GREMLIN Database
Q9HRW5 - Uncharacterized protein
UniProt: Q9HRW5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 76 (70)
Sequences: 163 (88)
Seq/√Len: 10.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_K25_E3.8030.99
22_K26_Y2.9990.94
40_L70_K2.5420.86
64_S72_L2.1870.76
61_S64_S2.1280.74
17_A30_L2.0610.72
20_V23_V1.9370.67
7_A10_L1.9360.67
33_R70_K1.9310.66
59_V74_T1.6850.55
55_D59_V1.6080.52
54_E61_S1.5500.49
46_V49_A1.5340.48
47_R68_A1.5310.48
17_A20_V1.4580.45
21_A70_K1.4050.42
13_L51_T1.3900.42
10_L58_I1.3460.40
52_R65_F1.3310.39
35_L40_L1.3080.38
34_E40_L1.2780.37
23_V68_A1.2370.35
31_S43_D1.2260.34
42_P62_R1.2080.34
19_L32_Q1.1920.33
48_Y62_R1.1680.32
42_P75_L1.1570.32
21_A61_S1.1320.31
43_D48_Y1.0930.29
35_L43_D1.0880.29
8_D27_N1.0880.29
43_D50_L1.0880.29
35_L50_L1.0730.28
32_Q68_A1.0680.28
49_A65_F1.0430.27
11_E52_R1.0410.27
29_T39_T1.0380.27
21_A71_R1.0310.27
38_K75_L0.9920.25
49_A64_S0.9770.25
8_D74_T0.9720.25
10_L55_D0.9310.23
23_V28_D0.9270.23
38_K58_I0.9220.23
56_H62_R0.9100.22
12_S38_K0.9040.22
59_V71_R0.8910.22
42_P72_L0.8870.22
15_P18_K0.8800.21
38_K60_S0.8770.21
40_L59_V0.8710.21
7_A21_A0.8640.21
36_A50_L0.8320.20
47_R73_Y0.8310.20
50_L59_V0.8150.19
16_S19_L0.7900.19
17_A56_H0.7830.19
63_F71_R0.7700.18
8_D29_T0.7690.18
37_E51_T0.7640.18
17_A49_A0.7610.18
33_R74_T0.7610.18
26_Y36_A0.7550.18
54_E59_V0.7500.18
55_D62_R0.7280.17
11_E57_D0.7260.17
35_L57_D0.7180.17
29_T34_E0.7180.17
52_R72_L0.7100.17
54_E60_S0.7080.17
29_T66_T0.6940.16
15_P19_L0.6910.16
7_A58_I0.6840.16
57_D60_S0.6840.16
38_K48_Y0.6740.16
8_D48_Y0.6720.16
30_L37_E0.6710.16
8_D60_S0.6480.15
49_A68_A0.6430.15
39_T46_V0.6420.15
9_A58_I0.6400.15
10_L29_T0.6360.15
42_P54_E0.6350.15
20_V49_A0.6160.14
20_V68_A0.6090.14
29_T63_F0.5690.13
7_A33_R0.5660.13
27_N75_L0.5620.13
11_E61_S0.5600.13
27_N72_L0.5540.13
23_V26_Y0.5520.13
12_S29_T0.5480.13
18_K47_R0.5470.13
33_R36_A0.5460.13
54_E58_I0.5410.13
61_S65_F0.5400.13
49_A61_S0.5360.13
21_A63_F0.5340.12
64_S74_T0.5310.12
8_D43_D0.5230.12
27_N59_V0.5210.12
31_S70_K0.5140.12
21_A62_R0.5040.12
20_V52_R0.5020.12
23_V35_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dk5A 1 1 98.7 0.675 Contact Map
2mlgA 1 0.8684 98.3 0.709 Contact Map
3nqoA 2 0.9868 98.3 0.713 Contact Map
1hsjA 2 1 98.3 0.716 Contact Map
3bddA 2 0.9737 98.2 0.72 Contact Map
2nnnA 2 0.9342 98.2 0.721 Contact Map
2fxaA 4 1 98.2 0.721 Contact Map
3zplA 2 1 98.2 0.722 Contact Map
4rbrA 2 0.9474 98.2 0.722 Contact Map
3cdhA 4 0.8947 98.2 0.722 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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