GREMLIN Database
Q9HRU8 - Transcription repressor
UniProt: Q9HRU8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (212)
Sequences: 1589 (1146)
Seq/√Len: 78.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_H164_L5.8081.00
166_V221_L3.8051.00
141_N145_E3.7521.00
103_E118_E3.4621.00
25_E76_E3.3851.00
192_T205_E3.2921.00
163_A192_T3.1151.00
164_L223_V3.1091.00
21_I61_I3.0421.00
91_S95_T2.9341.00
163_A190_E2.8691.00
124_A129_D2.7741.00
121_D142_A2.6581.00
101_W177_L2.4321.00
115_I120_E2.4271.00
89_L115_I2.3561.00
176_E217_V2.2571.00
159_A162_D2.2481.00
203_V210_A2.2321.00
19_K109_D2.2171.00
107_E116_S2.2041.00
125_E129_D2.1451.00
19_K133_D2.1171.00
166_V185_V2.1041.00
165_V190_E2.0981.00
127_L130_P2.0611.00
52_A61_I2.0461.00
92_F97_L2.0281.00
13_V47_T2.0161.00
165_V224_R2.0131.00
164_L191_L1.9311.00
16_D19_K1.8821.00
96_H126_K1.8751.00
102_D178_R1.8501.00
202_F218_A1.7891.00
47_T51_M1.7641.00
166_V191_L1.7471.00
156_A219_E1.6751.00
43_V48_V1.6311.00
92_F96_H1.6171.00
63_R66_Y1.6031.00
14_M58_R1.5781.00
186_Q189_T1.5771.00
86_H105_H1.5761.00
15_E113_H1.5490.99
123_L126_K1.5470.99
16_D109_D1.5140.99
137_D168_R1.4900.99
133_D137_D1.4690.99
90_E105_H1.4460.99
160_E195_E1.4210.99
92_F126_K1.4210.99
213_L218_A1.4000.99
89_L119_F1.3900.99
130_P139_I1.3770.99
205_E210_A1.3670.99
99_Y119_F1.3560.99
20_S37_I1.3320.98
36_T39_E1.3140.98
122_R125_E1.3090.98
21_I48_V1.3000.98
41_L51_M1.2970.98
74_D77_T1.2780.98
215_E219_E1.2650.98
34_T49_T1.2550.98
158_H193_V1.2520.97
15_E82_V1.2180.97
195_E203_V1.2110.97
194_T205_E1.2090.97
115_I119_F1.2030.97
34_T45_P1.1950.97
107_E110_A1.1880.97
84_R140_P1.1750.96
198_P201_L1.1740.96
158_H223_V1.1690.96
179_Y199_I1.1670.96
168_R222_E1.1630.96
15_E112_E1.1620.96
37_I48_V1.1530.96
21_I37_I1.1430.96
191_L204_V1.1070.95
100_D103_E1.0950.95
87_R139_I1.0610.94
87_R90_E1.0580.93
73_P76_E1.0550.93
81_E85_H1.0410.93
41_L45_P1.0380.93
88_L124_A1.0080.92
34_T48_V0.9920.91
107_E115_I0.9790.91
17_Y47_T0.9780.90
142_A145_E0.9710.90
85_H120_E0.9660.90
56_E63_R0.9540.89
22_Y51_M0.9530.89
204_V213_L0.9520.89
62_E70_E0.9510.89
184_G189_T0.9480.89
109_D112_E0.9380.89
197_A201_L0.9330.88
94_A104_V0.9300.88
90_E136_G0.9230.88
87_R140_P0.9230.88
56_E59_G0.9220.88
93_L104_V0.9190.88
180_L185_V0.9160.87
197_A203_V0.8970.86
17_Y48_V0.8920.86
76_E80_V0.8900.86
99_Y103_E0.8890.86
205_E208_G0.8860.86
22_Y83_I0.8830.85
43_V47_T0.8820.85
74_D78_V0.8740.85
151_D174_T0.8730.85
154_V157_D0.8720.85
132_V161_G0.8700.85
48_V52_A0.8580.84
190_E208_G0.8550.83
101_W135_H0.8530.83
174_T178_R0.8510.83
89_L123_L0.8460.83
86_H90_E0.8450.83
130_P140_P0.8360.82
88_L123_L0.8320.82
92_F123_L0.8280.81
100_D122_R0.8260.81
167_A224_R0.8260.81
200_G215_E0.8250.81
109_D113_H0.8240.81
86_H135_H0.8240.81
44_T51_M0.8220.81
24_L51_M0.8180.81
153_E157_D0.8170.81
23_N82_V0.8090.80
84_R139_I0.8090.80
118_E122_R0.8060.80
44_T50_S0.7960.79
20_S41_L0.7940.79
119_F123_L0.7940.79
86_H113_H0.7890.78
16_D114_H0.7880.78
184_G221_L0.7870.78
85_H114_H0.7860.78
195_E209_E0.7860.78
85_H117_E0.7850.78
24_L114_H0.7800.77
61_I64_E0.7780.77
59_G74_D0.7730.77
134_P139_I0.7730.77
152_T167_A0.7720.77
107_E114_H0.7720.77
111_L119_F0.7700.77
90_E135_H0.7670.76
52_A69_V0.7650.76
208_G213_L0.7620.76
158_H162_D0.7600.76
13_V51_M0.7600.76
13_V16_D0.7600.76
194_T203_V0.7580.75
158_H205_E0.7560.75
44_T47_T0.7550.75
44_T49_T0.7510.75
35_S45_P0.7500.75
62_E100_D0.7450.74
28_H106_D0.7440.74
34_T52_A0.7420.74
97_L123_L0.7410.74
90_E130_P0.7360.73
34_T51_M0.7350.73
54_K111_L0.7320.73
82_V85_H0.7280.72
135_H139_I0.7270.72
14_M51_M0.7160.71
161_G193_V0.7160.71
181_A186_Q0.7150.71
86_H112_E0.7140.71
153_E162_D0.7140.71
152_T222_E0.7140.71
102_D181_A0.7130.71
98_D122_R0.7130.71
189_T207_D0.7100.71
140_P144_L0.7090.70
35_S58_R0.7080.70
59_G162_D0.7080.70
73_P100_D0.7010.70
19_K23_N0.6940.69
15_E85_H0.6920.69
105_H135_H0.6880.68
97_L126_K0.6850.68
46_P51_M0.6810.67
65_K70_E0.6790.67
109_D135_H0.6750.67
74_D166_V0.6740.67
13_V46_P0.6670.66
20_S40_Y0.6640.65
25_E32_I0.6630.65
201_L214_P0.6620.65
18_L31_P0.6620.65
14_M22_Y0.6600.65
11_S43_V0.6590.65
194_T210_A0.6580.65
154_V219_E0.6580.65
38_A102_D0.6510.64
161_G210_A0.6500.64
166_V183_A0.6480.64
34_T68_G0.6470.63
53_E63_R0.6460.63
201_L212_H0.6460.63
38_A52_A0.6420.63
206_I209_E0.6420.63
131_T209_E0.6410.63
198_P216_R0.6410.63
15_E92_F0.6390.62
90_E134_P0.6360.62
104_V135_H0.6350.62
50_S119_F0.6340.62
164_L193_V0.6340.62
87_R130_P0.6340.62
120_E124_A0.6330.62
72_T151_D0.6330.62
45_P51_M0.6320.62
185_V206_I0.6300.61
124_A141_N0.6290.61
157_D195_E0.6270.61
172_R222_E0.6270.61
64_E70_E0.6230.61
121_D125_E0.6220.60
90_E140_P0.6200.60
160_E196_H0.6180.60
93_L108_A0.6140.59
130_P136_G0.6130.59
51_M54_K0.6110.59
45_P49_T0.6110.59
130_P134_P0.6090.59
19_K112_E0.6060.58
50_S137_D0.6050.58
99_Y107_E0.6040.58
12_D32_I0.6010.58
63_R69_V0.5990.58
35_S99_Y0.5980.57
134_P140_P0.5960.57
46_P120_E0.5940.57
193_V211_V0.5940.57
43_V51_M0.5920.57
65_K68_G0.5910.57
90_E127_L0.5910.57
90_E139_I0.5900.56
137_D171_D0.5870.56
34_T69_V0.5870.56
42_D170_S0.5870.56
15_E51_M0.5860.56
198_P215_E0.5830.56
32_I37_I0.5820.55
117_E120_E0.5810.55
84_R138_P0.5810.55
159_A166_V0.5800.55
214_P217_V0.5800.55
33_A110_A0.5790.55
16_D112_E0.5790.55
130_P135_H0.5770.55
89_L92_F0.5760.55
51_M67_A0.5740.54
127_L139_I0.5740.54
19_K80_V0.5730.54
164_L204_V0.5730.54
121_D129_D0.5720.54
136_G140_P0.5710.54
83_I87_R0.5710.54
154_V222_E0.5710.54
85_H107_E0.5690.54
87_R134_P0.5640.53
133_D140_P0.5640.53
25_E31_P0.5600.53
153_E156_A0.5570.52
47_T201_L0.5570.52
131_T165_V0.5570.52
93_L134_P0.5500.51
135_H177_L0.5500.51
68_G97_L0.5490.51
160_E186_Q0.5460.51
103_E122_R0.5420.50
89_L107_E0.5410.50
154_V220_T0.5410.50
93_L105_H0.5400.50
16_D168_R0.5380.50
46_P67_A0.5370.50
168_R171_D0.5370.50
15_E22_Y0.5330.49
37_I52_A0.5320.49
49_T63_R0.5300.49
78_V121_D0.5270.48
107_E168_R0.5250.48
73_P77_T0.5210.48
83_I135_H0.5210.48
88_L130_P0.5190.47
203_V212_H0.5170.47
37_I58_R0.5170.47
55_L60_L0.5170.47
89_L111_L0.5150.47
159_A205_E0.5150.47
50_S53_E0.5150.47
101_W187_P0.5140.47
21_I71_L0.5130.47
155_L193_V0.5120.46
84_R87_R0.5120.46
203_V224_R0.5110.46
53_E57_S0.5100.46
135_H168_R0.5090.46
36_T40_Y0.5090.46
159_A163_A0.5070.46
132_V188_G0.5060.46
33_A68_G0.5050.46
85_H115_I0.5030.45
141_N144_L0.5020.45
16_D107_E0.5010.45
149_H152_T0.5010.45
107_E118_E0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fx7A 4 0.9356 100 0.378 Contact Map
2qq9A 2 0.8798 100 0.387 Contact Map
4o5vA 2 0.9142 100 0.391 Contact Map
3hrsA 2 0.9142 100 0.395 Contact Map
2x4hA 3 0.5622 99.9 0.69 Contact Map
1on2A 2 0.5794 99.8 0.716 Contact Map
2h09A 2 0.5408 99.7 0.747 Contact Map
2p8tA 1 0.6996 99.7 0.748 Contact Map
2k5fA 1 0.3433 99.4 0.797 Contact Map
3mhxA 1 0.3476 99.3 0.803 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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