Q9HRV0 - HALSA - GREMLIN Contacts

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Q9HRV0 - Uncharacterized protein

UniProt:	Q9HRV0	Sequences: MAAFVRDYLEASVENETDGGRMRWYPWHSAEYRFTHIMNVVDIAERIAEATSANVDVVRVAALFHDIAKLEAEQDAHAEEGARIARKYLETHGQFPPSFVDQVAEAVSRHSYQGDLMDLPLEARCLVEADLLDKAGANGAALMLLRMGYEARTHVDAAEMIQRVLDRGEDAAERVESDAASSIAHRRLKRVRWLHDWLTSEVPAMNDTGY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	210 (187)
Sequences:	1545 (1170)
Seq/√Len:	85.6

ECOLI - YEDJ
BACSU - YPGQ
HALSA - Q9HRV0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
147_M	160_M	4.002	1.00
169_E	195_H	3.156	1.00
47_I	179_A	2.687	1.00
127_V	176_E	2.589	1.00
51_T	179_A	2.567	1.00
48_A	53_A	2.560	1.00
17_T	60_V	2.511	1.00
96_P	99_F	2.395	1.00
18_D	41_V	2.369	1.00
16_E	93_G	2.304	1.00
179_A	182_S	2.293	1.00
54_N	99_F	2.283	1.00
153_T	156_D	2.272	1.00
41_V	59_R	2.256	1.00
190_R	197_W	2.209	1.00
45_E	59_R	2.144	1.00
58_V	126_L	2.083	1.00
141_A	144_L	2.074	1.00
44_A	58_V	2.035	1.00
175_V	184_A	2.009	1.00
176_E	180_A	1.992	1.00
152_R	160_M	1.991	1.00
20_G	88_Y	1.938	1.00
161_I	195_H	1.915	1.00
60_V	103_V	1.881	1.00
175_V	180_A	1.872	1.00
189_K	193_W	1.869	1.00
172_A	188_L	1.854	1.00
198_L	202_V	1.823	1.00
41_V	45_E	1.810	1.00
127_V	131_L	1.810	1.00
186_R	197_W	1.808	1.00
48_A	55_V	1.796	1.00
168_G	191_V	1.755	1.00
109_R	123_A	1.748	1.00
50_A	182_S	1.709	1.00
24_W	84_I	1.689	1.00
121_L	124_R	1.663	1.00
162_Q	166_D	1.643	1.00
172_A	185_H	1.641	1.00
190_R	193_W	1.633	1.00
188_L	192_R	1.629	1.00
185_H	189_K	1.629	1.00
86_R	104_A	1.561	1.00
189_K	192_R	1.559	1.00
159_E	162_Q	1.534	1.00
41_V	63_L	1.516	1.00
53_A	58_V	1.455	0.99
110_H	123_A	1.417	0.99
105_E	109_R	1.413	0.99
56_D	99_F	1.400	0.99
17_T	88_Y	1.386	0.99
190_R	194_L	1.384	0.99
183_I	186_R	1.381	0.99
171_A	175_V	1.367	0.99
193_W	197_W	1.335	0.99
147_M	152_R	1.326	0.99
68_A	81_G	1.325	0.99
90_E	97_P	1.307	0.99
144_L	148_G	1.299	0.99
170_D	174_R	1.292	0.98
161_I	198_L	1.270	0.98
50_A	179_A	1.258	0.98
178_D	181_S	1.253	0.98
95_F	99_F	1.245	0.98
18_D	22_M	1.242	0.98
53_A	121_L	1.227	0.98
177_S	180_A	1.226	0.98
53_A	125_C	1.226	0.98
143_M	160_M	1.225	0.98
97_P	101_D	1.224	0.98
192_R	196_D	1.222	0.98
43_I	183_I	1.221	0.98
60_V	95_F	1.204	0.98
86_R	90_E	1.186	0.97
191_V	195_H	1.177	0.97
49_E	55_V	1.164	0.97
186_R	200_S	1.148	0.97
43_I	46_R	1.120	0.96
68_A	85_A	1.108	0.96
46_R	50_A	1.108	0.96
48_A	58_V	1.101	0.96
88_Y	93_G	1.085	0.95
102_Q	122_E	1.081	0.95
21_R	25_Y	1.066	0.95
86_R	100_V	1.063	0.95
195_H	199_T	1.058	0.95
124_R	176_E	1.051	0.95
135_A	188_L	1.046	0.94
28_H	31_E	1.042	0.94
85_A	89_L	1.016	0.94
78_A	81_G	1.012	0.93
32_Y	142_L	1.008	0.93
30_A	145_L	1.003	0.93
87_K	91_T	0.981	0.92
146_R	150_E	0.973	0.92
169_E	188_L	0.968	0.92
165_L	195_H	0.957	0.91
61_A	106_A	0.952	0.91
22_M	34_F	0.952	0.91
163_R	167_R	0.943	0.91
86_R	101_D	0.941	0.91
140_A	194_L	0.931	0.90
82_A	108_S	0.927	0.90
109_R	119_L	0.927	0.90
141_A	154_H	0.919	0.90
152_R	157_A	0.906	0.89
37_I	41_V	0.902	0.89
161_I	165_L	0.901	0.89
35_T	38_M	0.892	0.88
47_I	183_I	0.891	0.88
56_D	95_F	0.890	0.88
84_I	87_K	0.870	0.87
135_A	143_M	0.869	0.87
165_L	199_T	0.861	0.86
134_K	163_R	0.860	0.86
91_T	94_Q	0.859	0.86
17_T	64_F	0.853	0.86
109_R	116_L	0.851	0.86
99_F	103_V	0.843	0.85
46_R	179_A	0.842	0.85
47_I	180_A	0.839	0.85
145_L	160_M	0.837	0.85
85_A	107_V	0.833	0.85
158_A	162_Q	0.832	0.84
156_D	162_Q	0.832	0.84
133_D	139_G	0.824	0.84
37_I	133_D	0.817	0.83
68_A	82_A	0.815	0.83
56_D	60_V	0.811	0.83
82_A	85_A	0.810	0.83
39_N	133_D	0.810	0.83
134_K	167_R	0.808	0.83
193_W	196_D	0.804	0.82
132_L	180_A	0.800	0.82
144_L	183_I	0.797	0.82
180_A	183_I	0.797	0.82
52_S	121_L	0.796	0.82
64_F	85_A	0.786	0.81
31_E	176_E	0.785	0.81
169_E	192_R	0.782	0.81
17_T	20_G	0.782	0.81
61_A	110_H	0.781	0.81
119_L	124_R	0.777	0.80
54_N	102_Q	0.775	0.80
170_D	173_E	0.762	0.79
38_M	42_D	0.760	0.79
169_E	191_V	0.760	0.79
115_D	176_E	0.756	0.78
67_I	81_G	0.753	0.78
192_R	199_T	0.751	0.78
48_A	52_S	0.744	0.77
77_H	81_G	0.740	0.77
169_E	184_A	0.739	0.77
105_E	120_P	0.736	0.76
32_Y	167_R	0.732	0.76
104_A	108_S	0.726	0.75
46_R	183_I	0.724	0.75
100_V	104_A	0.719	0.75
57_V	102_Q	0.717	0.75
112_Y	170_D	0.715	0.74
48_A	62_A	0.710	0.74
121_L	125_C	0.706	0.73
32_Y	134_K	0.703	0.73
25_Y	37_I	0.699	0.73
113_Q	163_R	0.698	0.73
139_G	142_L	0.697	0.72
64_F	67_I	0.696	0.72
134_K	142_L	0.694	0.72
134_K	171_A	0.694	0.72
48_A	125_C	0.694	0.72
163_R	171_A	0.692	0.72
25_Y	110_H	0.692	0.72
181_S	185_H	0.691	0.72
137_A	201_E	0.691	0.72
61_A	126_L	0.690	0.72
112_Y	171_A	0.688	0.72
136_G	139_G	0.687	0.71
52_S	179_A	0.686	0.71
44_A	126_L	0.682	0.71
43_I	47_I	0.682	0.71
127_V	163_R	0.677	0.70
90_E	100_V	0.677	0.70
38_M	41_V	0.670	0.70
164_V	169_E	0.668	0.69
15_N	19_G	0.667	0.69
68_A	78_A	0.666	0.69
107_V	110_H	0.659	0.68
200_S	203_P	0.658	0.68
106_A	110_H	0.657	0.68
17_T	93_G	0.655	0.68
120_P	123_A	0.653	0.68
23_R	26_P	0.652	0.67
163_R	169_E	0.651	0.67
18_D	38_M	0.647	0.67
147_M	156_D	0.645	0.67
21_R	34_F	0.644	0.66
21_R	24_W	0.641	0.66
47_I	125_C	0.640	0.66
113_Q	127_V	0.640	0.66
135_A	184_A	0.640	0.66
89_L	103_V	0.639	0.66
111_S	163_R	0.638	0.66
60_V	99_F	0.636	0.66
137_A	190_R	0.631	0.65
41_V	62_A	0.631	0.65
22_M	26_P	0.628	0.65
53_A	122_E	0.627	0.64
86_R	98_S	0.622	0.64
143_M	164_V	0.620	0.64
111_S	131_L	0.619	0.63
43_I	197_W	0.617	0.63
69_K	166_D	0.614	0.63
141_A	148_G	0.610	0.62
133_D	155_V	0.609	0.62
179_A	183_I	0.606	0.62
139_G	175_V	0.604	0.62
112_Y	139_G	0.604	0.62
67_I	95_F	0.603	0.61
79_E	83_R	0.602	0.61
172_A	184_A	0.601	0.61
187_R	197_W	0.601	0.61
77_H	80_E	0.600	0.61
165_L	169_E	0.595	0.60
141_A	183_I	0.594	0.60
83_R	86_R	0.593	0.60
196_D	200_S	0.592	0.60
14_E	60_V	0.592	0.60
143_M	171_A	0.592	0.60
78_A	82_A	0.590	0.60
58_V	125_C	0.588	0.59
163_R	166_D	0.588	0.59
135_A	172_A	0.587	0.59
144_L	147_M	0.584	0.59
42_D	45_E	0.582	0.59
69_K	77_H	0.578	0.58
89_L	100_V	0.576	0.58
46_R	102_Q	0.572	0.57
30_A	149_Y	0.572	0.57
76_A	80_E	0.571	0.57
81_G	84_I	0.568	0.57
69_K	131_L	0.566	0.57
74_Q	77_H	0.562	0.56
68_A	84_I	0.554	0.55
29_S	145_L	0.551	0.55
19_G	182_S	0.550	0.54
69_K	126_L	0.544	0.54
15_N	38_M	0.542	0.53
88_Y	91_T	0.540	0.53
34_F	151_A	0.540	0.53
19_G	27_W	0.537	0.53
87_K	90_E	0.537	0.53
24_W	27_W	0.536	0.53
155_V	202_V	0.529	0.52
71_E	166_D	0.528	0.52
57_V	103_V	0.527	0.51
25_Y	68_A	0.527	0.51
123_A	145_L	0.527	0.51
68_A	77_H	0.526	0.51
14_E	18_D	0.525	0.51
57_V	122_E	0.524	0.51
105_E	108_S	0.524	0.51
22_M	38_M	0.522	0.51
47_I	126_L	0.522	0.51
45_E	55_V	0.518	0.50
147_M	162_Q	0.516	0.50
105_E	123_A	0.513	0.50
28_H	67_I	0.512	0.49
90_E	94_Q	0.512	0.49
69_K	110_H	0.511	0.49
17_T	25_Y	0.511	0.49
20_G	91_T	0.510	0.49
42_D	203_P	0.510	0.49
15_N	18_D	0.507	0.49
23_R	42_D	0.507	0.49
131_L	176_E	0.507	0.49
106_A	109_R	0.502	0.48
19_G	23_R	0.500	0.48
144_L	154_H	0.500	0.48
152_R	159_E	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2pjqA	2	0.919	100	0.297	Contact Map
2qgsA	2	0.9095	100	0.3	Contact Map
3dtoA	2	0.8286	100	0.309	Contact Map
3b57A	2	0.8429	100	0.31	Contact Map
3djbA	2	0.8714	100	0.313	Contact Map
3gw7A	2	0.8857	100	0.314	Contact Map
2pq7A	2	0.8095	100	0.334	Contact Map
2q14A	4	0.9476	99.6	0.738	Contact Map
2hekA	4	0.9476	99.6	0.742	Contact Map
2cqzA	5	0.8	99.5	0.752	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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