GREMLIN Database
Q9HRT3 - Succinoglycan biosynthesis transport protein
UniProt: Q9HRT3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 518 (463)
Sequences: 17135 (14713)
Seq/√Len: 683.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
309_D312_T4.7981.00
237_R241_D3.4531.00
167_S170_G3.1551.00
124_A127_R3.1511.00
66_A277_N3.0111.00
95_D98_R2.9901.00
382_H385_A2.9481.00
354_Y358_A2.9291.00
443_A447_R2.9151.00
166_G303_R2.7141.00
336_L358_A2.6981.00
382_H435_F2.6791.00
384_Y388_A2.6021.00
275_V352_R2.3441.00
91_L164_A2.3361.00
339_G354_Y2.2461.00
260_D276_Y2.2451.00
359_V411_V2.2321.00
122_W143_R2.2191.00
393_L424_Q2.2161.00
444_T447_R2.1791.00
366_V422_A2.1171.00
340_R344_A2.1131.00
458_A483_S2.1121.00
260_D401_T2.0871.00
339_G358_A2.0761.00
400_L416_G2.0641.00
248_M387_M2.0631.00
264_V268_L2.0581.00
304_L312_T2.0541.00
269_T272_A2.0241.00
196_S199_G2.0241.00
34_V169_R2.0121.00
303_R307_A2.0031.00
356_P410_L1.9931.00
139_P143_R1.9861.00
315_A319_S1.9811.00
359_V418_S1.9801.00
90_Y242_H1.9781.00
408_F415_L1.9461.00
58_G61_A1.9451.00
233_R237_R1.9321.00
101_R232_L1.9171.00
405_V413_A1.9061.00
334_V338_F1.9041.00
338_F341_D1.9021.00
389_L427_L1.9021.00
310_I314_N1.8721.00
263_L405_V1.8341.00
121_V146_G1.8241.00
268_L272_A1.8221.00
89_R93_A1.7991.00
98_R101_R1.7971.00
481_L485_L1.7781.00
263_L401_T1.7411.00
328_V368_S1.7331.00
260_D417_T1.7241.00
333_A456_A1.7151.00
455_M480_G1.7121.00
26_V30_H1.7061.00
455_M459_M1.7031.00
312_T315_A1.6941.00
55_R347_G1.6881.00
409_K412_G1.6771.00
396_L423_V1.6741.00
125_A143_R1.6721.00
67_L265_G1.6651.00
348_P351_T1.6651.00
334_V477_V1.6541.00
126_P139_P1.6531.00
232_L235_D1.6451.00
100_S104_G1.6311.00
268_L410_L1.6281.00
305_H380_T1.6131.00
317_Y376_L1.6121.00
412_G416_G1.6071.00
404_F416_G1.5961.00
355_G411_V1.5881.00
167_S222_V1.5811.00
341_D344_A1.5771.00
252_G391_W1.5751.00
54_A278_V1.5721.00
161_T165_D1.5621.00
404_F408_F1.5571.00
335_E361_L1.5571.00
459_M480_G1.5461.00
426_A430_L1.5461.00
166_G300_V1.5351.00
264_V413_A1.5271.00
329_V452_G1.5271.00
359_V415_L1.5221.00
332_L365_F1.5201.00
343_L353_G1.5181.00
326_T488_L1.5181.00
401_T405_V1.5161.00
65_Y69_W1.4981.00
340_R358_A1.4961.00
340_R354_Y1.4941.00
301_A313_L1.4901.00
366_V425_N1.4871.00
343_L357_L1.4841.00
359_V414_A1.4811.00
356_P414_A1.4791.00
68_A145_L1.4781.00
283_V360_Y1.4761.00
456_A460_L1.4691.00
169_R173_L1.4591.00
399_A403_V1.4431.00
263_L402_Y1.4391.00
338_F342_L1.4371.00
314_N318_S1.4331.00
403_V406_V1.4311.00
355_G358_A1.4301.00
87_L106_A1.4251.00
416_G420_A1.4201.00
183_R207_S1.4131.00
313_L376_L1.4031.00
451_A487_A1.4001.00
430_L434_R1.3981.00
363_G418_S1.3911.00
272_A410_L1.3901.00
93_A381_D1.3891.00
264_V273_A1.3861.00
388_A392_L1.3761.00
454_V487_A1.3701.00
279_V356_P1.3691.00
186_G203_A1.3661.00
199_G203_A1.3521.00
259_A398_V1.3391.00
195_Y199_G1.3351.00
103_T161_T1.3331.00
304_L316_V1.3261.00
245_P387_M1.3251.00
182_V210_V1.3251.00
41_A177_L1.3251.00
397_N401_T1.3241.00
311_D315_A1.3171.00
40_S44_A1.3101.00
50_E281_V1.3081.00
312_T316_V1.3051.00
279_V353_G1.2931.00
451_A455_M1.2931.00
174_F214_L1.2911.00
334_V455_M1.2701.00
325_V329_V1.2681.00
297_L320_V1.2591.00
47_A51_F1.2541.00
51_F55_R1.2521.00
343_L354_Y1.2511.00
141_A201_A1.2501.00
461_G465_L1.2481.00
263_L267_L1.2461.00
389_L431_L1.2371.00
404_F407_E1.2301.00
66_A274_G1.2231.00
397_N417_T1.2191.00
362_A418_S1.2181.00
59_P275_V1.2171.00
150_V153_G1.2131.00
352_R355_G1.2121.00
59_P349_T1.2041.00
461_G464_S1.2001.00
484_Y488_L1.1971.00
49_V184_L1.1911.00
275_V353_G1.1901.00
403_V407_E1.1901.00
42_Q180_P1.1891.00
264_V276_Y1.1791.00
347_G350_Y1.1751.00
174_F215_G1.1741.00
310_I380_T1.1741.00
389_L428_Q1.1701.00
411_V414_A1.1691.00
485_L489_S1.1641.00
86_T242_H1.1631.00
258_R261_I1.1601.00
65_Y200_V1.1591.00
38_G172_V1.1561.00
44_A48_V1.1551.00
318_S322_R1.1541.00
106_A239_F1.1431.00
401_T417_T1.1391.00
408_F412_G1.1361.00
244_A248_M1.1301.00
126_P143_R1.1301.00
50_E346_F1.1251.00
305_H313_L1.1231.00
332_L336_L1.1231.00
301_A379_M1.1231.00
112_G116_L1.1131.00
317_Y373_T1.1131.00
341_D463_R1.1121.00
151_L209_L1.1101.00
245_P384_Y1.1091.00
158_Y216_F1.1041.00
213_V217_P1.1041.00
363_G414_A1.1021.00
67_L273_A1.1021.00
62_Y66_A1.1011.00
376_L432_L1.1011.00
105_L236_A1.0991.00
118_T122_W1.0971.00
127_R130_A1.0961.00
298_P302_S1.0951.00
109_T236_A1.0941.00
59_P274_G1.0921.00
249_S386_R1.0831.00
452_G456_A1.0731.00
90_Y93_A1.0731.00
185_V189_T1.0721.00
151_L212_V1.0721.00
252_G387_M1.0721.00
274_G277_N1.0711.00
460_L464_S1.0691.00
93_A238_R1.0671.00
123_L126_P1.0651.00
35_T296_L1.0651.00
61_A64_V1.0631.00
391_W395_V1.0621.00
92_P164_A1.0591.00
373_T428_Q1.0581.00
356_P411_V1.0551.00
335_E357_L1.0551.00
336_L339_G1.0541.00
397_N420_A1.0531.00
147_V205_A1.0531.00
252_G394_A1.0511.00
101_R105_L1.0491.00
189_T193_L1.0481.00
396_L400_L1.0461.00
125_A139_P1.0411.00
168_A296_L1.0381.00
256_Q397_N1.0381.00
32_A296_L1.0381.00
388_A391_W1.0371.00
260_D397_N1.0361.00
448_P452_G1.0361.00
27_T30_H1.0331.00
401_T404_F1.0311.00
188_L192_A1.0311.00
373_T429_V1.0301.00
91_L99_R1.0281.00
118_T121_V1.0271.00
255_F394_A1.0261.00
202_G206_A1.0231.00
88_Q160_A1.0221.00
238_R381_D1.0201.00
86_T243_A1.0151.00
264_V410_L1.0141.00
395_V399_A1.0131.00
385_A431_L1.0081.00
126_P130_A1.0021.00
80_T84_V1.0011.00
457_A461_G1.0001.00
73_Q77_R1.0001.00
407_E411_V0.9991.00
56_G191_L0.9971.00
108_V112_G0.9971.00
170_G218_L0.9931.00
186_G190_A0.9931.00
122_W126_P0.9931.00
351_T354_Y0.9911.00
477_V481_L0.9901.00
147_V150_V0.9901.00
52_A56_G0.9891.00
242_H383_Q0.9881.00
474_A478_L0.9881.00
190_A195_Y0.9861.00
271_V275_V0.9841.00
267_L405_V0.9831.00
32_A293_F0.9811.00
363_G366_V0.9811.00
203_A207_S0.9811.00
279_V360_Y0.9801.00
430_L433_R0.9801.00
162_F219_T0.9791.00
86_T239_F0.9781.00
216_F220_A0.9741.00
45_L184_L0.9731.00
427_L431_L0.9681.00
54_A346_F0.9661.00
338_F476_G0.9661.00
369_A425_N0.9611.00
358_A362_A0.9551.00
439_W442_D0.9531.00
311_D314_N0.9521.00
31_G166_G0.9511.00
427_L430_L0.9441.00
35_T172_V0.9391.00
300_V304_L0.9371.00
406_V413_A0.9371.00
186_G206_A0.9361.00
415_L418_S0.9341.00
83_S106_A0.9341.00
377_L431_L0.9321.00
187_A203_A0.9311.00
91_L165_D0.9301.00
217_P221_R0.9291.00
64_V270_A0.9291.00
87_L91_L0.9281.00
463_R476_G0.9281.00
300_V303_R0.9281.00
207_S211_L0.9281.00
400_L404_F0.9251.00
304_L309_D0.9251.00
235_D238_R0.9221.00
330_P484_Y0.9211.00
269_T273_A0.9191.00
53_L200_V0.9181.00
418_S421_I0.9161.00
98_R235_D0.9151.00
120_G124_A0.9141.00
231_G236_A0.9131.00
143_R147_V0.9111.00
39_V43_R0.9101.00
198_V201_A0.9101.00
144_L205_A0.9071.00
472_A476_G0.9051.00
234_R237_R0.9041.00
137_S140_A0.9041.00
97_R101_R0.9031.00
240_Y244_A0.9031.00
123_L127_R0.9021.00
99_R165_D0.8971.00
82_G243_A0.8941.00
276_Y360_Y0.8921.00
415_L419_L0.8911.00
341_D476_G0.8861.00
118_T150_V0.8861.00
460_L463_R0.8851.00
378_M386_R0.8841.00
140_A198_V0.8841.00
240_Y243_A0.8821.00
33_V37_G0.8781.00
214_L218_L0.8771.00
360_Y414_A0.8741.00
423_V427_L0.8741.00
402_Y406_V0.8741.00
452_G455_M0.8741.00
89_R381_D0.8731.00
477_V480_G0.8721.00
112_G115_L0.8711.00
273_A277_N0.8701.00
400_L419_L0.8641.00
274_G278_V0.8631.00
58_G350_Y0.8601.00
131_A135_H0.8601.00
313_L380_T0.8581.00
202_G205_A0.8551.00
333_A452_G0.8541.00
324_I368_S0.8491.00
146_G150_V0.8481.00
29_S33_V0.8471.00
336_L340_R0.8461.00
36_S292_S0.8461.00
58_G349_T0.8461.00
68_A141_A0.8461.00
102_V106_A0.8461.00
339_G357_L0.8441.00
116_L120_G0.8441.00
183_R187_A0.8431.00
136_P140_A0.8421.00
470_S477_V0.8401.00
330_P333_A0.8391.00
125_A146_G0.8391.00
148_V208_M0.8381.00
400_L403_V0.8361.00
65_Y197_V0.8291.00
336_L362_A0.8291.00
151_L205_A0.8291.00
204_Y208_M0.8271.00
45_L49_V0.8251.00
140_A143_R0.8241.00
241_D244_A0.8231.00
353_G356_P0.8221.00
115_L119_A0.8191.00
283_V364_V0.8161.00
333_A337_V0.8151.00
261_I273_A0.8121.00
57_L61_A0.8111.00
60_V270_A0.8101.00
386_R390_D0.8091.00
30_H169_R0.8071.00
377_L386_R0.8041.00
322_R326_T0.8021.00
96_A100_S0.8011.00
63_G274_G0.8011.00
62_Y278_V0.8001.00
70_R261_I0.7991.00
279_V357_L0.7991.00
246_V383_Q0.7981.00
363_G417_T0.7981.00
32_A36_S0.7951.00
336_L361_L0.7941.00
104_G108_V0.7941.00
469_S472_A0.7941.00
319_S322_R0.7921.00
280_L284_S0.7921.00
464_S467_V0.7881.00
252_G390_D0.7871.00
155_V212_V0.7871.00
387_M391_W0.7871.00
296_L299_P0.7841.00
107_Y158_Y0.7841.00
51_F54_A0.7831.00
398_V402_Y0.7801.00
446_L450_A0.7781.00
34_V38_G0.7771.00
457_A460_L0.7761.00
53_L187_A0.7731.00
278_V350_Y0.7731.00
290_L294_N0.7711.00
86_T90_Y0.7701.00
462_V479_V0.7681.00
31_G296_L0.7671.00
265_G273_A0.7671.00
205_A208_M0.7651.00
448_P451_A0.7641.00
433_R436_E0.7621.00
362_A365_F0.7611.00
245_P383_Q0.7581.00
51_F346_F0.7521.00
189_T192_A0.7501.00
324_I372_A0.7491.00
114_G153_G0.7481.00
330_P452_G0.7461.00
362_A366_V0.7461.00
277_N281_V0.7451.00
93_A306_A0.7441.00
159_A163_R0.7431.00
251_F255_F0.7421.00
242_H246_V0.7411.00
316_V320_V0.7391.00
218_L222_V0.7361.00
111_A115_L0.7351.00
276_Y280_L0.7331.00
38_G177_L0.7301.00
385_A388_A0.7291.00
127_R131_A0.7291.00
298_P375_W0.7281.00
179_R183_R0.7271.00
186_G189_T0.7271.00
431_L434_R0.7261.00
28_I32_A0.7241.00
119_A123_L0.7231.00
344_A351_T0.7221.00
392_L395_V0.7221.00
281_V284_S0.7211.00
444_T448_P0.7211.00
114_G118_T0.7211.00
69_W73_Q0.7191.00
302_S306_A0.7191.00
401_T413_A0.7191.00
337_V456_A0.7181.00
281_V285_I0.7171.00
183_R203_A0.7161.00
389_L393_L0.7161.00
51_F345_L0.7151.00
105_L231_G0.7151.00
278_V281_V0.7141.00
326_T330_P0.7121.00
373_T425_N0.7091.00
80_T110_T0.7091.00
464_S468_D0.7091.00
304_L307_A0.7081.00
140_A144_L0.7081.00
316_V319_S0.7071.00
143_R146_G0.7071.00
454_V457_A0.7061.00
37_G41_A0.7061.00
96_A99_R0.7021.00
62_Y274_G0.7011.00
50_E54_A0.7011.00
52_A188_L0.7001.00
459_M476_G0.7001.00
254_V258_R0.7001.00
241_D384_Y0.6991.00
411_V415_L0.6991.00
330_P455_M0.6971.00
422_A426_A0.6971.00
278_V346_F0.6961.00
396_L399_A0.6941.00
260_D280_L0.6941.00
486_G490_V0.6931.00
392_L427_L0.6931.00
109_T113_V0.6841.00
298_P379_M0.6821.00
36_S40_S0.6821.00
154_L212_V0.6791.00
455_M458_A0.6771.00
429_V433_R0.6761.00
283_V286_A0.6761.00
108_V227_P0.6751.00
334_V480_G0.6751.00
174_F211_L0.6731.00
65_Y201_A0.6721.00
89_R383_Q0.6711.00
351_T355_G0.6701.00
377_L432_L0.6701.00
349_T352_R0.6691.00
431_L435_F0.6691.00
450_A453_A0.6681.00
179_R211_L0.6671.00
339_G361_L0.6661.00
73_Q76_S0.6661.00
88_Q164_A0.6661.00
445_F448_P0.6661.00
181_A185_V0.6641.00
29_S32_A0.6641.00
462_V465_L0.6591.00
414_A418_S0.6581.00
241_D245_P0.6571.00
88_Q92_P0.6531.00
453_A457_A0.6511.00
144_L201_A0.6491.00
87_L102_V0.6481.00
478_L481_L0.6481.00
487_A490_V0.6481.00
375_W378_M0.6461.00
256_Q394_A0.6461.00
125_A128_L0.6451.00
320_V372_A0.6431.00
246_V378_M0.6421.00
41_A45_L0.6411.00
94_A98_R0.6411.00
363_G421_I0.6411.00
54_A350_Y0.6401.00
375_W379_M0.6401.00
258_R262_L0.6391.00
272_A275_V0.6381.00
373_T432_L0.6371.00
463_R466_L0.6371.00
152_V208_M0.6301.00
142_M146_G0.6291.00
329_V365_F0.6271.00
465_L468_D0.6271.00
35_T168_A0.6271.00
205_A209_L0.6261.00
259_A263_L0.6241.00
90_Y238_R0.6241.00
476_G480_G0.6191.00
293_F297_L0.6181.00
121_V125_A0.6171.00
278_V353_G0.6161.00
249_S390_D0.6161.00
239_F243_A0.6151.00
144_L202_G0.6151.00
383_Q386_R0.6141.00
124_A128_L0.6141.00
134_D266_A0.6121.00
281_V346_F0.6121.00
173_L178_L0.6121.00
163_R171_E0.6121.00
162_F170_G0.6111.00
223_T227_P0.6101.00
462_V466_L0.6081.00
57_L197_V0.6081.00
59_P271_V0.6051.00
160_A164_A0.6051.00
59_P350_Y0.6051.00
470_S474_A0.6051.00
418_S422_A0.6041.00
97_R100_S0.6041.00
105_L233_R0.6031.00
33_V40_S0.6021.00
463_R472_A0.6021.00
215_G218_L0.5991.00
300_V316_V0.5991.00
405_V412_G0.5991.00
179_R207_S0.5971.00
180_P183_R0.5961.00
417_T420_A0.5961.00
258_R284_S0.5931.00
344_A354_Y0.5931.00
234_R238_R0.5931.00
331_I334_V0.5931.00
236_A240_Y0.5921.00
262_L266_A0.5921.00
449_L452_G0.5921.00
455_M483_S0.5911.00
459_M463_R0.5891.00
387_M390_D0.5861.00
182_V207_S0.5851.00
261_I277_N0.5841.00
261_I280_L0.5821.00
125_A142_M0.5811.00
396_L420_A0.5801.00
325_V365_F0.5801.00
478_L482_P0.5791.00
74_L254_V0.5771.00
89_R379_M0.5761.00
61_A197_V0.5761.00
108_V111_A0.5751.00
101_R104_G0.5741.00
184_L188_L0.5731.00
472_A475_A0.5731.00
267_L402_Y0.5711.00
367_G371_G0.5701.00
397_N400_L0.5701.00
366_V418_S0.5691.00
483_S487_A0.5691.00
67_L70_R0.5691.00
178_L214_L0.5691.00
357_L361_L0.5681.00
165_D222_V0.5671.00
291_L295_Q0.5661.00
158_Y219_T0.5661.00
297_L301_A0.5651.00
168_A172_V0.5641.00
26_V29_S0.5621.00
268_L409_K0.5611.00
238_R242_H0.5611.00
451_A488_L0.5611.00
170_G173_L0.5581.00
433_R437_G0.5571.00
322_R444_T0.5571.00
60_V64_V0.5541.00
136_P139_P0.5531.00
198_V202_G0.5521.00
447_R451_A0.5511.00
329_V333_A0.5511.00
313_L316_V0.5511.00
56_G192_A0.5501.00
211_L215_G0.5501.00
46_V50_E0.5501.00
217_P220_A0.5491.00
84_V160_A0.5491.00
424_Q428_Q0.5481.00
35_T39_V0.5451.00
370_V425_N0.5441.00
27_T166_G0.5441.00
108_V231_G0.5421.00
473_I477_V0.5421.00
314_N442_D0.5411.00
335_E342_L0.5401.00
374_G386_R0.5391.00
50_E62_Y0.5391.00
72_A76_S0.5391.00
474_A477_V0.5381.00
99_R103_T0.5381.00
110_T114_G0.5381.00
200_V204_Y0.5361.00
341_D472_A0.5341.00
313_L317_Y0.5331.00
190_A203_A0.5331.00
290_L371_G0.5331.00
53_L57_L0.5331.00
475_A478_L0.5321.00
53_L62_Y0.5311.00
101_R235_D0.5301.00
226_T230_R0.5301.00
267_L406_V0.5291.00
458_A461_G0.5291.00
76_S80_T0.5281.00
117_I121_V0.5281.00
182_V185_V0.5271.00
391_W394_A0.5271.00
116_L119_A0.5271.00
122_W125_A0.5261.00
67_L261_I0.5261.00
71_I75_L0.5251.00
122_W146_G0.5251.00
249_S387_M0.5251.00
393_L420_A0.5231.00
146_G149_V0.5221.00
118_T146_G0.5221.00
64_V141_A0.5221.00
104_G107_Y0.5221.00
70_R74_L0.5180.99
45_L48_V0.5180.99
401_T416_G0.5170.99
158_Y215_G0.5170.99
332_L361_L0.5150.99
159_A176_K0.5140.99
417_T421_I0.5140.99
103_T158_Y0.5140.99
46_V51_F0.5140.99
223_T226_T0.5140.99
338_F477_V0.5140.99
178_L182_V0.5130.99
115_L150_V0.5110.99
60_V63_G0.5110.99
299_P303_R0.5110.99
30_H34_V0.5100.99
211_L214_L0.5090.99
279_V283_V0.5080.99
249_S253_K0.5080.99
41_A181_A0.5070.99
310_I313_L0.5060.99
249_S252_G0.5050.99
385_A389_L0.5050.99
331_I335_E0.5030.99
374_G378_M0.5030.99
386_R428_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.8282 100 0.436 Contact Map
3w4tA 1 0.8205 100 0.445 Contact Map
4humA 1 0.8378 100 0.454 Contact Map
3mktA 1 0.8301 100 0.468 Contact Map
4j05A 3 0.7181 91.1 0.927 Contact Map
1pw4A 1 0.7761 90.9 0.927 Contact Map
3o7qA 1 0.7162 88.9 0.93 Contact Map
3wdoA 1 0.7683 86.7 0.932 Contact Map
4zw9A 1 0.8147 63.4 0.945 Contact Map
4pypA 1 0.7683 63.4 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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