GREMLIN Database
Q9HRV0 - Uncharacterized protein
UniProt: Q9HRV0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (187)
Sequences: 1545 (1170)
Seq/√Len: 85.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_M160_M4.0021.00
169_E195_H3.1561.00
47_I179_A2.6871.00
127_V176_E2.5891.00
51_T179_A2.5671.00
48_A53_A2.5601.00
17_T60_V2.5111.00
96_P99_F2.3951.00
18_D41_V2.3691.00
16_E93_G2.3041.00
179_A182_S2.2931.00
54_N99_F2.2831.00
153_T156_D2.2721.00
41_V59_R2.2561.00
190_R197_W2.2091.00
45_E59_R2.1441.00
58_V126_L2.0831.00
141_A144_L2.0741.00
44_A58_V2.0351.00
175_V184_A2.0091.00
176_E180_A1.9921.00
152_R160_M1.9911.00
20_G88_Y1.9381.00
161_I195_H1.9151.00
60_V103_V1.8811.00
175_V180_A1.8721.00
189_K193_W1.8691.00
172_A188_L1.8541.00
198_L202_V1.8231.00
41_V45_E1.8101.00
127_V131_L1.8101.00
186_R197_W1.8081.00
48_A55_V1.7961.00
168_G191_V1.7551.00
109_R123_A1.7481.00
50_A182_S1.7091.00
24_W84_I1.6891.00
121_L124_R1.6631.00
162_Q166_D1.6431.00
172_A185_H1.6411.00
190_R193_W1.6331.00
188_L192_R1.6291.00
185_H189_K1.6291.00
86_R104_A1.5611.00
189_K192_R1.5591.00
159_E162_Q1.5341.00
41_V63_L1.5161.00
53_A58_V1.4550.99
110_H123_A1.4170.99
105_E109_R1.4130.99
56_D99_F1.4000.99
17_T88_Y1.3860.99
190_R194_L1.3840.99
183_I186_R1.3810.99
171_A175_V1.3670.99
193_W197_W1.3350.99
147_M152_R1.3260.99
68_A81_G1.3250.99
90_E97_P1.3070.99
144_L148_G1.2990.99
170_D174_R1.2920.98
161_I198_L1.2700.98
50_A179_A1.2580.98
178_D181_S1.2530.98
95_F99_F1.2450.98
18_D22_M1.2420.98
53_A121_L1.2270.98
177_S180_A1.2260.98
53_A125_C1.2260.98
143_M160_M1.2250.98
97_P101_D1.2240.98
192_R196_D1.2220.98
43_I183_I1.2210.98
60_V95_F1.2040.98
86_R90_E1.1860.97
191_V195_H1.1770.97
49_E55_V1.1640.97
186_R200_S1.1480.97
43_I46_R1.1200.96
68_A85_A1.1080.96
46_R50_A1.1080.96
48_A58_V1.1010.96
88_Y93_G1.0850.95
102_Q122_E1.0810.95
21_R25_Y1.0660.95
86_R100_V1.0630.95
195_H199_T1.0580.95
124_R176_E1.0510.95
135_A188_L1.0460.94
28_H31_E1.0420.94
85_A89_L1.0160.94
78_A81_G1.0120.93
32_Y142_L1.0080.93
30_A145_L1.0030.93
87_K91_T0.9810.92
146_R150_E0.9730.92
169_E188_L0.9680.92
165_L195_H0.9570.91
61_A106_A0.9520.91
22_M34_F0.9520.91
163_R167_R0.9430.91
86_R101_D0.9410.91
140_A194_L0.9310.90
82_A108_S0.9270.90
109_R119_L0.9270.90
141_A154_H0.9190.90
152_R157_A0.9060.89
37_I41_V0.9020.89
161_I165_L0.9010.89
35_T38_M0.8920.88
47_I183_I0.8910.88
56_D95_F0.8900.88
84_I87_K0.8700.87
135_A143_M0.8690.87
165_L199_T0.8610.86
134_K163_R0.8600.86
91_T94_Q0.8590.86
17_T64_F0.8530.86
109_R116_L0.8510.86
99_F103_V0.8430.85
46_R179_A0.8420.85
47_I180_A0.8390.85
145_L160_M0.8370.85
85_A107_V0.8330.85
158_A162_Q0.8320.84
156_D162_Q0.8320.84
133_D139_G0.8240.84
37_I133_D0.8170.83
68_A82_A0.8150.83
56_D60_V0.8110.83
82_A85_A0.8100.83
39_N133_D0.8100.83
134_K167_R0.8080.83
193_W196_D0.8040.82
132_L180_A0.8000.82
144_L183_I0.7970.82
180_A183_I0.7970.82
52_S121_L0.7960.82
64_F85_A0.7860.81
31_E176_E0.7850.81
169_E192_R0.7820.81
17_T20_G0.7820.81
61_A110_H0.7810.81
119_L124_R0.7770.80
54_N102_Q0.7750.80
170_D173_E0.7620.79
38_M42_D0.7600.79
169_E191_V0.7600.79
115_D176_E0.7560.78
67_I81_G0.7530.78
192_R199_T0.7510.78
48_A52_S0.7440.77
77_H81_G0.7400.77
169_E184_A0.7390.77
105_E120_P0.7360.76
32_Y167_R0.7320.76
104_A108_S0.7260.75
46_R183_I0.7240.75
100_V104_A0.7190.75
57_V102_Q0.7170.75
112_Y170_D0.7150.74
48_A62_A0.7100.74
121_L125_C0.7060.73
32_Y134_K0.7030.73
25_Y37_I0.6990.73
113_Q163_R0.6980.73
139_G142_L0.6970.72
64_F67_I0.6960.72
134_K142_L0.6940.72
134_K171_A0.6940.72
48_A125_C0.6940.72
163_R171_A0.6920.72
25_Y110_H0.6920.72
181_S185_H0.6910.72
137_A201_E0.6910.72
61_A126_L0.6900.72
112_Y171_A0.6880.72
136_G139_G0.6870.71
52_S179_A0.6860.71
44_A126_L0.6820.71
43_I47_I0.6820.71
127_V163_R0.6770.70
90_E100_V0.6770.70
38_M41_V0.6700.70
164_V169_E0.6680.69
15_N19_G0.6670.69
68_A78_A0.6660.69
107_V110_H0.6590.68
200_S203_P0.6580.68
106_A110_H0.6570.68
17_T93_G0.6550.68
120_P123_A0.6530.68
23_R26_P0.6520.67
163_R169_E0.6510.67
18_D38_M0.6470.67
147_M156_D0.6450.67
21_R34_F0.6440.66
21_R24_W0.6410.66
47_I125_C0.6400.66
113_Q127_V0.6400.66
135_A184_A0.6400.66
89_L103_V0.6390.66
111_S163_R0.6380.66
60_V99_F0.6360.66
137_A190_R0.6310.65
41_V62_A0.6310.65
22_M26_P0.6280.65
53_A122_E0.6270.64
86_R98_S0.6220.64
143_M164_V0.6200.64
111_S131_L0.6190.63
43_I197_W0.6170.63
69_K166_D0.6140.63
141_A148_G0.6100.62
133_D155_V0.6090.62
179_A183_I0.6060.62
139_G175_V0.6040.62
112_Y139_G0.6040.62
67_I95_F0.6030.61
79_E83_R0.6020.61
172_A184_A0.6010.61
187_R197_W0.6010.61
77_H80_E0.6000.61
165_L169_E0.5950.60
141_A183_I0.5940.60
83_R86_R0.5930.60
196_D200_S0.5920.60
14_E60_V0.5920.60
143_M171_A0.5920.60
78_A82_A0.5900.60
58_V125_C0.5880.59
163_R166_D0.5880.59
135_A172_A0.5870.59
144_L147_M0.5840.59
42_D45_E0.5820.59
69_K77_H0.5780.58
89_L100_V0.5760.58
46_R102_Q0.5720.57
30_A149_Y0.5720.57
76_A80_E0.5710.57
81_G84_I0.5680.57
69_K131_L0.5660.57
74_Q77_H0.5620.56
68_A84_I0.5540.55
29_S145_L0.5510.55
19_G182_S0.5500.54
69_K126_L0.5440.54
15_N38_M0.5420.53
88_Y91_T0.5400.53
34_F151_A0.5400.53
19_G27_W0.5370.53
87_K90_E0.5370.53
24_W27_W0.5360.53
155_V202_V0.5290.52
71_E166_D0.5280.52
57_V103_V0.5270.51
25_Y68_A0.5270.51
123_A145_L0.5270.51
68_A77_H0.5260.51
14_E18_D0.5250.51
57_V122_E0.5240.51
105_E108_S0.5240.51
22_M38_M0.5220.51
47_I126_L0.5220.51
45_E55_V0.5180.50
147_M162_Q0.5160.50
105_E123_A0.5130.50
28_H67_I0.5120.49
90_E94_Q0.5120.49
69_K110_H0.5110.49
17_T25_Y0.5110.49
20_G91_T0.5100.49
42_D203_P0.5100.49
15_N18_D0.5070.49
23_R42_D0.5070.49
131_L176_E0.5070.49
106_A109_R0.5020.48
19_G23_R0.5000.48
144_L154_H0.5000.48
152_R159_E0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pjqA 2 0.919 100 0.297 Contact Map
2qgsA 2 0.9095 100 0.3 Contact Map
3dtoA 2 0.8286 100 0.309 Contact Map
3b57A 2 0.8429 100 0.31 Contact Map
3djbA 2 0.8714 100 0.313 Contact Map
3gw7A 2 0.8857 100 0.314 Contact Map
2pq7A 2 0.8095 100 0.334 Contact Map
2q14A 4 0.9476 99.6 0.738 Contact Map
2hekA 4 0.9476 99.6 0.742 Contact Map
2cqzA 5 0.8 99.5 0.752 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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