GREMLIN Database
Q9HRV7 - ABC transporter, ATP-binding protein
UniProt: Q9HRV7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (234)
Sequences: 69682 (40073)
Seq/√Len: 2619.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
271_R283_E3.5771.00
33_E271_R3.4051.00
5_E28_E3.2621.00
7_K64_E3.2091.00
8_D24_G3.1741.00
20_K23_D3.0281.00
30_P33_E2.9681.00
101_G220_S2.8851.00
180_S188_M2.8141.00
7_K66_L2.7991.00
64_E71_D2.6451.00
36_A269_P2.5651.00
23_D279_E2.4161.00
5_E66_L2.3991.00
10_H62_D2.3541.00
297_Y301_R2.3381.00
10_H20_K2.3281.00
286_A296_G2.3271.00
273_H283_E2.3111.00
12_E20_K2.3021.00
10_H24_G2.2731.00
180_S184_E2.2591.00
293_E297_Y2.1871.00
35_H273_H2.1741.00
114_G119_N2.0701.00
118_V122_R2.0151.00
49_A223_V1.9791.00
285_D288_L1.9271.00
244_N266_Y1.8891.00
192_F195_R1.8711.00
6_L9_V1.8531.00
282_M292_L1.8481.00
284_G288_L1.8361.00
288_L292_L1.8221.00
175_F180_S1.7691.00
11_A51_I1.7671.00
27_L273_H1.7091.00
218_E252_T1.6111.00
76_G97_R1.5931.00
282_M293_E1.5861.00
171_G174_D1.5821.00
118_V130_D1.5791.00
34_I256_Q1.5631.00
295_E298_D1.5491.00
31_S220_S1.5311.00
54_G59_D1.5041.00
12_E61_T1.4831.00
282_M294_D1.4771.00
8_D26_D1.4761.00
172_V176_Q1.4751.00
273_H280_V1.4681.00
49_A257_I1.4661.00
184_E190_E1.4571.00
68_T220_S1.4571.00
29_I35_H1.4561.00
33_E270_D1.4551.00
181_E185_T1.4521.00
34_I269_P1.4481.00
11_A58_Y1.4211.00
35_H271_R1.4181.00
6_L27_L1.4111.00
171_G180_S1.4051.00
36_A264_L1.3971.00
10_H23_D1.3741.00
48_T275_M1.3721.00
237_Q241_T1.3671.00
129_L132_R1.3641.00
195_R200_G1.3631.00
27_L48_T1.3611.00
265_D287_E1.3581.00
171_G175_F1.3551.00
179_L182_K1.3371.00
103_F219_P1.3301.00
276_L295_E1.3251.00
6_L52_I1.3131.00
174_D188_M1.3121.00
258_T264_L1.3111.00
190_E193_A1.2911.00
37_L273_H1.2891.00
276_L281_V1.2851.00
53_A104_L1.2821.00
71_D74_F1.2701.00
13_V47_T1.2681.00
178_I218_E1.2461.00
118_V189_D1.2461.00
180_S193_A1.2411.00
247_R254_I1.2351.00
30_P271_R1.2331.00
178_I181_E1.2281.00
29_I255_L1.2121.00
295_E299_W1.2001.00
59_D73_D1.1911.00
181_E184_E1.1591.00
125_L132_R1.1371.00
13_V21_I1.1301.00
294_D297_Y1.1221.00
52_I255_L1.1121.00
40_P276_L1.0951.00
37_L48_T1.0941.00
34_I247_R1.0931.00
9_V60_V1.0921.00
282_M297_Y1.0881.00
281_V295_E1.0801.00
130_D171_G1.0671.00
34_I254_I1.0541.00
176_Q180_S1.0531.00
182_K216_I1.0531.00
22_L25_V1.0501.00
7_K28_E1.0421.00
25_V48_T1.0411.00
231_L239_V1.0401.00
4_L255_L1.0311.00
118_V170_I1.0141.00
11_A47_T1.0111.00
97_R100_L1.0081.00
173_A177_E1.0021.00
203_G208_Q1.0011.00
66_L71_D1.0001.00
288_L291_K0.9991.00
115_V119_N0.9961.00
171_G184_E0.9921.00
119_N122_R0.9861.00
174_D177_E0.9751.00
236_L260_Y0.9661.00
70_E75_D0.9651.00
125_L128_K0.9591.00
7_K26_D0.9591.00
121_L174_D0.9561.00
248_D251_D0.9481.00
192_F201_F0.9441.00
287_E291_K0.9441.00
222_A252_T0.9341.00
177_E181_E0.9271.00
24_G279_E0.9271.00
292_L295_E0.9111.00
174_D183_M0.8971.00
226_E259_H0.8961.00
122_R175_F0.8931.00
16_D19_E0.8911.00
31_S68_T0.8881.00
68_T101_G0.8861.00
103_F214_A0.8811.00
272_V286_A0.8791.00
178_I238_D0.8791.00
242_G245_A0.8751.00
121_L216_I0.8651.00
122_R130_D0.8641.00
171_G188_M0.8601.00
43_S275_M0.8561.00
201_F209_N0.8551.00
240_S263_I0.8541.00
298_D302_D0.8511.00
41_N235_R0.8451.00
241_T245_A0.8451.00
11_A61_T0.8441.00
38_M274_I0.8421.00
8_D62_D0.8381.00
6_L48_T0.8381.00
296_G299_W0.8381.00
240_S266_Y0.8371.00
97_R101_G0.8321.00
35_H283_E0.8321.00
244_N247_R0.8321.00
6_L65_V0.8231.00
256_Q269_P0.8231.00
290_E300_V0.8171.00
40_P295_E0.8161.00
172_V175_F0.8121.00
109_P210_E0.8021.00
176_Q215_A0.7971.00
51_I60_V0.7931.00
238_D241_T0.7901.00
38_M264_L0.7871.00
98_A102_I0.7871.00
12_E21_I0.7851.00
280_V283_E0.7841.00
183_M193_A0.7831.00
182_K186_L0.7741.00
180_S190_E0.7731.00
111_E206_K0.7731.00
25_V280_V0.7721.00
293_E301_R0.7701.00
105_A224_L0.7691.00
128_K131_E0.7671.00
120_F213_Q0.7631.00
118_V194_N0.7621.00
33_E283_E0.7611.00
53_A223_V0.7471.00
224_L243_I0.7451.00
258_T263_I0.7391.00
70_E74_F0.7371.00
58_Y61_T0.7351.00
282_M289_A0.7341.00
175_F179_L0.7341.00
34_I244_N0.7331.00
128_K132_R0.7311.00
174_D180_S0.7281.00
122_R170_I0.7271.00
298_D301_R0.7231.00
241_T244_N0.7211.00
20_K62_D0.7181.00
234_D238_D0.7151.00
236_L263_I0.7141.00
289_A292_L0.7081.00
113_E191_K0.7071.00
174_D179_L0.7041.00
12_E18_G0.7041.00
66_L69_I0.7031.00
224_L254_I0.7021.00
55_H58_Y0.7011.00
67_F221_I0.7001.00
60_V73_D0.7001.00
35_H255_L0.6941.00
282_M288_L0.6921.00
9_V51_I0.6901.00
179_L183_M0.6901.00
222_A254_I0.6891.00
293_E298_D0.6891.00
271_R285_D0.6881.00
196_Y200_G0.6821.00
286_A290_E0.6811.00
64_E73_D0.6751.00
29_I253_G0.6721.00
28_E283_E0.6721.00
245_A248_D0.6691.00
223_V255_L0.6681.00
30_P253_G0.6671.00
128_K216_I0.6661.00
287_E290_E0.6661.00
75_D97_R0.6601.00
125_L129_L0.6581.00
5_E26_D0.6571.00
284_G287_E0.6571.00
288_L297_Y0.6571.00
38_M261_Q0.6571.00
295_E300_V0.6551.00
179_L185_T0.6491.00
71_D75_D0.6491.00
294_D299_W0.6461.00
289_A293_E0.6421.00
41_N226_E0.6401.00
31_S251_D0.6381.00
20_K61_T0.6371.00
50_K58_Y0.6361.00
292_L297_Y0.6351.00
22_L51_I0.6341.00
191_K195_R0.6321.00
182_K212_L0.6301.00
5_E69_I0.6301.00
122_R176_Q0.6291.00
274_I295_E0.6291.00
54_G77_A0.6291.00
51_I65_V0.6271.00
96_E100_L0.6271.00
184_E187_D0.6261.00
264_L272_V0.6241.00
276_L279_E0.6231.00
222_A247_R0.6181.00
12_E17_G0.6181.00
4_L52_I0.6181.00
12_E23_D0.6151.00
246_L252_T0.6121.00
174_D178_I0.6091.00
269_P272_V0.6031.00
186_L212_L0.6001.00
49_A53_A0.5981.00
182_K185_T0.5971.00
296_G300_V0.5961.00
193_A198_N0.5961.00
117_L209_N0.5931.00
275_M280_V0.5921.00
220_S252_T0.5911.00
70_E97_R0.5911.00
70_E101_G0.5891.00
281_V294_D0.5881.00
106_F109_P0.5881.00
76_G96_E0.5881.00
193_A196_Y0.5881.00
24_G62_D0.5861.00
118_V176_Q0.5851.00
50_K53_A0.5841.00
207_K230_G0.5801.00
4_L67_F0.5791.00
4_L221_I0.5791.00
77_A99_A0.5781.00
41_N208_Q0.5731.00
122_R128_K0.5711.00
36_A272_V0.5711.00
122_R179_L0.5701.00
122_R125_L0.5691.00
122_R126_N0.5681.00
105_A211_V0.5681.00
110_A206_K0.5681.00
118_V121_L0.5681.00
118_V179_L0.5611.00
130_D189_D0.5611.00
53_A102_I0.5611.00
183_M188_M0.5601.00
297_Y300_V0.5561.00
247_R270_D0.5561.00
125_L216_I0.5551.00
228_D263_I0.5551.00
262_R265_D0.5541.00
176_Q179_L0.5531.00
243_I254_I0.5531.00
265_D286_A0.5531.00
183_M186_L0.5531.00
12_E19_E0.5501.00
51_I58_Y0.5471.00
108_Y206_K0.5471.00
8_D11_A0.5461.00
105_A214_A0.5451.00
118_V193_A0.5421.00
233_I236_L0.5401.00
64_E74_F0.5381.00
178_I241_T0.5351.00
12_E62_D0.5341.00
12_E16_D0.5341.00
100_L217_L0.5331.00
123_T126_N0.5321.00
121_L183_M0.5311.00
122_R127_A0.5311.00
11_A22_L0.5301.00
25_V275_M0.5301.00
184_E188_M0.5281.00
264_L269_P0.5261.00
290_E293_E0.5241.00
17_G20_K0.5241.00
193_A197_L0.5231.00
120_F123_T0.5231.00
178_I235_R0.5211.00
102_I221_I0.5191.00
21_I47_T0.5151.00
37_L255_L0.5121.00
69_I72_D0.5121.00
264_L286_A0.5111.00
244_N248_D0.5091.00
131_E171_G0.5081.00
178_I182_K0.5081.00
288_L293_E0.5081.00
20_K24_G0.5071.00
228_D236_L0.5061.00
118_V171_G0.5041.00
124_A217_L0.5041.00
41_N231_L0.5031.00
197_L200_G0.5031.00
239_V242_G0.5031.00
265_D290_E0.5021.00
60_V65_V0.5001.00
113_E198_N0.5001.00
112_I115_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f4cA 1 0.75 100 0.177 Contact Map
4ry2A 2 0.776 100 0.18 Contact Map
3tuiC 2 0.8019 100 0.19 Contact Map
2yyzA 1 0.776 100 0.195 Contact Map
1v43A 2 0.7532 100 0.196 Contact Map
1g291 4 0.7987 100 0.197 Contact Map
2it1A 1 0.7792 100 0.197 Contact Map
3rlfA 2 0.776 100 0.198 Contact Map
1oxxK 1 0.8019 100 0.199 Contact Map
1z47A 2 0.7825 100 0.201 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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