GREMLIN Database
Q9HRU3 - Uncharacterized protein
UniProt: Q9HRU3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (405)
Sequences: 16896 (13795)
Seq/√Len: 685.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_E37_D4.3961.00
16_V254_A4.0081.00
43_R234_P3.8151.00
39_T230_E3.8111.00
14_E255_D3.6401.00
47_V231_P3.4351.00
259_V266_A3.1351.00
41_F252_I3.1131.00
47_V219_A3.0981.00
27_A258_V3.0531.00
16_V41_F2.7991.00
237_A246_D2.7941.00
45_P232_E2.7441.00
418_G422_A2.7261.00
213_A216_A2.6461.00
212_G216_A2.5861.00
37_D228_T2.5781.00
246_D251_R2.5511.00
87_R208_A2.4761.00
20_G47_V2.4701.00
16_V252_I2.4251.00
85_D208_A2.3931.00
239_H246_D2.3871.00
342_S345_A2.3831.00
41_F254_A2.3321.00
256_A400_Y2.3021.00
152_A160_A2.2961.00
219_A223_R2.2891.00
244_A247_V2.2791.00
18_V259_V2.2561.00
30_H419_R2.1731.00
230_E233_T2.1671.00
239_H244_A2.1671.00
260_A402_A2.1461.00
219_A229_I2.1171.00
15_A36_L2.1091.00
41_F230_E2.1051.00
114_L117_S2.0961.00
18_V261_T2.0941.00
244_A251_R2.0781.00
230_E250_E2.0221.00
26_V415_M1.9981.00
55_H60_T1.9751.00
14_E39_T1.9261.00
53_S60_T1.9231.00
30_H33_A1.9081.00
23_A260_A1.8971.00
233_T247_V1.8931.00
217_Q220_A1.8891.00
243_A247_V1.8831.00
22_L411_I1.8651.00
348_T352_D1.8491.00
46_T52_R1.8041.00
230_E252_I1.7941.00
279_W283_T1.7771.00
29_R221_R1.7751.00
165_D169_D1.7701.00
355_A360_E1.7611.00
155_E159_A1.7501.00
258_V425_A1.7391.00
13_E39_T1.7061.00
33_A81_F1.7021.00
247_V252_I1.6901.00
233_T248_P1.6811.00
153_T156_Q1.6781.00
236_E246_D1.6661.00
366_F369_L1.6561.00
244_A253_D1.6551.00
16_V245_V1.6531.00
30_H423_R1.6271.00
261_T266_A1.6181.00
47_V229_I1.5841.00
39_T228_T1.5821.00
55_H212_G1.5471.00
344_T348_T1.5421.00
247_V250_E1.5351.00
39_T254_A1.5221.00
15_A256_A1.5221.00
223_R228_T1.5011.00
239_H251_R1.5001.00
351_R355_A1.4931.00
233_T250_E1.4931.00
28_A40_L1.4901.00
402_A421_A1.4901.00
24_G260_A1.4851.00
76_K80_D1.4831.00
32_A225_A1.4801.00
389_L392_T1.4761.00
352_D355_A1.4721.00
400_Y421_A1.4621.00
283_T286_H1.4591.00
17_V28_A1.4381.00
50_R404_S1.4341.00
221_R225_A1.4301.00
74_A419_R1.4221.00
372_H376_F1.4161.00
41_F235_V1.4141.00
159_A169_D1.3991.00
15_A31_L1.3971.00
77_R81_F1.3891.00
86_L89_F1.3871.00
353_A356_D1.3831.00
51_V215_S1.3781.00
222_A229_I1.3761.00
382_P385_V1.3751.00
16_V39_T1.3611.00
347_A351_R1.3611.00
47_V215_S1.3441.00
216_A220_A1.3331.00
78_E81_F1.3241.00
349_A352_D1.3181.00
211_M411_I1.3131.00
312_T315_P1.3031.00
155_E185_L1.2941.00
40_L229_I1.2841.00
32_A222_A1.2811.00
29_R33_A1.2731.00
14_E36_L1.2681.00
220_A223_R1.2651.00
355_A362_S1.2601.00
365_A368_V1.2551.00
382_P387_D1.2521.00
32_A38_V1.2481.00
241_D253_D1.2371.00
113_A116_P1.2361.00
152_A156_Q1.2281.00
238_V259_V1.2241.00
39_T252_I1.2241.00
125_T128_K1.2221.00
41_F233_T1.2211.00
261_T269_L1.2191.00
114_L119_L1.2171.00
384_G387_D1.2151.00
332_A336_L1.2131.00
254_A257_V1.1991.00
107_P110_D1.1921.00
334_T337_G1.1901.00
377_S380_A1.1861.00
115_V119_L1.1841.00
111_P115_V1.1771.00
111_P114_L1.1751.00
112_G126_M1.1671.00
352_D356_D1.1651.00
347_A369_L1.1611.00
213_A217_Q1.1591.00
29_R218_L1.1541.00
421_A424_A1.1541.00
256_A425_A1.1531.00
343_S373_R1.1521.00
262_D265_A1.1501.00
281_G286_H1.1461.00
347_A350_A1.1441.00
256_A398_A1.1411.00
376_F380_A1.1391.00
355_A363_L1.1381.00
281_G289_L1.1361.00
30_H418_G1.1321.00
420_A424_A1.1311.00
406_T420_A1.1301.00
265_A268_E1.1291.00
110_D113_A1.1251.00
311_N316_M1.1241.00
17_V38_V1.1111.00
183_R186_S1.1071.00
55_H58_G1.1071.00
310_P313_V1.0971.00
14_E252_I1.0961.00
263_P405_Y1.0951.00
13_E255_D1.0901.00
236_E248_P1.0831.00
207_P214_I1.0801.00
382_P388_T1.0681.00
287_V290_P1.0671.00
209_A213_A1.0661.00
23_A417_S1.0651.00
259_V399_V1.0641.00
297_D302_H1.0641.00
400_Y424_A1.0591.00
54_T63_R1.0581.00
74_A77_R1.0551.00
124_S127_D1.0541.00
233_T252_I1.0511.00
13_E256_A1.0511.00
216_A219_A1.0501.00
113_A117_S1.0431.00
359_P362_S1.0401.00
300_R303_L1.0401.00
121_R125_T1.0391.00
219_A231_P1.0381.00
283_T290_P1.0381.00
78_E82_D1.0351.00
20_G40_L1.0351.00
286_H290_P1.0281.00
13_E37_D1.0261.00
285_Q289_L1.0261.00
341_R345_A1.0231.00
279_W282_C1.0201.00
122_E128_K1.0181.00
364_G367_E1.0151.00
400_Y425_A1.0131.00
375_P378_Q1.0051.00
406_T417_S1.0011.00
333_V336_L0.9971.00
329_E333_V0.9921.00
31_L422_A0.9921.00
332_A335_T0.9901.00
77_R419_R0.9841.00
345_A348_T0.9831.00
283_T287_V0.9831.00
20_G231_P0.9721.00
374_V377_S0.9721.00
283_T291_A0.9711.00
23_A402_A0.9681.00
121_R124_S0.9641.00
310_P314_A0.9641.00
110_D114_L0.9601.00
297_D301_I0.9541.00
389_L393_T0.9541.00
283_T289_L0.9531.00
276_P396_A0.9511.00
301_I304_N0.9491.00
309_V312_T0.9471.00
238_V257_V0.9461.00
29_R81_F0.9441.00
403_G417_S0.9441.00
215_S219_A0.9441.00
124_S128_K0.9411.00
366_F371_T0.9351.00
59_F325_P0.9351.00
112_G115_V0.9341.00
236_E249_G0.9321.00
416_E420_A0.9301.00
366_F372_H0.9301.00
367_E370_H0.9281.00
280_K284_T0.9261.00
77_R80_D0.9241.00
116_P119_L0.9211.00
419_R423_R0.9191.00
114_L118_V0.9171.00
33_A221_R0.9151.00
125_T129_L0.9151.00
390_P393_T0.9141.00
365_A369_L0.9141.00
23_A414_A0.9131.00
29_R222_A0.9091.00
279_W286_H0.9031.00
280_K283_T0.9031.00
374_V378_Q0.9021.00
343_S347_A0.9001.00
282_C287_V0.9001.00
309_V313_V0.8881.00
281_G290_P0.8831.00
80_D85_D0.8821.00
336_L339_P0.8801.00
346_L350_A0.8791.00
374_V379_F0.8761.00
97_R101_R0.8761.00
239_H272_V0.8761.00
112_G116_P0.8751.00
364_G369_L0.8751.00
282_C286_H0.8741.00
278_D281_G0.8741.00
243_A398_A0.8731.00
300_R304_N0.8721.00
366_F376_F0.8711.00
354_I358_Y0.8681.00
159_A165_D0.8631.00
286_H289_L0.8631.00
22_L51_V0.8621.00
234_P268_E0.8621.00
279_W290_P0.8621.00
354_I361_A0.8611.00
421_A425_A0.8591.00
221_R224_D0.8571.00
75_A415_M0.8571.00
122_E125_T0.8571.00
88_S205_V0.8561.00
137_E140_R0.8561.00
235_V245_V0.8561.00
281_G287_V0.8531.00
91_P94_V0.8501.00
349_A353_A0.8491.00
271_G274_A0.8491.00
13_E16_V0.8471.00
14_E253_D0.8441.00
345_A349_A0.8431.00
27_A418_G0.8421.00
370_H373_R0.8401.00
308_D356_D0.8391.00
240_S398_A0.8391.00
285_Q288_A0.8341.00
32_A228_T0.8341.00
373_R378_Q0.8331.00
370_H376_F0.8301.00
282_C288_A0.8291.00
297_D300_R0.8281.00
107_P111_P0.8261.00
30_H34_D0.8261.00
371_T374_V0.8241.00
295_L298_S0.8231.00
296_G299_D0.8221.00
240_S399_V0.8221.00
364_G368_V0.8211.00
74_A416_E0.8171.00
166_R170_R0.8171.00
14_E254_A0.8141.00
333_V338_T0.8131.00
41_F247_V0.8071.00
234_P379_F0.8071.00
25_L222_A0.8051.00
396_A399_V0.8051.00
240_S243_A0.8051.00
22_L414_A0.8041.00
44_N52_R0.8041.00
378_Q381_Q0.8031.00
284_T288_A0.8021.00
121_R128_K0.8011.00
310_P315_P0.8011.00
312_T316_M0.8011.00
152_A157_Y0.8001.00
373_R376_F0.7971.00
105_G114_L0.7971.00
302_H305_A0.7931.00
13_E36_L0.7921.00
295_L299_D0.7901.00
112_G117_S0.7901.00
28_A222_A0.7881.00
384_G388_T0.7881.00
123_V127_D0.7861.00
76_K79_L0.7851.00
355_A358_Y0.7831.00
79_L84_L0.7821.00
123_V128_K0.7771.00
37_D255_D0.7761.00
165_D168_V0.7751.00
279_W287_V0.7751.00
240_S396_A0.7741.00
97_R100_R0.7741.00
36_L39_T0.7721.00
42_E231_P0.7721.00
173_R184_S0.7721.00
284_T290_P0.7701.00
334_T339_P0.7701.00
359_P363_L0.7691.00
377_S381_Q0.7691.00
157_Y161_R0.7681.00
335_T350_A0.7671.00
353_A357_W0.7641.00
26_V418_G0.7641.00
366_F370_H0.7631.00
33_A225_A0.7631.00
278_D282_C0.7631.00
334_T338_T0.7621.00
53_S212_G0.7621.00
372_H378_Q0.7591.00
220_A224_D0.7571.00
236_E239_H0.7531.00
50_R64_G0.7511.00
26_V30_H0.7491.00
376_F381_Q0.7491.00
257_V398_A0.7481.00
94_V103_V0.7471.00
311_N314_A0.7431.00
22_L215_S0.7421.00
278_D283_T0.7401.00
166_R169_D0.7401.00
30_H81_F0.7391.00
414_A418_G0.7381.00
120_N123_V0.7371.00
73_P77_R0.7341.00
292_A297_D0.7331.00
18_V235_V0.7331.00
105_G110_D0.7331.00
281_G285_Q0.7321.00
315_P318_G0.7311.00
402_A418_G0.7291.00
294_P300_R0.7281.00
281_G288_A0.7281.00
17_V24_G0.7251.00
282_C285_Q0.7231.00
273_D276_P0.7231.00
286_H291_A0.7221.00
376_F379_F0.7211.00
106_D109_R0.7201.00
109_R113_A0.7191.00
279_W285_Q0.7151.00
180_T187_T0.7141.00
39_T255_D0.7141.00
309_V315_P0.7131.00
44_N380_A0.7131.00
136_R140_R0.7121.00
299_D304_N0.7111.00
344_T347_A0.7061.00
311_N315_P0.7001.00
110_D115_V0.6981.00
280_K286_H0.6981.00
356_D359_P0.6981.00
271_G275_I0.6971.00
241_D244_A0.6961.00
348_T351_R0.6951.00
119_L122_E0.6941.00
35_G38_V0.6941.00
281_G284_T0.6941.00
207_P213_A0.6931.00
119_L128_K0.6931.00
371_T376_F0.6931.00
284_T291_A0.6921.00
284_T287_V0.6911.00
298_S302_H0.6901.00
383_P388_T0.6881.00
59_F328_R0.6871.00
110_D119_L0.6831.00
62_D211_M0.6831.00
145_D148_S0.6811.00
279_W284_T0.6751.00
332_A337_G0.6751.00
75_A78_E0.6731.00
135_K138_L0.6671.00
366_F378_Q0.6661.00
335_T339_P0.6641.00
299_D302_H0.6631.00
65_F211_M0.6621.00
371_T378_Q0.6601.00
94_V97_R0.6591.00
324_A328_R0.6591.00
126_M129_L0.6571.00
383_P387_D0.6571.00
109_R112_G0.6571.00
370_H374_V0.6561.00
27_A421_A0.6541.00
282_C290_P0.6531.00
333_V339_P0.6531.00
236_E247_V0.6521.00
330_L334_T0.6511.00
422_A425_A0.6511.00
116_P120_N0.6501.00
163_F172_V0.6491.00
258_V400_Y0.6481.00
370_H378_Q0.6471.00
150_A153_T0.6461.00
382_P386_H0.6431.00
393_T424_A0.6391.00
79_L207_P0.6391.00
46_T212_G0.6361.00
371_T377_S0.6351.00
332_A339_P0.6351.00
288_A291_A0.6341.00
191_V194_Y0.6331.00
22_L26_V0.6321.00
279_W288_A0.6301.00
177_G183_R0.6291.00
367_E371_T0.6281.00
333_V337_G0.6271.00
299_D303_L0.6271.00
22_L415_M0.6261.00
287_V291_A0.6191.00
289_L292_A0.6191.00
294_P297_D0.6181.00
385_V388_T0.6151.00
34_D423_R0.6141.00
29_R225_A0.6141.00
100_R103_V0.6141.00
16_V257_V0.6121.00
360_E363_L0.6091.00
120_N128_K0.6081.00
123_V126_M0.6081.00
100_R104_L0.6071.00
72_Y76_K0.6061.00
297_D303_L0.6061.00
372_H377_S0.6051.00
53_S62_D0.6031.00
174_P177_G0.6021.00
378_Q382_P0.6021.00
298_S301_I0.6011.00
76_K83_A0.6011.00
409_A414_A0.6001.00
32_A223_R0.6001.00
86_L205_V0.5991.00
72_Y412_N0.5961.00
294_P298_S0.5961.00
310_P316_M0.5931.00
101_R167_Y0.5921.00
62_D67_V0.5921.00
78_E415_M0.5901.00
294_P299_D0.5901.00
237_A271_G0.5891.00
301_I305_A0.5891.00
146_I150_A0.5881.00
119_L123_V0.5871.00
278_D287_V0.5851.00
351_R354_I0.5851.00
184_S187_T0.5841.00
25_L40_L0.5831.00
51_V65_F0.5831.00
75_A411_I0.5821.00
30_H78_E0.5821.00
67_V179_I0.5811.00
119_L125_T0.5811.00
219_A222_A0.5801.00
297_D351_R0.5801.00
178_G181_L0.5791.00
237_A270_T0.5791.00
258_V421_A0.5761.00
350_A355_A0.5761.00
355_A359_P0.5741.00
180_T184_S0.5741.00
40_L47_V0.5731.00
90_S93_A0.5731.00
216_A223_R0.5721.00
92_G95_I0.5711.00
191_V198_L0.5711.00
346_L371_T0.5701.00
109_R115_V0.5671.00
313_V316_M0.5661.00
381_Q385_V0.5661.00
20_G25_L0.5661.00
107_P114_L0.5651.00
82_D218_L0.5641.00
367_E376_F0.5641.00
180_T192_F0.5631.00
329_E336_L0.5621.00
26_V218_L0.5611.00
17_V258_V0.5601.00
261_T265_A0.5591.00
243_A257_V0.5591.00
175_F178_G0.5581.00
105_G111_P0.5571.00
282_C289_L0.5561.00
115_V118_V0.5551.00
110_D118_V0.5531.00
333_V354_I0.5521.00
159_A168_V0.5501.00
217_Q221_R0.5491.00
324_A327_D0.5491.00
407_H420_A0.5471.00
292_A295_L0.5471.00
116_P122_E0.5471.00
75_A79_L0.5471.00
272_V275_I0.5471.00
293_H297_D0.5461.00
52_R63_R0.5451.00
74_A415_M0.5441.00
54_T370_H0.5441.00
379_F382_P0.5431.00
420_A423_R0.5421.00
38_V222_A0.5391.00
51_V211_M0.5371.00
278_D286_H0.5361.00
191_V195_T0.5341.00
343_S346_L0.5331.00
117_S121_R0.5331.00
195_T198_L0.5331.00
358_Y361_A0.5321.00
256_A259_V0.5321.00
31_L425_A0.5321.00
329_E332_A0.5311.00
316_M319_V0.5311.00
66_Q332_A0.5301.00
206_L211_M0.5301.00
108_L111_P0.5301.00
25_L215_S0.5301.00
51_V411_I0.5291.00
235_V247_V0.5261.00
351_R362_S0.5241.00
411_I415_M0.5241.00
111_P118_V0.5241.00
368_V376_F0.5231.00
182_D186_S0.5231.00
418_G421_A0.5231.00
259_V401_V0.5231.00
111_P117_S0.5231.00
346_L349_A0.5231.00
266_A401_V0.5221.00
373_R379_F0.5221.00
96_C101_R0.5221.00
93_A96_C0.5200.99
144_A147_W0.5200.99
314_A319_V0.5200.99
309_V314_A0.5200.99
279_W291_A0.5200.99
194_Y198_L0.5190.99
350_A353_A0.5180.99
365_A371_T0.5170.99
364_G376_F0.5170.99
20_G219_A0.5170.99
76_K205_V0.5140.99
366_F373_R0.5140.99
69_F204_T0.5140.99
164_S168_V0.5120.99
342_S346_L0.5110.99
367_E372_H0.5100.99
238_V245_V0.5090.99
394_A401_V0.5090.99
222_A225_A0.5080.99
404_S414_A0.5080.99
90_S94_V0.5070.99
371_T380_A0.5070.99
328_R332_A0.5060.99
121_R129_L0.5050.99
36_L255_D0.5050.99
111_P119_L0.5050.99
45_P231_P0.5040.99
112_G119_L0.5040.99
343_S351_R0.5010.99
159_A185_L0.5010.99
308_D353_A0.5010.99
74_A79_L0.5000.99
94_V101_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i59A 1 0.9442 100 0.353 Contact Map
2yg5A 2 0.9465 100 0.37 Contact Map
1s3eA 2 0.9581 100 0.378 Contact Map
3i6dA 1 0.8977 100 0.382 Contact Map
1sezA 3 0.9233 100 0.385 Contact Map
2ivdA 1 0.9233 100 0.392 Contact Map
3lovA 1 0.9442 100 0.392 Contact Map
2vvmA 2 0.9721 100 0.394 Contact Map
3nksA 2 0.9279 100 0.411 Contact Map
4dsgA 1 0.9395 100 0.412 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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