GREMLIN Database
Q9HRU5 - Immunogenic protein
UniProt: Q9HRU5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (300)
Sequences: 3328 (2444)
Seq/√Len: 141.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_A53_S4.1791.00
121_V274_V3.8831.00
241_T253_S3.7701.00
313_A317_E3.7611.00
41_H88_A3.6531.00
140_E218_E3.3601.00
145_L196_A3.1681.00
141_T144_D3.0371.00
146_D174_D2.9381.00
275_T314_A2.9161.00
120_G304_M2.6041.00
272_A276_A2.5151.00
150_I196_A2.5031.00
160_Q164_L2.4771.00
140_E144_D2.3861.00
151_N194_I2.3821.00
271_E310_P2.3491.00
270_D273_T2.2341.00
135_A218_E2.2221.00
221_P255_E2.2171.00
40_W68_L2.2061.00
117_N267_D2.2061.00
133_T218_E2.2051.00
60_V277_V2.2051.00
187_E191_N2.1351.00
138_G218_E2.1191.00
90_F265_T2.0581.00
83_L264_A2.0571.00
180_A188_Q2.0481.00
119_A267_D1.9951.00
78_E82_S1.9651.00
58_T62_D1.9391.00
244_S253_S1.9361.00
194_I197_A1.9351.00
269_V274_V1.8981.00
93_I264_A1.8951.00
296_D299_S1.8861.00
133_T220_V1.8821.00
117_N268_G1.8651.00
93_I98_A1.8211.00
271_E314_A1.8091.00
170_A226_A1.8041.00
83_L91_A1.7981.00
160_Q179_T1.7891.00
134_R137_T1.7471.00
127_E261_A1.7211.00
134_R215_N1.6691.00
49_Y127_E1.6691.00
283_E315_Y1.6531.00
151_N185_A1.6481.00
265_T269_V1.6451.00
83_L266_H1.6261.00
38_L90_F1.6141.00
39_S89_D1.6121.00
135_A216_D1.5711.00
41_H73_T1.5711.00
279_S283_E1.5681.00
133_T137_T1.5491.00
308_L313_A1.5481.00
240_D258_S1.5481.00
55_E290_I1.5311.00
282_F315_Y1.5131.00
201_G205_V1.5031.00
102_K307_D1.4971.00
122_A282_F1.4971.00
94_Q127_E1.4931.00
312_A316_F1.4911.00
90_F277_V1.4561.00
275_T279_S1.4441.00
163_A198_F1.4431.00
122_A281_I1.4331.00
275_T311_G1.4121.00
246_T250_I1.4091.00
239_D255_E1.3861.00
41_H82_S1.3831.00
99_Y103_N1.3811.00
80_V97_I1.3701.00
223_E226_A1.3641.00
149_T176_E1.3551.00
22_L25_C1.3551.00
90_F121_V1.3531.00
228_D232_E1.3481.00
130_T205_V1.3441.00
190_R210_E1.3351.00
241_T255_E1.3261.00
128_T240_D1.3251.00
224_G228_D1.3211.00
284_H287_D1.3091.00
228_D239_D1.3061.00
131_L198_F1.3051.00
100_F105_T1.3001.00
119_A265_T1.2941.00
285_T289_T1.2891.00
139_I148_A1.2871.00
76_S158_G1.2861.00
121_V269_V1.2811.00
244_S250_I1.2791.00
274_V309_H1.2591.00
149_T195_D1.2481.00
228_D231_K1.2341.00
130_T247_Y1.2301.00
49_Y261_A1.2281.00
149_T194_I1.2271.00
40_W53_S1.2031.00
245_G251_D1.1971.00
119_A310_P1.1971.00
224_G239_D1.1961.00
92_L124_L1.1811.00
94_Q200_V1.1711.00
188_Q193_D1.1590.99
100_F106_G1.1570.99
187_E190_R1.1510.99
224_G255_E1.1500.99
121_V278_T1.1490.99
73_T79_N1.1440.99
41_H91_A1.1410.99
63_N284_H1.1250.99
36_T270_D1.1240.99
122_A263_I1.1240.99
167_L172_V1.1210.99
137_T218_E1.1210.99
39_S71_Q1.1140.99
299_S302_D1.1050.99
94_Q158_G1.1040.99
80_V115_V1.0920.99
90_F263_I1.0820.99
18_S21_A1.0790.99
24_G29_D1.0780.99
142_V170_A1.0750.99
310_P313_A1.0660.99
63_N287_D1.0570.99
106_G109_A1.0570.99
43_G47_G1.0510.99
39_S69_N1.0510.99
286_G289_T1.0480.99
271_E311_G1.0420.99
96_D259_V1.0400.99
204_P247_Y1.0370.99
60_V68_L1.0320.99
190_R214_T1.0250.99
150_I198_F1.0160.99
151_N180_A1.0130.99
282_F300_A1.0120.99
184_Q187_E1.0090.99
55_E291_K1.0040.99
37_R67_S1.0000.98
131_L220_V0.9990.98
127_E200_V0.9980.98
226_A229_A0.9970.98
145_L150_I0.9960.98
49_Y158_G0.9940.98
130_T203_W0.9940.98
80_V264_A0.9930.98
25_C28_G0.9810.98
272_A275_T0.9720.98
289_T293_D0.9690.98
75_A79_N0.9680.98
189_L194_I0.9670.98
250_I254_I0.9610.98
80_V93_I0.9600.98
102_K116_D0.9530.98
123_T260_Q0.9510.98
50_Y54_N0.9510.98
182_F199_V0.9500.98
143_A170_A0.9480.98
43_G49_Y0.9460.98
129_I166_I0.9460.98
186_A211_L0.9450.98
49_Y76_S0.9450.98
243_P253_S0.9380.98
182_F197_A0.9370.98
229_A233_A0.9300.98
90_F274_V0.9260.97
301_Q308_L0.9230.97
278_T311_G0.9220.97
81_G85_K0.9220.97
40_W263_I0.9220.97
119_A271_E0.9210.97
17_T20_A0.9180.97
244_S252_R0.9180.97
272_A314_A0.9170.97
73_T76_S0.9090.97
245_G250_I0.9040.97
243_P246_T0.9030.97
106_G111_Q0.9010.97
94_Q261_A0.9000.97
84_A117_N0.9000.97
57_K68_L0.8990.97
168_E233_A0.8970.97
285_T288_L0.8910.97
84_A115_V0.8900.97
185_A197_A0.8890.97
60_V280_A0.8830.97
25_C30_D0.8830.97
90_F269_V0.8810.97
120_G262_M0.8810.97
266_H269_V0.8750.96
165_Q168_E0.8610.96
42_A50_Y0.8600.96
208_I217_I0.8580.96
203_W243_P0.8540.96
20_A23_A0.8540.96
133_T136_D0.8520.96
36_T273_T0.8490.96
45_Q72_T0.8450.96
57_K61_E0.8410.96
274_V278_T0.8400.96
212_A249_G0.8380.95
89_D269_V0.8380.95
190_R215_N0.8380.95
129_I200_V0.8340.95
86_G266_H0.8320.95
148_A195_D0.8320.95
212_A217_I0.8260.95
153_G157_S0.8260.95
95_N262_M0.8240.95
242_I256_T0.8230.95
229_A232_E0.8180.95
49_Y94_Q0.8160.95
131_L145_L0.8140.95
242_I247_Y0.8130.95
133_T196_A0.8130.95
22_L26_A0.8070.94
225_E229_A0.8040.94
120_G123_T0.8030.94
271_E275_T0.7990.94
131_L142_V0.7990.94
222_I227_R0.7980.94
245_G253_S0.7970.94
203_W246_T0.7910.94
311_G315_Y0.7890.94
278_T315_Y0.7880.94
308_L316_F0.7880.94
143_A226_A0.7880.94
71_Q82_S0.7870.94
188_Q194_I0.7870.94
40_W60_V0.7830.93
83_L88_A0.7820.93
271_E274_V0.7800.93
73_T78_E0.7760.93
94_Q97_I0.7750.93
265_T274_V0.7750.93
152_T163_A0.7730.93
25_C29_D0.7670.93
48_T202_G0.7640.93
43_G79_N0.7630.93
31_G34_D0.7610.93
162_N200_V0.7610.93
21_A24_G0.7580.92
311_G314_A0.7580.92
244_S251_D0.7580.92
74_G78_E0.7540.92
45_Q50_Y0.7530.92
73_T88_A0.7530.92
143_A146_D0.7510.92
181_S184_Q0.7500.92
180_A184_Q0.7450.92
276_A280_A0.7400.91
130_T219_I0.7380.91
99_Y236_W0.7350.91
182_F201_G0.7340.91
269_V277_V0.7340.91
82_S88_A0.7330.91
98_A262_M0.7320.91
61_E68_L0.7300.91
79_N157_S0.7290.91
132_I208_I0.7290.91
227_R257_V0.7280.91
134_R138_G0.7190.90
86_G89_D0.7150.90
276_A279_S0.7130.90
133_T138_G0.7080.90
80_V83_L0.7070.89
76_S261_A0.7040.89
120_G306_I0.7020.89
73_T82_S0.7010.89
71_Q87_N0.6950.89
140_E143_A0.6950.89
100_F109_A0.6940.89
49_Y79_N0.6910.88
265_T277_V0.6910.88
275_T278_T0.6900.88
16_A19_I0.6880.88
118_L265_T0.6880.88
168_E173_T0.6880.88
167_L175_Y0.6860.88
38_L89_D0.6850.88
52_L295_I0.6840.88
128_T256_T0.6840.88
129_I163_A0.6800.88
211_L217_I0.6730.87
57_K70_V0.6720.87
45_Q51_P0.6720.87
50_Y70_V0.6700.87
43_G75_A0.6700.87
279_S314_A0.6700.87
134_R220_V0.6700.87
304_M308_L0.6660.87
217_I250_I0.6660.87
231_K239_D0.6660.87
48_T291_K0.6650.86
42_A70_V0.6620.86
32_A35_G0.6600.86
219_I254_I0.6590.86
271_E276_A0.6550.86
74_G154_D0.6530.85
93_I97_I0.6520.85
29_D34_D0.6510.85
131_L196_A0.6510.85
52_L124_L0.6500.85
121_V263_I0.6500.85
138_G144_D0.6500.85
102_K306_I0.6500.85
101_A104_G0.6500.85
279_S315_Y0.6490.85
275_T315_Y0.6490.85
186_A190_R0.6490.85
278_T282_F0.6470.85
96_D237_F0.6450.85
23_A26_A0.6440.85
165_Q234_A0.6440.85
47_G125_Y0.6430.85
23_A176_E0.6420.84
219_I242_I0.6400.84
59_I284_H0.6400.84
132_I217_I0.6390.84
278_T312_A0.6370.84
39_S88_A0.6360.84
301_Q316_F0.6340.84
280_A284_H0.6320.84
49_Y53_S0.6320.84
82_S87_N0.6310.83
154_D180_A0.6310.83
20_A28_G0.6290.83
170_A223_E0.6270.83
149_T178_Q0.6260.83
125_Y261_A0.6220.83
282_F295_I0.6210.82
38_L68_L0.6200.82
131_L163_A0.6190.82
80_V118_L0.6180.82
25_C31_G0.6130.82
169_A230_A0.6130.82
124_L263_I0.6110.81
238_A258_S0.6110.81
160_Q163_A0.6110.81
164_L168_E0.6080.81
225_E228_D0.6080.81
30_D33_G0.6070.81
75_A94_Q0.6030.81
187_E210_E0.6030.81
208_I219_I0.6030.81
174_D177_E0.5990.80
56_F281_I0.5980.80
76_S153_G0.5980.80
162_N237_F0.5980.80
43_G127_E0.5970.80
20_A27_G0.5970.80
227_R255_E0.5960.80
28_G33_G0.5950.80
92_L263_I0.5940.80
163_A167_L0.5930.80
26_A29_D0.5920.79
169_A229_A0.5910.79
267_D270_D0.5890.79
125_Y202_G0.5850.79
272_A311_G0.5840.78
59_I280_A0.5830.78
130_T242_I0.5830.78
137_T140_E0.5820.78
237_F259_V0.5810.78
178_Q194_I0.5810.78
27_G34_D0.5800.78
31_G35_G0.5780.78
295_I300_A0.5780.78
142_V167_L0.5760.78
178_Q188_Q0.5750.77
119_A307_D0.5720.77
138_G148_A0.5690.77
134_R192_G0.5680.77
84_A116_D0.5670.76
44_G154_D0.5670.76
146_D314_A0.5660.76
120_G308_L0.5650.76
49_Y157_S0.5640.76
102_K119_A0.5630.76
152_T160_Q0.5630.76
24_G27_G0.5630.76
37_R69_N0.5620.76
195_D198_F0.5610.76
206_G209_E0.5610.76
99_Y305_S0.5600.76
71_Q88_A0.5600.76
28_G32_A0.5590.75
19_I25_C0.5540.75
282_F316_F0.5520.75
126_P294_F0.5500.74
184_Q188_Q0.5500.74
97_I161_V0.5490.74
203_W242_I0.5490.74
53_S79_N0.5490.74
106_G161_V0.5450.74
29_D32_A0.5450.74
15_G24_G0.5450.74
136_D215_N0.5430.73
270_D310_P0.5430.73
129_I198_F0.5420.73
51_P54_N0.5420.73
76_S79_N0.5410.73
101_A110_F0.5400.73
310_P314_A0.5400.73
28_G31_G0.5400.73
199_V205_V0.5400.73
52_L92_L0.5360.72
232_E235_S0.5340.72
227_R231_K0.5330.72
51_P55_E0.5320.72
25_C32_A0.5270.71
30_D34_D0.5270.71
169_A233_A0.5250.71
74_G156_G0.5240.71
54_N70_V0.5240.71
50_Y72_T0.5220.70
121_V265_T0.5220.70
139_I144_D0.5220.70
199_V208_I0.5200.70
151_N197_A0.5170.70
78_E81_G0.5160.70
238_A260_Q0.5150.69
15_G18_S0.5140.69
53_S125_Y0.5140.69
81_G84_A0.5140.69
17_T22_L0.5130.69
43_G125_Y0.5130.69
152_T179_T0.5120.69
97_I100_F0.5120.69
24_G30_D0.5100.69
15_G20_A0.5100.69
123_T315_Y0.5090.69
98_A120_G0.5090.69
45_Q54_N0.5080.68
109_A113_R0.5060.68
247_Y256_T0.5050.68
79_N156_G0.5050.68
44_G47_G0.5030.68
52_L56_F0.5030.68
79_N247_Y0.5030.68
241_T252_R0.5020.67
119_A309_H0.5010.67
274_V311_G0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1us5A 1 0.8899 100 0.397 Contact Map
4dddA 1 0.8899 100 0.471 Contact Map
2ozzA 1 0.7107 99.9 0.661 Contact Map
3un6A 1 0.7516 99.9 0.673 Contact Map
3qslA 1 0.8176 99.9 0.675 Contact Map
4x9tA 1 0.8302 99.9 0.691 Contact Map
2f5xA 1 0.8365 99.9 0.693 Contact Map
2qpqA 1 0.8333 99.9 0.695 Contact Map
2dvzA 1 0.8365 99.9 0.7 Contact Map
2g29A 1 0.8648 99.9 0.707 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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