GREMLIN Database
Q9HRW9 - Uncharacterized protein
UniProt: Q9HRW9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (247)
Sequences: 127 (102)
Seq/√Len: 6.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_L56_V4.1770.96
93_V246_V3.7530.93
107_G125_G3.5650.91
217_G254_G3.5370.90
93_V252_V3.2770.86
111_I129_I2.8470.77
66_D84_N2.7720.75
235_G271_G2.7200.74
139_F142_Y2.4740.66
38_V50_V2.2740.59
234_H253_L2.2170.57
149_L246_V2.1940.56
80_E98_H2.1840.56
66_D83_G2.1820.56
82_T281_V2.1590.55
149_L153_E2.0550.51
227_V279_M2.0480.51
133_M273_I2.0400.51
200_G271_G2.0380.51
223_N243_S1.9720.48
135_T186_V1.9290.47
65_G200_G1.8970.45
192_I202_I1.8880.45
85_V127_I1.8730.44
223_N259_H1.8460.43
101_E200_G1.8090.42
101_E271_G1.7990.42
136_L142_Y1.7150.39
109_L256_V1.6930.38
58_G244_V1.6790.38
200_G235_G1.6650.37
242_G254_G1.6640.37
261_V277_G1.6610.37
273_I277_G1.6390.36
215_V219_L1.6300.36
246_V252_V1.6290.36
255_D263_I1.6080.35
117_I134_P1.5930.35
156_Q164_A1.5790.34
65_G254_G1.5590.33
194_D210_G1.5580.33
277_G280_R1.5570.33
125_G235_G1.5540.33
205_T226_T1.5500.33
117_I142_Y1.5460.33
56_V89_G1.5450.33
40_I45_Q1.5220.32
103_L107_G1.5110.32
81_V129_I1.4780.31
47_R54_N1.4480.30
150_G156_Q1.4420.30
229_A263_I1.4270.29
141_M194_D1.4260.29
125_G131_N1.4210.29
61_V128_V1.4200.29
106_G173_I1.3940.28
106_G159_V1.3910.28
89_G144_T1.3810.28
157_E182_D1.3760.28
97_T275_A1.3410.27
223_N226_T1.3360.27
107_G242_G1.3350.27
236_D257_S1.3330.26
251_V261_V1.3310.26
152_A168_R1.3230.26
136_L139_F1.3210.26
39_L163_A1.3190.26
109_L218_S1.3170.26
35_D226_T1.3160.26
178_S248_G1.3140.26
69_A198_L1.3120.26
75_L179_V1.3100.26
52_G55_V1.3040.26
87_V93_V1.3020.26
169_G249_D1.2980.25
173_I176_S1.2940.25
173_I226_T1.2930.25
97_T128_V1.2920.25
59_E95_E1.2910.25
105_V252_V1.2850.25
273_I278_E1.2780.25
155_A171_L1.2780.25
99_I263_I1.2730.25
192_I225_V1.2730.25
211_R245_H1.2690.25
60_R180_S1.2660.25
42_A47_R1.2650.25
83_G102_R1.2610.24
71_G118_E1.2590.24
177_A236_D1.2580.24
173_I267_A1.2540.24
264_D280_R1.2510.24
97_T231_T1.2400.24
74_R121_F1.2290.24
71_G131_N1.2230.23
35_D89_G1.2050.23
233_I263_I1.2020.23
123_A127_I1.1840.22
159_V172_T1.1830.22
63_V149_L1.1830.22
233_I279_M1.1720.22
214_N260_D1.1710.22
130_R193_G1.1710.22
66_D281_V1.1700.22
94_G112_G1.1630.22
192_I206_E1.1600.22
266_A281_V1.1530.22
89_G268_D1.1460.21
84_N100_T1.1380.21
152_A155_A1.1350.21
45_Q48_L1.1320.21
157_E160_E1.1290.21
129_I143_L1.1170.21
65_G217_G1.1110.21
212_G260_D1.1110.21
53_H178_S1.0960.20
110_D115_V1.0930.20
43_Q60_R1.0910.20
206_E233_I1.0890.20
117_I129_I1.0810.20
73_C129_I1.0800.20
224_D260_D1.0670.20
258_G261_V1.0660.20
233_I247_Q1.0650.20
38_V261_V1.0500.19
120_G126_W1.0400.19
141_M230_G1.0360.19
107_G254_G1.0310.19
252_V276_R1.0230.19
256_V260_D1.0170.18
215_V264_D1.0140.18
88_E108_D1.0140.18
206_E268_D1.0120.18
191_T269_V1.0070.18
215_V252_V1.0060.18
64_D82_T1.0060.18
223_N263_I1.0040.18
38_V61_V0.9990.18
83_G153_E0.9950.18
52_G170_P0.9930.18
176_S242_G0.9870.18
94_G193_G0.9820.18
229_A281_V0.9800.18
215_V266_A0.9790.18
155_A179_V0.9710.17
166_S194_D0.9680.17
100_T173_I0.9640.17
54_N214_N0.9620.17
38_V45_Q0.9620.17
250_A257_S0.9590.17
148_R210_G0.9590.17
192_I279_M0.9550.17
163_A175_Q0.9510.17
82_T157_E0.9480.17
168_R245_H0.9400.17
266_A280_R0.9380.17
103_L244_V0.9370.17
89_G262_T0.9290.17
168_R232_K0.9280.17
128_V133_M0.9280.17
115_V127_I0.9260.16
158_L170_P0.9170.16
68_E238_T0.9160.16
255_D271_G0.9150.16
117_I156_Q0.9090.16
65_G72_D0.9090.16
53_H71_G0.9080.16
124_S151_E0.9070.16
63_V169_G0.9070.16
180_S190_A0.9060.16
251_V263_I0.9060.16
105_V265_E0.9060.16
89_G194_D0.9040.16
79_C198_L0.8960.16
172_T245_H0.8950.16
263_I268_D0.8930.16
227_V230_G0.8830.16
149_L164_A0.8770.15
260_D277_G0.8760.15
104_V245_H0.8720.15
75_L111_I0.8710.15
47_R50_V0.8690.15
104_V252_V0.8660.15
165_D208_D0.8600.15
50_V63_V0.8570.15
167_D208_D0.8370.15
48_L54_N0.8290.15
87_V222_Q0.8270.15
37_D42_A0.8250.15
57_A64_D0.8200.14
55_V158_L0.8200.14
100_T106_G0.8090.14
225_V243_S0.8050.14
164_A189_P0.8030.14
232_K251_V0.7990.14
224_D269_V0.7980.14
61_V231_T0.7960.14
65_G153_E0.7960.14
35_D39_L0.7950.14
177_A231_T0.7930.14
89_G207_I0.7910.14
70_A73_C0.7840.14
261_V266_A0.7840.14
148_R156_Q0.7820.14
87_V221_A0.7700.14
198_L269_V0.7690.14
91_A190_A0.7690.14
276_R279_M0.7670.13
58_G85_V0.7670.13
54_N180_S0.7660.13
71_G215_V0.7650.13
95_E127_I0.7560.13
176_S213_N0.7540.13
69_A87_V0.7510.13
213_N227_V0.7500.13
177_A233_I0.7440.13
117_I164_A0.7400.13
178_S230_G0.7380.13
211_R280_R0.7370.13
101_E112_G0.7360.13
68_E197_R0.7360.13
188_T231_T0.7360.13
119_E169_G0.7330.13
247_Q276_R0.7330.13
115_V132_P0.7300.13
213_N261_V0.7290.13
61_V97_T0.7270.13
71_G205_T0.7270.13
89_G248_G0.7260.13
145_H175_Q0.7250.13
256_V268_D0.7230.13
35_D56_V0.7170.13
125_G217_G0.7160.13
103_L125_G0.7150.13
213_N226_T0.7150.13
115_V217_G0.7120.13
81_V169_G0.7110.13
103_L117_I0.7110.13
91_A159_V0.7080.12
236_D277_G0.7030.12
231_T250_A0.6980.12
223_N272_V0.6920.12
145_H184_W0.6890.12
142_Y201_N0.6880.12
248_G277_G0.6870.12
245_H252_V0.6860.12
230_G280_R0.6840.12
191_T257_S0.6840.12
257_S260_D0.6800.12
176_S207_I0.6800.12
159_V179_V0.6790.12
160_E166_S0.6780.12
123_A132_P0.6770.12
122_E127_I0.6740.12
117_I275_A0.6670.12
102_R139_F0.6650.12
177_A281_V0.6630.12
217_G235_G0.6610.12
137_T144_T0.6610.12
99_I123_A0.6570.12
41_G95_E0.6560.12
92_Y103_L0.6550.12
87_V199_H0.6550.12
133_M179_V0.6540.12
101_E235_G0.6530.12
59_E73_C0.6520.12
246_V276_R0.6510.12
38_V44_S0.6470.12
52_G221_A0.6440.11
167_D173_I0.6440.11
173_I242_G0.6440.11
47_R82_T0.6430.11
115_V134_P0.6390.11
72_D254_G0.6360.11
156_Q171_L0.6350.11
99_I223_N0.6340.11
259_H270_D0.6270.11
96_R184_W0.6260.11
159_V246_V0.6250.11
41_G254_G0.6240.11
197_R220_R0.6220.11
117_I202_I0.6220.11
144_T161_E0.6200.11
197_R203_R0.6180.11
60_R182_D0.6150.11
116_D180_S0.6120.11
251_V258_G0.6110.11
79_C250_A0.6100.11
72_D103_L0.6070.11
88_E93_V0.6050.11
121_F127_I0.6050.11
92_Y105_V0.6040.11
125_G256_V0.6040.11
62_S165_D0.6020.11
159_V249_D0.6010.11
45_Q208_D0.6000.11
212_G245_H0.5970.11
101_E217_G0.5970.11
192_I227_V0.5970.11
172_T261_V0.5950.11
145_H255_D0.5950.11
45_Q80_E0.5940.11
226_T233_I0.5900.11
256_V270_D0.5900.11
53_H261_V0.5830.11
94_G217_G0.5830.11
263_I281_V0.5830.11
95_E196_C0.5780.11
193_G201_N0.5760.11
37_D185_R0.5750.10
35_D281_V0.5740.10
232_K261_V0.5730.10
87_V198_L0.5730.10
266_A273_I0.5630.10
46_L97_T0.5620.10
134_P142_Y0.5620.10
226_T248_G0.5610.10
114_D127_I0.5600.10
166_S252_V0.5600.10
109_L147_L0.5590.10
75_L135_T0.5580.10
261_V273_I0.5560.10
211_R233_I0.5550.10
117_I131_N0.5520.10
100_T177_A0.5520.10
59_E79_C0.5520.10
248_G264_D0.5510.10
57_A86_L0.5470.10
155_A236_D0.5460.10
97_T115_V0.5430.10
90_D95_E0.5430.10
163_A260_D0.5420.10
64_D81_V0.5420.10
142_Y159_V0.5410.10
83_G273_I0.5410.10
69_A252_V0.5410.10
268_D279_M0.5410.10
202_I225_V0.5380.10
195_D230_G0.5360.10
173_I205_T0.5350.10
173_I215_V0.5350.10
39_L139_F0.5340.10
141_M228_G0.5290.10
214_N256_V0.5260.10
86_L220_R0.5250.10
144_T159_V0.5250.10
169_G280_R0.5240.10
277_G281_V0.5240.10
94_G110_D0.5240.10
57_A276_R0.5220.10
183_A221_A0.5220.10
150_G210_G0.5200.10
109_L261_V0.5180.10
57_A60_R0.5160.10
157_E268_D0.5130.10
263_I269_V0.5110.10
250_A260_D0.5110.10
47_R181_D0.5110.10
135_T235_G0.5080.10
94_G174_P0.5070.10
227_V247_Q0.5060.10
101_E234_H0.5060.10
208_D243_S0.5060.10
86_L92_Y0.5050.10
229_A265_E0.5030.10
46_L242_G0.5030.10
42_A173_I0.5020.10
34_A38_V0.5010.10
65_G125_G0.5010.10
160_E243_S0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fs8A 3 0.7828 98.2 0.871 Contact Map
2pigA 1 0.9 98.1 0.874 Contact Map
3t57A 3 0.7931 97.9 0.879 Contact Map
4e79A 3 0.8862 97.7 0.884 Contact Map
2qiaA 3 0.7103 97.6 0.886 Contact Map
2iu8A 3 0.8828 97.6 0.887 Contact Map
3hsqA 3 0.7207 97.6 0.888 Contact Map
4eqyA 3 0.7241 97.6 0.888 Contact Map
4ihfA 4 0.8862 97.5 0.889 Contact Map
3pmoA 3 0.869 97.5 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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