Q9HRU0 - HALSA - GREMLIN Contacts

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Q9HRU0 - Uncharacterized protein

UniProt:	Q9HRU0	Sequences: MDELSIEWVAEPSLDDPALVEGLPGVGHVGKLVAEHVIAEADSELVCRVHSEYFPPQVTVGDDSVAELAAAEIHAVETGGRDLLVVTGDHQAQDTVGQYRVTEAFLDAAAEFDATDVFSLGGVPTGELVEDHDVIGAVSSAALKDGLADAGVEFRSEEPAGGIVGSSGLLVGLGGKRGFDAACLMGETSGYLVDPKAAKAVLAVLGARLDFEMDEEALDDRAEEMEEVVSRLQDMEETPSPGDEDLRYIG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	250 (221)
Sequences:	1287 (905)
Seq/√Len:	60.9

HALSA - Q9HRU0 Q9HRX6
SULSO - Q97ZI5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
196_K	226_E	4.612	1.00
19_L	114_A	3.679	1.00
53_Y	97_G	3.523	1.00
107_D	177_R	3.429	1.00
19_L	109_A	2.932	1.00
30_G	122_G	2.871	1.00
101_V	166_S	2.791	1.00
120_L	201_V	2.773	1.00
97_G	100_R	2.756	1.00
32_L	198_A	2.694	1.00
226_E	230_S	2.570	1.00
73_I	86_V	2.562	1.00
110_A	177_R	2.510	1.00
174_G	181_A	2.305	1.00
84_L	112_F	2.279	1.00
173_L	176_K	2.278	1.00
135_I	187_E	2.251	1.00
47_C	108_A	2.178	1.00
22_G	195_P	2.122	1.00
186_G	201_V	2.085	1.00
29_V	201_V	2.084	1.00
107_D	111_E	2.067	1.00
45_L	72_E	2.034	1.00
220_D	223_E	1.984	1.00
36_H	40_E	1.964	1.00
140_S	180_D	1.939	1.00
109_A	179_F	1.902	1.00
199_K	219_D	1.805	1.00
74_H	87_T	1.786	0.99
106_L	177_R	1.765	0.99
132_H	200_A	1.763	0.99
203_A	212_E	1.749	0.99
139_S	181_A	1.731	0.99
34_A	85_V	1.717	0.99
43_S	76_V	1.714	0.99
45_L	74_H	1.709	0.99
17_P	20_V	1.707	0.99
46_V	84_L	1.705	0.99
33_V	120_L	1.686	0.99
16_D	81_R	1.678	0.99
134_V	204_V	1.665	0.99
117_V	174_G	1.615	0.99
132_H	186_G	1.610	0.99
84_L	114_A	1.608	0.99
37_V	85_V	1.599	0.99
136_G	152_V	1.598	0.99
116_D	180_D	1.594	0.99
46_V	75_A	1.562	0.99
43_S	74_H	1.530	0.98
201_V	205_L	1.529	0.98
19_L	86_V	1.521	0.98
17_P	82_D	1.520	0.98
77_E	82_D	1.516	0.98
34_A	136_G	1.448	0.98
16_D	115_T	1.392	0.97
17_P	112_F	1.387	0.97
203_A	219_D	1.375	0.97
119_S	181_A	1.359	0.97
109_A	114_A	1.351	0.96
192_L	233_Q	1.351	0.96
20_V	211_F	1.342	0.96
76_V	83_L	1.337	0.96
199_K	222_A	1.332	0.96
224_E	228_V	1.326	0.96
128_L	189_S	1.319	0.96
147_L	152_V	1.316	0.96
233_Q	236_E	1.309	0.96
106_L	174_G	1.299	0.96
198_A	202_L	1.297	0.96
38_I	74_H	1.292	0.95
147_L	182_A	1.270	0.95
41_A	83_L	1.260	0.95
43_S	85_V	1.259	0.95
215_E	219_D	1.229	0.94
118_F	182_A	1.226	0.94
90_H	189_S	1.226	0.94
90_H	128_L	1.225	0.94
48_R	70_A	1.225	0.94
40_E	217_A	1.219	0.94
138_V	144_K	1.209	0.94
184_L	205_L	1.207	0.93
164_V	168_G	1.193	0.93
122_G	209_L	1.193	0.93
239_P	242_G	1.184	0.93
206_G	212_E	1.155	0.92
40_E	214_D	1.154	0.92
147_L	184_L	1.145	0.92
86_V	101_V	1.138	0.91
33_V	218_L	1.132	0.91
137_A	171_V	1.111	0.90
116_D	182_A	1.110	0.90
216_E	219_D	1.110	0.90
203_A	215_E	1.107	0.90
220_D	224_E	1.105	0.90
79_G	212_E	1.104	0.90
172_G	176_K	1.089	0.89
106_L	110_A	1.084	0.89
121_G	185_M	1.078	0.89
15_D	18_A	1.077	0.89
184_L	208_R	1.065	0.88
228_V	232_L	1.063	0.88
86_V	105_F	1.043	0.87
19_L	117_V	1.040	0.87
232_L	236_E	1.039	0.87
127_E	189_S	1.034	0.87
90_H	98_Q	1.033	0.87
52_E	100_R	1.029	0.86
196_K	222_A	1.028	0.86
54_F	104_A	1.027	0.86
98_Q	128_L	1.017	0.86
127_E	130_E	1.012	0.86
20_V	234_D	1.006	0.85
55_P	194_D	1.004	0.85
99_Y	173_L	1.003	0.85
118_F	208_R	0.997	0.85
45_L	48_R	0.984	0.84
222_A	226_E	0.978	0.84
55_P	71_A	0.976	0.83
92_A	98_Q	0.971	0.83
116_D	146_G	0.968	0.83
51_S	167_S	0.966	0.83
221_R	224_E	0.958	0.82
85_V	134_V	0.951	0.82
46_V	49_V	0.950	0.82
133_D	187_E	0.948	0.82
193_V	221_R	0.944	0.81
50_H	53_Y	0.942	0.81
188_T	197_A	0.941	0.81
22_G	34_A	0.940	0.81
42_D	80_G	0.935	0.81
227_E	231_R	0.930	0.80
44_E	205_L	0.927	0.80
173_L	177_R	0.925	0.80
206_G	209_L	0.921	0.80
30_G	194_D	0.906	0.79
199_K	221_R	0.905	0.79
98_Q	191_Y	0.904	0.78
46_V	241_P	0.903	0.78
189_S	229_V	0.894	0.78
98_Q	189_S	0.892	0.77
128_L	191_Y	0.890	0.77
207_A	216_E	0.890	0.77
98_Q	130_E	0.886	0.77
98_Q	164_V	0.885	0.77
231_R	234_D	0.881	0.77
72_E	235_M	0.881	0.77
117_V	179_F	0.865	0.75
54_F	73_I	0.863	0.75
69_A	90_H	0.859	0.75
53_Y	100_R	0.859	0.75
24_P	30_G	0.852	0.74
195_P	221_R	0.851	0.74
43_S	83_L	0.849	0.74
113_D	179_F	0.845	0.74
213_M	239_P	0.830	0.72
134_V	201_V	0.825	0.72
202_L	206_G	0.823	0.72
237_E	240_S	0.816	0.71
47_C	73_I	0.815	0.71
40_E	213_M	0.810	0.70
41_A	214_D	0.807	0.70
110_A	179_F	0.802	0.70
216_E	220_D	0.802	0.70
132_H	187_E	0.800	0.69
122_G	154_F	0.796	0.69
202_L	214_D	0.795	0.69
49_V	194_D	0.788	0.68
138_V	203_A	0.787	0.68
221_R	228_V	0.784	0.68
33_V	202_L	0.774	0.67
106_L	165_G	0.773	0.67
58_V	172_G	0.773	0.67
116_D	143_L	0.773	0.67
44_E	134_V	0.767	0.66
100_R	104_A	0.767	0.66
26_V	163_I	0.762	0.66
76_V	85_V	0.758	0.65
231_R	235_M	0.757	0.65
104_A	109_A	0.756	0.65
107_D	110_A	0.756	0.65
86_V	114_A	0.753	0.65
33_V	199_K	0.752	0.65
48_R	72_E	0.751	0.65
224_E	227_E	0.748	0.64
24_P	121_G	0.747	0.64
165_G	169_L	0.747	0.64
90_H	191_Y	0.734	0.63
60_V	229_V	0.728	0.62
56_P	195_P	0.728	0.62
54_F	232_L	0.727	0.62
28_H	102_T	0.723	0.62
210_D	239_P	0.718	0.61
230_S	234_D	0.715	0.61
200_A	204_V	0.714	0.61
30_G	121_G	0.712	0.60
165_G	168_G	0.706	0.60
35_E	63_D	0.703	0.59
64_S	165_G	0.700	0.59
21_E	167_S	0.689	0.58
178_G	222_A	0.688	0.58
16_D	19_L	0.685	0.57
117_V	244_E	0.685	0.57
80_G	170_L	0.682	0.57
26_V	189_S	0.682	0.57
71_A	88_G	0.681	0.57
59_T	67_E	0.678	0.57
111_E	156_S	0.677	0.57
98_Q	127_E	0.673	0.56
92_A	174_G	0.672	0.56
78_T	212_E	0.670	0.56
145_D	231_R	0.669	0.56
122_G	153_E	0.668	0.56
129_V	189_S	0.666	0.55
25_G	127_E	0.659	0.55
141_A	144_K	0.659	0.55
109_A	174_G	0.657	0.54
63_D	245_D	0.655	0.54
17_P	84_L	0.653	0.54
38_I	85_V	0.651	0.54
68_L	162_G	0.651	0.54
121_G	162_G	0.649	0.53
25_G	163_I	0.648	0.53
37_V	76_V	0.647	0.53
81_R	210_D	0.641	0.53
53_Y	222_A	0.640	0.52
19_L	108_A	0.640	0.52
161_G	194_D	0.637	0.52
170_L	186_G	0.635	0.52
44_E	75_A	0.635	0.52
25_G	55_P	0.630	0.51
30_G	168_G	0.628	0.51
55_P	68_L	0.624	0.51
65_V	141_A	0.622	0.50
196_K	199_K	0.619	0.50
120_L	126_G	0.619	0.50
27_G	194_D	0.618	0.50
105_F	144_K	0.615	0.50
127_E	131_D	0.610	0.49
15_D	212_E	0.609	0.49
96_V	198_A	0.608	0.49
66_A	185_M	0.603	0.48
110_A	178_G	0.598	0.48
26_V	98_Q	0.595	0.47
42_D	237_E	0.595	0.47
95_T	243_D	0.594	0.47
120_L	205_L	0.594	0.47
82_D	145_D	0.588	0.47
49_V	95_T	0.586	0.46
62_D	143_L	0.582	0.46
25_G	121_G	0.581	0.46
38_I	87_T	0.580	0.46
112_F	115_T	0.579	0.46
22_G	166_S	0.577	0.45
88_G	98_Q	0.577	0.45
69_A	92_A	0.576	0.45
101_V	105_F	0.575	0.45
15_D	141_A	0.574	0.45
57_Q	162_G	0.572	0.45
26_V	183_C	0.572	0.45
142_A	203_A	0.570	0.45
17_P	75_A	0.569	0.44
183_C	209_L	0.569	0.44
32_L	36_H	0.569	0.44
175_G	181_A	0.568	0.44
126_G	190_G	0.568	0.44
19_L	73_I	0.568	0.44
138_V	143_L	0.567	0.44
28_H	161_G	0.567	0.44
46_V	67_E	0.566	0.44
228_V	231_R	0.566	0.44
122_G	168_G	0.563	0.44
29_V	197_A	0.563	0.44
125_T	163_I	0.560	0.43
18_A	237_E	0.559	0.43
217_A	222_A	0.559	0.43
124_P	162_G	0.556	0.43
24_P	225_M	0.554	0.43
147_L	155_R	0.554	0.43
30_G	165_G	0.553	0.43
163_I	191_Y	0.553	0.43
145_D	241_P	0.551	0.42
32_L	181_A	0.550	0.42
39_A	234_D	0.548	0.42
162_G	191_Y	0.547	0.42
137_A	183_C	0.546	0.42
29_V	147_L	0.546	0.42
143_L	170_L	0.545	0.42
139_S	175_G	0.544	0.42
121_G	164_V	0.544	0.42
128_L	243_D	0.539	0.41
152_V	170_L	0.538	0.41
140_S	239_P	0.538	0.41
74_H	89_D	0.534	0.41
64_S	101_V	0.534	0.41
23_L	185_M	0.534	0.41
181_A	227_E	0.534	0.41
27_G	46_V	0.533	0.40
20_V	156_S	0.533	0.40
197_A	238_T	0.532	0.40
130_E	189_S	0.532	0.40
142_A	145_D	0.531	0.40
217_A	221_R	0.531	0.40
23_L	121_G	0.529	0.40
25_G	98_Q	0.529	0.40
26_V	29_V	0.528	0.40
48_R	74_H	0.524	0.39
88_G	191_Y	0.523	0.39
102_T	237_E	0.523	0.39
52_E	95_T	0.522	0.39
41_A	241_P	0.521	0.39
71_A	166_S	0.520	0.39
71_A	86_V	0.519	0.39
162_G	185_M	0.519	0.39
25_G	90_H	0.516	0.39
35_E	67_E	0.516	0.39
63_D	223_E	0.515	0.38
169_L	220_D	0.515	0.38
92_A	127_E	0.514	0.38
35_E	87_T	0.512	0.38
40_E	100_R	0.510	0.38
239_P	243_D	0.509	0.38
170_L	208_R	0.508	0.38
165_G	209_L	0.508	0.38
56_P	98_Q	0.508	0.38
90_H	130_E	0.507	0.38
157_E	162_G	0.506	0.38
134_V	195_P	0.506	0.38
47_C	213_M	0.506	0.38
107_D	156_S	0.506	0.38
120_L	213_M	0.505	0.37
25_G	56_P	0.501	0.37
37_V	206_G	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3gaaA	5	0.932	100	0.21	Contact Map
3wz2A	3	0.912	100	0.215	Contact Map
3vr0A	3	0.92	100	0.216	Contact Map
2wamA	4	0.964	100	0.273	Contact Map
3e35A	3	0.94	100	0.291	Contact Map
2p90A	3	0.952	100	0.293	Contact Map
3mnfA	4	0.868	100	0.294	Contact Map
4g4sP	1	0.632	99.9	0.632	Contact Map
3l9wA	2	0.636	55.8	0.941	Contact Map
3e48A	2	0.888	50.3	0.943	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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