GREMLIN Database
MRE11 - DNA double-strand break repair protein Mre11
UniProt: Q9HRW4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (335)
Sequences: 3683 (2972)
Seq/√Len: 162.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_V148_V4.5891.00
40_E230_S3.9931.00
213_G231_R3.8571.00
36_D214_Y3.5021.00
42_V216_I3.2721.00
5_I42_V3.2571.00
33_V201_T3.0181.00
4_V44_A3.0171.00
3_R218_S2.9841.00
211_P233_S2.9511.00
31_D71_P2.9071.00
37_A45_V2.8471.00
40_E232_K2.7571.00
80_L119_F2.7281.00
216_I232_K2.5861.00
7_T47_H2.5221.00
35_T39_D2.4511.00
215_N229_I2.4401.00
218_S230_S2.4341.00
36_D40_E2.4211.00
36_D232_K2.3861.00
8_G198_C2.3341.00
118_A143_D2.2911.00
241_F270_V2.2601.00
105_E109_D2.2521.00
7_T10_T2.2511.00
38_I75_A2.2221.00
196_T215_N2.2161.00
65_T69_L2.2001.00
187_T193_T2.1111.00
48_A148_V2.0331.00
6_H178_L2.0291.00
113_V118_A2.0191.00
243_D272_T2.0061.00
30_F68_L1.9811.00
156_F182_N1.9571.00
44_A80_L1.9171.00
4_V217_V1.9101.00
219_F227_V1.8831.00
40_E216_I1.8801.00
130_R134_D1.8021.00
46_V119_F1.7981.00
147_L174_F1.7931.00
240_V267_A1.7811.00
293_G297_T1.7681.00
256_Q259_L1.7481.00
32_A235_N1.7471.00
206_A270_V1.7471.00
119_F146_A1.7451.00
241_F272_T1.7391.00
44_A119_F1.7371.00
209_R241_F1.7311.00
214_Y234_L1.7201.00
7_T33_V1.7151.00
37_A72_L1.7041.00
255_I259_L1.6891.00
37_A77_I1.6881.00
25_D237_R1.6841.00
215_N231_R1.6731.00
245_D248_P1.6611.00
243_D274_T1.6531.00
10_T47_H1.6351.00
12_L65_T1.6171.00
218_S228_A1.6121.00
27_L64_D1.6081.00
131_D134_D1.6021.00
51_L81_A1.5951.00
5_I216_I1.5881.00
29_A201_T1.5751.00
80_L121_G1.5651.00
220_S223_A1.5541.00
203_R238_E1.5391.00
37_A42_V1.5311.00
185_P215_N1.5291.00
38_I71_P1.5041.00
177_V195_V1.5041.00
29_A33_V1.4991.00
116_D144_H1.4961.00
8_G48_A1.4891.00
6_H176_A1.4871.00
118_A145_A1.4811.00
147_L177_V1.4751.00
280_V283_A1.4731.00
35_T71_P1.4711.00
105_E108_D1.4701.00
117_T146_A1.4631.00
317_S320_D1.4581.00
25_D268_V1.4571.00
294_A297_T1.4561.00
217_V229_I1.4501.00
340_D344_I1.4461.00
282_P286_E1.4321.00
64_D68_L1.4071.00
174_F177_V1.4061.00
295_L298_R1.3901.00
33_V214_Y1.3791.00
31_D68_L1.3591.00
5_I214_Y1.3561.00
22_R25_D1.3491.00
16_Q22_R1.3431.00
28_D236_T1.3351.00
2_A218_S1.3321.00
196_T229_I1.3271.00
58_G61_D1.3271.00
140_H143_D1.3081.00
185_P213_G1.2991.00
245_D274_T1.2981.00
119_F148_V1.2951.00
14_Y204_A1.2831.00
24_Q28_D1.2761.00
5_I37_A1.2721.00
47_H79_F1.2691.00
200_S204_A1.2691.00
65_T81_A1.2641.00
36_D39_D1.2541.00
327_Q333_G1.2541.00
5_I36_D1.2481.00
94_W98_F1.2441.00
71_P74_D1.2441.00
35_T38_I1.2431.00
144_H219_F1.2321.00
166_V170_A1.2291.00
26_F204_A1.2121.00
335_D338_A1.2061.00
3_R40_E1.2041.00
31_D35_T1.1861.00
82_V148_V1.1801.00
131_D135_Y1.1801.00
69_L79_F1.1751.00
129_K133_H1.1681.00
296_L299_V1.1641.00
320_D323_D1.1551.00
129_K134_D1.1471.00
51_L65_T1.1431.00
27_L31_D1.1401.00
299_V302_R1.1361.00
343_R347_D1.1231.00
50_D86_H1.1221.00
120_Y174_F1.1191.00
185_P231_R1.1181.00
257_E260_R1.1111.00
296_L300_N1.1051.00
258_R261_E1.1021.00
106_R109_D1.0951.00
238_E267_A1.0851.00
342_D346_R1.0830.99
29_A202_E1.0810.99
316_V324_A1.0780.99
121_G148_V1.0750.99
323_D339_R1.0680.99
120_Y145_A1.0640.99
101_L104_A1.0630.99
29_A234_L1.0620.99
32_A234_L1.0550.99
242_V271_V1.0490.99
34_I72_L1.0490.99
14_Y53_H1.0430.99
34_I68_L1.0390.99
217_V227_V1.0330.99
32_A35_T1.0260.99
130_R133_H1.0230.99
336_E339_R1.0210.99
339_R343_R1.0200.99
293_G299_V1.0140.99
4_V46_V1.0130.99
44_A146_A1.0050.99
86_H183_H0.9980.99
344_I348_D0.9970.99
293_G296_L0.9930.99
27_L67_A0.9910.99
334_L338_A0.9890.99
38_I77_I0.9870.99
129_K132_D0.9870.99
324_A328_R0.9850.99
38_I74_D0.9810.99
287_R290_D0.9790.99
6_H179_L0.9700.99
50_D183_H0.9670.99
25_D202_E0.9590.99
145_A175_D0.9580.99
46_V146_A0.9550.99
46_V217_V0.9530.99
33_V37_A0.9520.99
10_T51_L0.9510.99
154_T165_A0.9510.99
323_D326_E0.9490.99
206_A239_F0.9400.99
50_D85_N0.9380.99
294_A298_R0.9380.99
187_T196_T0.9120.98
153_F188_A0.9070.98
322_D326_E0.9060.98
117_T144_H0.9030.98
66_I96_D0.8990.98
111_P118_A0.8960.98
83_V123_D0.8920.98
146_A217_V0.8920.98
334_L342_D0.8890.98
258_R262_R0.8890.98
78_P104_A0.8840.98
301_D304_E0.8840.98
28_D31_D0.8760.98
200_S212_R0.8730.98
69_L103_L0.8720.98
185_P196_T0.8710.98
27_L71_P0.8600.97
53_H204_A0.8580.97
52_Y62_I0.8570.97
138_A173_E0.8520.97
53_H212_R0.8520.97
46_V178_L0.8510.97
138_A174_F0.8510.97
113_V116_D0.8490.97
189_Q193_T0.8480.97
13_G57_P0.8480.97
336_E340_D0.8460.97
91_D94_W0.8450.97
44_A117_T0.8410.97
293_G300_N0.8310.97
200_S205_S0.8290.97
216_I230_S0.8240.97
12_L58_G0.8230.97
163_L166_V0.8220.97
140_H145_A0.8220.97
341_V345_V0.8210.97
13_G61_D0.8210.97
324_A327_Q0.8200.97
150_H181_D0.8160.96
111_P114_V0.8130.96
345_V348_D0.8110.96
155_P160_N0.8100.96
293_G298_R0.8060.96
255_I258_R0.8040.96
294_A299_V0.8000.96
156_F159_A0.7990.96
71_P75_A0.7970.96
110_S113_V0.7960.96
3_R216_I0.7950.96
81_A103_L0.7950.96
101_L105_E0.7930.96
175_D222_D0.7920.96
65_T93_Q0.7920.96
132_D135_Y0.7920.96
85_N183_H0.7900.96
203_R212_R0.7880.96
45_V75_A0.7880.96
11_H183_H0.7860.96
58_G62_I0.7850.96
23_R26_F0.7840.96
45_V79_F0.7840.96
12_L30_F0.7790.95
297_T301_D0.7780.95
110_S114_V0.7760.95
337_P340_D0.7730.95
214_Y232_K0.7670.95
187_T215_N0.7660.95
34_I75_A0.7660.95
340_D343_R0.7640.95
264_L267_A0.7620.95
6_H198_C0.7610.95
52_Y94_W0.7600.95
300_N304_E0.7590.95
122_L149_S0.7590.95
23_R60_R0.7550.95
319_A323_D0.7550.95
59_L62_I0.7530.95
321_P325_V0.7510.94
149_S179_L0.7490.94
133_H136_T0.7480.94
315_D319_A0.7480.94
72_L79_F0.7470.94
270_V298_R0.7420.94
123_D197_Y0.7420.94
68_L71_P0.7410.94
43_D218_S0.7390.94
48_A82_V0.7390.94
131_D136_T0.7370.94
52_Y65_T0.7350.94
7_T45_V0.7300.94
162_D166_V0.7270.93
24_Q27_L0.7250.93
335_D339_R0.7240.93
128_S131_D0.7220.93
25_D200_S0.7210.93
318_F321_P0.7200.93
189_Q194_W0.7200.93
86_H150_H0.7180.93
330_R338_A0.7180.93
297_T300_N0.7160.93
22_R202_E0.7150.93
176_A196_T0.7150.93
63_L67_A0.7100.93
338_A346_R0.7080.93
146_A219_F0.7060.92
273_I281_T0.7050.92
48_A198_C0.7040.92
25_D28_D0.7030.92
166_V169_D0.7010.92
144_H175_D0.6980.92
11_H181_D0.6980.92
33_V45_V0.6980.92
285_I296_L0.6970.92
31_D64_D0.6970.92
326_E330_R0.6950.92
207_S210_D0.6920.92
39_D232_K0.6870.91
244_A248_P0.6870.91
45_V72_L0.6860.91
10_T30_F0.6860.91
4_V219_F0.6810.91
128_S132_D0.6790.91
299_V303_R0.6780.91
336_E341_V0.6780.91
308_G313_D0.6770.91
161_W166_V0.6770.91
256_Q262_R0.6750.91
345_V349_T0.6740.91
155_P159_A0.6730.91
213_G234_L0.6710.90
36_D216_I0.6700.90
162_D165_A0.6680.90
319_A322_D0.6650.90
85_N124_Y0.6650.90
72_L77_I0.6630.90
34_I37_A0.6600.90
283_A286_E0.6600.90
313_D321_P0.6590.90
45_V77_I0.6580.90
16_Q239_F0.6560.89
178_L196_T0.6560.89
22_R200_S0.6560.89
157_P169_D0.6530.89
272_T276_D0.6500.89
285_I291_D0.6500.89
16_Q206_A0.6490.89
311_A340_D0.6480.89
341_V346_R0.6480.89
311_A314_V0.6470.89
34_I71_P0.6460.89
111_P116_D0.6440.89
78_P102_G0.6440.89
184_T210_D0.6440.89
246_L273_I0.6430.88
118_A140_H0.6430.88
22_R26_F0.6420.88
102_G105_E0.6420.88
97_L101_L0.6420.88
44_A217_V0.6420.88
167_L170_A0.6400.88
124_Y152_L0.6390.88
94_W97_L0.6380.88
23_R64_D0.6350.88
208_E212_R0.6280.87
10_T33_V0.6260.87
56_Q66_I0.6260.87
318_F325_V0.6260.87
5_I45_V0.6240.87
104_A112_R0.6230.87
86_H181_D0.6230.87
334_L346_R0.6230.87
32_A236_T0.6210.87
338_A341_V0.6180.86
26_F202_E0.6160.86
42_V45_V0.6150.86
85_N150_H0.6130.86
275_G278_D0.6120.86
100_T104_A0.6110.86
4_V117_T0.6100.86
7_T201_T0.6090.86
5_I33_V0.6060.85
144_H223_A0.6050.85
164_D168_A0.6040.85
14_Y22_R0.6040.85
176_A217_V0.6030.85
165_A170_A0.6020.85
223_A227_V0.6010.85
338_A342_D0.5990.85
321_P324_A0.5980.85
34_I38_I0.5980.85
123_D149_S0.5980.85
150_H183_H0.5970.84
286_E290_D0.5970.84
333_G336_E0.5970.84
334_L337_P0.5970.84
339_R344_I0.5960.84
88_G91_D0.5960.84
11_H50_D0.5950.84
48_A69_L0.5950.84
264_L269_V0.5940.84
30_F34_I0.5920.84
111_P120_Y0.5910.84
36_D42_V0.5910.84
22_R237_R0.5900.84
312_P315_D0.5890.84
63_L99_E0.5870.83
300_N305_F0.5840.83
298_R301_D0.5840.83
162_D167_L0.5810.83
318_F334_L0.5810.83
52_Y268_V0.5810.83
168_A195_V0.5800.83
295_L299_V0.5800.83
45_V68_L0.5790.83
337_P341_V0.5780.83
130_R135_Y0.5780.83
47_H51_L0.5770.82
294_A300_N0.5750.82
152_L182_N0.5740.82
91_D95_L0.5710.82
33_V42_V0.5700.82
332_L338_A0.5690.82
172_V192_D0.5690.82
196_T231_R0.5680.81
22_R239_F0.5680.81
44_A78_P0.5680.81
346_R349_T0.5670.81
53_H91_D0.5650.81
332_L335_D0.5650.81
223_A228_A0.5640.81
23_R61_D0.5620.81
67_A306_D0.5620.81
333_G337_P0.5610.81
281_T285_I0.5600.81
325_V329_V0.5580.80
62_I90_R0.5580.80
122_L133_H0.5580.80
285_I294_A0.5580.80
27_L61_D0.5560.80
39_D264_L0.5560.80
14_Y200_S0.5550.80
117_T219_F0.5550.80
73_Q102_G0.5540.80
52_Y66_I0.5540.80
315_D318_F0.5510.79
111_P115_A0.5500.79
257_E261_E0.5500.79
53_H57_P0.5490.79
338_A345_V0.5480.79
319_A343_R0.5480.79
301_D305_F0.5480.79
26_F200_S0.5470.79
163_L201_T0.5460.79
313_D323_D0.5450.79
12_L27_L0.5440.79
145_A151_G0.5440.79
9_D13_G0.5430.78
296_L304_E0.5420.78
68_L72_L0.5410.78
201_T234_L0.5390.78
201_T214_Y0.5390.78
281_T284_E0.5370.78
168_A188_A0.5360.78
96_D99_E0.5360.78
323_D333_G0.5350.77
93_Q127_Q0.5350.77
322_D342_D0.5350.77
14_Y121_G0.5340.77
313_D316_V0.5330.77
70_R74_D0.5320.77
178_L198_C0.5310.77
321_P326_E0.5310.77
331_D335_D0.5300.77
202_E239_F0.5290.77
98_F102_G0.5290.77
194_W227_V0.5290.77
299_V309_D0.5280.77
184_T211_P0.5270.76
151_G206_A0.5270.76
25_D29_A0.5250.76
230_S233_S0.5240.76
5_I213_G0.5230.76
39_D309_D0.5230.76
311_A343_R0.5230.76
307_T348_D0.5220.76
128_S134_D0.5220.76
337_P343_R0.5210.76
23_R27_L0.5180.75
10_T201_T0.5180.75
242_V285_I0.5180.75
48_A178_L0.5170.75
98_F104_A0.5170.75
304_E307_T0.5140.75
308_G349_T0.5140.75
176_A179_L0.5130.75
26_F212_R0.5130.75
29_A235_N0.5120.74
256_Q260_R0.5120.74
61_D83_V0.5110.74
152_L204_A0.5110.74
296_L302_R0.5110.74
127_Q152_L0.5110.74
37_A78_P0.5060.74
333_G348_D0.5060.74
319_A327_Q0.5050.73
120_Y147_L0.5040.73
13_G204_A0.5030.73
10_T68_L0.5030.73
151_G182_N0.5010.73
50_D181_D0.5010.73
237_R267_A0.5010.73
80_L112_R0.5000.73
151_G165_A0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ltyC 1 0.7519 100 0.432 Contact Map
1ii7A 2 0.7519 100 0.443 Contact Map
4ykeA 2 0.77 100 0.447 Contact Map
3av0A 1 0.9096 100 0.449 Contact Map
3thoB 2 0.8553 100 0.449 Contact Map
4nzvA 1 0.7339 100 0.48 Contact Map
4fbwA 2 0.7597 100 0.501 Contact Map
3t1iA 2 0.7649 100 0.505 Contact Map
4fbkA 2 0.77 100 0.506 Contact Map
2a22A 1 0.4884 99.9 0.704 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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