GREMLIN Database
PAN1 - Proteasome-activating nucleotidase 1
UniProt: Q9HRW6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 406 (329)
Sequences: 9495 (5572)
Seq/√Len: 307.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_E344_G5.3781.00
321_V348_A4.8701.00
329_R343_F4.1651.00
345_E349_D3.9611.00
141_D144_D3.3931.00
143_P147_Y3.0441.00
328_F358_V2.9951.00
339_D342_D2.9871.00
233_L245_V2.9611.00
351_G354_S2.9341.00
148_E204_S2.8841.00
145_V148_E2.8011.00
149_D204_S2.7961.00
326_K330_I2.7881.00
326_K329_R2.7701.00
329_R340_S2.6751.00
325_E329_R2.6611.00
320_N323_G2.6481.00
147_Y154_D2.6151.00
292_A310_F2.4641.00
41_D45_D2.3781.00
351_G355_G2.3551.00
94_Q101_T2.2321.00
76_T80_L2.2001.00
96_A100_V2.1901.00
94_Q98_T2.1641.00
34_E38_E2.1531.00
85_A88_K2.1161.00
84_G88_K2.1011.00
246_F293_A2.0841.00
352_D355_G2.0791.00
253_I275_L2.0511.00
274_Q278_E2.0011.00
359_K363_T1.9711.00
133_R239_D1.9581.00
186_L310_F1.9251.00
132_V287_D1.9181.00
241_E287_D1.8851.00
132_V241_E1.8571.00
171_P174_F1.8461.00
91_G95_E1.8201.00
363_T367_M1.8051.00
211_I245_V1.8001.00
90_H93_N1.7811.00
296_R299_M1.7411.00
187_L316_V1.7271.00
98_T101_T1.6971.00
93_N96_A1.6831.00
77_V81_T1.6821.00
362_C366_G1.6781.00
91_G94_Q1.6631.00
87_I90_H1.6361.00
147_Y157_L1.6331.00
321_V344_G1.6111.00
202_V291_I1.6071.00
333_R336_N1.6021.00
97_L101_T1.5911.00
350_T358_V1.5751.00
70_S74_I1.4791.00
357_D360_A1.4781.00
366_G370_I1.4711.00
87_I91_G1.4701.00
40_R44_L1.4651.00
367_M371_R1.4461.00
77_V80_L1.4451.00
78_Q90_H1.4451.00
305_L313_L1.4441.00
95_E101_T1.4431.00
186_L250_I1.4071.00
345_E348_A1.4031.00
27_E31_T1.3911.00
170_D175_E1.3881.00
278_E290_I1.3841.00
96_A99_E1.3731.00
361_I365_A1.3721.00
88_K93_N1.3641.00
350_T353_L1.3441.00
97_L124_R1.3341.00
95_E99_E1.3321.00
209_S240_H1.3291.00
344_G348_A1.3291.00
325_E343_F1.2911.00
101_T105_R1.2871.00
184_G279_M1.2841.00
101_T104_L1.2561.00
171_P176_T1.2531.00
43_L47_N1.2511.00
188_H313_L1.2461.00
48_A52_K1.2451.00
83_E87_I1.2261.00
41_D44_L1.2221.00
342_D347_A1.2211.00
365_A369_A1.2151.00
250_I292_A1.2141.00
47_N51_N1.2131.00
340_S344_G1.1991.00
170_D173_L1.1921.00
302_R305_L1.1911.00
328_F343_F1.1901.00
297_F313_L1.1891.00
86_V90_H1.1841.00
249_E295_N1.1831.00
328_F346_L1.1691.00
211_I243_A1.1671.00
199_A291_I1.1661.00
215_G247_I1.1601.00
342_D346_L1.1561.00
199_A246_F1.1461.00
211_I237_A1.1391.00
325_E340_S1.1351.00
100_V103_E1.1331.00
58_E62_H1.1321.00
78_Q81_T1.1291.00
321_V347_A1.1271.00
341_V347_A1.1241.00
89_Q97_L1.1201.00
35_E39_M1.1201.00
94_Q100_V1.1161.00
335_M362_C1.1161.00
254_A304_I1.1151.00
88_K92_N1.1151.00
84_G87_I1.1151.00
51_N55_Q1.1141.00
88_K91_G1.1091.00
221_K270_R1.1011.00
157_L198_M1.0961.00
55_Q59_R1.0951.00
341_V344_G1.0921.00
355_G359_K1.0871.00
154_D158_R1.0841.00
86_V89_Q1.0831.00
48_A51_N1.0811.00
83_E91_G1.0761.00
297_F305_L1.0761.00
354_S357_D1.0711.00
104_L107_T1.0641.00
95_E100_V1.0631.00
151_G330_I1.0611.00
39_M43_L1.0591.00
72_L76_T1.0571.00
145_V204_S1.0561.00
141_D145_V1.0481.00
65_K69_Q1.0421.00
53_Y56_K1.0341.00
44_L48_A1.0321.00
90_H94_Q1.0311.00
69_Q73_F1.0301.00
46_A50_N1.0281.00
357_D361_I1.0281.00
50_N53_Y1.0261.00
52_K55_Q1.0261.00
53_Y64_N1.0231.00
45_D49_E1.0171.00
36_N40_R1.0171.00
198_M316_V1.0111.00
143_P158_R1.0091.00
89_Q101_T1.0071.00
67_L70_S1.0021.00
56_K60_L1.0021.00
363_T368_F1.0001.00
363_T371_R0.9981.00
74_I78_Q0.9961.00
80_L83_E0.9921.00
39_M62_H0.9921.00
142_S205_Q0.9881.00
89_Q92_N0.9861.00
28_Q31_T0.9831.00
322_G325_E0.9831.00
143_P165_E0.9831.00
86_V91_G0.9811.00
213_M233_L0.9801.00
79_E83_E0.9781.00
366_G371_R0.9761.00
352_D356_A0.9721.00
102_D106_A0.9711.00
55_Q58_E0.9701.00
358_V361_I0.9691.00
363_T366_G0.9671.00
365_A370_I0.9671.00
66_K69_Q0.9651.00
235_Q239_D0.9631.00
108_L112_S0.9571.00
99_E106_A0.9561.00
100_V104_L0.9531.00
51_N54_Q0.9531.00
133_R209_S0.9511.00
70_S73_F0.9501.00
317_P323_G0.9491.00
210_F246_F0.9461.00
95_E98_T0.9411.00
149_D197_L0.9371.00
355_G358_V0.9361.00
77_V82_D0.9331.00
39_M42_R0.9311.00
151_G326_K0.9311.00
75_A78_Q0.9261.00
97_L100_V0.9261.00
249_E309_R0.9251.00
342_D345_E0.9251.00
210_F244_V0.9231.00
99_E103_E0.9101.00
87_I92_N0.9081.00
70_S94_Q0.9051.00
354_S359_K0.9051.00
74_I81_T0.9051.00
108_L111_G0.9031.00
29_L33_E0.9031.00
81_T97_L0.9021.00
30_S34_E0.8921.00
275_L278_E0.8881.00
219_V273_M0.8871.00
331_H334_A0.8811.00
173_L176_T0.8801.00
325_E347_A0.8791.00
57_L60_L0.8781.00
38_E42_R0.8771.00
44_L47_N0.8771.00
361_I367_M0.8731.00
83_E89_Q0.8731.00
306_R356_A0.8711.00
172_G176_T0.8701.00
89_Q93_N0.8671.00
113_R117_N0.8671.00
174_F177_V0.8671.00
248_D309_R0.8671.00
72_L75_A0.8641.00
61_S64_N0.8621.00
272_M301_D0.8571.00
143_P371_R0.8561.00
73_F76_T0.8541.00
78_Q82_D0.8531.00
37_E41_D0.8531.00
161_R165_E0.8521.00
85_A92_N0.8511.00
201_A204_S0.8511.00
42_R45_D0.8511.00
120_L124_R0.8431.00
324_R347_A0.8391.00
50_N54_Q0.8381.00
81_T84_G0.8351.00
32_L35_E0.8331.00
59_R63_E0.8321.00
55_Q60_L0.8291.00
115_A118_N0.8291.00
30_S33_E0.8181.00
89_Q95_E0.8171.00
353_L357_D0.8151.00
92_N96_A0.8131.00
101_T107_T0.8131.00
361_I364_E0.8121.00
350_T354_S0.8111.00
354_S358_V0.8111.00
170_D174_F0.8111.00
87_I94_Q0.8061.00
211_I233_L0.8051.00
213_M245_V0.8021.00
234_F241_E0.7971.00
75_A79_E0.7941.00
154_D323_G0.7931.00
86_V92_N0.7911.00
318_H354_S0.7901.00
34_E37_E0.7861.00
332_T362_C0.7851.00
53_Y57_L0.7851.00
178_G208_A0.7841.00
84_G91_G0.7841.00
40_R43_L0.7810.99
130_A241_E0.7740.99
108_L115_A0.7740.99
28_Q32_L0.7730.99
95_E106_A0.7730.99
188_H294_T0.7720.99
145_V205_Q0.7720.99
83_E90_H0.7720.99
350_T357_D0.7700.99
210_F214_A0.7690.99
176_T180_N0.7680.99
209_S243_A0.7670.99
53_Y60_L0.7670.99
73_F77_V0.7670.99
187_L202_V0.7650.99
341_V345_E0.7620.99
71_P98_T0.7610.99
89_Q94_Q0.7610.99
67_L94_Q0.7590.99
155_D158_R0.7580.99
31_T34_E0.7560.99
137_M141_D0.7560.99
62_H65_K0.7540.99
110_P115_A0.7520.99
358_V363_T0.7510.99
102_D105_R0.7500.99
87_I93_N0.7480.99
295_N309_R0.7450.99
90_H101_T0.7440.99
249_E276_L0.7400.99
276_L295_N0.7390.99
180_N183_S0.7390.99
350_T355_G0.7380.99
62_H66_K0.7370.99
363_T370_I0.7370.99
73_F80_L0.7370.99
97_L103_E0.7360.99
38_E41_D0.7360.99
64_N68_K0.7350.99
149_D201_A0.7340.99
101_T106_A0.7320.99
231_R234_F0.7300.99
70_S77_V0.7300.99
52_K56_K0.7260.99
89_Q98_T0.7250.99
85_A89_Q0.7240.99
69_Q72_L0.7230.99
49_E53_Y0.7220.99
94_Q104_L0.7150.99
116_V120_L0.7140.99
139_V143_P0.7130.99
32_L36_N0.7130.99
369_A372_D0.7130.99
359_K362_C0.7130.99
349_D361_I0.7120.99
328_F347_A0.7110.99
350_T361_I0.7110.99
93_N101_T0.7110.99
114_V117_N0.7100.99
358_V362_C0.7070.99
60_L63_E0.7030.99
119_S123_V0.7030.99
367_M370_I0.7010.99
88_K130_A0.6990.99
366_G369_A0.6970.99
41_D48_A0.6960.99
37_E40_R0.6960.99
109_E114_V0.6960.99
352_D357_D0.6960.99
68_K72_L0.6930.99
131_D134_A0.6890.99
50_N64_N0.6880.99
81_T98_T0.6880.99
59_R62_H0.6880.99
329_R333_R0.6870.99
94_Q105_R0.6860.99
218_L232_D0.6830.99
32_L39_M0.6820.99
35_E59_R0.6760.99
321_V325_E0.6750.99
110_P114_V0.6750.99
98_T102_D0.6720.98
112_S115_A0.6710.98
206_T289_R0.6690.98
144_D147_Y0.6690.98
352_D359_K0.6680.98
57_L61_S0.6670.98
122_V126_L0.6660.98
158_R162_E0.6640.98
136_V141_D0.6630.98
85_A93_N0.6610.98
146_G201_A0.6590.98
42_R46_A0.6570.98
347_A350_T0.6530.98
56_K63_E0.6520.98
209_S239_D0.6490.98
244_V291_I0.6480.98
248_D295_N0.6470.98
80_L86_V0.6460.98
94_Q97_L0.6460.98
332_T343_F0.6440.98
247_I275_L0.6430.98
275_L304_I0.6370.98
57_L64_N0.6350.98
71_P75_A0.6340.98
356_A364_E0.6330.98
153_L316_V0.6320.98
338_A341_V0.6300.98
121_S125_Q0.6250.98
275_L279_M0.6250.98
63_E66_K0.6230.98
353_L361_I0.6230.98
85_A91_G0.6230.98
36_N43_L0.6210.97
186_L313_L0.6200.97
123_V235_Q0.6190.97
31_T35_E0.6190.97
362_C367_M0.6190.97
171_P177_V0.6180.97
84_G93_N0.6160.97
142_S161_R0.6130.97
133_R141_D0.6120.97
87_I131_D0.6110.97
41_D51_N0.6100.97
365_A371_R0.6080.97
254_A267_E0.6070.97
108_L114_V0.6050.97
364_E371_R0.6040.97
171_P175_E0.5990.97
86_V93_N0.5980.97
83_E86_V0.5970.97
66_K93_N0.5960.97
111_G116_V0.5910.97
270_R273_M0.5900.97
63_E79_E0.5890.97
354_S360_A0.5870.96
76_T79_E0.5850.96
94_Q103_E0.5840.96
361_I366_G0.5840.96
50_N56_K0.5840.96
191_P303_A0.5810.96
143_P161_R0.5790.96
44_L55_Q0.5790.96
89_Q124_R0.5790.96
60_L64_N0.5780.96
28_Q35_E0.5780.96
83_E95_E0.5780.96
52_K59_R0.5780.96
36_N41_D0.5740.96
53_Y61_S0.5740.96
295_N303_A0.5740.96
111_G115_A0.5740.96
58_E65_K0.5710.96
93_N97_L0.5700.96
191_P249_E0.5650.96
365_A372_D0.5630.96
83_E88_K0.5610.95
199_A210_F0.5600.95
73_F85_A0.5590.95
200_K282_F0.5590.95
84_G89_Q0.5570.95
135_R206_T0.5570.95
200_K210_F0.5550.95
40_R59_R0.5550.95
78_Q105_R0.5550.95
33_E37_E0.5540.95
196_T248_D0.5540.95
155_D317_P0.5530.95
280_D309_R0.5490.95
58_E61_S0.5490.95
59_R66_K0.5490.95
70_S93_N0.5480.95
40_R52_K0.5460.95
33_E52_K0.5450.95
63_E101_T0.5440.95
30_S38_E0.5420.94
149_D207_D0.5420.94
346_L361_I0.5420.94
99_E102_D0.5400.94
219_V270_R0.5400.94
232_D236_V0.5400.94
337_V341_V0.5390.94
211_I240_H0.5380.94
360_A366_G0.5380.94
34_E41_D0.5380.94
81_T101_T0.5360.94
249_E303_A0.5350.94
219_V271_T0.5350.94
74_I77_V0.5340.94
27_E34_E0.5330.94
95_E104_L0.5310.94
156_Q314_I0.5290.94
234_F237_A0.5270.94
76_T81_T0.5270.94
44_L51_N0.5260.94
94_Q107_T0.5260.94
30_S37_E0.5240.93
196_T309_R0.5210.93
233_L236_V0.5210.93
322_G344_G0.5180.93
111_G119_S0.5180.93
352_D358_V0.5180.93
37_E43_L0.5180.93
146_G205_Q0.5180.93
95_E105_R0.5160.93
51_N58_E0.5160.93
178_G334_A0.5160.93
57_L63_E0.5160.93
112_S116_V0.5150.93
162_E165_E0.5150.93
89_Q125_Q0.5150.93
50_N55_Q0.5140.93
38_E44_L0.5140.93
87_I101_T0.5140.93
43_L55_Q0.5130.93
91_G106_A0.5120.93
93_N99_E0.5110.93
208_A244_V0.5100.93
74_I94_Q0.5090.92
67_L74_I0.5090.92
241_E288_I0.5070.92
71_P74_I0.5070.92
319_P324_R0.5060.92
156_Q187_L0.5050.92
27_E30_S0.5040.92
159_E312_R0.5030.92
47_N54_Q0.5010.92
98_T105_R0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cr2J 1 0.9138 100 0.354 Contact Map
3cf2A 3 0.7931 100 0.376 Contact Map
4cr2L 1 0.8842 100 0.387 Contact Map
2ce7A 3 0.6305 100 0.409 Contact Map
4cr2M 1 0.8744 100 0.41 Contact Map
4cr2K 1 0.9286 100 0.42 Contact Map
2x8aA 1 0.5714 100 0.42 Contact Map
3cf0A 3 0.6724 100 0.425 Contact Map
4ww0A 4 0.633 100 0.431 Contact Map
4cr2I 1 0.8793 100 0.434 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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