GREMLIN Database
Q9HRU0 - Uncharacterized protein
UniProt: Q9HRU0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 250 (221)
Sequences: 1287 (905)
Seq/√Len: 60.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_K226_E4.6121.00
19_L114_A3.6791.00
53_Y97_G3.5231.00
107_D177_R3.4291.00
19_L109_A2.9321.00
30_G122_G2.8711.00
101_V166_S2.7911.00
120_L201_V2.7731.00
97_G100_R2.7561.00
32_L198_A2.6941.00
226_E230_S2.5701.00
73_I86_V2.5621.00
110_A177_R2.5101.00
174_G181_A2.3051.00
84_L112_F2.2791.00
173_L176_K2.2781.00
135_I187_E2.2511.00
47_C108_A2.1781.00
22_G195_P2.1221.00
186_G201_V2.0851.00
29_V201_V2.0841.00
107_D111_E2.0671.00
45_L72_E2.0341.00
220_D223_E1.9841.00
36_H40_E1.9641.00
140_S180_D1.9391.00
109_A179_F1.9021.00
199_K219_D1.8051.00
74_H87_T1.7860.99
106_L177_R1.7650.99
132_H200_A1.7630.99
203_A212_E1.7490.99
139_S181_A1.7310.99
34_A85_V1.7170.99
43_S76_V1.7140.99
45_L74_H1.7090.99
17_P20_V1.7070.99
46_V84_L1.7050.99
33_V120_L1.6860.99
16_D81_R1.6780.99
134_V204_V1.6650.99
117_V174_G1.6150.99
132_H186_G1.6100.99
84_L114_A1.6080.99
37_V85_V1.5990.99
136_G152_V1.5980.99
116_D180_D1.5940.99
46_V75_A1.5620.99
43_S74_H1.5300.98
201_V205_L1.5290.98
19_L86_V1.5210.98
17_P82_D1.5200.98
77_E82_D1.5160.98
34_A136_G1.4480.98
16_D115_T1.3920.97
17_P112_F1.3870.97
203_A219_D1.3750.97
119_S181_A1.3590.97
109_A114_A1.3510.96
192_L233_Q1.3510.96
20_V211_F1.3420.96
76_V83_L1.3370.96
199_K222_A1.3320.96
224_E228_V1.3260.96
128_L189_S1.3190.96
147_L152_V1.3160.96
233_Q236_E1.3090.96
106_L174_G1.2990.96
198_A202_L1.2970.96
38_I74_H1.2920.95
147_L182_A1.2700.95
41_A83_L1.2600.95
43_S85_V1.2590.95
215_E219_D1.2290.94
118_F182_A1.2260.94
90_H189_S1.2260.94
90_H128_L1.2250.94
48_R70_A1.2250.94
40_E217_A1.2190.94
138_V144_K1.2090.94
184_L205_L1.2070.93
164_V168_G1.1930.93
122_G209_L1.1930.93
239_P242_G1.1840.93
206_G212_E1.1550.92
40_E214_D1.1540.92
147_L184_L1.1450.92
86_V101_V1.1380.91
33_V218_L1.1320.91
137_A171_V1.1110.90
116_D182_A1.1100.90
216_E219_D1.1100.90
203_A215_E1.1070.90
220_D224_E1.1050.90
79_G212_E1.1040.90
172_G176_K1.0890.89
106_L110_A1.0840.89
121_G185_M1.0780.89
15_D18_A1.0770.89
184_L208_R1.0650.88
228_V232_L1.0630.88
86_V105_F1.0430.87
19_L117_V1.0400.87
232_L236_E1.0390.87
127_E189_S1.0340.87
90_H98_Q1.0330.87
52_E100_R1.0290.86
196_K222_A1.0280.86
54_F104_A1.0270.86
98_Q128_L1.0170.86
127_E130_E1.0120.86
20_V234_D1.0060.85
55_P194_D1.0040.85
99_Y173_L1.0030.85
118_F208_R0.9970.85
45_L48_R0.9840.84
222_A226_E0.9780.84
55_P71_A0.9760.83
92_A98_Q0.9710.83
116_D146_G0.9680.83
51_S167_S0.9660.83
221_R224_E0.9580.82
85_V134_V0.9510.82
46_V49_V0.9500.82
133_D187_E0.9480.82
193_V221_R0.9440.81
50_H53_Y0.9420.81
188_T197_A0.9410.81
22_G34_A0.9400.81
42_D80_G0.9350.81
227_E231_R0.9300.80
44_E205_L0.9270.80
173_L177_R0.9250.80
206_G209_L0.9210.80
30_G194_D0.9060.79
199_K221_R0.9050.79
98_Q191_Y0.9040.78
46_V241_P0.9030.78
189_S229_V0.8940.78
98_Q189_S0.8920.77
128_L191_Y0.8900.77
207_A216_E0.8900.77
98_Q130_E0.8860.77
98_Q164_V0.8850.77
231_R234_D0.8810.77
72_E235_M0.8810.77
117_V179_F0.8650.75
54_F73_I0.8630.75
69_A90_H0.8590.75
53_Y100_R0.8590.75
24_P30_G0.8520.74
195_P221_R0.8510.74
43_S83_L0.8490.74
113_D179_F0.8450.74
213_M239_P0.8300.72
134_V201_V0.8250.72
202_L206_G0.8230.72
237_E240_S0.8160.71
47_C73_I0.8150.71
40_E213_M0.8100.70
41_A214_D0.8070.70
110_A179_F0.8020.70
216_E220_D0.8020.70
132_H187_E0.8000.69
122_G154_F0.7960.69
202_L214_D0.7950.69
49_V194_D0.7880.68
138_V203_A0.7870.68
221_R228_V0.7840.68
33_V202_L0.7740.67
106_L165_G0.7730.67
58_V172_G0.7730.67
116_D143_L0.7730.67
44_E134_V0.7670.66
100_R104_A0.7670.66
26_V163_I0.7620.66
76_V85_V0.7580.65
231_R235_M0.7570.65
104_A109_A0.7560.65
107_D110_A0.7560.65
86_V114_A0.7530.65
33_V199_K0.7520.65
48_R72_E0.7510.65
224_E227_E0.7480.64
24_P121_G0.7470.64
165_G169_L0.7470.64
90_H191_Y0.7340.63
60_V229_V0.7280.62
56_P195_P0.7280.62
54_F232_L0.7270.62
28_H102_T0.7230.62
210_D239_P0.7180.61
230_S234_D0.7150.61
200_A204_V0.7140.61
30_G121_G0.7120.60
165_G168_G0.7060.60
35_E63_D0.7030.59
64_S165_G0.7000.59
21_E167_S0.6890.58
178_G222_A0.6880.58
16_D19_L0.6850.57
117_V244_E0.6850.57
80_G170_L0.6820.57
26_V189_S0.6820.57
71_A88_G0.6810.57
59_T67_E0.6780.57
111_E156_S0.6770.57
98_Q127_E0.6730.56
92_A174_G0.6720.56
78_T212_E0.6700.56
145_D231_R0.6690.56
122_G153_E0.6680.56
129_V189_S0.6660.55
25_G127_E0.6590.55
141_A144_K0.6590.55
109_A174_G0.6570.54
63_D245_D0.6550.54
17_P84_L0.6530.54
38_I85_V0.6510.54
68_L162_G0.6510.54
121_G162_G0.6490.53
25_G163_I0.6480.53
37_V76_V0.6470.53
81_R210_D0.6410.53
53_Y222_A0.6400.52
19_L108_A0.6400.52
161_G194_D0.6370.52
170_L186_G0.6350.52
44_E75_A0.6350.52
25_G55_P0.6300.51
30_G168_G0.6280.51
55_P68_L0.6240.51
65_V141_A0.6220.50
196_K199_K0.6190.50
120_L126_G0.6190.50
27_G194_D0.6180.50
105_F144_K0.6150.50
127_E131_D0.6100.49
15_D212_E0.6090.49
96_V198_A0.6080.49
66_A185_M0.6030.48
110_A178_G0.5980.48
26_V98_Q0.5950.47
42_D237_E0.5950.47
95_T243_D0.5940.47
120_L205_L0.5940.47
82_D145_D0.5880.47
49_V95_T0.5860.46
62_D143_L0.5820.46
25_G121_G0.5810.46
38_I87_T0.5800.46
112_F115_T0.5790.46
22_G166_S0.5770.45
88_G98_Q0.5770.45
69_A92_A0.5760.45
101_V105_F0.5750.45
15_D141_A0.5740.45
57_Q162_G0.5720.45
26_V183_C0.5720.45
142_A203_A0.5700.45
17_P75_A0.5690.44
183_C209_L0.5690.44
32_L36_H0.5690.44
175_G181_A0.5680.44
126_G190_G0.5680.44
19_L73_I0.5680.44
138_V143_L0.5670.44
28_H161_G0.5670.44
46_V67_E0.5660.44
228_V231_R0.5660.44
122_G168_G0.5630.44
29_V197_A0.5630.44
125_T163_I0.5600.43
18_A237_E0.5590.43
217_A222_A0.5590.43
124_P162_G0.5560.43
24_P225_M0.5540.43
147_L155_R0.5540.43
30_G165_G0.5530.43
163_I191_Y0.5530.43
145_D241_P0.5510.42
32_L181_A0.5500.42
39_A234_D0.5480.42
162_G191_Y0.5470.42
137_A183_C0.5460.42
29_V147_L0.5460.42
143_L170_L0.5450.42
139_S175_G0.5440.42
121_G164_V0.5440.42
128_L243_D0.5390.41
152_V170_L0.5380.41
140_S239_P0.5380.41
74_H89_D0.5340.41
64_S101_V0.5340.41
23_L185_M0.5340.41
181_A227_E0.5340.41
27_G46_V0.5330.40
20_V156_S0.5330.40
197_A238_T0.5320.40
130_E189_S0.5320.40
142_A145_D0.5310.40
217_A221_R0.5310.40
23_L121_G0.5290.40
25_G98_Q0.5290.40
26_V29_V0.5280.40
48_R74_H0.5240.39
88_G191_Y0.5230.39
102_T237_E0.5230.39
52_E95_T0.5220.39
41_A241_P0.5210.39
71_A166_S0.5200.39
71_A86_V0.5190.39
162_G185_M0.5190.39
25_G90_H0.5160.39
35_E67_E0.5160.39
63_D223_E0.5150.38
169_L220_D0.5150.38
92_A127_E0.5140.38
35_E87_T0.5120.38
40_E100_R0.5100.38
239_P243_D0.5090.38
170_L208_R0.5080.38
165_G209_L0.5080.38
56_P98_Q0.5080.38
90_H130_E0.5070.38
157_E162_G0.5060.38
134_V195_P0.5060.38
47_C213_M0.5060.38
107_D156_S0.5060.38
120_L213_M0.5050.37
25_G56_P0.5010.37
37_V206_G0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gaaA 5 0.932 100 0.21 Contact Map
3wz2A 3 0.912 100 0.215 Contact Map
3vr0A 3 0.92 100 0.216 Contact Map
2wamA 4 0.964 100 0.273 Contact Map
3e35A 3 0.94 100 0.291 Contact Map
2p90A 3 0.952 100 0.293 Contact Map
3mnfA 4 0.868 100 0.294 Contact Map
4g4sP 1 0.632 99.9 0.632 Contact Map
3l9wA 2 0.636 55.8 0.941 Contact Map
3e48A 2 0.888 50.3 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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