PAN1 - HALSA - GREMLIN Contacts

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PAN1 - Proteasome-activating nucleotidase 1

UniProt:	Q9HRW6	Sequences: MTDTVEDVELPYDDSASQQDKLEALEEQLSTLEEENEEMRDRLLDANAENNKYQQKLERLSHENKKLKQSPLFIATVQELTDEGAVIKQHGNNQEALTEVTDELRATLEPGSRVAVNNSLSVVRQLDDEADVRARVMEVDDSPDVGYEDIGGLDDQLREVRETVELPMKDPGLFETVGINPPSGVLLHGPPGTGKTLMAKAVASQTDASFIKMAGSELVHKFIGEGAKLVRDLFQVARDHEPAVVFIDEIDAIASKRTDSKTSGDAEVQRTMMQLLSEMDGFDERGDIRIIAATNRFDMLDRAILRPGRFDRLIEVPHPNVGGREKIFRIHTRAMNVADSVDFGELAADTGDLSGADVKAICTEAGMFAIRDDRTEVRMQDFQSAREKLDQDSEPAAATDVSRTFA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	406 (329)
Sequences:	9495 (5572)
Seq/√Len:	307.2

ECOLI - FTSH
BACSU - FTSH YJOB SP5K
HALSA - PAN1 CDCH Q9HHW2 Q9HPU1 PAN2 Q9HPV0 Q9HPG1 Q9HNK6
SULSO - Q980U9 Q97ZZ9 PAN Q97W25 Q97V06 Q97ZJ7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
325_E	344_G	5.378	1.00
321_V	348_A	4.870	1.00
329_R	343_F	4.165	1.00
345_E	349_D	3.961	1.00
141_D	144_D	3.393	1.00
143_P	147_Y	3.044	1.00
328_F	358_V	2.995	1.00
339_D	342_D	2.987	1.00
233_L	245_V	2.961	1.00
351_G	354_S	2.934	1.00
148_E	204_S	2.884	1.00
145_V	148_E	2.801	1.00
149_D	204_S	2.796	1.00
326_K	330_I	2.788	1.00
326_K	329_R	2.770	1.00
329_R	340_S	2.675	1.00
325_E	329_R	2.661	1.00
320_N	323_G	2.648	1.00
147_Y	154_D	2.615	1.00
292_A	310_F	2.464	1.00
41_D	45_D	2.378	1.00
351_G	355_G	2.355	1.00
94_Q	101_T	2.232	1.00
76_T	80_L	2.200	1.00
96_A	100_V	2.190	1.00
94_Q	98_T	2.164	1.00
34_E	38_E	2.153	1.00
85_A	88_K	2.116	1.00
84_G	88_K	2.101	1.00
246_F	293_A	2.084	1.00
352_D	355_G	2.079	1.00
253_I	275_L	2.051	1.00
274_Q	278_E	2.001	1.00
359_K	363_T	1.971	1.00
133_R	239_D	1.958	1.00
186_L	310_F	1.925	1.00
132_V	287_D	1.918	1.00
241_E	287_D	1.885	1.00
132_V	241_E	1.857	1.00
171_P	174_F	1.846	1.00
91_G	95_E	1.820	1.00
363_T	367_M	1.805	1.00
211_I	245_V	1.800	1.00
90_H	93_N	1.781	1.00
296_R	299_M	1.741	1.00
187_L	316_V	1.727	1.00
98_T	101_T	1.697	1.00
93_N	96_A	1.683	1.00
77_V	81_T	1.682	1.00
362_C	366_G	1.678	1.00
91_G	94_Q	1.663	1.00
87_I	90_H	1.636	1.00
147_Y	157_L	1.633	1.00
321_V	344_G	1.611	1.00
202_V	291_I	1.607	1.00
333_R	336_N	1.602	1.00
97_L	101_T	1.591	1.00
350_T	358_V	1.575	1.00
70_S	74_I	1.479	1.00
357_D	360_A	1.478	1.00
366_G	370_I	1.471	1.00
87_I	91_G	1.470	1.00
40_R	44_L	1.465	1.00
367_M	371_R	1.446	1.00
77_V	80_L	1.445	1.00
78_Q	90_H	1.445	1.00
305_L	313_L	1.444	1.00
95_E	101_T	1.443	1.00
186_L	250_I	1.407	1.00
345_E	348_A	1.403	1.00
27_E	31_T	1.391	1.00
170_D	175_E	1.388	1.00
278_E	290_I	1.384	1.00
96_A	99_E	1.373	1.00
361_I	365_A	1.372	1.00
88_K	93_N	1.364	1.00
350_T	353_L	1.344	1.00
97_L	124_R	1.334	1.00
95_E	99_E	1.332	1.00
209_S	240_H	1.329	1.00
344_G	348_A	1.329	1.00
325_E	343_F	1.291	1.00
101_T	105_R	1.287	1.00
184_G	279_M	1.284	1.00
101_T	104_L	1.256	1.00
171_P	176_T	1.253	1.00
43_L	47_N	1.251	1.00
188_H	313_L	1.246	1.00
48_A	52_K	1.245	1.00
83_E	87_I	1.226	1.00
41_D	44_L	1.222	1.00
342_D	347_A	1.221	1.00
365_A	369_A	1.215	1.00
250_I	292_A	1.214	1.00
47_N	51_N	1.213	1.00
340_S	344_G	1.199	1.00
170_D	173_L	1.192	1.00
302_R	305_L	1.191	1.00
328_F	343_F	1.190	1.00
297_F	313_L	1.189	1.00
86_V	90_H	1.184	1.00
249_E	295_N	1.183	1.00
328_F	346_L	1.169	1.00
211_I	243_A	1.167	1.00
199_A	291_I	1.166	1.00
215_G	247_I	1.160	1.00
342_D	346_L	1.156	1.00
199_A	246_F	1.146	1.00
211_I	237_A	1.139	1.00
325_E	340_S	1.135	1.00
100_V	103_E	1.133	1.00
58_E	62_H	1.132	1.00
78_Q	81_T	1.129	1.00
321_V	347_A	1.127	1.00
341_V	347_A	1.124	1.00
89_Q	97_L	1.120	1.00
35_E	39_M	1.120	1.00
94_Q	100_V	1.116	1.00
335_M	362_C	1.116	1.00
254_A	304_I	1.115	1.00
88_K	92_N	1.115	1.00
84_G	87_I	1.115	1.00
51_N	55_Q	1.114	1.00
88_K	91_G	1.109	1.00
221_K	270_R	1.101	1.00
157_L	198_M	1.096	1.00
55_Q	59_R	1.095	1.00
341_V	344_G	1.092	1.00
355_G	359_K	1.087	1.00
154_D	158_R	1.084	1.00
86_V	89_Q	1.083	1.00
48_A	51_N	1.081	1.00
83_E	91_G	1.076	1.00
297_F	305_L	1.076	1.00
354_S	357_D	1.071	1.00
104_L	107_T	1.064	1.00
95_E	100_V	1.063	1.00
151_G	330_I	1.061	1.00
39_M	43_L	1.059	1.00
72_L	76_T	1.057	1.00
145_V	204_S	1.056	1.00
141_D	145_V	1.048	1.00
65_K	69_Q	1.042	1.00
53_Y	56_K	1.034	1.00
44_L	48_A	1.032	1.00
90_H	94_Q	1.031	1.00
69_Q	73_F	1.030	1.00
46_A	50_N	1.028	1.00
357_D	361_I	1.028	1.00
50_N	53_Y	1.026	1.00
52_K	55_Q	1.026	1.00
53_Y	64_N	1.023	1.00
45_D	49_E	1.017	1.00
36_N	40_R	1.017	1.00
198_M	316_V	1.011	1.00
143_P	158_R	1.009	1.00
89_Q	101_T	1.007	1.00
67_L	70_S	1.002	1.00
56_K	60_L	1.002	1.00
363_T	368_F	1.000	1.00
363_T	371_R	0.998	1.00
74_I	78_Q	0.996	1.00
80_L	83_E	0.992	1.00
39_M	62_H	0.992	1.00
142_S	205_Q	0.988	1.00
89_Q	92_N	0.986	1.00
28_Q	31_T	0.983	1.00
322_G	325_E	0.983	1.00
143_P	165_E	0.983	1.00
86_V	91_G	0.981	1.00
213_M	233_L	0.980	1.00
79_E	83_E	0.978	1.00
366_G	371_R	0.976	1.00
352_D	356_A	0.972	1.00
102_D	106_A	0.971	1.00
55_Q	58_E	0.970	1.00
358_V	361_I	0.969	1.00
363_T	366_G	0.967	1.00
365_A	370_I	0.967	1.00
66_K	69_Q	0.965	1.00
235_Q	239_D	0.963	1.00
108_L	112_S	0.957	1.00
99_E	106_A	0.956	1.00
100_V	104_L	0.953	1.00
51_N	54_Q	0.953	1.00
133_R	209_S	0.951	1.00
70_S	73_F	0.950	1.00
317_P	323_G	0.949	1.00
210_F	246_F	0.946	1.00
95_E	98_T	0.941	1.00
149_D	197_L	0.937	1.00
355_G	358_V	0.936	1.00
77_V	82_D	0.933	1.00
39_M	42_R	0.931	1.00
151_G	326_K	0.931	1.00
75_A	78_Q	0.926	1.00
97_L	100_V	0.926	1.00
249_E	309_R	0.925	1.00
342_D	345_E	0.925	1.00
210_F	244_V	0.923	1.00
99_E	103_E	0.910	1.00
87_I	92_N	0.908	1.00
70_S	94_Q	0.905	1.00
354_S	359_K	0.905	1.00
74_I	81_T	0.905	1.00
108_L	111_G	0.903	1.00
29_L	33_E	0.903	1.00
81_T	97_L	0.902	1.00
30_S	34_E	0.892	1.00
275_L	278_E	0.888	1.00
219_V	273_M	0.887	1.00
331_H	334_A	0.881	1.00
173_L	176_T	0.880	1.00
325_E	347_A	0.879	1.00
57_L	60_L	0.878	1.00
38_E	42_R	0.877	1.00
44_L	47_N	0.877	1.00
361_I	367_M	0.873	1.00
83_E	89_Q	0.873	1.00
306_R	356_A	0.871	1.00
172_G	176_T	0.870	1.00
89_Q	93_N	0.867	1.00
113_R	117_N	0.867	1.00
174_F	177_V	0.867	1.00
248_D	309_R	0.867	1.00
72_L	75_A	0.864	1.00
61_S	64_N	0.862	1.00
272_M	301_D	0.857	1.00
143_P	371_R	0.856	1.00
73_F	76_T	0.854	1.00
78_Q	82_D	0.853	1.00
37_E	41_D	0.853	1.00
161_R	165_E	0.852	1.00
85_A	92_N	0.851	1.00
201_A	204_S	0.851	1.00
42_R	45_D	0.851	1.00
120_L	124_R	0.843	1.00
324_R	347_A	0.839	1.00
50_N	54_Q	0.838	1.00
81_T	84_G	0.835	1.00
32_L	35_E	0.833	1.00
59_R	63_E	0.832	1.00
55_Q	60_L	0.829	1.00
115_A	118_N	0.829	1.00
30_S	33_E	0.818	1.00
89_Q	95_E	0.817	1.00
353_L	357_D	0.815	1.00
92_N	96_A	0.813	1.00
101_T	107_T	0.813	1.00
361_I	364_E	0.812	1.00
350_T	354_S	0.811	1.00
354_S	358_V	0.811	1.00
170_D	174_F	0.811	1.00
87_I	94_Q	0.806	1.00
211_I	233_L	0.805	1.00
213_M	245_V	0.802	1.00
234_F	241_E	0.797	1.00
75_A	79_E	0.794	1.00
154_D	323_G	0.793	1.00
86_V	92_N	0.791	1.00
318_H	354_S	0.790	1.00
34_E	37_E	0.786	1.00
332_T	362_C	0.785	1.00
53_Y	57_L	0.785	1.00
178_G	208_A	0.784	1.00
84_G	91_G	0.784	1.00
40_R	43_L	0.781	0.99
130_A	241_E	0.774	0.99
108_L	115_A	0.774	0.99
28_Q	32_L	0.773	0.99
95_E	106_A	0.773	0.99
188_H	294_T	0.772	0.99
145_V	205_Q	0.772	0.99
83_E	90_H	0.772	0.99
350_T	357_D	0.770	0.99
210_F	214_A	0.769	0.99
176_T	180_N	0.768	0.99
209_S	243_A	0.767	0.99
53_Y	60_L	0.767	0.99
73_F	77_V	0.767	0.99
187_L	202_V	0.765	0.99
341_V	345_E	0.762	0.99
71_P	98_T	0.761	0.99
89_Q	94_Q	0.761	0.99
67_L	94_Q	0.759	0.99
155_D	158_R	0.758	0.99
31_T	34_E	0.756	0.99
137_M	141_D	0.756	0.99
62_H	65_K	0.754	0.99
110_P	115_A	0.752	0.99
358_V	363_T	0.751	0.99
102_D	105_R	0.750	0.99
87_I	93_N	0.748	0.99
295_N	309_R	0.745	0.99
90_H	101_T	0.744	0.99
249_E	276_L	0.740	0.99
276_L	295_N	0.739	0.99
180_N	183_S	0.739	0.99
350_T	355_G	0.738	0.99
62_H	66_K	0.737	0.99
363_T	370_I	0.737	0.99
73_F	80_L	0.737	0.99
97_L	103_E	0.736	0.99
38_E	41_D	0.736	0.99
64_N	68_K	0.735	0.99
149_D	201_A	0.734	0.99
101_T	106_A	0.732	0.99
231_R	234_F	0.730	0.99
70_S	77_V	0.730	0.99
52_K	56_K	0.726	0.99
89_Q	98_T	0.725	0.99
85_A	89_Q	0.724	0.99
69_Q	72_L	0.723	0.99
49_E	53_Y	0.722	0.99
94_Q	104_L	0.715	0.99
116_V	120_L	0.714	0.99
139_V	143_P	0.713	0.99
32_L	36_N	0.713	0.99
369_A	372_D	0.713	0.99
359_K	362_C	0.713	0.99
349_D	361_I	0.712	0.99
328_F	347_A	0.711	0.99
350_T	361_I	0.711	0.99
93_N	101_T	0.711	0.99
114_V	117_N	0.710	0.99
358_V	362_C	0.707	0.99
60_L	63_E	0.703	0.99
119_S	123_V	0.703	0.99
367_M	370_I	0.701	0.99
88_K	130_A	0.699	0.99
366_G	369_A	0.697	0.99
41_D	48_A	0.696	0.99
37_E	40_R	0.696	0.99
109_E	114_V	0.696	0.99
352_D	357_D	0.696	0.99
68_K	72_L	0.693	0.99
131_D	134_A	0.689	0.99
50_N	64_N	0.688	0.99
81_T	98_T	0.688	0.99
59_R	62_H	0.688	0.99
329_R	333_R	0.687	0.99
94_Q	105_R	0.686	0.99
218_L	232_D	0.683	0.99
32_L	39_M	0.682	0.99
35_E	59_R	0.676	0.99
321_V	325_E	0.675	0.99
110_P	114_V	0.675	0.99
98_T	102_D	0.672	0.98
112_S	115_A	0.671	0.98
206_T	289_R	0.669	0.98
144_D	147_Y	0.669	0.98
352_D	359_K	0.668	0.98
57_L	61_S	0.667	0.98
122_V	126_L	0.666	0.98
158_R	162_E	0.664	0.98
136_V	141_D	0.663	0.98
85_A	93_N	0.661	0.98
146_G	201_A	0.659	0.98
42_R	46_A	0.657	0.98
347_A	350_T	0.653	0.98
56_K	63_E	0.652	0.98
209_S	239_D	0.649	0.98
244_V	291_I	0.648	0.98
248_D	295_N	0.647	0.98
80_L	86_V	0.646	0.98
94_Q	97_L	0.646	0.98
332_T	343_F	0.644	0.98
247_I	275_L	0.643	0.98
275_L	304_I	0.637	0.98
57_L	64_N	0.635	0.98
71_P	75_A	0.634	0.98
356_A	364_E	0.633	0.98
153_L	316_V	0.632	0.98
338_A	341_V	0.630	0.98
121_S	125_Q	0.625	0.98
275_L	279_M	0.625	0.98
63_E	66_K	0.623	0.98
353_L	361_I	0.623	0.98
85_A	91_G	0.623	0.98
36_N	43_L	0.621	0.97
186_L	313_L	0.620	0.97
123_V	235_Q	0.619	0.97
31_T	35_E	0.619	0.97
362_C	367_M	0.619	0.97
171_P	177_V	0.618	0.97
84_G	93_N	0.616	0.97
142_S	161_R	0.613	0.97
133_R	141_D	0.612	0.97
87_I	131_D	0.611	0.97
41_D	51_N	0.610	0.97
365_A	371_R	0.608	0.97
254_A	267_E	0.607	0.97
108_L	114_V	0.605	0.97
364_E	371_R	0.604	0.97
171_P	175_E	0.599	0.97
86_V	93_N	0.598	0.97
83_E	86_V	0.597	0.97
66_K	93_N	0.596	0.97
111_G	116_V	0.591	0.97
270_R	273_M	0.590	0.97
63_E	79_E	0.589	0.97
354_S	360_A	0.587	0.96
76_T	79_E	0.585	0.96
94_Q	103_E	0.584	0.96
361_I	366_G	0.584	0.96
50_N	56_K	0.584	0.96
191_P	303_A	0.581	0.96
143_P	161_R	0.579	0.96
44_L	55_Q	0.579	0.96
89_Q	124_R	0.579	0.96
60_L	64_N	0.578	0.96
28_Q	35_E	0.578	0.96
83_E	95_E	0.578	0.96
52_K	59_R	0.578	0.96
36_N	41_D	0.574	0.96
53_Y	61_S	0.574	0.96
295_N	303_A	0.574	0.96
111_G	115_A	0.574	0.96
58_E	65_K	0.571	0.96
93_N	97_L	0.570	0.96
191_P	249_E	0.565	0.96
365_A	372_D	0.563	0.96
83_E	88_K	0.561	0.95
199_A	210_F	0.560	0.95
73_F	85_A	0.559	0.95
200_K	282_F	0.559	0.95
84_G	89_Q	0.557	0.95
135_R	206_T	0.557	0.95
200_K	210_F	0.555	0.95
40_R	59_R	0.555	0.95
78_Q	105_R	0.555	0.95
33_E	37_E	0.554	0.95
196_T	248_D	0.554	0.95
155_D	317_P	0.553	0.95
280_D	309_R	0.549	0.95
58_E	61_S	0.549	0.95
59_R	66_K	0.549	0.95
70_S	93_N	0.548	0.95
40_R	52_K	0.546	0.95
33_E	52_K	0.545	0.95
63_E	101_T	0.544	0.95
30_S	38_E	0.542	0.94
149_D	207_D	0.542	0.94
346_L	361_I	0.542	0.94
99_E	102_D	0.540	0.94
219_V	270_R	0.540	0.94
232_D	236_V	0.540	0.94
337_V	341_V	0.539	0.94
211_I	240_H	0.538	0.94
360_A	366_G	0.538	0.94
34_E	41_D	0.538	0.94
81_T	101_T	0.536	0.94
249_E	303_A	0.535	0.94
219_V	271_T	0.535	0.94
74_I	77_V	0.534	0.94
27_E	34_E	0.533	0.94
95_E	104_L	0.531	0.94
156_Q	314_I	0.529	0.94
234_F	237_A	0.527	0.94
76_T	81_T	0.527	0.94
44_L	51_N	0.526	0.94
94_Q	107_T	0.526	0.94
30_S	37_E	0.524	0.93
196_T	309_R	0.521	0.93
233_L	236_V	0.521	0.93
322_G	344_G	0.518	0.93
111_G	119_S	0.518	0.93
352_D	358_V	0.518	0.93
37_E	43_L	0.518	0.93
146_G	205_Q	0.518	0.93
95_E	105_R	0.516	0.93
51_N	58_E	0.516	0.93
178_G	334_A	0.516	0.93
57_L	63_E	0.516	0.93
112_S	116_V	0.515	0.93
162_E	165_E	0.515	0.93
89_Q	125_Q	0.515	0.93
50_N	55_Q	0.514	0.93
38_E	44_L	0.514	0.93
87_I	101_T	0.514	0.93
43_L	55_Q	0.513	0.93
91_G	106_A	0.512	0.93
93_N	99_E	0.511	0.93
208_A	244_V	0.510	0.93
74_I	94_Q	0.509	0.92
67_L	74_I	0.509	0.92
241_E	288_I	0.507	0.92
71_P	74_I	0.507	0.92
319_P	324_R	0.506	0.92
156_Q	187_L	0.505	0.92
27_E	30_S	0.504	0.92
159_E	312_R	0.503	0.92
47_N	54_Q	0.501	0.92
98_T	105_R	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cr2J	1	0.9138	100	0.354	Contact Map
3cf2A	3	0.7931	100	0.376	Contact Map
4cr2L	1	0.8842	100	0.387	Contact Map
2ce7A	3	0.6305	100	0.409	Contact Map
4cr2M	1	0.8744	100	0.41	Contact Map
4cr2K	1	0.9286	100	0.42	Contact Map
2x8aA	1	0.5714	100	0.42	Contact Map
3cf0A	3	0.6724	100	0.425	Contact Map
4ww0A	4	0.633	100	0.431	Contact Map
4cr2I	1	0.8793	100	0.434	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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