Q9HRU5 - HALSA - GREMLIN Contacts

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Q9HRU5 - Immunogenic protein

UniProt:	Q9HRU5	Sequences: MPTEHTRRRFLQATGATSIAALAGCAGGDDGAGDGTRLSWHAGGQSGTYYPLSNEFKTIVEDNTDYSLNVQTTGASVENVGSLAKGNADFALIQNDIAYFAKNGTGIDAFQDRAVDNLAGVATLYPETITLITRADTGIETVADLDGATINTGDLGSGTQVNALQILEAAGVTDYEEQTASFAQAAEQLRNGDIDAAFVVGGWPVGAIEELANTNDIEIVPIEGEARDAAKEAASWFADDTIPSGTYSGIDRSIETVSVQAMIATHDGVDEATVTAVTSAIFEHTGDLTIKPDFIDTASAQDGMSIDLHPGAAAYFES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	318 (300)
Sequences:	3328 (2444)
Seq/√Len:	141.1

HALSA - Q9HRU5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_A	53_S	4.179	1.00
121_V	274_V	3.883	1.00
241_T	253_S	3.770	1.00
313_A	317_E	3.761	1.00
41_H	88_A	3.653	1.00
140_E	218_E	3.360	1.00
145_L	196_A	3.168	1.00
141_T	144_D	3.037	1.00
146_D	174_D	2.938	1.00
275_T	314_A	2.916	1.00
120_G	304_M	2.604	1.00
272_A	276_A	2.515	1.00
150_I	196_A	2.503	1.00
160_Q	164_L	2.477	1.00
140_E	144_D	2.386	1.00
151_N	194_I	2.382	1.00
271_E	310_P	2.349	1.00
270_D	273_T	2.234	1.00
135_A	218_E	2.222	1.00
221_P	255_E	2.217	1.00
40_W	68_L	2.206	1.00
117_N	267_D	2.206	1.00
133_T	218_E	2.205	1.00
60_V	277_V	2.205	1.00
187_E	191_N	2.135	1.00
138_G	218_E	2.119	1.00
90_F	265_T	2.058	1.00
83_L	264_A	2.057	1.00
180_A	188_Q	2.048	1.00
119_A	267_D	1.995	1.00
78_E	82_S	1.965	1.00
58_T	62_D	1.939	1.00
244_S	253_S	1.936	1.00
194_I	197_A	1.935	1.00
269_V	274_V	1.898	1.00
93_I	264_A	1.895	1.00
296_D	299_S	1.886	1.00
133_T	220_V	1.882	1.00
117_N	268_G	1.865	1.00
93_I	98_A	1.821	1.00
271_E	314_A	1.809	1.00
170_A	226_A	1.804	1.00
83_L	91_A	1.798	1.00
160_Q	179_T	1.789	1.00
134_R	137_T	1.747	1.00
127_E	261_A	1.721	1.00
134_R	215_N	1.669	1.00
49_Y	127_E	1.669	1.00
283_E	315_Y	1.653	1.00
151_N	185_A	1.648	1.00
265_T	269_V	1.645	1.00
83_L	266_H	1.626	1.00
38_L	90_F	1.614	1.00
39_S	89_D	1.612	1.00
135_A	216_D	1.571	1.00
41_H	73_T	1.571	1.00
279_S	283_E	1.568	1.00
133_T	137_T	1.549	1.00
308_L	313_A	1.548	1.00
240_D	258_S	1.548	1.00
55_E	290_I	1.531	1.00
282_F	315_Y	1.513	1.00
201_G	205_V	1.503	1.00
102_K	307_D	1.497	1.00
122_A	282_F	1.497	1.00
94_Q	127_E	1.493	1.00
312_A	316_F	1.491	1.00
90_F	277_V	1.456	1.00
275_T	279_S	1.444	1.00
163_A	198_F	1.443	1.00
122_A	281_I	1.433	1.00
275_T	311_G	1.412	1.00
246_T	250_I	1.409	1.00
239_D	255_E	1.386	1.00
41_H	82_S	1.383	1.00
99_Y	103_N	1.381	1.00
80_V	97_I	1.370	1.00
223_E	226_A	1.364	1.00
149_T	176_E	1.355	1.00
22_L	25_C	1.355	1.00
90_F	121_V	1.353	1.00
228_D	232_E	1.348	1.00
130_T	205_V	1.344	1.00
190_R	210_E	1.335	1.00
241_T	255_E	1.326	1.00
128_T	240_D	1.325	1.00
224_G	228_D	1.321	1.00
284_H	287_D	1.309	1.00
228_D	239_D	1.306	1.00
131_L	198_F	1.305	1.00
100_F	105_T	1.300	1.00
119_A	265_T	1.294	1.00
285_T	289_T	1.289	1.00
139_I	148_A	1.287	1.00
76_S	158_G	1.286	1.00
121_V	269_V	1.281	1.00
244_S	250_I	1.279	1.00
274_V	309_H	1.259	1.00
149_T	195_D	1.248	1.00
228_D	231_K	1.234	1.00
130_T	247_Y	1.230	1.00
49_Y	261_A	1.228	1.00
149_T	194_I	1.227	1.00
40_W	53_S	1.203	1.00
245_G	251_D	1.197	1.00
119_A	310_P	1.197	1.00
224_G	239_D	1.196	1.00
92_L	124_L	1.181	1.00
94_Q	200_V	1.171	1.00
188_Q	193_D	1.159	0.99
100_F	106_G	1.157	0.99
187_E	190_R	1.151	0.99
224_G	255_E	1.150	0.99
121_V	278_T	1.149	0.99
73_T	79_N	1.144	0.99
41_H	91_A	1.141	0.99
63_N	284_H	1.125	0.99
36_T	270_D	1.124	0.99
122_A	263_I	1.124	0.99
167_L	172_V	1.121	0.99
137_T	218_E	1.121	0.99
39_S	71_Q	1.114	0.99
299_S	302_D	1.105	0.99
94_Q	158_G	1.104	0.99
80_V	115_V	1.092	0.99
90_F	263_I	1.082	0.99
18_S	21_A	1.079	0.99
24_G	29_D	1.078	0.99
142_V	170_A	1.075	0.99
310_P	313_A	1.066	0.99
63_N	287_D	1.057	0.99
106_G	109_A	1.057	0.99
43_G	47_G	1.051	0.99
39_S	69_N	1.051	0.99
286_G	289_T	1.048	0.99
271_E	311_G	1.042	0.99
96_D	259_V	1.040	0.99
204_P	247_Y	1.037	0.99
60_V	68_L	1.032	0.99
190_R	214_T	1.025	0.99
150_I	198_F	1.016	0.99
151_N	180_A	1.013	0.99
282_F	300_A	1.012	0.99
184_Q	187_E	1.009	0.99
55_E	291_K	1.004	0.99
37_R	67_S	1.000	0.98
131_L	220_V	0.999	0.98
127_E	200_V	0.998	0.98
226_A	229_A	0.997	0.98
145_L	150_I	0.996	0.98
49_Y	158_G	0.994	0.98
130_T	203_W	0.994	0.98
80_V	264_A	0.993	0.98
25_C	28_G	0.981	0.98
272_A	275_T	0.972	0.98
289_T	293_D	0.969	0.98
75_A	79_N	0.968	0.98
189_L	194_I	0.967	0.98
250_I	254_I	0.961	0.98
80_V	93_I	0.960	0.98
102_K	116_D	0.953	0.98
123_T	260_Q	0.951	0.98
50_Y	54_N	0.951	0.98
182_F	199_V	0.950	0.98
143_A	170_A	0.948	0.98
43_G	49_Y	0.946	0.98
129_I	166_I	0.946	0.98
186_A	211_L	0.945	0.98
49_Y	76_S	0.945	0.98
243_P	253_S	0.938	0.98
182_F	197_A	0.937	0.98
229_A	233_A	0.930	0.98
90_F	274_V	0.926	0.97
301_Q	308_L	0.923	0.97
278_T	311_G	0.922	0.97
81_G	85_K	0.922	0.97
40_W	263_I	0.922	0.97
119_A	271_E	0.921	0.97
17_T	20_A	0.918	0.97
244_S	252_R	0.918	0.97
272_A	314_A	0.917	0.97
73_T	76_S	0.909	0.97
245_G	250_I	0.904	0.97
243_P	246_T	0.903	0.97
106_G	111_Q	0.901	0.97
94_Q	261_A	0.900	0.97
84_A	117_N	0.900	0.97
57_K	68_L	0.899	0.97
168_E	233_A	0.897	0.97
285_T	288_L	0.891	0.97
84_A	115_V	0.890	0.97
185_A	197_A	0.889	0.97
60_V	280_A	0.883	0.97
25_C	30_D	0.883	0.97
90_F	269_V	0.881	0.97
120_G	262_M	0.881	0.97
266_H	269_V	0.875	0.96
165_Q	168_E	0.861	0.96
42_A	50_Y	0.860	0.96
208_I	217_I	0.858	0.96
203_W	243_P	0.854	0.96
20_A	23_A	0.854	0.96
133_T	136_D	0.852	0.96
36_T	273_T	0.849	0.96
45_Q	72_T	0.845	0.96
57_K	61_E	0.841	0.96
274_V	278_T	0.840	0.96
212_A	249_G	0.838	0.95
89_D	269_V	0.838	0.95
190_R	215_N	0.838	0.95
129_I	200_V	0.834	0.95
86_G	266_H	0.832	0.95
148_A	195_D	0.832	0.95
212_A	217_I	0.826	0.95
153_G	157_S	0.826	0.95
95_N	262_M	0.824	0.95
242_I	256_T	0.823	0.95
229_A	232_E	0.818	0.95
49_Y	94_Q	0.816	0.95
131_L	145_L	0.814	0.95
242_I	247_Y	0.813	0.95
133_T	196_A	0.813	0.95
22_L	26_A	0.807	0.94
225_E	229_A	0.804	0.94
120_G	123_T	0.803	0.94
271_E	275_T	0.799	0.94
131_L	142_V	0.799	0.94
222_I	227_R	0.798	0.94
245_G	253_S	0.797	0.94
203_W	246_T	0.791	0.94
311_G	315_Y	0.789	0.94
278_T	315_Y	0.788	0.94
308_L	316_F	0.788	0.94
143_A	226_A	0.788	0.94
71_Q	82_S	0.787	0.94
188_Q	194_I	0.787	0.94
40_W	60_V	0.783	0.93
83_L	88_A	0.782	0.93
271_E	274_V	0.780	0.93
73_T	78_E	0.776	0.93
94_Q	97_I	0.775	0.93
265_T	274_V	0.775	0.93
152_T	163_A	0.773	0.93
25_C	29_D	0.767	0.93
48_T	202_G	0.764	0.93
43_G	79_N	0.763	0.93
31_G	34_D	0.761	0.93
162_N	200_V	0.761	0.93
21_A	24_G	0.758	0.92
311_G	314_A	0.758	0.92
244_S	251_D	0.758	0.92
74_G	78_E	0.754	0.92
45_Q	50_Y	0.753	0.92
73_T	88_A	0.753	0.92
143_A	146_D	0.751	0.92
181_S	184_Q	0.750	0.92
180_A	184_Q	0.745	0.92
276_A	280_A	0.740	0.91
130_T	219_I	0.738	0.91
99_Y	236_W	0.735	0.91
182_F	201_G	0.734	0.91
269_V	277_V	0.734	0.91
82_S	88_A	0.733	0.91
98_A	262_M	0.732	0.91
61_E	68_L	0.730	0.91
79_N	157_S	0.729	0.91
132_I	208_I	0.729	0.91
227_R	257_V	0.728	0.91
134_R	138_G	0.719	0.90
86_G	89_D	0.715	0.90
276_A	279_S	0.713	0.90
133_T	138_G	0.708	0.90
80_V	83_L	0.707	0.89
76_S	261_A	0.704	0.89
120_G	306_I	0.702	0.89
73_T	82_S	0.701	0.89
71_Q	87_N	0.695	0.89
140_E	143_A	0.695	0.89
100_F	109_A	0.694	0.89
49_Y	79_N	0.691	0.88
265_T	277_V	0.691	0.88
275_T	278_T	0.690	0.88
16_A	19_I	0.688	0.88
118_L	265_T	0.688	0.88
168_E	173_T	0.688	0.88
167_L	175_Y	0.686	0.88
38_L	89_D	0.685	0.88
52_L	295_I	0.684	0.88
128_T	256_T	0.684	0.88
129_I	163_A	0.680	0.88
211_L	217_I	0.673	0.87
57_K	70_V	0.672	0.87
45_Q	51_P	0.672	0.87
50_Y	70_V	0.670	0.87
43_G	75_A	0.670	0.87
279_S	314_A	0.670	0.87
134_R	220_V	0.670	0.87
304_M	308_L	0.666	0.87
217_I	250_I	0.666	0.87
231_K	239_D	0.666	0.87
48_T	291_K	0.665	0.86
42_A	70_V	0.662	0.86
32_A	35_G	0.660	0.86
219_I	254_I	0.659	0.86
271_E	276_A	0.655	0.86
74_G	154_D	0.653	0.85
93_I	97_I	0.652	0.85
29_D	34_D	0.651	0.85
131_L	196_A	0.651	0.85
52_L	124_L	0.650	0.85
121_V	263_I	0.650	0.85
138_G	144_D	0.650	0.85
102_K	306_I	0.650	0.85
101_A	104_G	0.650	0.85
279_S	315_Y	0.649	0.85
275_T	315_Y	0.649	0.85
186_A	190_R	0.649	0.85
278_T	282_F	0.647	0.85
96_D	237_F	0.645	0.85
23_A	26_A	0.644	0.85
165_Q	234_A	0.644	0.85
47_G	125_Y	0.643	0.85
23_A	176_E	0.642	0.84
219_I	242_I	0.640	0.84
59_I	284_H	0.640	0.84
132_I	217_I	0.639	0.84
278_T	312_A	0.637	0.84
39_S	88_A	0.636	0.84
301_Q	316_F	0.634	0.84
280_A	284_H	0.632	0.84
49_Y	53_S	0.632	0.84
82_S	87_N	0.631	0.83
154_D	180_A	0.631	0.83
20_A	28_G	0.629	0.83
170_A	223_E	0.627	0.83
149_T	178_Q	0.626	0.83
125_Y	261_A	0.622	0.83
282_F	295_I	0.621	0.82
38_L	68_L	0.620	0.82
131_L	163_A	0.619	0.82
80_V	118_L	0.618	0.82
25_C	31_G	0.613	0.82
169_A	230_A	0.613	0.82
124_L	263_I	0.611	0.81
238_A	258_S	0.611	0.81
160_Q	163_A	0.611	0.81
164_L	168_E	0.608	0.81
225_E	228_D	0.608	0.81
30_D	33_G	0.607	0.81
75_A	94_Q	0.603	0.81
187_E	210_E	0.603	0.81
208_I	219_I	0.603	0.81
174_D	177_E	0.599	0.80
56_F	281_I	0.598	0.80
76_S	153_G	0.598	0.80
162_N	237_F	0.598	0.80
43_G	127_E	0.597	0.80
20_A	27_G	0.597	0.80
227_R	255_E	0.596	0.80
28_G	33_G	0.595	0.80
92_L	263_I	0.594	0.80
163_A	167_L	0.593	0.80
26_A	29_D	0.592	0.79
169_A	229_A	0.591	0.79
267_D	270_D	0.589	0.79
125_Y	202_G	0.585	0.79
272_A	311_G	0.584	0.78
59_I	280_A	0.583	0.78
130_T	242_I	0.583	0.78
137_T	140_E	0.582	0.78
237_F	259_V	0.581	0.78
178_Q	194_I	0.581	0.78
27_G	34_D	0.580	0.78
31_G	35_G	0.578	0.78
295_I	300_A	0.578	0.78
142_V	167_L	0.576	0.78
178_Q	188_Q	0.575	0.77
119_A	307_D	0.572	0.77
138_G	148_A	0.569	0.77
134_R	192_G	0.568	0.77
84_A	116_D	0.567	0.76
44_G	154_D	0.567	0.76
146_D	314_A	0.566	0.76
120_G	308_L	0.565	0.76
49_Y	157_S	0.564	0.76
102_K	119_A	0.563	0.76
152_T	160_Q	0.563	0.76
24_G	27_G	0.563	0.76
37_R	69_N	0.562	0.76
195_D	198_F	0.561	0.76
206_G	209_E	0.561	0.76
99_Y	305_S	0.560	0.76
71_Q	88_A	0.560	0.76
28_G	32_A	0.559	0.75
19_I	25_C	0.554	0.75
282_F	316_F	0.552	0.75
126_P	294_F	0.550	0.74
184_Q	188_Q	0.550	0.74
97_I	161_V	0.549	0.74
203_W	242_I	0.549	0.74
53_S	79_N	0.549	0.74
106_G	161_V	0.545	0.74
29_D	32_A	0.545	0.74
15_G	24_G	0.545	0.74
136_D	215_N	0.543	0.73
270_D	310_P	0.543	0.73
129_I	198_F	0.542	0.73
51_P	54_N	0.542	0.73
76_S	79_N	0.541	0.73
101_A	110_F	0.540	0.73
310_P	314_A	0.540	0.73
28_G	31_G	0.540	0.73
199_V	205_V	0.540	0.73
52_L	92_L	0.536	0.72
232_E	235_S	0.534	0.72
227_R	231_K	0.533	0.72
51_P	55_E	0.532	0.72
25_C	32_A	0.527	0.71
30_D	34_D	0.527	0.71
169_A	233_A	0.525	0.71
74_G	156_G	0.524	0.71
54_N	70_V	0.524	0.71
50_Y	72_T	0.522	0.70
121_V	265_T	0.522	0.70
139_I	144_D	0.522	0.70
199_V	208_I	0.520	0.70
151_N	197_A	0.517	0.70
78_E	81_G	0.516	0.70
238_A	260_Q	0.515	0.69
15_G	18_S	0.514	0.69
53_S	125_Y	0.514	0.69
81_G	84_A	0.514	0.69
17_T	22_L	0.513	0.69
43_G	125_Y	0.513	0.69
152_T	179_T	0.512	0.69
97_I	100_F	0.512	0.69
24_G	30_D	0.510	0.69
15_G	20_A	0.510	0.69
123_T	315_Y	0.509	0.69
98_A	120_G	0.509	0.69
45_Q	54_N	0.508	0.68
109_A	113_R	0.506	0.68
247_Y	256_T	0.505	0.68
79_N	156_G	0.505	0.68
44_G	47_G	0.503	0.68
52_L	56_F	0.503	0.68
79_N	247_Y	0.503	0.68
241_T	252_R	0.502	0.67
119_A	309_H	0.501	0.67
274_V	311_G	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1us5A	1	0.8899	100	0.397	Contact Map
4dddA	1	0.8899	100	0.471	Contact Map
2ozzA	1	0.7107	99.9	0.661	Contact Map
3un6A	1	0.7516	99.9	0.673	Contact Map
3qslA	1	0.8176	99.9	0.675	Contact Map
4x9tA	1	0.8302	99.9	0.691	Contact Map
2f5xA	1	0.8365	99.9	0.693	Contact Map
2qpqA	1	0.8333	99.9	0.695	Contact Map
2dvzA	1	0.8365	99.9	0.7	Contact Map
2g29A	1	0.8648	99.9	0.707	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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