Q9HRV7 - HALSA - GREMLIN Contacts

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Q9HRV7 - ABC transporter, ATP-binding protein

UniProt:	Q9HRV7	Sequences: MATLELKDVHAEVAEDGGEKILDGVDLEIPSGEIHALMGPNGSGKSTTAKIIAGHPAYDVTDGEVLFTIEDDDFDGAEELPADDRTFDLLGLEPNERAALGIFLAFQYPAEIEGVTLVNFLRTALNAKLDEREELLFEDDDEDADDAADDDEDAGYETSPMEGPADDGEIGVADFQEILSEKMETLDMDEKFANRYLNAGFSGGEKKQNEVLQAAILEPSIAVLDEIDSGLDIDRLQDVSTGINALRDEQDTGILQITHYQRILDYVEPDRVHIMLDGEVVMEGDAELAEKLEDEGYDWVRDQVYETA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	308 (234)
Sequences:	69682 (40073)
Seq/√Len:	2619.7

ECOLI - MALK YCJV UGPC PROV POTA POTG CYSA FBPC ARAG METN RBSA SAPD MACB DPPD YDCT YEHX YADG DPPF MDLB CYDD MDLA DDPD OPPF MSBA CYDC OPPD YECC MODC YTFR HISP LPTB LSRA PHNC FEPC GSIA YOJI MLAF SAPF NIKE DDPF TAUB FHUC FECE YPHE YHES XYLG GLNQ ALSA LIVG GLTL SUFC MGLA THIQ ARTP YHDZ SSUB UUP MODF PHNK LIVF PSTB FTSE BTUD LOLD ZNUC FETA ETTA NIKD CCMA YBBA YEJF PHNL YNJD YBHF YDDA UVRA YBIT YHIH
BACSU - YVRA OPUCA OPUBA MSMX YURJ OPUAA TAGH YHEH YFMM METN YFIC YKPA YFIL RBSA OPPD YDBJ YKFD YXLF YHCH DPPD APPF YCBN YGAD YHAQ YWJA YKNV FHUC BMRA YFIB CYDC YVFR CYDD YHEI YFMF SUNT APPD OPPF YKNU ECFA1 ECSA BCEA YVCR YUSV SKFE YTRB YCLP TCYN ALBC SUFC YTLC YXDL YXEO YLMA TCYC NATA GLNQ YFMR MNTB YKOD FTSE YJKB PSTB1 ARTM YUFO YCLH ZNUC YVRO SSUB ECFA2 PSTB2 YTHP YDIF YKNY EXPZ YYBJ YHCG YTRE YYDI UVRA
HALSA - Q9HRV7 Q9HMX3 Q9HMW0 Q9HHQ5 BTUDA Q9HMT3 Q9HNZ9 Q9HR06 Q9HSQ7 Q9HMU8 Q9HMX2 Q9HRJ6 Q9HMG1 PHNC PSTB2 Q9HRH8 Q9HMG6 Q9HHM2 Y1631 Q9HNY3 Y2317 PSTB1 Q9HRZ9 Q9HHR7 Q9HR96 Q9HT03 Q9HR21 Q9HQA8 Q9HS04 Q9HMC1 Q9HMA2 Q9HMW1
SULSO - Q97UJ9 Q97UF2 Q97YY4 Q97UY8 Q97VF5 Q7LX64 Q97VH6 Q97VK8 Q97ZC0 Q97VC1 Q97UH3 Q97UD4 Q97YK2 Q97YP3 Q97X18 Q97YP8 Q97YP7 Q97VK9 Y2030 Q97VF4 Y1893 Q97V01 Q97YQ7 Q97Z03 Q97UH4 Q97U54 PSTB Q97V00 Q97W42 Q980W0 Q7LY07 Q7LXM4 Q97VM2 Q97VY4 Q97Z56 Q7LX80 Q97UG5 Q97YP4 Q97Z96 Q97UC2 Q97ZU0 Q980K5 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
271_R	283_E	3.577	1.00
33_E	271_R	3.405	1.00
5_E	28_E	3.262	1.00
7_K	64_E	3.209	1.00
8_D	24_G	3.174	1.00
20_K	23_D	3.028	1.00
30_P	33_E	2.968	1.00
101_G	220_S	2.885	1.00
180_S	188_M	2.814	1.00
7_K	66_L	2.799	1.00
64_E	71_D	2.645	1.00
36_A	269_P	2.565	1.00
23_D	279_E	2.416	1.00
5_E	66_L	2.399	1.00
10_H	62_D	2.354	1.00
297_Y	301_R	2.338	1.00
10_H	20_K	2.328	1.00
286_A	296_G	2.327	1.00
273_H	283_E	2.311	1.00
12_E	20_K	2.302	1.00
10_H	24_G	2.273	1.00
180_S	184_E	2.259	1.00
293_E	297_Y	2.187	1.00
35_H	273_H	2.174	1.00
114_G	119_N	2.070	1.00
118_V	122_R	2.015	1.00
49_A	223_V	1.979	1.00
285_D	288_L	1.927	1.00
244_N	266_Y	1.889	1.00
192_F	195_R	1.871	1.00
6_L	9_V	1.853	1.00
282_M	292_L	1.848	1.00
284_G	288_L	1.836	1.00
288_L	292_L	1.822	1.00
175_F	180_S	1.769	1.00
11_A	51_I	1.767	1.00
27_L	273_H	1.709	1.00
218_E	252_T	1.611	1.00
76_G	97_R	1.593	1.00
282_M	293_E	1.586	1.00
171_G	174_D	1.582	1.00
118_V	130_D	1.579	1.00
34_I	256_Q	1.563	1.00
295_E	298_D	1.549	1.00
31_S	220_S	1.531	1.00
54_G	59_D	1.504	1.00
12_E	61_T	1.483	1.00
282_M	294_D	1.477	1.00
8_D	26_D	1.476	1.00
172_V	176_Q	1.475	1.00
273_H	280_V	1.468	1.00
49_A	257_I	1.466	1.00
184_E	190_E	1.457	1.00
68_T	220_S	1.457	1.00
29_I	35_H	1.456	1.00
33_E	270_D	1.455	1.00
181_E	185_T	1.452	1.00
34_I	269_P	1.448	1.00
11_A	58_Y	1.421	1.00
35_H	271_R	1.418	1.00
6_L	27_L	1.411	1.00
171_G	180_S	1.405	1.00
36_A	264_L	1.397	1.00
10_H	23_D	1.374	1.00
48_T	275_M	1.372	1.00
237_Q	241_T	1.367	1.00
129_L	132_R	1.364	1.00
195_R	200_G	1.363	1.00
27_L	48_T	1.361	1.00
265_D	287_E	1.358	1.00
171_G	175_F	1.355	1.00
179_L	182_K	1.337	1.00
103_F	219_P	1.330	1.00
276_L	295_E	1.325	1.00
6_L	52_I	1.313	1.00
174_D	188_M	1.312	1.00
258_T	264_L	1.311	1.00
190_E	193_A	1.291	1.00
37_L	273_H	1.289	1.00
276_L	281_V	1.285	1.00
53_A	104_L	1.282	1.00
71_D	74_F	1.270	1.00
13_V	47_T	1.268	1.00
178_I	218_E	1.246	1.00
118_V	189_D	1.246	1.00
180_S	193_A	1.241	1.00
247_R	254_I	1.235	1.00
30_P	271_R	1.233	1.00
178_I	181_E	1.228	1.00
29_I	255_L	1.212	1.00
295_E	299_W	1.200	1.00
59_D	73_D	1.191	1.00
181_E	184_E	1.159	1.00
125_L	132_R	1.137	1.00
13_V	21_I	1.130	1.00
294_D	297_Y	1.122	1.00
52_I	255_L	1.112	1.00
40_P	276_L	1.095	1.00
37_L	48_T	1.094	1.00
34_I	247_R	1.093	1.00
9_V	60_V	1.092	1.00
282_M	297_Y	1.088	1.00
281_V	295_E	1.080	1.00
130_D	171_G	1.067	1.00
34_I	254_I	1.054	1.00
176_Q	180_S	1.053	1.00
182_K	216_I	1.053	1.00
22_L	25_V	1.050	1.00
7_K	28_E	1.042	1.00
25_V	48_T	1.041	1.00
231_L	239_V	1.040	1.00
4_L	255_L	1.031	1.00
118_V	170_I	1.014	1.00
11_A	47_T	1.011	1.00
97_R	100_L	1.008	1.00
173_A	177_E	1.002	1.00
203_G	208_Q	1.001	1.00
66_L	71_D	1.000	1.00
288_L	291_K	0.999	1.00
115_V	119_N	0.996	1.00
171_G	184_E	0.992	1.00
119_N	122_R	0.986	1.00
174_D	177_E	0.975	1.00
236_L	260_Y	0.966	1.00
70_E	75_D	0.965	1.00
125_L	128_K	0.959	1.00
7_K	26_D	0.959	1.00
121_L	174_D	0.956	1.00
248_D	251_D	0.948	1.00
192_F	201_F	0.944	1.00
287_E	291_K	0.944	1.00
222_A	252_T	0.934	1.00
177_E	181_E	0.927	1.00
24_G	279_E	0.927	1.00
292_L	295_E	0.911	1.00
174_D	183_M	0.897	1.00
226_E	259_H	0.896	1.00
122_R	175_F	0.893	1.00
16_D	19_E	0.891	1.00
31_S	68_T	0.888	1.00
68_T	101_G	0.886	1.00
103_F	214_A	0.881	1.00
272_V	286_A	0.879	1.00
178_I	238_D	0.879	1.00
242_G	245_A	0.875	1.00
121_L	216_I	0.865	1.00
122_R	130_D	0.864	1.00
171_G	188_M	0.860	1.00
43_S	275_M	0.856	1.00
201_F	209_N	0.855	1.00
240_S	263_I	0.854	1.00
298_D	302_D	0.851	1.00
41_N	235_R	0.845	1.00
241_T	245_A	0.845	1.00
11_A	61_T	0.844	1.00
38_M	274_I	0.842	1.00
8_D	62_D	0.838	1.00
6_L	48_T	0.838	1.00
296_G	299_W	0.838	1.00
240_S	266_Y	0.837	1.00
97_R	101_G	0.832	1.00
35_H	283_E	0.832	1.00
244_N	247_R	0.832	1.00
6_L	65_V	0.823	1.00
256_Q	269_P	0.823	1.00
290_E	300_V	0.817	1.00
40_P	295_E	0.816	1.00
172_V	175_F	0.812	1.00
109_P	210_E	0.802	1.00
176_Q	215_A	0.797	1.00
51_I	60_V	0.793	1.00
238_D	241_T	0.790	1.00
38_M	264_L	0.787	1.00
98_A	102_I	0.787	1.00
12_E	21_I	0.785	1.00
280_V	283_E	0.784	1.00
183_M	193_A	0.783	1.00
182_K	186_L	0.774	1.00
180_S	190_E	0.773	1.00
111_E	206_K	0.773	1.00
25_V	280_V	0.772	1.00
293_E	301_R	0.770	1.00
105_A	224_L	0.769	1.00
128_K	131_E	0.767	1.00
120_F	213_Q	0.763	1.00
118_V	194_N	0.762	1.00
33_E	283_E	0.761	1.00
53_A	223_V	0.747	1.00
224_L	243_I	0.745	1.00
258_T	263_I	0.739	1.00
70_E	74_F	0.737	1.00
58_Y	61_T	0.735	1.00
282_M	289_A	0.734	1.00
175_F	179_L	0.734	1.00
34_I	244_N	0.733	1.00
128_K	132_R	0.731	1.00
174_D	180_S	0.728	1.00
122_R	170_I	0.727	1.00
298_D	301_R	0.723	1.00
241_T	244_N	0.721	1.00
20_K	62_D	0.718	1.00
234_D	238_D	0.715	1.00
236_L	263_I	0.714	1.00
289_A	292_L	0.708	1.00
113_E	191_K	0.707	1.00
174_D	179_L	0.704	1.00
12_E	18_G	0.704	1.00
66_L	69_I	0.703	1.00
224_L	254_I	0.702	1.00
55_H	58_Y	0.701	1.00
67_F	221_I	0.700	1.00
60_V	73_D	0.700	1.00
35_H	255_L	0.694	1.00
282_M	288_L	0.692	1.00
9_V	51_I	0.690	1.00
179_L	183_M	0.690	1.00
222_A	254_I	0.689	1.00
293_E	298_D	0.689	1.00
271_R	285_D	0.688	1.00
196_Y	200_G	0.682	1.00
286_A	290_E	0.681	1.00
64_E	73_D	0.675	1.00
29_I	253_G	0.672	1.00
28_E	283_E	0.672	1.00
245_A	248_D	0.669	1.00
223_V	255_L	0.668	1.00
30_P	253_G	0.667	1.00
128_K	216_I	0.666	1.00
287_E	290_E	0.666	1.00
75_D	97_R	0.660	1.00
125_L	129_L	0.658	1.00
5_E	26_D	0.657	1.00
284_G	287_E	0.657	1.00
288_L	297_Y	0.657	1.00
38_M	261_Q	0.657	1.00
295_E	300_V	0.655	1.00
179_L	185_T	0.649	1.00
71_D	75_D	0.649	1.00
294_D	299_W	0.646	1.00
289_A	293_E	0.642	1.00
41_N	226_E	0.640	1.00
31_S	251_D	0.638	1.00
20_K	61_T	0.637	1.00
50_K	58_Y	0.636	1.00
292_L	297_Y	0.635	1.00
22_L	51_I	0.634	1.00
191_K	195_R	0.632	1.00
182_K	212_L	0.630	1.00
5_E	69_I	0.630	1.00
122_R	176_Q	0.629	1.00
274_I	295_E	0.629	1.00
54_G	77_A	0.629	1.00
51_I	65_V	0.627	1.00
96_E	100_L	0.627	1.00
184_E	187_D	0.626	1.00
264_L	272_V	0.624	1.00
276_L	279_E	0.623	1.00
222_A	247_R	0.618	1.00
12_E	17_G	0.618	1.00
4_L	52_I	0.618	1.00
12_E	23_D	0.615	1.00
246_L	252_T	0.612	1.00
174_D	178_I	0.609	1.00
269_P	272_V	0.603	1.00
186_L	212_L	0.600	1.00
49_A	53_A	0.598	1.00
182_K	185_T	0.597	1.00
296_G	300_V	0.596	1.00
193_A	198_N	0.596	1.00
117_L	209_N	0.593	1.00
275_M	280_V	0.592	1.00
220_S	252_T	0.591	1.00
70_E	97_R	0.591	1.00
70_E	101_G	0.589	1.00
281_V	294_D	0.588	1.00
106_F	109_P	0.588	1.00
76_G	96_E	0.588	1.00
193_A	196_Y	0.588	1.00
24_G	62_D	0.586	1.00
118_V	176_Q	0.585	1.00
50_K	53_A	0.584	1.00
207_K	230_G	0.580	1.00
4_L	67_F	0.579	1.00
4_L	221_I	0.579	1.00
77_A	99_A	0.578	1.00
41_N	208_Q	0.573	1.00
122_R	128_K	0.571	1.00
36_A	272_V	0.571	1.00
122_R	179_L	0.570	1.00
122_R	125_L	0.569	1.00
122_R	126_N	0.568	1.00
105_A	211_V	0.568	1.00
110_A	206_K	0.568	1.00
118_V	121_L	0.568	1.00
118_V	179_L	0.561	1.00
130_D	189_D	0.561	1.00
53_A	102_I	0.561	1.00
183_M	188_M	0.560	1.00
297_Y	300_V	0.556	1.00
247_R	270_D	0.556	1.00
125_L	216_I	0.555	1.00
228_D	263_I	0.555	1.00
262_R	265_D	0.554	1.00
176_Q	179_L	0.553	1.00
243_I	254_I	0.553	1.00
265_D	286_A	0.553	1.00
183_M	186_L	0.553	1.00
12_E	19_E	0.550	1.00
51_I	58_Y	0.547	1.00
108_Y	206_K	0.547	1.00
8_D	11_A	0.546	1.00
105_A	214_A	0.545	1.00
118_V	193_A	0.542	1.00
233_I	236_L	0.540	1.00
64_E	74_F	0.538	1.00
178_I	241_T	0.535	1.00
12_E	62_D	0.534	1.00
12_E	16_D	0.534	1.00
100_L	217_L	0.533	1.00
123_T	126_N	0.532	1.00
121_L	183_M	0.531	1.00
122_R	127_A	0.531	1.00
11_A	22_L	0.530	1.00
25_V	275_M	0.530	1.00
184_E	188_M	0.528	1.00
264_L	269_P	0.526	1.00
290_E	293_E	0.524	1.00
17_G	20_K	0.524	1.00
193_A	197_L	0.523	1.00
120_F	123_T	0.523	1.00
178_I	235_R	0.521	1.00
102_I	221_I	0.519	1.00
21_I	47_T	0.515	1.00
37_L	255_L	0.512	1.00
69_I	72_D	0.512	1.00
264_L	286_A	0.511	1.00
244_N	248_D	0.509	1.00
131_E	171_G	0.508	1.00
178_I	182_K	0.508	1.00
288_L	293_E	0.508	1.00
20_K	24_G	0.507	1.00
228_D	236_L	0.506	1.00
118_V	171_G	0.504	1.00
124_A	217_L	0.504	1.00
41_N	231_L	0.503	1.00
197_L	200_G	0.503	1.00
239_V	242_G	0.503	1.00
265_D	290_E	0.502	1.00
60_V	65_V	0.500	1.00
113_E	198_N	0.500	1.00
112_I	115_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4f4cA	1	0.75	100	0.177	Contact Map
4ry2A	2	0.776	100	0.18	Contact Map
3tuiC	2	0.8019	100	0.19	Contact Map
2yyzA	1	0.776	100	0.195	Contact Map
1v43A	2	0.7532	100	0.196	Contact Map
1g291	4	0.7987	100	0.197	Contact Map
2it1A	1	0.7792	100	0.197	Contact Map
3rlfA	2	0.776	100	0.198	Contact Map
1oxxK	1	0.8019	100	0.199	Contact Map
1z47A	2	0.7825	100	0.201	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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