GREMLIN Database
Q9HRU4 - Threonine synthase
UniProt: Q9HRU4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (310)
Sequences: 13658 (7335)
Seq/√Len: 416.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_A154_A4.0241.00
97_E373_T3.5481.00
224_T375_V3.2821.00
85_P97_E3.1751.00
332_E361_E3.1601.00
190_A193_D3.0201.00
160_S181_Q2.9191.00
164_F168_A2.8221.00
235_H269_Y2.8121.00
193_D197_E2.7201.00
267_A324_G2.7181.00
122_A212_Y2.5721.00
124_A127_G2.4991.00
157_F194_A2.4951.00
274_E329_S2.4921.00
153_D176_D2.4831.00
80_A227_Q2.4711.00
280_V284_Q2.3991.00
155_H176_D2.3761.00
236_V253_A2.3711.00
198_H202_W2.2791.00
80_A226_E2.1781.00
257_R266_P2.1771.00
277_A281_R2.1701.00
369_G372_D2.1601.00
250_W321_S2.1581.00
257_R265_V2.1451.00
155_H178_N2.0501.00
83_L375_V2.0061.00
234_D372_D1.9331.00
85_P99_Y1.9131.00
355_A376_V1.8951.00
271_A358_G1.8631.00
85_P90_A1.8611.00
329_S332_E1.8291.00
221_L249_M1.8081.00
233_P375_V1.7941.00
130_E155_H1.7921.00
303_I354_A1.7891.00
339_A360_W1.7461.00
231_E373_T1.7311.00
99_Y373_T1.7251.00
99_Y228_L1.7231.00
269_Y324_G1.7151.00
92_E339_A1.7131.00
339_A343_R1.7081.00
236_V249_M1.6931.00
119_A210_T1.6771.00
237_V271_A1.6481.00
194_A198_H1.6471.00
234_D373_T1.6351.00
130_E153_D1.6311.00
340_V348_M1.6221.00
218_K222_Y1.5931.00
292_P307_D1.5761.00
254_T323_G1.5701.00
246_L322_N1.5681.00
108_T145_A1.5511.00
167_K179_V1.5191.00
221_L252_A1.5191.00
221_L253_A1.5171.00
277_A327_A1.4851.00
120_M131_V1.4841.00
316_E320_E1.4751.00
281_R284_Q1.4701.00
87_P91_D1.4641.00
348_M378_S1.4621.00
249_M377_V1.4601.00
92_E343_R1.4331.00
237_V362_L1.4201.00
192_E196_D1.4141.00
168_A171_N1.4121.00
225_V256_L1.4121.00
285_E289_A1.4071.00
235_H372_D1.4071.00
300_C333_I1.3981.00
235_H267_A1.3811.00
235_H374_V1.3711.00
188_N192_E1.3681.00
167_K171_N1.3661.00
237_V359_A1.3651.00
158_L170_V1.3631.00
183_R186_D1.3481.00
281_R285_E1.3451.00
299_I334_L1.3431.00
124_A152_L1.3391.00
280_V327_A1.3171.00
188_N191_F1.3141.00
135_S140_G1.2921.00
340_V356_A1.2891.00
215_E218_K1.2861.00
269_Y326_V1.2781.00
228_L375_V1.2661.00
270_A325_A1.2641.00
88_G91_D1.2631.00
83_L228_L1.2581.00
140_G170_V1.2561.00
98_L359_A1.2431.00
84_V102_D1.2411.00
275_G330_D1.2391.00
283_F325_A1.2381.00
228_L233_P1.2231.00
222_Y252_A1.2191.00
120_M150_A1.2111.00
337_G384_K1.2081.00
326_V358_G1.2061.00
77_D117_T1.2061.00
298_T304_E1.2031.00
336_A357_A1.2011.00
133_L156_V1.1831.00
250_W268_M1.1811.00
73_A118_V1.1781.00
286_G319_R1.1781.00
86_C100_I1.1761.00
88_G343_R1.1751.00
83_L224_T1.1721.00
240_T270_A1.1601.00
334_L392_H1.1571.00
157_F190_A1.1521.00
331_E335_E1.1461.00
277_A280_V1.1441.00
190_A194_A1.1431.00
280_V325_A1.1411.00
158_L179_V1.1371.00
193_D196_D1.1361.00
208_F247_V1.1361.00
341_A347_E1.1341.00
93_L360_W1.1321.00
121_T150_A1.1311.00
336_A356_A1.1251.00
267_A372_D1.1241.00
148_G154_A1.1221.00
273_A303_I1.1201.00
338_T342_S1.1081.00
240_T325_A1.1071.00
81_T106_N1.0981.00
279_I308_P1.0901.00
368_F372_D1.0801.00
337_G353_A1.0741.00
189_A193_D1.0731.00
171_N176_D1.0721.00
352_C379_T1.0711.00
257_R264_D1.0691.00
279_I318_L1.0591.00
246_L270_A1.0581.00
224_T233_P1.0571.00
335_E339_A1.0561.00
303_I351_T1.0501.00
237_V269_Y1.0471.00
95_V98_L1.0461.00
82_A105_R1.0411.00
209_A312_R1.0401.00
170_V175_G1.0401.00
332_E335_E1.0391.00
167_K177_M1.0341.00
276_C283_F1.0311.00
246_L318_L1.0291.00
155_H202_W1.0271.00
122_A126_H1.0231.00
284_Q324_G1.0221.00
359_A376_V1.0131.00
100_I378_S1.0111.00
94_G370_E1.0071.00
253_A266_P1.0041.00
132_A202_W0.9941.00
232_T373_T0.9871.00
225_V253_A0.9751.00
279_I325_A0.9751.00
72_S76_M0.9721.00
207_A210_T0.9711.00
238_Y249_M0.9681.00
240_T279_I0.9661.00
78_E106_N0.9651.00
328_A357_A0.9581.00
128_A152_L0.9561.00
271_A326_V0.9561.00
274_E327_A0.9561.00
251_K255_E0.9551.00
318_L322_N0.9551.00
192_E195_M0.9491.00
143_A154_A0.9441.00
186_D189_A0.9431.00
117_T121_T0.9401.00
168_A172_V0.9381.00
144_G175_G0.9371.00
313_L316_E0.9321.00
102_D378_S0.9311.00
240_T246_L0.9291.00
337_G389_L0.9281.00
211_P313_L0.9281.00
206_Q210_T0.9271.00
165_T386_A0.9271.00
90_A97_E0.9241.00
348_M353_A0.9241.00
220_L245_G0.9231.00
116_Q142_S0.9221.00
220_L377_V0.9191.00
220_L249_M0.9161.00
278_P281_R0.9131.00
228_L373_T0.9101.00
267_A323_G0.9031.00
387_D391_S0.9031.00
316_E319_R0.9001.00
357_A361_E0.8941.00
352_C378_S0.8931.00
88_G344_A0.8921.00
134_A184_I0.8911.00
247_V314_V0.8901.00
124_A128_A0.8891.00
388_V391_S0.8861.00
235_H368_F0.8861.00
348_M352_C0.8811.00
145_A173_H0.8811.00
132_A191_F0.8801.00
89_L356_A0.8801.00
237_V358_G0.8781.00
267_A367_A0.8751.00
336_A360_W0.8751.00
307_D312_R0.8741.00
145_A149_R0.8731.00
143_A156_V0.8721.00
97_E371_D0.8711.00
224_T249_M0.8711.00
100_I340_V0.8701.00
333_I354_A0.8701.00
73_A121_T0.8581.00
141_Q170_V0.8521.00
214_H251_K0.8461.00
176_D198_H0.8451.00
162_S301_G0.8451.00
119_A205_L0.8371.00
72_S75_S0.8351.00
189_A192_E0.8301.00
364_D368_F0.8251.00
324_G367_A0.8221.00
356_A376_V0.8191.00
358_G362_L0.8161.00
148_G173_H0.8151.00
340_V378_S0.8151.00
326_V361_E0.8141.00
171_N179_V0.8131.00
214_H317_A0.8131.00
78_E113_D0.8121.00
249_M268_M0.8101.00
184_I187_A0.8101.00
160_S182_G0.8091.00
119_A213_R0.8091.00
194_A197_E0.8041.00
332_E357_A0.8031.00
214_H313_L0.8021.00
224_T377_V0.8021.00
178_N190_A0.8011.00
180_V190_A0.7981.00
215_E251_K0.7951.00
275_G296_P0.7941.00
272_Q278_P0.7931.00
361_E364_D0.7911.00
217_K255_E0.7881.00
95_V374_V0.7851.00
239_P379_T0.7831.00
104_G346_P0.7761.00
388_V392_H0.7741.00
86_C344_A0.7741.00
131_V152_L0.7691.00
129_S153_D0.7681.00
315_L319_R0.7641.00
164_F167_K0.7641.00
164_F171_N0.7631.00
71_G226_E0.7601.00
119_A212_Y0.7601.00
113_D145_A0.7581.00
275_G297_D0.7551.00
132_A194_A0.7551.00
123_A127_G0.7511.00
160_S179_V0.7481.00
184_I188_N0.7461.00
302_G351_T0.7451.00
254_T320_E0.7451.00
252_A256_L0.7431.00
317_A321_S0.7421.00
364_D367_A0.7371.00
191_F195_M0.7331.00
131_V147_A0.7301.00
154_A175_G0.7291.00
363_A368_F0.7291.00
222_Y226_E0.7281.00
182_G186_D0.7251.00
238_Y246_L0.7241.00
212_Y215_E0.7201.00
195_M198_H0.7181.00
334_L350_A0.7171.00
71_G75_S0.7161.00
79_G107_P0.7151.00
329_S361_E0.7091.00
387_D390_R0.7091.00
95_V372_D0.7071.00
232_T266_P0.7071.00
185_G189_A0.7071.00
136_T302_G0.7071.00
236_V268_M0.7061.00
118_V121_T0.7051.00
83_L99_Y0.7031.00
281_R289_A0.6991.00
362_L367_A0.6961.00
229_D232_T0.6941.00
101_K223_E0.6911.00
341_A389_L0.6881.00
92_E360_W0.6871.00
127_G203_Y0.6861.00
125_Q128_A0.6841.00
102_D105_R0.6841.00
220_L224_T0.6831.00
157_F180_V0.6801.00
246_L268_M0.6801.00
153_D202_W0.6731.00
360_W364_D0.6670.99
222_Y256_L0.6630.99
226_E256_L0.6600.99
141_Q169_M0.6580.99
312_R316_E0.6570.99
122_A125_Q0.6550.99
124_A150_A0.6540.99
362_L368_F0.6540.99
120_M143_A0.6530.99
166_T301_G0.6510.99
165_T387_D0.6510.99
282_A315_L0.6490.99
288_D312_R0.6480.99
284_Q287_R0.6470.99
130_E202_W0.6440.99
98_L376_V0.6430.99
225_V252_A0.6410.99
228_L231_E0.6400.99
77_D121_T0.6400.99
249_M253_A0.6400.99
314_V325_A0.6380.99
93_L339_A0.6370.99
116_Q146_Y0.6360.99
282_A308_P0.6340.99
120_M152_L0.6330.99
89_L339_A0.6310.99
155_H194_A0.6270.99
108_T113_D0.6270.99
229_D233_P0.6260.99
225_V257_R0.6260.99
121_T125_Q0.6250.99
194_A202_W0.6230.99
89_L92_E0.6230.99
71_G222_Y0.6220.99
90_A95_V0.6220.99
118_V215_E0.6200.99
90_A98_L0.6170.99
93_L359_A0.6140.99
104_G378_S0.6130.99
278_P308_P0.6130.99
102_D346_P0.6110.99
328_A358_G0.6110.99
271_A328_A0.6090.99
331_E334_L0.6090.99
113_D149_R0.6090.99
269_Y362_L0.6090.99
233_P266_P0.6070.99
157_F178_N0.6060.99
184_I207_A0.6050.99
127_G130_E0.6050.99
181_Q186_D0.6040.99
169_M172_V0.6040.99
222_Y255_E0.6020.99
271_A354_A0.6020.99
254_T268_M0.6000.99
324_G362_L0.5980.99
288_D315_L0.5970.99
67_P70_R0.5970.99
228_L232_T0.5900.99
205_L209_A0.5900.99
123_A203_Y0.5890.99
132_A195_M0.5860.99
118_V122_A0.5850.99
134_A188_N0.5840.99
269_Y358_G0.5840.99
155_H198_H0.5840.99
191_F204_S0.5810.99
235_H362_L0.5800.99
119_A206_Q0.5800.99
157_F187_A0.5800.99
218_K252_A0.5790.99
254_T321_S0.5770.99
283_F286_G0.5760.98
288_D292_P0.5750.98
123_A128_A0.5750.98
139_A217_K0.5740.98
206_Q209_A0.5720.98
87_P90_A0.5690.98
239_P355_A0.5680.98
238_Y245_G0.5670.98
178_N194_A0.5640.98
337_G350_A0.5640.98
73_A76_M0.5620.98
256_L264_D0.5590.98
232_T265_V0.5580.98
142_S146_Y0.5570.98
224_T253_A0.5570.98
79_G106_N0.5560.98
252_A255_E0.5550.98
368_F371_D0.5530.98
91_D94_G0.5520.98
236_V377_V0.5520.98
78_E117_T0.5510.98
213_R217_K0.5480.98
271_A327_A0.5460.98
95_V370_E0.5450.98
157_F193_D0.5450.98
328_A354_A0.5450.98
359_A363_A0.5450.98
254_T265_V0.5430.98
81_T101_K0.5420.98
126_H129_S0.5410.98
86_C90_A0.5410.98
83_L227_Q0.5400.98
199_G202_W0.5400.98
318_L325_A0.5370.98
236_V375_V0.5370.98
352_C355_A0.5360.98
134_A191_F0.5360.98
119_A203_Y0.5340.98
330_D333_I0.5330.98
139_A205_L0.5330.98
196_D199_G0.5330.98
86_C89_L0.5320.97
89_L93_L0.5310.97
358_G361_E0.5310.97
300_C303_I0.5290.97
119_A122_A0.5280.97
136_T184_I0.5280.97
119_A127_G0.5260.97
124_A203_Y0.5240.97
333_I353_A0.5230.97
336_A353_A0.5230.97
90_A93_L0.5220.97
168_A390_R0.5220.97
214_H247_V0.5220.97
224_T236_V0.5210.97
95_V363_A0.5210.97
78_E81_T0.5210.97
100_I348_M0.5200.97
111_F245_G0.5200.97
186_D190_A0.5190.97
232_T257_R0.5180.97
89_L100_I0.5180.97
234_D371_D0.5170.97
81_T110_T0.5170.97
241_G302_G0.5160.97
247_V313_L0.5100.97
282_A288_D0.5080.97
299_I330_D0.5070.97
127_G152_L0.5060.97
221_L224_T0.5050.97
239_P377_V0.5040.97
340_V346_P0.5040.97
276_C296_P0.5030.96
195_M199_G0.5030.96
328_A333_I0.5030.96
351_T354_A0.5020.96
347_E382_A0.5010.96
249_M252_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e5xA 2 0.9347 100 0.196 Contact Map
1tdjA 2 0.8241 100 0.286 Contact Map
2zsjA 2 0.8367 100 0.29 Contact Map
3aeyA 2 0.8317 100 0.293 Contact Map
2d1fA 2 0.8392 100 0.295 Contact Map
3ss7X 1 0.9523 100 0.297 Contact Map
2rkbA 2 0.7839 100 0.319 Contact Map
2gn0A 2 0.8241 100 0.32 Contact Map
1v71A 2 0.7965 100 0.325 Contact Map
4h27A 1 0.7814 100 0.329 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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