GREMLIN Database
IF2A - Translation initiation factor 2 subunit alpha
UniProt: Q9HRT8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (231)
Sequences: 766 (567)
Seq/√Len: 37.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_G78_L5.7301.00
43_E68_G3.6221.00
79_S84_N3.5211.00
29_L78_L3.3621.00
16_K61_T2.8671.00
135_G138_Q2.7561.00
64_A80_L2.7301.00
132_L136_F2.4281.00
198_A201_G2.3501.00
187_D191_T2.2860.99
15_G62_V2.2810.99
208_E214_T2.2460.99
13_V64_A2.1610.99
25_V56_V2.1160.99
15_G26_F2.0950.99
133_Y136_F2.0940.99
131_S135_G2.0910.99
39_V75_Q2.0180.99
23_F40_H1.9630.98
136_F139_A1.9610.98
47_G50_K1.9160.98
145_E149_D1.9150.98
142_H145_E1.8930.98
38_L42_S1.8880.98
216_V220_E1.8630.98
69_V80_L1.8460.98
16_K28_D1.8340.97
224_R227_A1.8330.97
119_R124_G1.8310.97
208_E212_D1.8200.97
227_A233_A1.7880.97
210_D214_T1.7790.97
12_L63_V1.7580.97
209_V212_D1.7500.97
39_V80_L1.7410.97
30_E45_A1.7100.96
118_F122_A1.7050.96
207_D212_D1.6810.96
101_A132_L1.6760.96
96_K100_K1.6220.95
194_D200_E1.6020.94
224_R228_P1.5380.93
207_D214_T1.5350.93
16_K30_E1.5080.92
145_E162_E1.4990.92
135_G142_H1.4980.92
39_V64_A1.4970.92
188_G192_I1.4750.92
126_L131_S1.4730.92
130_G136_F1.4530.91
15_G39_V1.4480.91
211_L216_V1.4460.91
118_F123_N1.4430.91
75_Q80_L1.4320.90
223_L226_Q1.4160.90
20_I49_I1.4060.89
18_D36_R1.4020.89
9_E22_D1.3950.89
39_V70_D1.3880.89
207_D211_L1.3820.89
116_D119_R1.3710.88
181_L192_I1.3380.87
50_K66_V1.3340.87
44_V56_V1.3320.87
23_F38_L1.3220.86
31_Q50_K1.3140.86
28_D34_D1.3080.86
205_V210_D1.2900.85
109_F128_D1.2890.85
19_D58_E1.2720.84
30_E61_T1.2650.84
13_V80_L1.2560.83
12_L44_V1.2430.83
76_I80_L1.2300.82
210_D217_G1.2200.81
131_S137_E1.2090.81
188_G215_Y1.2060.81
23_F41_V1.1910.80
185_D191_T1.1910.80
18_D44_V1.1890.80
36_R79_S1.1780.79
17_V53_R1.1760.79
38_L67_L1.1760.79
75_Q78_L1.1630.78
165_R194_D1.1600.78
223_L227_A1.1560.78
217_G220_E1.1540.78
41_V64_A1.1480.77
27_V39_V1.1440.77
164_A181_L1.1340.76
98_E101_A1.1320.76
40_H67_L1.1220.76
209_V237_L1.1180.75
38_L49_I1.1180.75
148_A151_A1.1160.75
11_E32_Y1.1140.75
67_L79_S1.1110.75
131_S136_F1.1070.75
43_E48_W1.1020.74
214_T217_G1.1010.74
26_F38_L1.0970.74
153_E156_E1.0930.74
19_D36_R1.0730.72
7_P66_V1.0720.72
207_D217_G1.0690.72
205_V212_D1.0660.72
43_E81_K1.0650.72
194_D202_N1.0650.72
70_D87_Q1.0630.72
225_V228_P1.0480.71
22_D41_V1.0450.70
220_E223_L1.0370.70
207_D210_D1.0320.69
223_L229_N1.0260.69
66_V158_D1.0240.69
121_I125_L1.0220.69
208_E217_G1.0210.68
115_D126_L1.0130.68
8_D68_G1.0120.68
151_A155_D1.0080.67
7_P13_V1.0080.67
205_V209_V1.0080.67
130_G134_D1.0070.67
202_N210_D1.0000.67
44_V52_V0.9820.65
145_E151_A0.9810.65
223_L237_L0.9740.65
14_V30_E0.9710.65
146_A150_T0.9630.64
144_H148_A0.9600.64
7_P31_Q0.9550.63
114_A120_R0.9510.63
13_V75_Q0.9440.62
231_K235_S0.9380.62
90_D94_E0.9360.62
21_E37_G0.9350.62
164_A170_V0.9330.61
212_D216_V0.9290.61
87_Q92_I0.9260.61
7_P69_V0.9250.61
212_D217_G0.9170.60
225_V230_Y0.9120.60
119_R148_A0.9120.60
193_K196_L0.9090.59
102_D122_A0.9080.59
40_H46_S0.9030.59
32_Y79_S0.8910.58
23_F81_K0.8900.58
119_R128_D0.8840.57
66_V155_D0.8800.57
187_D194_D0.8780.57
87_Q173_V0.8710.56
121_I124_G0.8700.56
59_D78_L0.8680.56
122_A127_A0.8660.56
61_T80_L0.8660.56
132_L135_G0.8650.56
119_R139_A0.8600.55
115_D121_I0.8530.55
210_D216_V0.8480.54
126_L132_L0.8480.54
219_P222_R0.8480.54
131_S134_D0.8410.53
112_D118_F0.8370.53
199_A213_V0.8350.53
151_A159_A0.8320.53
160_I164_A0.8310.53
174_T213_V0.8310.53
11_E235_S0.8260.52
121_I129_F0.8240.52
66_V69_V0.8220.52
119_R151_A0.8200.52
120_R156_E0.8190.52
193_K200_E0.8180.51
217_G225_V0.8160.51
232_T238_E0.8120.51
68_G73_A0.8110.51
208_E211_L0.8060.50
20_I41_V0.8040.50
18_D21_E0.8010.50
130_G140_A0.7980.50
117_Q127_A0.7910.49
40_H77_D0.7870.49
57_N63_V0.7820.48
205_V208_E0.7810.48
16_K21_E0.7790.48
148_A155_D0.7780.48
22_D25_V0.7780.48
13_V76_I0.7780.48
146_A149_D0.7760.48
31_Q69_V0.7750.48
201_G238_E0.7730.47
218_A221_Y0.7720.47
44_V58_E0.7700.47
10_G100_K0.7650.47
222_R234_E0.7620.46
99_Q102_D0.7620.46
211_L214_T0.7580.46
118_F121_I0.7580.46
81_K85_D0.7580.46
23_F42_S0.7570.46
117_Q122_A0.7540.46
38_L44_V0.7520.46
211_L218_A0.7520.46
202_N226_Q0.7500.45
12_L57_N0.7480.45
149_D153_E0.7470.45
69_V136_F0.7440.45
224_R236_A0.7440.45
105_L124_G0.7430.45
143_G146_A0.7420.45
210_D236_A0.7410.45
23_F62_V0.7400.45
16_K19_D0.7350.44
196_L213_V0.7350.44
87_Q171_P0.7280.43
191_T194_D0.7280.43
234_E237_L0.7280.43
68_G75_Q0.7260.43
14_V29_L0.7230.43
224_R232_T0.7140.42
109_F117_Q0.7140.42
102_D105_L0.7100.42
230_Y234_E0.7090.42
41_V71_E0.7080.42
9_E185_D0.6950.41
46_S75_Q0.6920.40
159_A163_T0.6910.40
26_F75_Q0.6880.40
181_L187_D0.6850.40
85_D90_D0.6840.40
219_P223_L0.6830.40
139_A142_H0.6790.39
58_E72_S0.6780.39
110_G162_E0.6780.39
217_G221_Y0.6780.39
39_V62_V0.6780.39
12_L15_G0.6780.39
23_F39_V0.6770.39
12_L52_V0.6750.39
114_A148_A0.6730.39
163_T166_D0.6710.39
226_Q235_S0.6700.39
215_Y218_A0.6630.38
133_Y138_Q0.6620.38
145_E158_D0.6610.38
49_I61_T0.6570.37
6_W60_Q0.6560.37
130_G133_Y0.6560.37
147_L152_L0.6540.37
102_D126_L0.6540.37
205_V214_T0.6460.37
186_G194_D0.6440.36
34_D185_D0.6440.36
217_G222_R0.6390.36
24_G29_L0.6380.36
96_K101_A0.6350.36
180_S183_S0.6310.35
29_L174_T0.6290.35
18_D28_D0.6290.35
25_V55_H0.6270.35
57_N65_K0.6250.35
19_D78_L0.6240.35
177_G180_S0.6210.35
34_D206_P0.6210.35
53_R69_V0.6210.35
23_F46_S0.6190.34
133_Y173_V0.6190.34
49_I187_D0.6170.34
179_V183_S0.6140.34
17_V46_S0.6120.34
202_N205_V0.6100.34
124_G135_G0.6100.34
225_V233_A0.6100.34
11_E61_T0.6090.34
12_L84_N0.6080.33
200_E232_T0.6080.33
138_Q155_D0.6080.33
207_D232_T0.6080.33
218_A223_L0.6070.33
223_L228_P0.6040.33
217_G223_L0.6020.33
111_E162_E0.5980.33
31_Q52_V0.5980.33
36_R190_D0.5980.33
95_W188_G0.5980.33
161_V165_R0.5970.33
78_L92_I0.5950.32
106_T110_G0.5940.32
86_H93_Q0.5900.32
140_A145_E0.5880.32
20_I44_V0.5870.32
113_M152_L0.5840.32
209_V214_T0.5840.32
158_D162_E0.5820.31
39_V58_E0.5810.31
103_K106_T0.5780.31
124_G150_T0.5770.31
54_D86_H0.5760.31
66_V83_V0.5760.31
202_N236_A0.5730.31
42_S48_W0.5680.30
32_Y42_S0.5670.30
25_V29_L0.5640.30
62_V116_D0.5630.30
84_N87_Q0.5590.30
49_I55_H0.5570.30
22_D52_V0.5540.29
22_D38_L0.5540.29
184_P187_D0.5510.29
212_D218_A0.5500.29
105_L108_A0.5500.29
15_G27_V0.5480.29
27_V43_E0.5480.29
208_E236_A0.5480.29
105_L122_A0.5480.29
95_W99_Q0.5450.29
200_E226_Q0.5450.29
86_H90_D0.5450.29
29_L77_D0.5420.28
218_A227_A0.5400.28
130_G135_G0.5400.28
234_E238_E0.5380.28
140_A161_V0.5370.28
201_G210_D0.5360.28
216_V219_P0.5360.28
13_V32_Y0.5350.28
49_I58_E0.5350.28
144_H158_D0.5330.28
102_D153_E0.5280.27
91_T94_E0.5250.27
228_P234_E0.5230.27
120_R142_H0.5210.27
65_K80_L0.5200.27
214_T231_K0.5190.27
131_S138_Q0.5180.27
232_T237_L0.5160.27
106_T111_E0.5150.27
230_Y233_A0.5110.26
39_V42_S0.5110.26
42_S49_I0.5110.26
114_A124_G0.5110.26
106_T109_F0.5060.26
93_Q97_N0.5020.26
200_E213_V0.5010.26
195_A201_G0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j81j 1 0.9139 100 0.296 Contact Map
1q8kA 1 0.9888 100 0.308 Contact Map
3aevA 1 0.6217 100 0.334 Contact Map
3cw2C 1 0.9738 100 0.344 Contact Map
1yz7A 1 0.6517 100 0.525 Contact Map
1kl9A 2 0.5768 99.9 0.57 Contact Map
2a19A 1 0.588 99.9 0.576 Contact Map
4aidA 3 0 99.7 0.694 Contact Map
3psfA 1 0.1124 99.7 0.694 Contact Map
1luzA 1 0.3146 99.7 0.696 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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