GREMLIN Database
Q9HRU6 - Uncharacterized protein
UniProt: Q9HRU6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (145)
Sequences: 322 (289)
Seq/√Len: 24.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_S85_S3.9671.00
56_Y65_V3.9641.00
61_E88_W3.0081.00
52_V76_L3.0001.00
65_V90_F2.6170.99
57_T64_R2.6160.99
56_Y90_F2.5100.99
60_V85_S2.3010.97
119_G124_H2.2430.97
84_E102_T2.2370.97
63_S84_E2.1890.97
86_Y103_F2.0920.96
65_V103_F1.9840.94
60_V81_A1.9320.93
68_A80_R1.8560.92
14_L21_A1.8210.91
50_S129_D1.8060.91
61_E65_V1.7720.90
115_T145_D1.7670.90
83_F96_V1.7590.89
55_E66_Y1.7300.88
60_V90_F1.7180.88
82_E102_T1.7140.88
56_Y83_F1.6600.86
60_V87_G1.6480.86
81_A87_G1.5810.83
126_L144_V1.5760.83
61_E67_E1.5700.83
116_V146_L1.5690.83
80_R104_V1.5500.82
65_V119_G1.5430.82
63_S90_F1.4840.79
80_R106_S1.4780.79
61_E96_V1.4690.79
14_L19_V1.4350.77
72_R77_E1.4100.76
45_P126_L1.3970.75
65_V116_V1.3230.71
24_V114_L1.3160.70
46_V50_S1.2950.69
32_A153_L1.2690.67
51_T99_E1.2670.67
88_W120_R1.2640.67
96_V103_F1.2460.66
57_T119_G1.2290.65
117_S143_S1.2240.65
49_G71_V1.2190.64
65_V91_P1.2170.64
21_A32_A1.2020.63
11_A46_V1.1890.62
65_V121_I1.1880.62
61_E103_F1.1870.62
71_V116_V1.1760.61
75_T110_T1.1690.61
62_R85_S1.1680.61
52_V128_V1.1510.60
61_E85_S1.1500.60
118_P138_V1.1460.59
85_S90_F1.1450.59
61_E90_F1.1410.59
77_E108_D1.1320.58
65_V141_A1.1290.58
67_E88_W1.1150.57
56_Y103_F1.1030.56
34_D138_V1.1020.56
116_V135_L1.0730.54
95_N106_S1.0720.54
31_V54_L1.0650.54
12_S70_A1.0610.53
10_A13_V1.0520.53
82_E100_N1.0490.53
93_A96_V1.0370.52
57_T124_H1.0210.51
81_A90_F1.0170.50
119_G123_G1.0140.50
18_T113_V1.0110.50
13_V19_V1.0110.50
16_V75_T0.9820.48
29_V32_A0.9820.48
119_G141_A0.9770.47
46_V52_V0.9720.47
59_S89_G0.9630.46
49_G64_R0.9600.46
16_V73_G0.9530.46
57_T129_D0.9460.45
70_A77_E0.9360.45
61_E119_G0.9360.45
15_A77_E0.9350.44
54_L132_S0.9280.44
78_M111_A0.9100.43
61_E91_P0.9050.42
97_T137_S0.9030.42
67_E101_G0.8960.42
81_A85_S0.8850.41
65_V124_H0.8820.41
54_L113_V0.8670.40
58_H87_G0.8650.40
56_Y61_E0.8590.39
10_A40_R0.8540.39
21_A100_N0.8510.39
12_S40_R0.8490.39
55_E67_E0.8350.38
15_A74_E0.8340.38
12_S16_V0.8320.37
119_G122_A0.8310.37
30_L39_Q0.8280.37
19_V38_D0.8250.37
28_T130_D0.8230.37
58_H91_P0.8190.37
33_D53_A0.8120.36
132_S135_L0.8030.36
32_A144_V0.7990.35
11_A19_V0.7950.35
118_P135_L0.7930.35
97_T106_S0.7930.35
116_V119_G0.7890.35
25_P29_V0.7890.35
58_H89_G0.7810.34
60_V88_W0.7770.34
35_T143_S0.7770.34
113_V145_D0.7750.34
61_E105_Y0.7700.33
32_A69_Y0.7670.33
122_A141_A0.7560.33
69_Y94_A0.7480.32
64_R125_T0.7440.32
76_L128_V0.7410.32
41_Y63_S0.7410.32
33_D147_H0.7400.32
54_L116_V0.7370.31
56_Y63_S0.7340.31
125_T132_S0.7310.31
20_I47_S0.7300.31
91_P103_F0.7280.31
78_M81_A0.7260.31
17_L75_T0.7250.31
15_A137_S0.7220.30
95_N114_L0.7200.30
70_A110_T0.7140.30
62_R88_W0.7030.29
125_T134_D0.7000.29
15_A38_D0.6950.29
62_R83_F0.6900.29
67_E119_G0.6890.28
12_S49_G0.6880.28
33_D38_D0.6840.28
11_A30_L0.6800.28
36_D48_E0.6780.28
126_L148_V0.6760.28
67_E99_E0.6750.28
103_F141_A0.6750.28
33_D145_D0.6750.28
81_A114_L0.6730.28
20_I77_E0.6700.27
56_Y78_M0.6700.27
74_E112_T0.6650.27
55_E128_V0.6480.26
78_M134_D0.6430.26
65_V105_Y0.6420.26
56_Y119_G0.6360.26
81_A107_P0.6340.25
29_V45_P0.6340.25
101_G120_R0.6260.25
30_L71_V0.6210.25
121_I124_H0.6200.25
19_V131_R0.6150.24
56_Y121_I0.6100.24
76_L94_A0.6050.24
24_V130_D0.6010.24
35_T67_E0.6000.24
48_E74_E0.5980.24
81_A88_W0.5970.23
16_V151_R0.5960.23
91_P96_V0.5930.23
17_L24_V0.5860.23
38_D144_V0.5850.23
83_F90_F0.5840.23
21_A40_R0.5810.23
56_Y89_G0.5790.23
26_A37_T0.5790.23
69_Y78_M0.5760.22
51_T71_V0.5740.22
56_Y67_E0.5700.22
108_D149_V0.5690.22
85_S122_A0.5660.22
16_V126_L0.5660.22
55_E125_T0.5660.22
83_F98_I0.5640.22
78_M87_G0.5620.22
17_L130_D0.5600.22
53_A84_E0.5590.22
18_T49_G0.5590.22
19_V48_E0.5570.21
115_T143_S0.5550.21
69_Y92_S0.5550.21
62_R98_I0.5540.21
54_L140_D0.5480.21
90_F107_P0.5480.21
28_T62_R0.5450.21
17_L23_V0.5410.21
52_V118_P0.5400.21
22_A70_A0.5400.21
60_V124_H0.5390.21
93_A103_F0.5320.20
45_P70_A0.5290.20
90_F135_L0.5270.20
94_A106_S0.5220.20
30_L34_D0.5180.20
100_N120_R0.5160.20
20_I127_H0.5150.20
25_P90_F0.5090.19
79_T96_V0.5070.19
85_S105_Y0.5070.19
64_R84_E0.5070.19
80_R105_Y0.5060.19
34_D113_V0.5020.19
111_A146_L0.5010.19
130_D154_L0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qtqA 1 0.638 17.3 0.94 Contact Map
2e1bA 1 0.6258 7.5 0.949 Contact Map
3hunA 1 0.6933 6.8 0.95 Contact Map
2l55A 1 0.4479 6.3 0.951 Contact Map
5ajoA 1 0.4785 5 0.953 Contact Map
2mc7A 1 0.184 4.6 0.954 Contact Map
3hb3B 1 0.9202 4.1 0.955 Contact Map
4hgkC 1 0.5951 3.5 0.956 Contact Map
4g6tB 1 0.2699 3.5 0.957 Contact Map
4zdxA 1 0.7301 3 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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