GREMLIN Database
RL44E - 50S ribosomal protein L44e
UniProt: Q9HRT6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 93 (89)
Sequences: 371 (174)
Seq/√Len: 18.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_S30_S4.6841.00
30_S37_A3.6981.00
71_R78_A3.0340.99
11_C75_C2.8610.99
37_A41_K2.4870.96
9_S20_L2.1970.93
11_C14_C2.1480.92
14_C75_C2.0140.89
66_T89_L1.9770.88
40_T43_A1.8530.85
6_R19_Q1.8260.84
32_G37_A1.7720.82
21_E26_R1.7600.82
43_A52_R1.6640.78
41_K52_R1.6130.75
39_R54_S1.5750.74
40_T52_R1.5270.71
15_D77_N1.4910.69
85_R90_V1.4310.66
74_E81_R1.3970.64
31_S35_W1.3710.63
11_C17_H1.3640.62
31_S37_A1.3260.60
15_D19_Q1.3080.59
12_P77_N1.3020.59
16_E74_E1.3000.58
44_N50_H1.2860.58
18_H76_G1.2450.55
76_G80_L1.1720.51
42_R88_R1.1690.50
2_E5_R1.1130.47
10_Y16_E1.1120.47
38_R72_C1.0930.46
3_M68_L1.0920.46
73_S82_E1.0840.45
36_D40_T1.0840.45
13_N74_E1.0740.44
37_A51_G1.0700.44
24_K58_V1.0570.43
42_R45_A1.0410.42
10_Y19_Q1.0240.41
3_M9_S1.0230.41
36_D39_R1.0040.40
15_D18_H1.0030.40
67_D91_L0.9990.40
61_K64_N0.9980.40
36_D54_S0.9960.40
70_Y79_H0.9930.40
62_P78_A0.9830.39
3_M6_R0.9690.38
36_D49_N0.9620.38
49_N54_S0.9550.37
14_C61_K0.9460.37
51_G56_V0.8800.33
49_N56_V0.8790.33
38_R61_K0.8660.32
49_N57_P0.8620.32
38_R75_C0.8620.32
5_R91_L0.8600.32
2_E88_R0.8590.32
12_P81_R0.8550.32
55_K77_N0.8490.31
29_R90_V0.8380.31
69_K78_A0.8370.31
40_T44_N0.8370.31
5_R68_L0.8330.30
44_N51_G0.8320.30
77_N80_L0.8300.30
11_C63_T0.8240.30
42_R90_V0.8140.29
70_Y82_E0.8130.29
17_H22_A0.8130.29
48_G52_R0.8130.29
19_Q80_L0.7930.28
25_V78_A0.7900.28
42_R47_I0.7710.27
21_E71_R0.7680.27
37_A42_R0.7650.27
8_N77_N0.7590.27
58_V89_L0.7440.26
68_L71_R0.7160.25
2_E64_N0.7150.25
38_R48_G0.7120.24
22_A68_L0.7050.24
31_S34_K0.6980.24
55_K59_G0.6920.24
43_A50_H0.6910.24
18_H80_L0.6810.23
8_N69_K0.6790.23
19_Q79_H0.6760.23
16_E89_L0.6680.23
14_C17_H0.6670.22
56_V59_G0.6650.22
40_T51_G0.6650.22
6_R82_E0.6640.22
28_G65_R0.6460.22
79_H83_G0.6320.21
5_R14_C0.6320.21
73_S79_H0.6270.21
11_C38_R0.6270.21
61_K72_C0.6180.20
80_L88_R0.6090.20
67_D71_R0.6070.20
19_Q73_S0.6010.20
39_R42_R0.5980.20
12_P79_H0.5970.20
69_K74_E0.5870.19
12_P33_M0.5850.19
3_M10_Y0.5840.19
6_R89_L0.5840.19
18_H78_A0.5800.19
35_W52_R0.5770.19
72_C90_V0.5740.19
57_P77_N0.5620.18
41_K44_N0.5590.18
21_E45_A0.5550.18
20_L33_M0.5540.18
49_N59_G0.5350.17
42_R52_R0.5320.17
36_D46_S0.5310.17
43_A51_G0.5290.17
44_N52_R0.5280.17
61_K85_R0.5270.17
71_R76_G0.5270.17
70_Y80_L0.5230.17
62_P66_T0.5190.17
60_N65_R0.5190.17
34_K60_N0.5180.17
79_H91_L0.5150.17
13_N55_K0.5150.17
10_Y33_M0.5070.16
2_E63_T0.5070.16
40_T50_H0.5040.16
73_S77_N0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j21j 1 0.9892 100 0.09 Contact Map
4a18C 1 0.9892 100 0.093 Contact Map
1vx7i 1 0.9892 100 0.097 Contact Map
1vq83 1 0.9785 100 0.098 Contact Map
3j39o 1 0.9892 100 0.101 Contact Map
3zf7t 1 0.9892 100 0.105 Contact Map
4ujrb 1 0.9892 100 0.116 Contact Map
1vw4X 1 0.4301 84.4 0.89 Contact Map
4rb66 1 0.2688 61 0.909 Contact Map
4tp91 1 0.2581 59.6 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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