Q9HRV1 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HRV1 - Uncharacterized protein

UniProt:	Q9HRV1	Sequences: MGCGGDLAHEAVRLRFVMNIDQFNAADTASDDAPFAIENSYTLAIDVDGDVMAKAGAMVAYTGEFSFTGKRSAEGGLTGIIKEAATGEGTPIMRAEGTGTLYLADAQKKVQILELAADDRITVNGEDVLAFESELSYEVTTMDSLAGSFAGGFTNVAISGPGCVALTTHGDPLVVAPPVTTDPSATVAWSATTPSVDVNASLSDMVGQESGERFQMEFDDAGTDSGFVVVQPYEEHV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	237 (192)
Sequences:	2029 (1078)
Seq/√Len:	77.8

HALSA - Q9HRV1 Q9HPJ4 Q9HMA6
SULSO - Q97XI4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
174_V	227_F	4.142	1.00
128_V	131_F	3.221	1.00
176_A	225_S	3.166	1.00
197_D	217_E	2.975	1.00
43_L	165_A	2.971	1.00
158_I	164_V	2.943	1.00
44_A	100_T	2.918	1.00
50_D	96_E	2.879	1.00
120_R	191_A	2.726	1.00
179_V	228_V	2.503	1.00
60_A	102_Y	2.502	1.00
114_E	163_C	2.483	1.00
113_L	121_I	2.479	1.00
178_P	219_D	2.408	1.00
118_D	161_P	2.286	1.00
112_I	163_C	2.230	1.00
177_P	225_S	2.123	1.00
174_V	229_V	2.110	1.00
121_I	188_A	2.097	1.00
186_T	189_W	2.065	1.00
123_V	166_L	2.008	1.00
190_S	227_F	1.960	1.00
120_R	157_A	1.911	1.00
110_V	129_L	1.886	1.00
112_I	165_A	1.870	1.00
68_T	96_E	1.838	1.00
119_D	190_S	1.774	1.00
193_T	219_D	1.761	1.00
82_K	138_E	1.755	1.00
50_D	94_R	1.734	1.00
45_I	51_V	1.691	1.00
121_I	229_V	1.674	1.00
46_D	100_T	1.661	1.00
120_R	159_S	1.660	1.00
180_T	217_E	1.628	1.00
76_G	81_I	1.619	1.00
48_D	98_T	1.619	1.00
136_S	159_S	1.617	1.00
123_V	158_I	1.617	1.00
65_F	101_L	1.610	1.00
123_V	127_D	1.600	1.00
155_N	189_W	1.598	1.00
64_E	97_G	1.584	1.00
202_L	206_V	1.555	0.99
182_D	212_E	1.546	0.99
178_P	217_E	1.541	0.99
168_T	187_V	1.524	0.99
42_T	59_V	1.521	0.99
46_D	98_T	1.504	0.99
53_A	103_L	1.494	0.99
47_V	101_L	1.465	0.99
41_Y	109_K	1.453	0.99
138_E	157_A	1.435	0.99
219_D	225_S	1.415	0.99
38_E	109_K	1.385	0.99
110_V	165_A	1.383	0.99
195_S	217_E	1.345	0.98
189_W	194_P	1.322	0.98
88_E	182_D	1.311	0.98
137_Y	158_I	1.308	0.98
68_T	94_R	1.291	0.98
50_D	133_S	1.284	0.98
135_L	158_I	1.284	0.98
70_K	94_R	1.279	0.98
65_F	95_A	1.258	0.97
111_Q	168_T	1.239	0.97
61_Y	180_T	1.236	0.97
64_E	99_G	1.233	0.97
205_M	214_F	1.221	0.97
113_L	166_L	1.218	0.97
202_L	205_M	1.190	0.96
95_A	101_L	1.173	0.96
64_E	98_T	1.166	0.96
52_M	131_F	1.162	0.96
109_K	171_D	1.152	0.96
115_L	164_V	1.139	0.95
186_T	194_P	1.128	0.95
142_M	155_N	1.110	0.95
42_T	232_P	1.107	0.95
67_F	199_N	1.105	0.95
175_V	230_V	1.101	0.95
116_A	161_P	1.095	0.94
42_T	60_A	1.094	0.94
44_A	102_Y	1.089	0.94
140_T	157_A	1.085	0.94
168_T	172_P	1.084	0.94
58_M	182_D	1.077	0.94
45_I	103_L	1.067	0.94
119_D	191_A	1.066	0.94
59_V	104_A	1.056	0.93
103_L	130_A	1.047	0.93
198_V	205_M	1.044	0.93
62_T	100_T	1.043	0.93
132_E	163_C	1.042	0.93
115_L	161_P	1.042	0.93
80_I	83_E	1.018	0.92
63_G	178_P	1.016	0.92
79_G	136_S	1.003	0.91
81_I	84_A	0.999	0.91
121_I	164_V	0.998	0.91
34_P	100_T	0.995	0.91
181_T	230_V	0.975	0.90
58_M	212_E	0.972	0.90
131_F	135_L	0.966	0.90
108_K	232_P	0.964	0.90
220_D	226_G	0.959	0.89
104_A	129_L	0.954	0.89
172_P	229_V	0.949	0.89
62_T	99_G	0.946	0.89
119_D	161_P	0.929	0.88
51_V	103_L	0.928	0.88
54_K	167_T	0.918	0.87
125_G	153_F	0.912	0.87
134_E	161_P	0.902	0.86
69_G	93_M	0.899	0.86
197_D	219_D	0.898	0.86
54_K	91_P	0.896	0.86
114_E	119_D	0.878	0.85
63_G	99_G	0.875	0.85
111_Q	166_L	0.874	0.84
181_T	218_F	0.871	0.84
151_G	184_S	0.868	0.84
155_N	194_P	0.864	0.84
43_L	110_V	0.858	0.83
115_L	119_D	0.853	0.83
52_M	70_K	0.852	0.83
122_T	189_W	0.847	0.83
146_A	153_F	0.846	0.82
175_V	179_V	0.845	0.82
140_T	194_P	0.845	0.82
159_S	191_A	0.835	0.82
67_F	93_M	0.816	0.80
53_A	95_A	0.814	0.80
54_K	89_G	0.814	0.80
196_V	214_F	0.809	0.80
181_T	186_T	0.808	0.79
135_L	192_T	0.797	0.79
71_R	76_G	0.797	0.79
122_T	140_T	0.792	0.78
198_V	201_S	0.789	0.78
116_A	119_D	0.782	0.77
190_S	229_V	0.780	0.77
122_T	157_A	0.777	0.77
68_T	203_S	0.766	0.76
171_D	232_P	0.765	0.76
47_V	65_F	0.763	0.75
200_A	204_D	0.762	0.75
133_S	202_L	0.760	0.75
63_G	97_G	0.758	0.75
172_P	188_A	0.746	0.74
80_I	136_S	0.740	0.73
122_T	155_N	0.737	0.73
157_A	191_A	0.730	0.72
86_T	156_V	0.724	0.72
52_M	94_R	0.717	0.71
170_G	231_Q	0.715	0.71
189_W	218_F	0.713	0.70
186_T	218_F	0.712	0.70
99_G	175_V	0.709	0.70
67_F	135_L	0.709	0.70
71_R	74_E	0.708	0.70
37_I	41_Y	0.707	0.70
201_S	205_M	0.707	0.70
52_M	74_E	0.706	0.70
53_A	93_M	0.704	0.69
141_T	189_W	0.700	0.69
180_T	215_Q	0.695	0.68
115_L	120_R	0.693	0.68
199_N	204_D	0.690	0.68
124_N	155_N	0.690	0.68
139_V	158_I	0.690	0.68
111_Q	174_V	0.689	0.68
189_W	210_S	0.689	0.68
74_E	81_I	0.685	0.67
66_S	96_E	0.682	0.67
56_G	150_A	0.682	0.67
197_D	200_A	0.680	0.67
160_G	220_D	0.675	0.66
64_E	177_P	0.673	0.66
52_M	137_Y	0.671	0.66
59_V	189_W	0.670	0.66
71_R	79_G	0.664	0.65
218_F	230_V	0.663	0.65
74_E	78_T	0.662	0.65
90_T	156_V	0.662	0.65
149_F	184_S	0.661	0.65
71_R	81_I	0.660	0.64
151_G	183_P	0.657	0.64
149_F	194_P	0.655	0.64
135_L	164_V	0.652	0.64
171_D	185_A	0.651	0.63
169_H	232_P	0.650	0.63
169_H	233_Y	0.649	0.63
152_G	226_G	0.647	0.63
75_G	83_E	0.644	0.63
120_R	193_T	0.642	0.62
37_I	40_S	0.630	0.61
186_T	190_S	0.628	0.61
124_N	156_V	0.626	0.60
180_T	197_D	0.623	0.60
131_F	137_Y	0.623	0.60
49_G	66_S	0.621	0.60
88_E	212_E	0.620	0.60
34_P	181_T	0.620	0.60
71_R	77_L	0.614	0.59
53_A	57_A	0.609	0.58
52_M	92_I	0.609	0.58
39_N	171_D	0.609	0.58
201_S	204_D	0.608	0.58
200_A	203_S	0.607	0.58
57_A	182_D	0.607	0.58
200_A	206_V	0.605	0.58
88_E	124_N	0.604	0.58
62_T	179_V	0.596	0.57
115_L	121_I	0.588	0.56
149_F	152_G	0.587	0.56
70_K	74_E	0.587	0.56
93_M	155_N	0.586	0.55
142_M	146_A	0.585	0.55
130_A	164_V	0.583	0.55
79_G	82_K	0.582	0.55
57_A	88_E	0.582	0.55
89_G	210_S	0.581	0.55
43_L	130_A	0.581	0.55
180_T	195_S	0.581	0.55
142_M	145_L	0.579	0.55
99_G	218_F	0.579	0.55
124_N	183_P	0.578	0.54
187_V	229_V	0.574	0.54
138_E	159_S	0.571	0.54
201_S	210_S	0.571	0.54
58_M	99_G	0.571	0.54
88_E	126_E	0.570	0.53
39_N	109_K	0.568	0.53
199_N	213_R	0.567	0.53
71_R	90_T	0.566	0.53
66_S	94_R	0.565	0.53
65_F	120_R	0.564	0.53
127_D	186_T	0.564	0.53
195_S	219_D	0.563	0.53
55_A	89_G	0.563	0.53
181_T	185_A	0.560	0.52
48_D	159_S	0.553	0.51
74_E	94_R	0.553	0.51
119_D	158_I	0.552	0.51
98_T	136_S	0.545	0.50
47_V	220_D	0.545	0.50
141_T	154_T	0.540	0.50
151_G	154_T	0.540	0.50
60_A	230_V	0.536	0.49
132_E	135_L	0.536	0.49
70_K	79_G	0.535	0.49
119_D	159_S	0.534	0.49
140_T	187_V	0.533	0.49
71_R	80_I	0.533	0.49
97_G	123_V	0.532	0.49
115_L	172_P	0.530	0.48
88_E	183_P	0.529	0.48
66_S	204_D	0.527	0.48
78_T	81_I	0.527	0.48
158_I	203_S	0.525	0.48
125_G	156_V	0.525	0.48
100_T	179_V	0.522	0.47
75_G	91_P	0.522	0.47
71_R	84_A	0.522	0.47
84_A	89_G	0.519	0.47
141_T	146_A	0.518	0.47
44_A	111_Q	0.516	0.47
33_A	37_I	0.516	0.47
75_G	79_G	0.515	0.46
127_D	187_V	0.515	0.46
80_I	84_A	0.513	0.46
53_A	115_L	0.512	0.46
123_V	164_V	0.511	0.46
66_S	74_E	0.511	0.46
88_E	211_G	0.510	0.46
99_G	226_G	0.509	0.46
139_V	154_T	0.509	0.46
81_I	90_T	0.509	0.46
200_A	213_R	0.508	0.45
105_D	169_H	0.508	0.45
62_T	175_V	0.505	0.45
133_S	136_S	0.505	0.45
51_V	98_T	0.504	0.45
123_V	156_V	0.503	0.45
203_S	209_E	0.501	0.45
141_T	144_S	0.501	0.45
78_T	193_T	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pg6A	3	0.8143	100	0.336	Contact Map
1yoxA	3	0.7975	100	0.343	Contact Map
1smpI	1	0.4177	7	0.964	Contact Map
4hdjA	1	0.5148	6.4	0.965	Contact Map
2be1A	2	0.4473	4.8	0.967	Contact Map
1rkiA	1	0.211	4.5	0.967	Contact Map
1kcaA	6	0.3122	4.3	0.968	Contact Map
4g55A	1	0.5232	3.4	0.969	Contact Map
4m0nA	1	0.5316	2.5	0.971	Contact Map
3obaA	4	0.7848	2.4	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0076 seconds.