GREMLIN Database
Q9HRV3 - Iron-dependent repressor
UniProt: Q9HRV3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 144 (117)
Sequences: 2675 (1772)
Seq/√Len: 163.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_A70_R3.0321.00
80_E93_R2.8771.00
83_L99_L2.7551.00
9_K76_Y2.6431.00
95_E104_D2.6021.00
4_A48_R2.3721.00
74_Q112_D2.3561.00
11_I51_V2.3351.00
91_S106_T2.2921.00
15_E66_A2.1091.00
52_T60_S2.0911.00
24_T38_V2.0761.00
112_D117_R1.8601.00
110_R113_M1.8591.00
71_D105_E1.7581.00
103_I108_A1.7491.00
5_D101_P1.6871.00
33_V38_V1.6781.00
50_L64_D1.6481.00
13_L73_L1.6471.00
42_V51_V1.6441.00
40_E44_K1.5951.00
86_V114_I1.5861.00
9_K97_R1.5781.00
63_E66_A1.5351.00
64_D67_A1.4491.00
98_Q102_V1.4441.00
42_V59_A1.4431.00
82_F87_L1.4331.00
79_L103_I1.4291.00
97_R101_P1.4261.00
37_S41_M1.3991.00
10_T30_R1.3981.00
17_L30_R1.3901.00
53_H56_Y1.3791.00
113_M117_R1.3661.00
46_E53_H1.3161.00
80_E84_A1.2691.00
11_I22_A1.2651.00
82_F114_I1.2451.00
82_F86_V1.2451.00
26_E29_D1.2371.00
5_D100_E1.2361.00
76_Y93_R1.2221.00
95_E107_V1.1541.00
15_E22_A1.1491.00
84_A92_F1.1331.00
79_L111_L1.1271.00
12_F73_L1.1261.00
7_Y37_S1.1241.00
97_R100_E1.1201.00
10_T27_L1.1051.00
71_D75_T1.1021.00
105_E109_E1.0841.00
13_L30_R1.0821.00
74_Q78_I1.0660.99
39_N53_H1.0430.99
35_P41_M1.0390.99
8_L12_F1.0260.99
27_L42_V1.0190.99
6_Q97_R1.0060.99
5_D72_A1.0040.99
89_V95_E0.9680.99
15_E20_G0.9650.99
24_T42_V0.9520.99
14_V22_A0.9480.99
31_L41_M0.9460.99
51_V59_A0.9420.99
92_F97_R0.9310.99
9_K100_E0.9300.99
10_T31_L0.9250.98
89_V107_V0.9240.98
75_T108_A0.9120.98
8_L68_R0.9110.98
67_A71_D0.9060.98
27_L59_A0.9010.98
21_P58_G0.8870.98
87_L110_R0.8870.98
52_T62_T0.8860.98
115_I118_K0.8810.98
106_T110_R0.8790.98
25_G35_P0.8630.98
75_T105_E0.8620.98
76_Y100_E0.8610.98
91_S95_E0.8530.97
6_Q9_K0.8500.97
45_L50_L0.8410.97
24_T35_P0.8400.97
4_A44_K0.8400.97
15_E21_P0.8350.97
43_G46_E0.8230.97
82_F115_I0.8220.97
41_M44_K0.8180.97
77_C80_E0.8150.97
6_Q102_V0.8000.96
79_L107_V0.7930.96
16_Q77_C0.7910.96
21_P60_S0.7830.96
68_R71_D0.7790.96
33_V37_S0.7670.95
12_F69_A0.7640.95
24_T39_N0.7570.95
76_Y97_R0.7430.94
103_I107_V0.7420.94
76_Y80_E0.7420.94
34_S40_E0.7330.94
10_T13_L0.7320.94
11_I38_V0.7310.94
6_Q101_P0.7260.94
49_G64_D0.7240.93
6_Q100_E0.7190.93
96_A102_V0.7140.93
9_K13_L0.7130.93
27_L38_V0.7090.93
23_A58_G0.7010.92
95_E103_I0.7010.92
34_S39_N0.6960.92
43_G47_D0.6890.92
63_E67_A0.6790.91
95_E102_V0.6740.91
82_F111_L0.6730.91
6_Q40_E0.6690.90
12_F70_R0.6670.90
4_A43_G0.6650.90
9_K81_R0.6610.90
7_Y38_V0.6540.89
5_D68_R0.6270.87
12_F16_Q0.6250.87
18_T26_E0.6200.87
24_T53_H0.6170.87
95_E98_Q0.6150.86
42_V53_H0.6130.86
76_Y101_P0.6120.86
88_G110_R0.6090.86
40_E43_G0.6090.86
95_E106_T0.6080.86
23_A26_E0.6020.85
6_Q76_Y0.6020.85
64_D68_R0.5990.85
23_A98_Q0.5970.85
109_E113_M0.5950.85
54_E58_G0.5950.85
14_V26_E0.5930.84
99_L102_V0.5850.84
108_A112_D0.5820.83
109_E112_D0.5770.83
28_A37_S0.5750.83
36_A39_N0.5720.82
73_L77_C0.5580.81
78_I86_V0.5540.80
97_R121_C0.5540.80
72_A75_T0.5510.80
18_T21_P0.5460.79
14_V18_T0.5440.79
33_V36_A0.5440.79
28_A38_V0.5420.79
77_C118_K0.5400.78
28_A33_V0.5400.78
57_K60_S0.5350.78
38_V42_V0.5310.77
87_L114_I0.5300.77
6_Q10_T0.5290.77
73_L80_E0.5290.77
75_T104_D0.5280.77
91_S107_V0.5270.77
95_E110_R0.5250.76
16_Q66_A0.5250.76
80_E92_F0.5230.76
78_I115_I0.5170.75
63_E90_E0.5110.75
31_L35_P0.5090.74
54_E60_S0.5080.74
4_A41_M0.5040.74
33_V41_M0.5030.73
9_K73_L0.5020.73
48_R64_D0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fx7A 4 0.9931 100 0.424 Contact Map
2qq9A 2 0.9444 99.9 0.431 Contact Map
4o5vA 2 0.9861 99.9 0.433 Contact Map
3hrsA 2 0.9931 99.9 0.441 Contact Map
2x4hA 3 0.8819 99.8 0.578 Contact Map
1on2A 2 0.9167 99.7 0.607 Contact Map
2h09A 2 0.7986 99.6 0.646 Contact Map
2p8tA 1 0.8889 99.6 0.648 Contact Map
2fxaA 4 0.8611 98.9 0.747 Contact Map
2o0mA 1 0.4653 98.7 0.762 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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