00
239_V	259_H	1.580	1.00
293_L	297_D	1.567	1.00
111_L	115_A	1.565	1.00
268_S	271_D	1.550	1.00
236_D	335_G	1.531	1.00
266_G	273_R	1.528	1.00
16_G	82_V	1.526	1.00
24_N	72_I	1.524	1.00
239_V	262_Y	1.510	1.00
67_G	151_W	1.500	1.00
153_R	156_S	1.497	1.00
53_R	145_A	1.484	1.00
23_G	75_C	1.460	1.00
309_M	314_A	1.459	1.00
48_T	51_L	1.441	1.00
43_S	55_W	1.428	1.00
27_F	71_G	1.416	1.00
235_V	270_D	1.411	1.00
87_L	90_L	1.407	1.00
144_C	147_L	1.406	1.00
77_V	80_G	1.402	1.00
261_R	324_E	1.401	1.00
284_D	298_V	1.384	1.00
54_A	145_A	1.381	1.00
156_S	160_R	1.380	1.00
249_T	252_D	1.366	1.00
15_F	19_A	1.361	1.00
316_D	319_Q	1.355	1.00
45_F	48_T	1.344	1.00
146_P	150_W	1.340	1.00
228_V	328_V	1.338	1.00
52_R	56_E	1.327	1.00
55_W	59_D	1.327	1.00
275_V	325_L	1.326	1.00
92_T	96_E	1.320	1.00
317_R	321_E	1.317	1.00
229_G	307_A	1.316	1.00
50_G	142_H	1.316	1.00
330_D	333_T	1.312	1.00
14_I	18_I	1.309	1.00
346_L	350_T	1.308	1.00
47_E	51_L	1.306	1.00
54_A	141_A	1.300	1.00
91_F	94_V	1.299	1.00
164_R	167_K	1.297	1.00
12_L	16_G	1.294	1.00
107_T	111_L	1.294	1.00
235_V	335_G	1.265	1.00
17_G	79_L	1.250	1.00
272_F	327_F	1.249	1.00
29_A	140_V	1.248	1.00
50_G	146_P	1.244	1.00
270_D	335_G	1.241	1.00
147_L	150_W	1.240	1.00
67_G	159_I	1.236	1.00
239_V	257_S	1.232	1.00
257_S	262_Y	1.231	1.00
325_L	341_T	1.230	1.00
228_V	305_F	1.225	1.00
49_A	52_R	1.220	1.00
302_P	327_F	1.219	1.00
245_D	253_R	1.216	1.00
306_D	309_M	1.185	1.00
32_F	35_T	1.185	1.00
270_D	336_V	1.174	1.00
168_A	171_S	1.172	1.00
204_L	214_R	1.168	1.00
216_E	349_I	1.162	1.00
305_F	326_A	1.152	1.00
150_W	153_R	1.146	1.00
26_F	144_C	1.145	1.00
29_A	133_G	1.144	1.00
21_L	120_A	1.144	1.00
27_F	151_W	1.143	1.00
330_D	335_G	1.127	1.00
242_S	267_E	1.118	1.00
19_A	23_G	1.115	1.00
330_D	334_G	1.109	1.00
56_E	60_R	1.107	1.00
318_F	326_A	1.085	1.00
143_Y	146_P	1.084	1.00
128_A	169_I	1.083	1.00
276_V	298_V	1.082	1.00
306_D	332_D	1.078	1.00
203_L	207_T	1.068	1.00
12_L	15_F	1.066	1.00
191_D	199_R	1.062	1.00
31_E	130_T	1.055	1.00
42_E	55_W	1.054	1.00
261_R	343_T	1.052	1.00
76_S	121_H	1.051	1.00
196_L	203_L	1.049	1.00
109_S	113_A	1.048	1.00
69_Q	72_I	1.034	1.00
293_L	298_V	1.031	1.00
273_R	299_A	1.029	1.00
251_L	255_A	1.027	1.00
170_L	175_V	1.024	1.00
72_I	76_S	1.023	1.00
67_G	152_T	1.021	1.00
60_R	63_I	1.017	1.00
132_L	175_V	1.017	1.00
248_E	252_D	1.013	1.00
223_I	312_S	1.012	1.00
157_P	161_A	1.012	1.00
235_V	330_D	1.012	1.00
305_F	328_V	1.004	1.00
244_T	296_E	1.000	1.00
252_D	255_A	0.990	1.00
17_G	117_M	0.989	1.00
240_A	336_V	0.988	1.00
309_M	313_D	0.984	1.00
254_M	262_Y	0.980	1.00
90_L	93_P	0.978	1.00
243_T	299_A	0.977	1.00
53_R	56_E	0.970	1.00
161_A	164_R	0.970	1.00
192_G	196_L	0.969	1.00
192_G	195_D	0.968	1.00
57_M	145_A	0.963	1.00
42_E	58_T	0.962	1.00
303_L	317_R	0.957	1.00
81_V	114_L	0.956	1.00
304_V	329_T	0.953	1.00
57_M	64_Y	0.952	1.00
235_V	333_T	0.950	1.00
223_I	315_I	0.942	1.00
227_P	230_D	0.936	1.00
50_G	54_A	0.936	1.00
343_T	353_V	0.933	1.00
241_V	295_L	0.933	1.00
48_T	52_R	0.926	1.00
242_S	265_V	0.917	1.00
263_P	272_F	0.916	1.00
201_G	218_I	0.916	1.00
68_C	148_H	0.916	1.00
63_I	152_T	0.914	1.00
332_D	335_G	0.911	1.00
28_V	32_F	0.907	1.00
261_R	277_Y	0.906	1.00
314_A	345_V	0.903	1.00
25_G	29_A	0.902	1.00
39_Q	59_D	0.901	1.00
37_V	137_A	0.897	1.00
267_E	271_D	0.891	1.00
238_V	269_M	0.888	1.00
20_L	78_G	0.888	1.00
291_G	294_A	0.876	1.00
62_E	167_K	0.874	1.00
214_R	218_I	0.874	1.00
296_E	299_A	0.865	1.00
329_T	336_V	0.863	1.00
219_G	349_I	0.862	1.00
89_V	92_T	0.862	1.00
290_D	293_L	0.862	1.00
223_I	345_V	0.857	1.00
280_E	357_Y	0.856	1.00
30_T	148_H	0.855	1.00
231_E	345_V	0.854	1.00
303_L	326_A	0.850	1.00
73_T	130_T	0.847	1.00
243_T	250_N	0.846	1.00
252_D	286_D	0.845	1.00
115_A	119_V	0.843	1.00
228_V	340_V	0.842	1.00
70_L	158_I	0.838	1.00
167_K	177_M	0.837	1.00
52_R	55_W	0.835	1.00
317_R	320_A	0.833	1.00
316_D	320_A	0.831	1.00
51_L	142_H	0.830	1.00
171_S	176_E	0.828	1.00
197_R	222_D	0.820	1.00
24_N	28_V	0.819	1.00
265_V	268_S	0.817	1.00
96_E	105_I	0.817	1.00
235_V	334_G	0.815	1.00
16_G	19_A	0.814	1.00
247_L	250_N	0.813	1.00
154_T	157_P	0.813	1.00
260_V	279_P	0.813	1.00
353_V	358_D	0.811	1.00
170_L	174_G	0.808	1.00
254_M	278_L	0.807	1.00
152_T	156_S	0.806	1.00
92_T	106_A	0.801	1.00
247_L	293_L	0.798	1.00
110_V	114_L	0.798	1.00
263_P	327_F	0.794	1.00
263_P	275_V	0.793	1.00
193_R	225_R	0.793	1.00
79_L	117_M	0.790	1.00
277_Y	280_E	0.788	1.00
105_I	109_S	0.788	1.00
72_I	126_E	0.787	1.00
91_F	95_F	0.785	1.00
32_F	133_G	0.784	1.00
324_E	343_T	0.780	0.99
79_L	121_H	0.779	0.99
347_E	352_E	0.778	0.99
272_F	336_V	0.774	0.99
22_A	25_G	0.769	0.99
41_D	44_A	0.768	0.99
167_K	171_S	0.767	0.99
37_V	42_E	0.766	0.99
314_A	318_F	0.763	0.99
125_A	130_T	0.762	0.99
140_V	144_C	0.762	0.99
343_T	348_A	0.759	0.99
226_I	348_A	0.756	0.99
343_T	352_E	0.754	0.99
303_L	321_E	0.748	0.99
324_E	346_L	0.747	0.99
72_I	121_H	0.747	0.99
87_L	91_F	0.743	0.99
196_L	209_V	0.742	0.99
289_R	292_T	0.740	0.99
241_V	253_R	0.739	0.99
241_V	245_D	0.739	0.99
329_T	332_D	0.737	0.99
255_A	283_R	0.737	0.99
91_F	109_S	0.735	0.99
233_V	354_E	0.733	0.99
126_E	130_T	0.732	0.99
229_G	337_V	0.728	0.99
50_G	53_R	0.728	0.99
305_F	309_M	0.728	0.99
277_Y	324_E	0.727	0.99
249_T	253_R	0.727	0.99
254_M	281_A	0.726	0.99
241_V	262_Y	0.724	0.99
307_A	332_D	0.723	0.99
342_I	353_V	0.723	0.99
37_V	138_K	0.718	0.99
304_V	327_F	0.717	0.99
330_D	337_V	0.717	0.99
29_A	33_A	0.717	0.99
146_P	149_Y	0.716	0.99
37_V	54_A	0.716	0.99
261_R	325_L	0.713	0.99
253_R	256_D	0.713	0.99
193_R	221_L	0.713	0.99
80_G	118_N	0.711	0.99
61_L	64_Y	0.711	0.99
72_I	75_C	0.711	0.99
26_F	71_G	0.709	0.99
135_E	175_V	0.705	0.99
277_Y	300_H	0.703	0.99
127_Q	162_G	0.701	0.99
151_W	155_M	0.701	0.99
139_T	142_H	0.696	0.99
306_D	333_T	0.696	0.99
315_I	318_F	0.695	0.99
248_E	292_T	0.694	0.99
72_I	125_A	0.693	0.99
77_V	118_N	0.692	0.99
62_E	131_Y	0.691	0.99
324_E	353_V	0.689	0.99
215_E	219_G	0.689	0.99
242_S	271_D	0.688	0.99
88_A	109_S	0.688	0.99
197_R	218_I	0.685	0.99
73_T	118_N	0.685	0.99
77_V	114_L	0.685	0.99
93_P	96_E	0.683	0.99
348_A	352_E	0.682	0.99
39_Q	55_W	0.681	0.99
217_V	221_L	0.679	0.99
232_A	338_G	0.676	0.99
20_L	75_C	0.674	0.99
260_V	355_D	0.672	0.99
193_R	224_D	0.672	0.99
228_V	309_M	0.671	0.98
193_R	197_R	0.669	0.98
41_D	45_F	0.668	0.98
250_N	254_M	0.668	0.98
81_V	110_V	0.667	0.98
24_N	121_H	0.665	0.98
69_Q	121_H	0.664	0.98
241_V	254_M	0.664	0.98
289_R	293_L	0.662	0.98
224_D	312_S	0.662	0.98
108_L	112_V	0.660	0.98
286_D	293_L	0.660	0.98
315_I	345_V	0.659	0.98
60_R	152_T	0.659	0.98
265_V	271_D	0.656	0.98
235_V	337_V	0.653	0.98
243_T	246_D	0.650	0.98
23_G	27_F	0.649	0.98
47_E	52_R	0.647	0.98
21_L	79_L	0.646	0.98
24_N	75_C	0.643	0.98
69_Q	76_S	0.643	0.98
306_D	329_T	0.643	0.98
347_E	355_D	0.641	0.98
303_L	323_Q	0.639	0.98
306_D	334_G	0.638	0.98
92_T	105_I	0.636	0.98
16_G	20_L	0.636	0.98
132_L	140_V	0.635	0.98
163_D	167_K	0.632	0.98
72_I	127_Q	0.631	0.98
235_V	332_D	0.631	0.98
13_R	17_G	0.630	0.98
250_N	295_L	0.624	0.98
343_T	355_D	0.623	0.98
28_V	126_E	0.621	0.98
54_A	58_T	0.621	0.98
33_A	141_A	0.619	0.97
297_D	301_P	0.619	0.97
73_T	114_L	0.618	0.97
51_L	55_W	0.618	0.97
300_H	323_Q	0.617	0.97
65_L	69_Q	0.612	0.97
69_Q	80_G	0.610	0.97
170_L	177_M	0.607	0.97
89_V	93_P	0.605	0.97
234_P	237_E	0.604	0.97
88_A	106_A	0.603	0.97
28_V	72_I	0.602	0.97
191_D	196_L	0.602	0.97
73_T	121_H	0.601	0.97
302_P	325_L	0.599	0.97
261_R	275_V	0.598	0.97
158_I	162_G	0.597	0.97
250_N	294_A	0.597	0.97
77_V	81_V	0.596	0.97
273_R	296_E	0.595	0.97
343_T	356_P	0.594	0.97
235_V	238_V	0.594	0.97
21_L	125_A	0.593	0.97
77_V	113_A	0.592	0.97
232_A	337_V	0.591	0.97
20_L	25_G	0.590	0.97
28_V	121_H	0.590	0.97
253_R	257_S	0.589	0.97
307_A	334_G	0.588	0.97
169_I	173_V	0.588	0.97
88_A	91_F	0.587	0.97
236_D	333_T	0.587	0.97
284_D	293_L	0.587	0.97
88_A	94_V	0.584	0.96
347_E	351_G	0.584	0.96
32_F	36_R	0.583	0.96
45_F	51_L	0.580	0.96
29_A	144_C	0.579	0.96
141_A	145_A	0.578	0.96
28_V	68_C	0.577	0.96
285_L	290_D	0.576	0.96
269_M	336_V	0.573	0.96
162_G	166_A	0.572	0.96
265_V	269_M	0.571	0.96
353_V	356_P	0.569	0.96
57_M	152_T	0.568	0.96
324_E	342_I	0.568	0.96
324_E	347_E	0.561	0.95
34_L	141_A	0.560	0.95
283_R	286_D	0.559	0.95
159_I	163_D	0.558	0.95
73_T	76_S	0.558	0.95
239_V	256_D	0.557	0.95
37_V	64_Y	0.557	0.95
50_G	143_Y	0.556	0.95
63_I	160_R	0.556	0.95
315_I	342_I	0.556	0.95
33_A	140_V	0.555	0.95
248_E	291_G	0.555	0.95
58_T	61_L	0.552	0.95
222_D	225_R	0.551	0.95
65_L	125_A	0.549	0.95
37_V	142_H	0.548	0.95
78_G	82_V	0.548	0.95
307_A	330_D	0.548	0.95
315_I	350_T	0.547	0.95
132_L	136_R	0.545	0.95
75_C	79_L	0.545	0.95
248_E	251_L	0.543	0.95
153_R	157_P	0.543	0.95
24_N	73_T	0.540	0.94
197_R	217_V	0.540	0.94
343_T	358_D	0.539	0.94
51_L	141_A	0.539	0.94
21_L	24_N	0.539	0.94
118_N	122_L	0.538	0.94
71_G	118_N	0.538	0.94
49_A	53_R	0.535	0.94
62_E	163_D	0.535	0.94
114_L	117_M	0.534	0.94
31_E	73_T	0.534	0.94
251_L	286_D	0.533	0.94
284_D	290_D	0.533	0.94
236_D	337_V	0.531	0.94
313_D	316_D	0.531	0.94
339_M	344_D	0.531	0.94
342_I	357_Y	0.530	0.94
223_I	310_S	0.528	0.94
352_E	356_P	0.526	0.94
70_L	73_T	0.526	0.94
280_E	283_R	0.525	0.94
204_L	211_D	0.524	0.94
198_S	202_D	0.524	0.94
110_V	121_H	0.521	0.93
68_C	114_L	0.520	0.93
18_I	22_A	0.519	0.93
216_E	223_I	0.518	0.93
346_L	355_D	0.517	0.93
227_P	308_D	0.516	0.93
78_G	81_V	0.515	0.93
57_M	61_L	0.513	0.93
90_L	94_V	0.513	0.93
292_T	297_D	0.511	0.93
200_M	209_V	0.510	0.93
265_V	273_R	0.509	0.93
270_D	332_D	0.509	0.93
342_I	350_T	0.508	0.93
91_F	116_V	0.508	0.93
21_L	25_G	0.507	0.92
69_Q	73_T	0.506	0.92
35_T	134_V	0.506	0.92
329_T	333_T	0.505	0.92
32_F	61_L	0.504	0.92
36_R	134_V	0.504	0.92
121_H	127_Q	0.503	0.92
78_G	110_V	0.502	0.92
50_G	145_A	0.502	0.92
73_T	77_V	0.502	0.92
295_L	299_A	0.500	0.92
202_D	205_S	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4hg0A	2	0.4235	100	0.591	Contact Map
3lhhA	1	0.3415	100	0.697	Contact Map
3ocoA	2	0.3689	99.9	0.716	Contact Map
3oi8A	2	0.4262	99.9	0.723	Contact Map
3ocmA	5	0.4071	99.9	0.725	Contact Map
3kxrA	3	0.4399	99.9	0.732	Contact Map
2v8qE	1	0.4153	99.9	0.739	Contact Map
3lv9A	2	0.3552	99.9	0.74	Contact Map
4iysA	2	0.388	99.9	0.745	Contact Map
3lfrA	2	0.3552	99.9	0.76	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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