Q9HRU8 - HALSA - GREMLIN Contacts

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Q9HRU8 - Transcription repressor

UniProt:	Q9HRU8	Sequences: MHLNDGVGMLSDVMEDYLKSIYNLEREHEPPIATSTIAEYLDVTPPTVTSMAEKLESRGLIEREKYAGVELTPDGETVAVEVIRHHRLLESFLATHLDYDWDEVHDEADALEHHISEEFEDRLAEKLGDPTVDPHGDPIPNADLEPPEHPDTEVLADHAEGDALVVARASDRNTDELRYLADAGVQPGTELTVTEHAPIGLFVVEIDGEAVHLPERVAETLEVRPAADEVTDA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	233 (212)
Sequences:	1589 (1146)
Seq/√Len:	78.7

ECOLI - MNTR
BACSU - MNTR
HALSA - Q9HRU8 Q9HRV3 Q9HME7
SULSO - Q7LXP0 Q97WF3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
158_H	164_L	5.808	1.00
166_V	221_L	3.805	1.00
141_N	145_E	3.752	1.00
103_E	118_E	3.462	1.00
25_E	76_E	3.385	1.00
192_T	205_E	3.292	1.00
163_A	192_T	3.115	1.00
164_L	223_V	3.109	1.00
21_I	61_I	3.042	1.00
91_S	95_T	2.934	1.00
163_A	190_E	2.869	1.00
124_A	129_D	2.774	1.00
121_D	142_A	2.658	1.00
101_W	177_L	2.432	1.00
115_I	120_E	2.427	1.00
89_L	115_I	2.356	1.00
176_E	217_V	2.257	1.00
159_A	162_D	2.248	1.00
203_V	210_A	2.232	1.00
19_K	109_D	2.217	1.00
107_E	116_S	2.204	1.00
125_E	129_D	2.145	1.00
19_K	133_D	2.117	1.00
166_V	185_V	2.104	1.00
165_V	190_E	2.098	1.00
127_L	130_P	2.061	1.00
52_A	61_I	2.046	1.00
92_F	97_L	2.028	1.00
13_V	47_T	2.016	1.00
165_V	224_R	2.013	1.00
164_L	191_L	1.931	1.00
16_D	19_K	1.882	1.00
96_H	126_K	1.875	1.00
102_D	178_R	1.850	1.00
202_F	218_A	1.789	1.00
47_T	51_M	1.764	1.00
166_V	191_L	1.747	1.00
156_A	219_E	1.675	1.00
43_V	48_V	1.631	1.00
92_F	96_H	1.617	1.00
63_R	66_Y	1.603	1.00
14_M	58_R	1.578	1.00
186_Q	189_T	1.577	1.00
86_H	105_H	1.576	1.00
15_E	113_H	1.549	0.99
123_L	126_K	1.547	0.99
16_D	109_D	1.514	0.99
137_D	168_R	1.490	0.99
133_D	137_D	1.469	0.99
90_E	105_H	1.446	0.99
160_E	195_E	1.421	0.99
92_F	126_K	1.421	0.99
213_L	218_A	1.400	0.99
89_L	119_F	1.390	0.99
130_P	139_I	1.377	0.99
205_E	210_A	1.367	0.99
99_Y	119_F	1.356	0.99
20_S	37_I	1.332	0.98
36_T	39_E	1.314	0.98
122_R	125_E	1.309	0.98
21_I	48_V	1.300	0.98
41_L	51_M	1.297	0.98
74_D	77_T	1.278	0.98
215_E	219_E	1.265	0.98
34_T	49_T	1.255	0.98
158_H	193_V	1.252	0.97
15_E	82_V	1.218	0.97
195_E	203_V	1.211	0.97
194_T	205_E	1.209	0.97
115_I	119_F	1.203	0.97
34_T	45_P	1.195	0.97
107_E	110_A	1.188	0.97
84_R	140_P	1.175	0.96
198_P	201_L	1.174	0.96
158_H	223_V	1.169	0.96
179_Y	199_I	1.167	0.96
168_R	222_E	1.163	0.96
15_E	112_E	1.162	0.96
37_I	48_V	1.153	0.96
21_I	37_I	1.143	0.96
191_L	204_V	1.107	0.95
100_D	103_E	1.095	0.95
87_R	139_I	1.061	0.94
87_R	90_E	1.058	0.93
73_P	76_E	1.055	0.93
81_E	85_H	1.041	0.93
41_L	45_P	1.038	0.93
88_L	124_A	1.008	0.92
34_T	48_V	0.992	0.91
107_E	115_I	0.979	0.91
17_Y	47_T	0.978	0.90
142_A	145_E	0.971	0.90
85_H	120_E	0.966	0.90
56_E	63_R	0.954	0.89
22_Y	51_M	0.953	0.89
204_V	213_L	0.952	0.89
62_E	70_E	0.951	0.89
184_G	189_T	0.948	0.89
109_D	112_E	0.938	0.89
197_A	201_L	0.933	0.88
94_A	104_V	0.930	0.88
90_E	136_G	0.923	0.88
87_R	140_P	0.923	0.88
56_E	59_G	0.922	0.88
93_L	104_V	0.919	0.88
180_L	185_V	0.916	0.87
197_A	203_V	0.897	0.86
17_Y	48_V	0.892	0.86
76_E	80_V	0.890	0.86
99_Y	103_E	0.889	0.86
205_E	208_G	0.886	0.86
22_Y	83_I	0.883	0.85
43_V	47_T	0.882	0.85
74_D	78_V	0.874	0.85
151_D	174_T	0.873	0.85
154_V	157_D	0.872	0.85
132_V	161_G	0.870	0.85
48_V	52_A	0.858	0.84
190_E	208_G	0.855	0.83
101_W	135_H	0.853	0.83
174_T	178_R	0.851	0.83
89_L	123_L	0.846	0.83
86_H	90_E	0.845	0.83
130_P	140_P	0.836	0.82
88_L	123_L	0.832	0.82
92_F	123_L	0.828	0.81
100_D	122_R	0.826	0.81
167_A	224_R	0.826	0.81
200_G	215_E	0.825	0.81
109_D	113_H	0.824	0.81
86_H	135_H	0.824	0.81
44_T	51_M	0.822	0.81
24_L	51_M	0.818	0.81
153_E	157_D	0.817	0.81
23_N	82_V	0.809	0.80
84_R	139_I	0.809	0.80
118_E	122_R	0.806	0.80
44_T	50_S	0.796	0.79
20_S	41_L	0.794	0.79
119_F	123_L	0.794	0.79
86_H	113_H	0.789	0.78
16_D	114_H	0.788	0.78
184_G	221_L	0.787	0.78
85_H	114_H	0.786	0.78
195_E	209_E	0.786	0.78
85_H	117_E	0.785	0.78
24_L	114_H	0.780	0.77
61_I	64_E	0.778	0.77
59_G	74_D	0.773	0.77
134_P	139_I	0.773	0.77
152_T	167_A	0.772	0.77
107_E	114_H	0.772	0.77
111_L	119_F	0.770	0.77
90_E	135_H	0.767	0.76
52_A	69_V	0.765	0.76
208_G	213_L	0.762	0.76
158_H	162_D	0.760	0.76
13_V	51_M	0.760	0.76
13_V	16_D	0.760	0.76
194_T	203_V	0.758	0.75
158_H	205_E	0.756	0.75
44_T	47_T	0.755	0.75
44_T	49_T	0.751	0.75
35_S	45_P	0.750	0.75
62_E	100_D	0.745	0.74
28_H	106_D	0.744	0.74
34_T	52_A	0.742	0.74
97_L	123_L	0.741	0.74
90_E	130_P	0.736	0.73
34_T	51_M	0.735	0.73
54_K	111_L	0.732	0.73
82_V	85_H	0.728	0.72
135_H	139_I	0.727	0.72
14_M	51_M	0.716	0.71
161_G	193_V	0.716	0.71
181_A	186_Q	0.715	0.71
86_H	112_E	0.714	0.71
153_E	162_D	0.714	0.71
152_T	222_E	0.714	0.71
102_D	181_A	0.713	0.71
98_D	122_R	0.713	0.71
189_T	207_D	0.710	0.71
140_P	144_L	0.709	0.70
35_S	58_R	0.708	0.70
59_G	162_D	0.708	0.70
73_P	100_D	0.701	0.70
19_K	23_N	0.694	0.69
15_E	85_H	0.692	0.69
105_H	135_H	0.688	0.68
97_L	126_K	0.685	0.68
46_P	51_M	0.681	0.67
65_K	70_E	0.679	0.67
109_D	135_H	0.675	0.67
74_D	166_V	0.674	0.67
13_V	46_P	0.667	0.66
20_S	40_Y	0.664	0.65
25_E	32_I	0.663	0.65
201_L	214_P	0.662	0.65
18_L	31_P	0.662	0.65
14_M	22_Y	0.660	0.65
11_S	43_V	0.659	0.65
194_T	210_A	0.658	0.65
154_V	219_E	0.658	0.65
38_A	102_D	0.651	0.64
161_G	210_A	0.650	0.64
166_V	183_A	0.648	0.64
34_T	68_G	0.647	0.63
53_E	63_R	0.646	0.63
201_L	212_H	0.646	0.63
38_A	52_A	0.642	0.63
206_I	209_E	0.642	0.63
131_T	209_E	0.641	0.63
198_P	216_R	0.641	0.63
15_E	92_F	0.639	0.62
90_E	134_P	0.636	0.62
104_V	135_H	0.635	0.62
50_S	119_F	0.634	0.62
164_L	193_V	0.634	0.62
87_R	130_P	0.634	0.62
120_E	124_A	0.633	0.62
72_T	151_D	0.633	0.62
45_P	51_M	0.632	0.62
185_V	206_I	0.630	0.61
124_A	141_N	0.629	0.61
157_D	195_E	0.627	0.61
172_R	222_E	0.627	0.61
64_E	70_E	0.623	0.61
121_D	125_E	0.622	0.60
90_E	140_P	0.620	0.60
160_E	196_H	0.618	0.60
93_L	108_A	0.614	0.59
130_P	136_G	0.613	0.59
51_M	54_K	0.611	0.59
45_P	49_T	0.611	0.59
130_P	134_P	0.609	0.59
19_K	112_E	0.606	0.58
50_S	137_D	0.605	0.58
99_Y	107_E	0.604	0.58
12_D	32_I	0.601	0.58
63_R	69_V	0.599	0.58
35_S	99_Y	0.598	0.57
134_P	140_P	0.596	0.57
46_P	120_E	0.594	0.57
193_V	211_V	0.594	0.57
43_V	51_M	0.592	0.57
65_K	68_G	0.591	0.57
90_E	127_L	0.591	0.57
90_E	139_I	0.590	0.56
137_D	171_D	0.587	0.56
34_T	69_V	0.587	0.56
42_D	170_S	0.587	0.56
15_E	51_M	0.586	0.56
198_P	215_E	0.583	0.56
32_I	37_I	0.582	0.55
117_E	120_E	0.581	0.55
84_R	138_P	0.581	0.55
159_A	166_V	0.580	0.55
214_P	217_V	0.580	0.55
33_A	110_A	0.579	0.55
16_D	112_E	0.579	0.55
130_P	135_H	0.577	0.55
89_L	92_F	0.576	0.55
51_M	67_A	0.574	0.54
127_L	139_I	0.574	0.54
19_K	80_V	0.573	0.54
164_L	204_V	0.573	0.54
121_D	129_D	0.572	0.54
136_G	140_P	0.571	0.54
83_I	87_R	0.571	0.54
154_V	222_E	0.571	0.54
85_H	107_E	0.569	0.54
87_R	134_P	0.564	0.53
133_D	140_P	0.564	0.53
25_E	31_P	0.560	0.53
153_E	156_A	0.557	0.52
47_T	201_L	0.557	0.52
131_T	165_V	0.557	0.52
93_L	134_P	0.550	0.51
135_H	177_L	0.550	0.51
68_G	97_L	0.549	0.51
160_E	186_Q	0.546	0.51
103_E	122_R	0.542	0.50
89_L	107_E	0.541	0.50
154_V	220_T	0.541	0.50
93_L	105_H	0.540	0.50
16_D	168_R	0.538	0.50
46_P	67_A	0.537	0.50
168_R	171_D	0.537	0.50
15_E	22_Y	0.533	0.49
37_I	52_A	0.532	0.49
49_T	63_R	0.530	0.49
78_V	121_D	0.527	0.48
107_E	168_R	0.525	0.48
73_P	77_T	0.521	0.48
83_I	135_H	0.521	0.48
88_L	130_P	0.519	0.47
203_V	212_H	0.517	0.47
37_I	58_R	0.517	0.47
55_L	60_L	0.517	0.47
89_L	111_L	0.515	0.47
159_A	205_E	0.515	0.47
50_S	53_E	0.515	0.47
101_W	187_P	0.514	0.47
21_I	71_L	0.513	0.47
155_L	193_V	0.512	0.46
84_R	87_R	0.512	0.46
203_V	224_R	0.511	0.46
53_E	57_S	0.510	0.46
135_H	168_R	0.509	0.46
36_T	40_Y	0.509	0.46
159_A	163_A	0.507	0.46
132_V	188_G	0.506	0.46
33_A	68_G	0.505	0.46
85_H	115_I	0.503	0.45
141_N	144_L	0.502	0.45
16_D	107_E	0.501	0.45
149_H	152_T	0.501	0.45
107_E	118_E	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1fx7A	4	0.9356	100	0.378	Contact Map
2qq9A	2	0.8798	100	0.387	Contact Map
4o5vA	2	0.9142	100	0.391	Contact Map
3hrsA	2	0.9142	100	0.395	Contact Map
2x4hA	3	0.5622	99.9	0.69	Contact Map
1on2A	2	0.5794	99.8	0.716	Contact Map
2h09A	2	0.5408	99.7	0.747	Contact Map
2p8tA	1	0.6996	99.7	0.748	Contact Map
2k5fA	1	0.3433	99.4	0.797	Contact Map
3mhxA	1	0.3476	99.3	0.803	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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