GREMLIN Database
Q9HRV6 - Uncharacterized protein
UniProt: Q9HRV6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 474 (411)
Sequences: 3118 (1674)
Seq/√Len: 82.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_T233_E5.0151.00
287_V291_G4.8281.00
199_E230_E4.7101.00
228_A265_V4.4951.00
199_E229_E4.4311.00
228_A232_S4.3591.00
230_E261_E3.9661.00
261_E288_E3.6861.00
261_E289_G3.6541.00
433_D436_D3.5801.00
259_V263_A3.5601.00
262_D290_N3.5301.00
151_F195_V3.5111.00
328_A361_G3.4151.00
230_E260_G3.3511.00
233_E264_H3.2981.00
153_N156_E3.2761.00
285_A293_M3.2151.00
316_R346_D3.1841.00
196_Y229_E3.1801.00
346_D377_D3.1341.00
434_D438_K3.0811.00
234_V265_V3.0691.00
259_V293_M3.0231.00
290_N317_G2.9921.00
259_V291_G2.9281.00
167_E260_G2.8581.00
231_G262_D2.7311.00
316_R345_P2.7251.00
257_V265_V2.6901.00
264_H292_T2.6891.00
326_A355_S2.5631.00
341_Y372_A2.5451.00
47_D51_D2.5351.00
228_A263_A2.4611.00
376_E405_E2.4251.00
185_H223_H2.3381.00
314_K343_N2.3231.00
377_D407_K2.2971.00
286_V314_K2.2961.00
319_T348_S2.2811.00
200_D231_G2.2451.00
208_Q239_G2.2441.00
150_V196_Y2.2391.00
58_E62_K2.2121.00
342_H349_S2.2061.00
56_A186_G2.1931.00
360_G392_D2.1781.00
362_R396_D2.1511.00
362_R394_T2.1241.00
259_V265_V2.1121.00
428_Q434_D2.0791.00
357_A361_G2.0671.00
292_T319_T2.0401.00
249_N277_T2.0391.00
52_R186_G2.0241.00
197_V234_V2.0121.00
173_C258_F1.9981.00
381_N411_A1.9641.00
228_A234_V1.9601.00
226_I236_Y1.9551.00
259_V287_V1.9071.00
79_D82_E1.8821.00
207_V234_V1.8691.00
289_G316_R1.8511.00
316_R344_A1.8361.00
350_T379_K1.7301.00
49_M158_V1.7111.00
106_E109_D1.6911.00
153_N191_G1.6891.00
313_L347_T1.6301.00
343_N372_A1.5761.00
150_V198_P1.5741.00
376_E407_K1.5471.00
51_D55_R1.5240.99
312_I341_Y1.5210.99
317_G346_D1.5180.99
149_V197_V1.5150.99
318_A344_A1.5130.99
267_Y293_M1.5030.99
57_L61_T1.5020.99
50_L54_L1.4950.99
174_V254_G1.4850.99
331_G360_G1.4840.99
328_A334_I1.4810.99
289_G317_G1.4690.99
371_I410_V1.4640.99
147_K204_N1.4610.99
302_S305_T1.4550.99
419_I441_I1.4410.99
384_C397_T1.4260.99
196_Y227_I1.3790.99
348_S379_K1.3760.99
363_T395_S1.3700.99
378_S408_V1.3650.99
344_A347_T1.3590.99
318_A347_T1.3550.99
128_G135_V1.3530.99
55_R58_E1.3420.99
232_S265_V1.3390.99
324_T353_S1.3260.99
125_S128_G1.3250.99
59_Q62_K1.3240.99
397_T414_A1.3240.99
330_D359_D1.3210.99
155_D191_G1.3170.98
162_P166_K1.3090.98
58_E61_T1.3070.98
261_E290_N1.3030.98
131_Y136_V1.2980.98
288_E291_G1.2870.98
157_A194_F1.2780.98
168_H227_I1.2720.98
369_V380_T1.2600.98
366_R398_M1.2480.98
195_V207_V1.2410.98
288_E315_G1.2390.98
44_D159_Q1.2370.98
325_I446_I1.2300.98
197_V228_A1.2280.98
156_E160_E1.2150.97
336_T353_S1.2150.97
203_V234_V1.2150.97
152_C160_E1.2010.97
333_D364_N1.1970.97
235_H266_Q1.1960.97
371_I378_S1.1910.97
202_T231_G1.1890.97
288_E314_K1.1830.97
356_I446_I1.1800.97
235_H268_S1.1790.97
262_D317_G1.1700.97
172_S258_F1.1570.97
47_D50_L1.1550.96
273_W279_N1.1540.96
357_A395_S1.1520.96
65_M181_F1.1480.96
55_R59_Q1.1300.96
287_V293_M1.1280.96
211_F240_C1.1270.96
200_D262_D1.1140.96
304_A333_D1.1130.96
48_W166_K1.1100.96
312_I343_N1.0930.95
126_G129_A1.0910.95
59_Q63_M1.0910.95
397_T416_V1.0890.95
374_G405_E1.0870.95
169_F189_W1.0860.95
49_M189_W1.0790.95
152_C157_A1.0780.95
403_I408_V1.0760.95
128_G214_N1.0760.95
287_V311_T1.0750.95
308_Y337_G1.0700.95
260_G288_E1.0640.94
125_S136_V1.0620.94
64_P180_K1.0600.94
265_V293_M1.0530.94
432_L440_M1.0490.94
132_E135_V1.0480.94
386_A397_T1.0460.94
311_T320_D1.0440.94
81_E304_A1.0430.94
212_R241_S1.0430.94
126_G131_Y1.0410.94
105_D109_D1.0380.94
289_G315_G1.0370.94
296_V323_I1.0350.94
197_V203_V1.0300.93
364_N398_M1.0290.93
52_R55_R1.0260.93
238_E267_Y1.0210.93
223_H254_G1.0100.93
337_G366_R1.0080.93
221_F252_S1.0050.93
229_E260_G1.0020.92
150_V194_F1.0000.92
198_P201_V0.9970.92
227_I258_F0.9940.92
120_E205_M0.9940.92
298_G461_L0.9870.92
345_P376_E0.9850.92
369_V378_S0.9840.92
185_H254_G0.9770.91
401_M410_V0.9770.91
146_E149_V0.9730.91
307_L336_T0.9710.91
375_A378_S0.9670.91
371_I382_V0.9660.91
317_G344_A0.9650.91
267_Y295_W0.9560.91
287_V320_D0.9540.91
81_E333_D0.9510.90
151_F207_V0.9470.90
152_C156_E0.9460.90
370_H404_N0.9450.90
347_T378_S0.9410.90
125_S129_A0.9400.90
313_L344_A0.9370.90
286_V312_I0.9340.90
168_H225_L0.9320.89
108_Q111_F0.9290.89
266_Q294_E0.9270.89
59_Q176_P0.9250.89
341_Y370_H0.9250.89
54_L58_E0.9230.89
357_A363_T0.9220.89
129_A132_E0.9200.89
186_G223_H0.9180.89
154_M158_V0.9170.89
154_M165_V0.9080.88
133_S136_V0.8990.88
157_A165_V0.8970.88
228_A259_V0.8940.87
198_P227_I0.8900.87
131_Y135_V0.8880.87
226_I257_V0.8870.87
128_G132_E0.8870.87
382_V410_V0.8840.87
104_P107_I0.8840.87
171_T256_E0.8750.86
59_Q177_S0.8750.86
351_I369_V0.8750.86
356_I387_L0.8730.86
225_L256_E0.8690.86
130_Q133_S0.8680.86
194_F227_I0.8670.86
197_V232_S0.8640.86
168_H258_F0.8620.85
179_N308_Y0.8550.85
382_V401_M0.8550.85
360_G393_S0.8550.85
269_T281_N0.8520.85
303_K331_G0.8510.85
337_G386_A0.8500.85
311_T322_H0.8440.84
371_I402_E0.8430.84
171_T185_H0.8410.84
76_T79_D0.8400.84
269_T279_N0.8350.84
368_L402_E0.8330.83
400_Y404_N0.8320.83
76_T306_M0.8300.83
308_Y366_R0.8300.83
313_L417_G0.8290.83
427_L441_I0.8270.83
211_F224_T0.8260.83
240_C279_N0.8240.83
116_I119_A0.8240.83
161_Y194_F0.8220.83
261_E317_G0.8170.82
432_L437_A0.8160.82
338_A353_S0.8150.82
199_E261_E0.8120.82
400_Y411_A0.8120.82
282_T310_S0.8120.82
60_Y180_K0.8090.82
127_V135_V0.8060.81
333_D362_R0.8050.81
459_V462_N0.8020.81
344_A374_G0.8010.81
49_M169_F0.8000.81
168_H256_E0.7910.80
224_T255_V0.7900.80
371_I379_K0.7900.80
157_A164_L0.7900.80
80_I181_F0.7900.80
387_L394_T0.7900.80
301_G305_T0.7890.80
360_G390_D0.7890.80
368_L400_Y0.7860.80
256_E284_R0.7850.80
51_D54_L0.7830.79
358_K390_D0.7830.79
238_E269_T0.7820.79
122_N205_M0.7790.79
211_F238_E0.7780.79
322_H340_V0.7780.79
222_E253_G0.7740.79
366_R400_Y0.7710.78
329_G359_D0.7700.78
171_T223_H0.7680.78
149_V203_V0.7600.77
289_G346_D0.7590.77
389_F425_F0.7580.77
453_L459_V0.7550.77
225_L258_F0.7530.77
271_Q332_Q0.7520.77
405_E408_V0.7520.77
230_E262_D0.7500.76
339_K370_H0.7470.76
97_A103_L0.7460.76
164_L167_E0.7460.76
324_T336_T0.7440.76
455_I458_A0.7440.76
329_G332_Q0.7440.76
328_A357_A0.7430.76
126_G136_V0.7390.75
130_Q137_Y0.7390.75
379_K409_D0.7380.75
200_D230_E0.7340.75
338_A351_I0.7330.75
357_A393_S0.7330.75
359_D390_D0.7330.75
403_I407_K0.7320.75
447_E462_N0.7310.75
351_I354_K0.7290.74
314_K344_A0.7280.74
179_N282_T0.7260.74
371_I403_I0.7240.74
226_I234_V0.7240.74
377_D405_E0.7230.74
318_A345_P0.7230.74
161_Y164_L0.7200.74
269_T273_W0.7180.73
149_V201_V0.7170.73
262_D289_G0.7170.73
427_L432_L0.7160.73
234_V259_V0.7140.73
401_M408_V0.7140.73
257_V293_M0.7130.73
249_N273_W0.7120.73
57_L188_V0.7100.72
345_P351_I0.7090.72
307_L353_S0.7010.72
127_V131_Y0.7000.71
378_S410_V0.7000.71
158_V165_V0.7000.71
343_N374_G0.6990.71
255_V267_Y0.6970.71
387_L442_V0.6970.71
165_V194_F0.6970.71
129_A135_V0.6960.71
53_R183_A0.6950.71
376_E406_S0.6940.71
148_G201_V0.6940.71
164_L196_Y0.6930.71
266_Q454_P0.6930.71
260_G291_G0.6900.70
78_L81_E0.6890.70
124_L129_A0.6890.70
197_V236_Y0.6880.70
368_L382_V0.6860.70
346_D376_E0.6860.70
366_R395_S0.6860.70
127_V136_V0.6850.70
411_A417_G0.6850.70
251_H273_W0.6840.70
305_T334_I0.6840.70
99_E102_D0.6830.70
371_I408_V0.6830.70
53_R56_A0.6830.70
161_Y168_H0.6790.69
285_A311_T0.6790.69
129_A136_V0.6770.69
107_I111_F0.6760.69
56_A176_P0.6760.69
169_F225_L0.6750.69
323_I452_E0.6720.68
56_A183_A0.6700.68
283_K307_L0.6680.68
419_I438_K0.6670.68
403_I410_V0.6670.68
261_E318_A0.6660.68
213_M220_Q0.6650.68
184_L456_E0.6620.67
327_F465_I0.6610.67
373_D376_E0.6600.67
410_V420_G0.6580.67
60_Y183_A0.6580.67
230_E291_G0.6580.67
380_T386_A0.6560.66
104_P148_G0.6560.66
186_G254_G0.6550.66
293_M311_T0.6520.66
193_S224_T0.6500.66
258_F286_V0.6500.66
271_Q302_S0.6490.66
181_F280_L0.6490.66
44_D47_D0.6490.66
342_H372_A0.6490.66
340_V349_S0.6490.66
376_E409_D0.6490.66
417_G420_G0.6480.66
79_D83_I0.6470.65
62_K172_S0.6450.65
373_D392_D0.6430.65
366_R386_A0.6400.65
271_Q297_S0.6400.65
78_L125_S0.6360.64
56_A187_A0.6360.64
322_H380_T0.6360.64
405_E415_T0.6350.64
67_T75_L0.6300.63
390_D393_S0.6290.63
284_R414_A0.6290.63
99_E216_E0.6290.63
290_N316_R0.6280.63
255_V296_V0.6250.63
373_D404_N0.6240.63
56_A59_Q0.6240.63
261_E291_G0.6240.63
461_L469_M0.6230.62
321_N350_T0.6230.62
404_N417_G0.6220.62
213_M277_T0.6220.62
317_G348_S0.6220.62
380_T384_C0.6210.62
414_A442_V0.6210.62
46_P158_V0.6200.62
88_R340_V0.6190.62
410_V413_E0.6150.61
60_Y64_P0.6140.61
327_F358_K0.6140.61
132_E136_V0.6140.61
127_V214_N0.6130.61
146_E204_N0.6130.61
271_Q301_G0.6110.61
119_A122_N0.6110.61
343_N370_H0.6090.61
285_A291_G0.6090.61
102_D106_E0.6070.60
367_G402_E0.6070.60
398_M411_A0.6070.60
52_R56_A0.6060.60
121_R237_I0.6060.60
283_K309_P0.6060.60
206_P387_L0.6060.60
83_I86_Y0.6050.60
333_D353_S0.6040.60
415_T446_I0.6040.60
386_A418_K0.6030.60
319_T350_T0.6020.60
178_D284_R0.6020.60
126_G211_F0.6010.60
223_H417_G0.6010.60
375_A405_E0.6010.60
154_M189_W0.5990.59
91_V250_L0.5980.59
98_D102_D0.5980.59
149_V389_F0.5980.59
173_C256_E0.5970.59
147_K203_V0.5960.59
337_G446_I0.5960.59
157_A227_I0.5960.59
318_A343_N0.5950.59
173_C423_D0.5950.59
311_T417_G0.5940.59
195_V203_V0.5940.59
285_A369_V0.5940.59
286_V311_T0.5940.59
183_A256_E0.5940.59
185_H252_S0.5930.59
57_L156_E0.5930.59
52_R166_K0.5920.59
415_T448_P0.5910.58
246_G276_N0.5910.58
168_H194_F0.5900.58
355_S384_C0.5900.58
456_E460_E0.5890.58
69_W82_E0.5890.58
313_L318_A0.5890.58
353_S365_Y0.5880.58
342_H404_N0.5880.58
336_T397_T0.5880.58
219_G354_K0.5860.58
65_M75_L0.5860.58
65_M83_I0.5840.58
157_A161_Y0.5820.57
337_G397_T0.5820.57
107_I110_T0.5810.57
329_G358_K0.5800.57
192_G224_T0.5800.57
260_G263_A0.5790.57
209_A226_I0.5790.57
150_V161_Y0.5790.57
158_V161_Y0.5780.57
337_G384_C0.5760.57
150_V168_H0.5760.57
377_D406_S0.5760.57
270_V300_M0.5750.56
164_L194_F0.5730.56
280_L306_M0.5730.56
371_I405_E0.5710.56
307_L417_G0.5710.56
354_K465_I0.5700.56
157_A225_L0.5700.56
287_V318_A0.5700.56
124_L128_G0.5690.56
202_T319_T0.5690.56
329_G427_L0.5680.55
216_E247_S0.5680.55
337_G380_T0.5670.55
388_M398_M0.5650.55
56_A171_T0.5630.55
353_S366_R0.5630.55
204_N226_I0.5620.55
44_D59_Q0.5620.55
52_R176_P0.5610.55
51_D101_E0.5610.55
125_S135_V0.5600.54
388_M395_S0.5600.54
378_S405_E0.5580.54
281_N297_S0.5550.54
147_K201_V0.5550.54
84_V362_R0.5540.54
45_E54_L0.5530.54
134_E137_Y0.5530.54
300_M468_E0.5530.54
349_S379_K0.5520.53
394_T465_I0.5510.53
280_L297_S0.5500.53
157_A192_G0.5490.53
403_I406_S0.5490.53
162_P194_F0.5480.53
55_R176_P0.5470.53
427_L468_E0.5470.53
213_M251_H0.5470.53
240_C269_T0.5460.53
258_F288_E0.5460.53
102_D117_P0.5460.53
229_E232_S0.5460.53
268_S454_P0.5460.53
171_T186_G0.5430.52
187_A263_A0.5430.52
144_W203_V0.5420.52
206_P235_H0.5410.52
109_D167_E0.5400.52
87_I350_T0.5400.52
299_S326_A0.5390.52
100_W103_L0.5390.52
355_S363_T0.5380.52
198_P229_E0.5370.51
306_M413_E0.5370.51
371_I415_T0.5360.51
405_E413_E0.5360.51
148_G198_P0.5350.51
174_V182_A0.5350.51
309_P353_S0.5340.51
279_N305_T0.5340.51
352_E420_G0.5330.51
215_S218_M0.5330.51
412_H426_Y0.5330.51
349_S369_V0.5310.51
385_D415_T0.5310.51
47_D146_E0.5310.51
316_R377_D0.5310.51
380_T401_M0.5290.50
154_M194_F0.5290.50
193_S211_F0.5290.50
145_E148_G0.5280.50
132_E137_Y0.5270.50
79_D420_G0.5270.50
105_D120_E0.5250.50
410_V441_I0.5250.50
309_P312_I0.5250.50
99_E421_D0.5250.50
348_S411_A0.5240.50
239_G272_N0.5240.50
299_S307_L0.5220.49
450_T465_I0.5220.49
393_S427_L0.5220.49
128_G137_Y0.5220.49
231_G264_H0.5210.49
257_V278_F0.5210.49
337_G353_S0.5210.49
240_C251_H0.5200.49
294_E321_N0.5190.49
202_T264_H0.5190.49
370_H402_E0.5190.49
349_S380_T0.5190.49
365_Y398_M0.5180.49
211_F423_D0.5180.49
212_R219_G0.5170.49
236_Y255_V0.5170.49
271_Q299_S0.5160.49
275_K330_D0.5160.49
417_G446_I0.5160.49
353_S384_C0.5150.49
386_A398_M0.5150.49
288_E318_A0.5130.48
127_V132_E0.5130.48
251_H279_N0.5130.48
398_M405_E0.5130.48
97_A100_W0.5130.48
325_I375_A0.5120.48
306_M335_D0.5120.48
362_R393_S0.5120.48
223_H256_E0.5120.48
366_R384_C0.5120.48
378_S459_V0.5110.48
128_G138_Q0.5110.48
308_Y382_V0.5110.48
256_E315_G0.5110.48
342_H402_E0.5110.48
371_I406_S0.5100.48
259_V311_T0.5100.48
128_G136_V0.5100.48
58_E216_E0.5100.48
53_R188_V0.5090.48
380_T410_V0.5090.48
53_R192_G0.5090.48
147_K459_V0.5090.48
371_I381_N0.5080.48
375_A410_V0.5080.48
351_I382_V0.5070.47
262_D292_T0.5050.47
352_E449_I0.5040.47
336_T357_A0.5040.47
144_W204_N0.5030.47
303_K395_S0.5030.47
398_M406_S0.5030.47
350_T371_I0.5020.47
372_A404_N0.5010.47
415_T450_T0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vh4A 2 0.8629 100 0.255 Contact Map
4dn7A 2 0.8544 100 0.324 Contact Map
4xfmA 2 0.1498 69.1 0.969 Contact Map
3dqqA 2 0.154 45.3 0.973 Contact Map
1yzyA 1 0.1456 31.6 0.975 Contact Map
4xg0A 2 0.154 25.9 0.976 Contact Map
1ifyA 1 0.0907 19.4 0.978 Contact Map
4k6mA 2 0.1266 19 0.978 Contact Map
4v0qA 2 0.1245 18.5 0.978 Contact Map
1wjiA 1 0.1181 17 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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