GREMLIN Database
Q9HRV5 - Uncharacterized protein
UniProt: Q9HRV5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 404 (373)
Sequences: 3794 (2122)
Seq/√Len: 109.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_D165_T4.9741.00
160_T164_A4.4781.00
220_A224_A4.4741.00
134_A161_E4.4421.00
134_A162_D4.3191.00
366_T369_Q4.0441.00
194_E222_T3.9131.00
165_T197_Y3.8731.00
160_T198_V3.7781.00
192_A196_S3.6661.00
162_D194_E3.6301.00
195_N223_Y3.6121.00
194_E221_D3.5561.00
259_F288_G3.2731.00
261_G294_A3.2311.00
163_N195_N3.2191.00
192_A226_V3.1981.00
162_D193_G3.0951.00
218_G226_V3.0761.00
85_V130_V2.9831.00
131_Y161_E2.9291.00
223_Y250_A2.8521.00
197_Y225_T2.8091.00
367_A371_T2.7491.00
160_T196_S2.7281.00
192_A224_A2.7091.00
279_H310_D2.6941.00
249_D279_H2.6881.00
274_W305_G2.6491.00
166_A198_V2.5941.00
87_S90_D2.5731.00
135_G163_N2.5481.00
219_H247_A2.3411.00
249_D278_E2.2821.00
190_V198_V2.2501.00
309_W338_N2.2171.00
283_D312_S2.2061.00
275_H282_A2.1821.00
310_D340_D2.1621.00
225_T252_E2.1171.00
295_R327_E2.1131.00
295_R329_D2.0971.00
132_V166_A2.0921.00
120_S155_Y2.0341.00
76_D80_A2.0121.00
25_A29_E1.9851.00
252_E281_T1.9731.00
361_Q367_A1.9411.00
330_A347_A1.9181.00
142_T171_R1.8991.00
247_A276_R1.8691.00
103_D193_G1.8621.00
131_Y159_I1.8381.00
192_A198_V1.8301.00
36_E40_D1.8121.00
293_D325_E1.8101.00
160_T166_A1.8021.00
246_L280_T1.7931.00
314_Y344_S1.7871.00
222_T249_D1.7761.00
182_R210_T1.7441.00
235_S238_T1.7271.00
192_A220_A1.7261.00
249_D277_A1.6971.00
34_A121_T1.6521.00
296_S328_A1.6511.00
49_T52_R1.6391.00
82_N85_V1.6311.00
290_I294_A1.6081.00
108_V191_D1.5911.00
76_D79_G1.5741.00
261_G267_F1.5561.00
106_G189_E1.5021.00
30_T121_T1.4921.00
245_E274_W1.4461.00
82_N87_S1.4401.00
132_V160_T1.4381.00
84_R133_P1.4281.00
84_R131_Y1.4261.00
222_T250_A1.4111.00
28_R32_L1.4021.00
158_V168_I1.4001.00
244_T253_T1.3871.00
35_L39_D1.3661.00
304_V343_A1.3641.00
264_D293_D1.3631.00
167_T201_G1.3611.00
82_N86_E1.3511.00
277_A280_T1.3501.00
84_R87_S1.3381.00
27_L92_L1.3291.00
257_G286_T1.3210.99
276_R305_G1.3130.99
309_W340_D1.3090.99
97_L100_R1.2900.99
219_H245_E1.2880.99
132_V138_A1.2820.99
167_T199_Q1.2790.99
251_S280_T1.2780.99
37_A40_D1.2740.99
29_E33_D1.2740.99
105_F157_L1.2600.99
317_E330_A1.2470.99
244_T255_I1.2430.99
200_Y226_V1.2380.99
221_D224_A1.2330.99
120_S187_I1.2230.99
194_E223_Y1.2210.99
158_V190_V1.2200.99
251_S277_A1.2190.99
263_D292_D1.2160.99
170_E200_Y1.2150.99
245_E276_R1.2150.99
250_A279_H1.2150.99
133_P136_V1.2140.99
91_A101_V1.2130.99
289_V379_F1.2100.99
281_T312_S1.2080.99
352_V374_L1.2050.99
79_G82_N1.1970.99
33_D36_E1.1930.99
266_H297_V1.1930.99
88_F92_L1.1800.99
36_E39_D1.1760.99
189_E217_R1.1750.99
155_Y189_E1.1680.99
221_D248_G1.1680.99
302_Q313_S1.1650.99
138_A166_A1.1620.99
50_P53_K1.1610.99
105_F124_F1.1600.99
86_E94_D1.1430.99
299_E331_S1.1430.99
25_A28_R1.1420.99
246_L277_A1.1420.99
135_G162_D1.1310.98
91_A129_V1.1310.98
290_I328_A1.1270.98
199_Q227_N1.1250.98
195_N250_A1.1230.98
160_T192_A1.1220.98
141_V166_A1.1160.98
114_N241_G1.1160.98
106_G120_S1.1100.98
220_A244_T1.1070.98
312_S342_E1.1000.98
307_D338_N1.0980.98
90_D94_D1.0960.98
52_R237_L1.0940.98
280_T311_T1.0870.98
311_T341_T1.0850.98
159_I193_G1.0830.98
109_I187_I1.0830.98
153_F185_S1.0790.98
107_S191_D1.0770.98
304_V311_T1.0680.98
32_L36_E1.0630.98
330_A349_V1.0520.97
30_T33_D1.0490.97
258_A379_F1.0490.97
206_F212_N1.0490.97
237_L266_H1.0410.97
80_A83_A1.0380.97
302_Q311_T1.0380.97
220_A226_V1.0300.97
135_G195_N1.0290.97
26_W102_E1.0230.97
392_R396_E1.0220.97
254_K283_D1.0220.97
52_R266_H1.0220.97
98_A102_E1.0200.97
63_D66_V1.0140.97
269_L286_T1.0130.97
98_A101_V1.0120.97
133_P161_E1.0110.97
159_I191_D1.0090.97
83_A86_E0.9960.96
33_D37_A0.9950.96
308_A311_T0.9950.96
221_D247_A0.9930.96
190_V200_Y0.9920.96
137_D163_N0.9860.96
129_V159_I0.9740.96
49_T54_W0.9650.96
132_V164_A0.9630.96
304_V315_Q0.9620.96
84_R129_V0.9560.96
386_V392_R0.9560.96
171_R205_D0.9530.95
47_I52_R0.9520.95
204_Q234_G0.9510.95
104_A159_I0.9490.95
116_L213_Y0.9470.95
29_E32_L0.9460.95
181_E209_Q0.9420.95
81_E139_E0.9260.95
200_Y228_W0.9260.95
86_E91_A0.9250.95
222_T248_G0.9240.95
27_L124_F0.9240.95
261_G296_S0.9180.94
231_G395_L0.9160.94
303_D337_N0.9140.94
147_M150_R0.9070.94
156_T188_V0.9050.94
81_E85_V0.9030.94
389_Q392_R0.9010.94
217_R243_S0.8990.94
37_A41_L0.8940.94
162_D195_N0.8910.94
313_S343_A0.8820.93
94_D97_L0.8780.93
79_G83_A0.8720.93
274_W303_D0.8720.93
170_E202_S0.8720.93
297_V331_S0.8720.93
303_D335_I0.8720.93
47_I53_K0.8660.93
291_D323_S0.8620.92
49_T55_T0.8600.92
383_L399_I0.8600.92
50_P55_T0.8600.92
154_N186_G0.8590.92
87_S126_T0.8550.92
270_D299_E0.8510.92
301_V333_K0.8490.92
310_D338_N0.8460.92
52_R55_T0.8370.91
315_Q343_A0.8350.91
86_E90_D0.8330.91
148_N180_G0.8300.91
215_L243_S0.8260.91
319_T330_A0.8220.90
380_V396_E0.8210.90
241_G270_D0.8200.90
236_R264_D0.8190.90
221_D251_S0.8190.90
334_L343_A0.8170.90
38_L115_R0.8170.90
290_I296_S0.8160.90
161_E193_G0.8160.90
262_H265_Q0.8110.90
89_H126_T0.8100.90
278_E308_A0.7990.89
223_Y249_D0.7950.89
278_E309_W0.7940.89
47_I50_P0.7940.89
365_L373_M0.7910.89
343_A346_S0.7890.89
90_D93_Q0.7870.88
388_V391_L0.7870.88
133_P159_I0.7850.88
304_V336_I0.7840.88
338_N341_T0.7830.88
121_T187_I0.7820.88
42_A115_R0.7800.88
65_L69_L0.7790.88
155_Y187_I0.7760.88
229_I256_V0.7750.88
194_E224_A0.7740.88
250_A277_A0.7700.87
279_H309_W0.7670.87
290_I326_S0.7660.87
202_S206_F0.7640.87
270_D319_T0.7630.87
88_F94_D0.7630.87
134_A194_E0.7600.87
273_V282_A0.7580.87
190_V226_V0.7580.87
380_V384_E0.7570.86
127_G156_T0.7530.86
262_H292_D0.7490.86
100_R103_D0.7480.86
233_I402_R0.7450.86
202_S212_N0.7420.85
246_L251_S0.7410.85
216_K240_T0.7400.85
104_A107_S0.7370.85
37_A111_P0.7360.85
68_P72_T0.7350.85
266_H295_R0.7340.85
306_S337_N0.7220.84
109_I112_H0.7210.84
234_G238_T0.7210.84
268_D299_E0.7200.84
191_D219_H0.7200.84
322_L358_F0.7160.83
82_N88_F0.7140.83
261_G290_I0.7120.83
66_V69_L0.7120.83
240_T269_L0.7120.83
336_I343_A0.7120.83
333_K344_S0.7100.83
119_L123_L0.7080.83
121_T155_Y0.7070.82
119_L389_Q0.7070.82
272_K303_D0.7070.82
336_I341_T0.7060.82
164_A198_V0.7050.82
205_D398_R0.7050.82
202_S214_T0.7040.82
299_E333_K0.7030.82
106_G155_Y0.7000.82
301_V335_I0.6990.82
218_G244_T0.6960.81
284_L302_Q0.6950.81
376_A400_A0.6910.81
49_T53_K0.6900.81
116_L185_S0.6890.81
315_Q334_L0.6890.81
232_N269_L0.6870.81
220_A253_T0.6860.81
199_Q229_I0.6830.80
165_T199_Q0.6820.80
83_A136_V0.6820.80
46_V53_K0.6810.80
106_G157_L0.6800.80
52_R297_V0.6770.80
320_L375_V0.6730.79
247_A277_A0.6720.79
360_M374_L0.6720.79
107_S189_E0.6720.79
81_E84_R0.6700.79
34_A37_A0.6700.79
168_I198_V0.6670.79
59_D70_S0.6660.79
65_L68_P0.6650.78
246_L350_G0.6640.78
57_L60_L0.6620.78
320_L327_E0.6620.78
204_Q235_S0.6610.78
293_D326_S0.6610.78
118_A189_E0.6610.78
365_L370_A0.6610.78
333_K337_N0.6600.78
83_A132_V0.6600.78
193_G221_D0.6590.78
338_N346_S0.6580.78
85_V90_D0.6580.78
387_E392_R0.6550.77
293_D323_S0.6540.77
137_D197_Y0.6540.77
193_G224_A0.6490.77
56_T63_D0.6470.77
310_D339_H0.6460.76
204_Q232_N0.6420.76
43_F116_L0.6410.76
128_T156_T0.6390.76
285_V382_V0.6370.75
276_R307_D0.6360.75
241_G299_E0.6340.75
61_D66_V0.6340.75
59_D63_D0.6310.75
56_T236_R0.6310.75
184_Y206_F0.6300.75
201_G387_E0.6270.74
61_D64_A0.6260.74
182_R206_F0.6260.74
104_A133_P0.6260.74
338_N343_A0.6250.74
306_S309_W0.6250.74
34_A118_A0.6240.74
271_A284_L0.6230.74
64_A67_D0.6230.74
56_T59_D0.6230.74
190_V218_G0.6200.73
194_E251_S0.6180.73
77_Q80_A0.6180.73
227_N254_K0.6140.73
311_T338_N0.6120.73
188_V229_I0.6110.72
318_N348_T0.6110.72
222_T279_H0.6100.72
104_A191_D0.6100.72
48_E52_R0.6080.72
232_N267_F0.6080.72
186_G214_T0.6080.72
47_I55_T0.6080.72
94_D98_A0.6070.72
71_Q75_K0.6060.72
240_T286_T0.6060.72
85_V88_F0.6050.72
260_F291_D0.6050.72
115_R118_A0.6030.71
51_G54_W0.6030.71
348_T362_D0.6020.71
260_F399_I0.6020.71
198_V226_V0.6020.71
336_I340_D0.6010.71
154_N184_Y0.6000.71
256_V385_E0.6000.71
78_V81_E0.5980.71
262_H291_D0.5960.71
91_A97_L0.5950.70
259_F269_L0.5950.70
220_A251_S0.5940.70
226_V244_T0.5930.70
300_G335_I0.5910.70
104_A108_V0.5910.70
372_D400_A0.5890.70
84_R97_L0.5890.70
270_D379_F0.5890.70
286_T317_E0.5880.70
287_R318_N0.5850.69
104_A129_V0.5850.69
48_E54_W0.5850.69
81_E86_E0.5850.69
43_F51_G0.5850.69
305_G338_N0.5840.69
114_N215_L0.5830.69
270_D317_E0.5830.69
140_D169_L0.5830.69
216_K242_V0.5810.69
35_L123_L0.5800.68
226_V253_T0.5800.68
134_A137_D0.5790.68
157_L191_D0.5790.68
91_A94_D0.5790.68
85_V354_Q0.5790.68
88_F101_V0.5780.68
350_G353_D0.5780.68
297_V300_G0.5760.68
196_S224_A0.5760.68
304_V312_S0.5760.68
304_V331_S0.5750.68
271_A286_T0.5750.68
134_A164_A0.5750.68
72_T209_Q0.5730.68
170_E188_V0.5720.67
30_T34_A0.5720.67
155_Y350_G0.5720.67
100_R131_Y0.5710.67
38_L41_L0.5710.67
97_L129_V0.5710.67
62_F183_Y0.5690.67
308_A338_N0.5670.67
292_D323_S0.5660.67
27_L105_F0.5640.66
374_L377_G0.5640.66
240_T253_T0.5630.66
334_L341_T0.5630.66
135_G165_T0.5610.66
158_V166_A0.5610.66
360_M365_L0.5600.66
273_V284_L0.5580.66
285_V316_R0.5580.66
66_V70_S0.5580.66
284_L311_T0.5560.65
227_N387_E0.5550.65
138_A141_V0.5540.65
288_G317_E0.5540.65
151_S183_Y0.5530.65
78_V85_V0.5530.65
152_L184_Y0.5520.65
97_L104_A0.5520.65
313_S317_E0.5520.65
38_L43_F0.5520.65
323_S326_S0.5510.65
101_V157_L0.5500.64
246_L276_R0.5490.64
37_A42_A0.5490.64
289_V320_L0.5490.64
234_G295_R0.5450.64
117_T187_I0.5450.64
282_A302_Q0.5450.64
146_S354_Q0.5440.64
316_R356_T0.5430.63
304_V339_H0.5420.63
188_V214_T0.5420.63
119_L153_F0.5410.63
319_T328_A0.5410.63
37_A112_H0.5400.63
35_L38_L0.5400.63
208_E263_D0.5390.63
144_R156_T0.5390.63
304_V341_T0.5380.63
327_E399_I0.5370.63
119_L361_Q0.5370.63
31_R123_L0.5360.62
138_A180_G0.5360.62
295_R326_S0.5350.62
120_S126_T0.5350.62
113_Q117_T0.5340.62
31_R35_L0.5330.62
304_V340_D0.5330.62
50_P54_W0.5320.62
214_T230_E0.5310.62
244_T350_G0.5310.62
268_D298_Y0.5300.62
130_V141_V0.5290.61
306_S325_E0.5290.61
139_E158_V0.5290.61
301_V315_Q0.5280.61
288_G296_S0.5260.61
347_A375_V0.5260.61
284_L315_Q0.5260.61
165_T225_T0.5260.61
298_Y341_T0.5260.61
287_R381_P0.5250.61
191_D221_D0.5250.61
317_E346_S0.5250.61
287_R316_R0.5240.61
33_D111_P0.5230.61
268_D343_A0.5230.61
171_R394_D0.5220.60
394_D398_R0.5220.60
188_V200_Y0.5210.60
80_A87_S0.5200.60
231_G383_L0.5200.60
212_N238_T0.5200.60
285_V385_E0.5200.60
126_T129_V0.5190.60
211_Y236_R0.5190.60
238_T267_F0.5180.60
195_N222_T0.5180.60
61_D67_D0.5180.60
88_F124_F0.5180.60
278_E284_L0.5170.60
266_H325_E0.5170.60
173_D176_D0.5160.60
80_A85_V0.5150.59
101_V129_V0.5150.59
286_T319_T0.5140.59
104_A157_L0.5140.59
83_A138_A0.5140.59
203_L233_I0.5140.59
202_S216_K0.5130.59
217_R245_E0.5130.59
160_T193_G0.5120.59
305_G337_N0.5120.59
81_E138_A0.5120.59
65_L146_S0.5120.59
202_S230_E0.5120.59
302_Q321_M0.5120.59
149_S181_E0.5110.59
255_I273_V0.5110.59
199_Q387_E0.5100.59
343_A353_D0.5100.59
164_A196_S0.5100.59
216_K226_V0.5100.59
257_G269_L0.5090.59
159_I189_E0.5080.58
358_F362_D0.5080.58
83_A166_A0.5080.58
275_H286_T0.5060.58
331_S339_H0.5060.58
306_S338_N0.5050.58
276_R303_D0.5050.58
344_S350_G0.5050.58
335_I338_N0.5040.58
185_S313_S0.5040.58
120_S185_S0.5030.58
280_T284_L0.5030.58
204_Q265_Q0.5020.57
309_W339_H0.5010.57
48_E55_T0.5010.57
154_N185_S0.5010.57
337_N350_G0.5010.57
319_T349_V0.5000.57
311_T336_I0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vh4A 2 0.9406 100 0.181 Contact Map
4dn7A 2 0.901 100 0.264 Contact Map
4edgA 1 0.1931 17.5 0.973 Contact Map
4na1A 2 0.2599 15.8 0.974 Contact Map
1vegA 1 0.1807 15.4 0.974 Contact Map
2ekkA 1 0.1163 15.2 0.974 Contact Map
1ifyA 1 0.1213 14.8 0.974 Contact Map
4v0qA 2 0.1361 14.4 0.974 Contact Map
4k6mA 2 0.1337 14.1 0.974 Contact Map
3ezqB 1 0.1337 12.6 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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