GREMLIN Database
Q9HRV1 - Uncharacterized protein
UniProt: Q9HRV1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (192)
Sequences: 2029 (1078)
Seq/√Len: 77.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_V227_F4.1421.00
128_V131_F3.2211.00
176_A225_S3.1661.00
197_D217_E2.9751.00
43_L165_A2.9711.00
158_I164_V2.9431.00
44_A100_T2.9181.00
50_D96_E2.8791.00
120_R191_A2.7261.00
179_V228_V2.5031.00
60_A102_Y2.5021.00
114_E163_C2.4831.00
113_L121_I2.4791.00
178_P219_D2.4081.00
118_D161_P2.2861.00
112_I163_C2.2301.00
177_P225_S2.1231.00
174_V229_V2.1101.00
121_I188_A2.0971.00
186_T189_W2.0651.00
123_V166_L2.0081.00
190_S227_F1.9601.00
120_R157_A1.9111.00
110_V129_L1.8861.00
112_I165_A1.8701.00
68_T96_E1.8381.00
119_D190_S1.7741.00
193_T219_D1.7611.00
82_K138_E1.7551.00
50_D94_R1.7341.00
45_I51_V1.6911.00
121_I229_V1.6741.00
46_D100_T1.6611.00
120_R159_S1.6601.00
180_T217_E1.6281.00
76_G81_I1.6191.00
48_D98_T1.6191.00
136_S159_S1.6171.00
123_V158_I1.6171.00
65_F101_L1.6101.00
123_V127_D1.6001.00
155_N189_W1.5981.00
64_E97_G1.5841.00
202_L206_V1.5550.99
182_D212_E1.5460.99
178_P217_E1.5410.99
168_T187_V1.5240.99
42_T59_V1.5210.99
46_D98_T1.5040.99
53_A103_L1.4940.99
47_V101_L1.4650.99
41_Y109_K1.4530.99
138_E157_A1.4350.99
219_D225_S1.4150.99
38_E109_K1.3850.99
110_V165_A1.3830.99
195_S217_E1.3450.98
189_W194_P1.3220.98
88_E182_D1.3110.98
137_Y158_I1.3080.98
68_T94_R1.2910.98
50_D133_S1.2840.98
135_L158_I1.2840.98
70_K94_R1.2790.98
65_F95_A1.2580.97
111_Q168_T1.2390.97
61_Y180_T1.2360.97
64_E99_G1.2330.97
205_M214_F1.2210.97
113_L166_L1.2180.97
202_L205_M1.1900.96
95_A101_L1.1730.96
64_E98_T1.1660.96
52_M131_F1.1620.96
109_K171_D1.1520.96
115_L164_V1.1390.95
186_T194_P1.1280.95
142_M155_N1.1100.95
42_T232_P1.1070.95
67_F199_N1.1050.95
175_V230_V1.1010.95
116_A161_P1.0950.94
42_T60_A1.0940.94
44_A102_Y1.0890.94
140_T157_A1.0850.94
168_T172_P1.0840.94
58_M182_D1.0770.94
45_I103_L1.0670.94
119_D191_A1.0660.94
59_V104_A1.0560.93
103_L130_A1.0470.93
198_V205_M1.0440.93
62_T100_T1.0430.93
132_E163_C1.0420.93
115_L161_P1.0420.93
80_I83_E1.0180.92
63_G178_P1.0160.92
79_G136_S1.0030.91
81_I84_A0.9990.91
121_I164_V0.9980.91
34_P100_T0.9950.91
181_T230_V0.9750.90
58_M212_E0.9720.90
131_F135_L0.9660.90
108_K232_P0.9640.90
220_D226_G0.9590.89
104_A129_L0.9540.89
172_P229_V0.9490.89
62_T99_G0.9460.89
119_D161_P0.9290.88
51_V103_L0.9280.88
54_K167_T0.9180.87
125_G153_F0.9120.87
134_E161_P0.9020.86
69_G93_M0.8990.86
197_D219_D0.8980.86
54_K91_P0.8960.86
114_E119_D0.8780.85
63_G99_G0.8750.85
111_Q166_L0.8740.84
181_T218_F0.8710.84
151_G184_S0.8680.84
155_N194_P0.8640.84
43_L110_V0.8580.83
115_L119_D0.8530.83
52_M70_K0.8520.83
122_T189_W0.8470.83
146_A153_F0.8460.82
175_V179_V0.8450.82
140_T194_P0.8450.82
159_S191_A0.8350.82
67_F93_M0.8160.80
53_A95_A0.8140.80
54_K89_G0.8140.80
196_V214_F0.8090.80
181_T186_T0.8080.79
135_L192_T0.7970.79
71_R76_G0.7970.79
122_T140_T0.7920.78
198_V201_S0.7890.78
116_A119_D0.7820.77
190_S229_V0.7800.77
122_T157_A0.7770.77
68_T203_S0.7660.76
171_D232_P0.7650.76
47_V65_F0.7630.75
200_A204_D0.7620.75
133_S202_L0.7600.75
63_G97_G0.7580.75
172_P188_A0.7460.74
80_I136_S0.7400.73
122_T155_N0.7370.73
157_A191_A0.7300.72
86_T156_V0.7240.72
52_M94_R0.7170.71
170_G231_Q0.7150.71
189_W218_F0.7130.70
186_T218_F0.7120.70
99_G175_V0.7090.70
67_F135_L0.7090.70
71_R74_E0.7080.70
37_I41_Y0.7070.70
201_S205_M0.7070.70
52_M74_E0.7060.70
53_A93_M0.7040.69
141_T189_W0.7000.69
180_T215_Q0.6950.68
115_L120_R0.6930.68
199_N204_D0.6900.68
124_N155_N0.6900.68
139_V158_I0.6900.68
111_Q174_V0.6890.68
189_W210_S0.6890.68
74_E81_I0.6850.67
66_S96_E0.6820.67
56_G150_A0.6820.67
197_D200_A0.6800.67
160_G220_D0.6750.66
64_E177_P0.6730.66
52_M137_Y0.6710.66
59_V189_W0.6700.66
71_R79_G0.6640.65
218_F230_V0.6630.65
74_E78_T0.6620.65
90_T156_V0.6620.65
149_F184_S0.6610.65
71_R81_I0.6600.64
151_G183_P0.6570.64
149_F194_P0.6550.64
135_L164_V0.6520.64
171_D185_A0.6510.63
169_H232_P0.6500.63
169_H233_Y0.6490.63
152_G226_G0.6470.63
75_G83_E0.6440.63
120_R193_T0.6420.62
37_I40_S0.6300.61
186_T190_S0.6280.61
124_N156_V0.6260.60
180_T197_D0.6230.60
131_F137_Y0.6230.60
49_G66_S0.6210.60
88_E212_E0.6200.60
34_P181_T0.6200.60
71_R77_L0.6140.59
53_A57_A0.6090.58
52_M92_I0.6090.58
39_N171_D0.6090.58
201_S204_D0.6080.58
200_A203_S0.6070.58
57_A182_D0.6070.58
200_A206_V0.6050.58
88_E124_N0.6040.58
62_T179_V0.5960.57
115_L121_I0.5880.56
149_F152_G0.5870.56
70_K74_E0.5870.56
93_M155_N0.5860.55
142_M146_A0.5850.55
130_A164_V0.5830.55
79_G82_K0.5820.55
57_A88_E0.5820.55
89_G210_S0.5810.55
43_L130_A0.5810.55
180_T195_S0.5810.55
142_M145_L0.5790.55
99_G218_F0.5790.55
124_N183_P0.5780.54
187_V229_V0.5740.54
138_E159_S0.5710.54
201_S210_S0.5710.54
58_M99_G0.5710.54
88_E126_E0.5700.53
39_N109_K0.5680.53
199_N213_R0.5670.53
71_R90_T0.5660.53
66_S94_R0.5650.53
65_F120_R0.5640.53
127_D186_T0.5640.53
195_S219_D0.5630.53
55_A89_G0.5630.53
181_T185_A0.5600.52
48_D159_S0.5530.51
74_E94_R0.5530.51
119_D158_I0.5520.51
98_T136_S0.5450.50
47_V220_D0.5450.50
141_T154_T0.5400.50
151_G154_T0.5400.50
60_A230_V0.5360.49
132_E135_L0.5360.49
70_K79_G0.5350.49
119_D159_S0.5340.49
140_T187_V0.5330.49
71_R80_I0.5330.49
97_G123_V0.5320.49
115_L172_P0.5300.48
88_E183_P0.5290.48
66_S204_D0.5270.48
78_T81_I0.5270.48
158_I203_S0.5250.48
125_G156_V0.5250.48
100_T179_V0.5220.47
75_G91_P0.5220.47
71_R84_A0.5220.47
84_A89_G0.5190.47
141_T146_A0.5180.47
44_A111_Q0.5160.47
33_A37_I0.5160.47
75_G79_G0.5150.46
127_D187_V0.5150.46
80_I84_A0.5130.46
53_A115_L0.5120.46
123_V164_V0.5110.46
66_S74_E0.5110.46
88_E211_G0.5100.46
99_G226_G0.5090.46
139_V154_T0.5090.46
81_I90_T0.5090.46
200_A213_R0.5080.45
105_D169_H0.5080.45
62_T175_V0.5050.45
133_S136_S0.5050.45
51_V98_T0.5040.45
123_V156_V0.5030.45
203_S209_E0.5010.45
141_T144_S0.5010.45
78_T193_T0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pg6A 3 0.8143 100 0.336 Contact Map
1yoxA 3 0.7975 100 0.343 Contact Map
1smpI 1 0.4177 7 0.964 Contact Map
4hdjA 1 0.5148 6.4 0.965 Contact Map
2be1A 2 0.4473 4.8 0.967 Contact Map
1rkiA 1 0.211 4.5 0.967 Contact Map
1kcaA 6 0.3122 4.3 0.968 Contact Map
4g55A 1 0.5232 3.4 0.969 Contact Map
4m0nA 1 0.5316 2.5 0.971 Contact Map
3obaA 4 0.7848 2.4 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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