GREMLIN Database
Q9HRT2 - Uncharacterized protein
UniProt: Q9HRT2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (204)
Sequences: 2708 (1823)
Seq/√Len: 127.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_T215_A4.2931.00
141_D145_E3.8681.00
180_E183_A3.6591.00
205_V223_E3.0151.00
153_P188_W2.9701.00
155_E193_D2.9631.00
219_R222_D2.8701.00
178_E182_V2.7711.00
154_N179_D2.7421.00
33_T86_Y2.6081.00
91_F107_A2.5471.00
148_S187_D2.5101.00
82_T85_E2.4111.00
147_R202_G2.3991.00
41_P73_N2.3781.00
189_D197_S2.3461.00
114_A119_D2.2821.00
148_S189_D2.2601.00
116_A138_D2.1221.00
77_P80_A2.0491.00
198_V219_R2.0181.00
159_G193_D1.9911.00
123_L220_L1.9851.00
115_V203_D1.9841.00
142_F184_V1.9381.00
200_V223_E1.9311.00
180_E184_V1.9311.00
24_T218_D1.9021.00
116_A137_T1.8511.00
200_V219_R1.8241.00
25_L220_L1.8241.00
79_A106_D1.7421.00
88_T220_L1.7091.00
192_L195_E1.6881.00
215_A219_R1.6671.00
30_F221_L1.6371.00
23_T27_D1.5931.00
18_C34_V1.5891.00
83_A113_N1.5531.00
103_Q134_W1.5341.00
150_T188_W1.5281.00
137_T141_D1.5191.00
91_F131_I1.4601.00
158_E170_G1.4201.00
25_L217_A1.4051.00
205_V216_A1.3931.00
214_A218_D1.3761.00
26_D32_V1.3671.00
123_L205_V1.3661.00
106_D109_R1.3541.00
59_A62_V1.3381.00
200_V205_V1.3351.00
109_R113_N1.3261.00
111_L135_T1.3131.00
177_V181_V1.3091.00
118_E203_D1.2631.00
133_A180_E1.2601.00
49_V63_Q1.2601.00
124_V132_L1.2551.00
124_V129_I1.2461.00
58_T61_W1.2441.00
147_R201_D1.2230.99
35_A78_L1.2110.99
76_E81_Q1.2090.99
195_E211_G1.2030.99
198_V215_A1.1990.99
34_V71_R1.1980.99
111_L122_A1.1930.99
59_A63_Q1.1910.99
28_A221_L1.1900.99
70_E74_D1.1890.99
178_E190_A1.1690.99
115_V147_R1.1640.99
132_L204_L1.1640.99
35_A76_E1.1570.99
16_E213_S1.1530.99
21_P213_S1.1450.99
26_D71_R1.1400.99
21_P90_V1.1360.99
13_Y42_A1.1270.99
134_W184_V1.1180.99
76_E80_A1.1050.99
50_D53_E1.0960.99
130_G177_V1.0910.99
55_D58_T1.0840.99
57_D60_E1.0840.99
151_G188_W1.0760.99
25_L30_F1.0750.99
91_F111_L1.0740.99
16_E20_E1.0530.98
115_V143_L1.0500.98
154_N176_W1.0280.98
92_P101_V1.0180.98
107_A131_I1.0160.98
112_R116_A1.0130.98
24_T221_L1.0100.98
13_Y44_L1.0070.98
84_A113_N0.9990.98
136_R142_F0.9890.98
26_D67_E0.9860.98
114_A122_A0.9820.98
15_G44_L0.9810.98
91_F101_V0.9810.98
105_V109_R0.9760.97
97_A101_V0.9750.97
24_T214_A0.9600.97
149_I186_A0.9500.97
33_T76_E0.9450.97
102_N134_W0.9430.97
158_E171_R0.9400.97
83_A114_A0.9400.97
76_E86_Y0.9390.97
130_G133_A0.9330.97
37_P104_D0.9300.97
36_T75_P0.9290.97
159_G194_S0.9280.97
179_D182_V0.9280.97
189_D199_T0.9200.96
108_R135_T0.9100.96
130_G175_Y0.9080.96
108_R112_R0.9070.96
194_S211_G0.9070.96
125_V216_A0.9060.96
14_W48_S0.9040.96
25_L32_V0.8980.96
156_W208_R0.8970.96
84_A117_G0.8930.96
148_S201_D0.8900.96
83_A110_L0.8900.96
55_D61_W0.8860.96
40_G75_P0.8840.95
215_A218_D0.8830.95
176_W179_D0.8810.95
89_V111_L0.8780.95
115_V122_A0.8730.95
126_C210_P0.8710.95
197_S200_V0.8670.95
15_G49_V0.8580.95
218_D222_D0.8530.95
133_A177_V0.8530.95
152_F194_S0.8520.95
69_D73_N0.8460.94
153_P156_W0.8430.94
148_S199_T0.8430.94
42_A75_P0.8420.94
155_E159_G0.8380.94
22_L26_D0.8350.94
79_A104_D0.8320.94
200_V222_D0.8100.93
55_D59_A0.8090.93
17_E126_C0.8020.93
98_E175_Y0.8010.92
47_R50_D0.8000.92
208_R212_S0.8000.92
149_I181_V0.7940.92
68_N71_R0.7900.92
36_T40_G0.7900.92
66_H69_D0.7870.92
144_A149_I0.7870.92
23_T65_V0.7810.92
112_R137_T0.7800.91
90_V216_A0.7800.91
102_N130_G0.7800.91
198_V216_A0.7790.91
95_H210_P0.7740.91
213_S217_A0.7700.91
89_V110_L0.7670.91
170_G176_W0.7660.91
60_E63_Q0.7660.91
58_T62_V0.7650.91
136_R140_G0.7640.91
113_N117_G0.7610.90
20_E213_S0.7580.90
92_P97_A0.7520.90
179_D183_A0.7440.89
22_L34_V0.7390.89
19_I68_N0.7390.89
66_H70_E0.7370.89
108_R134_W0.7360.89
19_I58_T0.7320.89
109_R112_R0.7310.89
217_A221_L0.7290.88
124_V206_T0.7270.88
33_T71_R0.7230.88
219_R223_E0.7220.88
42_A72_L0.7060.87
149_I204_L0.7030.87
45_D48_S0.6980.86
90_V125_V0.6980.86
136_R184_V0.6970.86
65_V68_N0.6960.86
23_T61_W0.6960.86
56_A62_V0.6950.86
128_T131_I0.6920.86
155_E190_A0.6870.85
40_G43_V0.6850.85
144_A181_V0.6830.85
132_L135_T0.6810.85
25_L123_L0.6780.85
97_A102_N0.6740.84
98_E177_V0.6740.84
146_G185_G0.6690.84
30_F224_L0.6680.84
56_A61_W0.6670.84
70_E73_N0.6630.83
110_L119_D0.6570.83
90_V207_A0.6570.83
95_H157_E0.6550.83
154_N158_E0.6470.82
95_H173_L0.6460.82
196_T218_D0.6450.82
136_R143_L0.6440.81
151_G186_A0.6430.81
209_G212_S0.6420.81
115_V137_T0.6420.81
112_R138_D0.6420.81
77_P106_D0.6360.81
191_E195_E0.6350.81
102_N133_A0.6340.80
30_F87_D0.6300.80
65_V69_D0.6290.80
88_T224_L0.6280.80
22_L68_N0.6280.80
160_I194_S0.6230.79
21_P25_L0.6230.79
112_R136_R0.6230.79
119_D203_D0.6190.79
102_N175_Y0.6190.79
101_V107_A0.6180.79
67_E71_R0.6140.78
13_Y92_P0.6120.78
123_L216_A0.6120.78
203_D220_L0.6100.78
22_L32_V0.6050.77
115_V118_E0.6050.77
207_A216_A0.6020.77
81_Q86_Y0.6010.77
142_F186_A0.5990.77
96_G100_D0.5980.77
191_E197_S0.5920.76
30_F86_Y0.5920.76
37_P97_A0.5910.76
124_V128_T0.5890.75
205_V220_L0.5880.75
142_F149_I0.5840.75
115_V138_D0.5820.75
146_G187_D0.5790.74
58_T63_Q0.5790.74
78_L111_L0.5780.74
83_A117_G0.5740.74
148_S197_S0.5720.73
58_T214_A0.5710.73
108_R194_S0.5690.73
188_W197_S0.5690.73
89_V107_A0.5690.73
99_W172_K0.5690.73
181_V186_A0.5680.73
182_V187_D0.5680.73
18_C92_P0.5670.73
45_D95_H0.5660.73
153_P209_G0.5650.72
112_R143_L0.5640.72
200_V203_D0.5630.72
19_I213_S0.5630.72
25_L88_T0.5620.72
129_I181_V0.5620.72
157_E209_G0.5570.71
110_L114_A0.5540.71
20_E214_A0.5540.71
56_A59_A0.5540.71
34_V42_A0.5530.71
89_V114_A0.5520.71
15_G36_T0.5500.70
57_D61_W0.5470.70
22_L65_V0.5440.70
37_P78_L0.5430.69
161_V170_G0.5420.69
196_T200_V0.5410.69
178_E188_W0.5400.69
33_T87_D0.5390.69
156_W209_G0.5390.69
107_A111_L0.5340.68
177_V180_E0.5340.68
154_N182_V0.5320.68
129_I204_L0.5300.68
61_W68_N0.5300.68
95_H160_I0.5290.67
86_Y114_A0.5280.67
191_E198_V0.5270.67
45_D157_E0.5240.67
122_A203_D0.5240.67
151_G177_V0.5230.67
24_T27_D0.5210.66
34_V75_P0.5200.66
129_I206_T0.5180.66
17_E94_G0.5170.66
99_W173_L0.5170.66
23_T57_D0.5110.65
11_E95_H0.5110.65
13_Y36_T0.5090.65
150_T197_S0.5070.64
159_G192_L0.5070.64
150_T216_A0.5040.64
63_Q69_D0.5030.64
95_H152_F0.5000.63
151_G179_D0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p5pA 1 0.9469 100 0.378 Contact Map
4i4nA 2 0.9425 100 0.4 Contact Map
3kklA 2 0.8938 100 0.408 Contact Map
4qyxA 2 0.9735 100 0.409 Contact Map
1u9cA 1 0.9204 100 0.409 Contact Map
3n7tA 2 0.9779 100 0.411 Contact Map
4lruA 1 0.9779 100 0.411 Contact Map
1n57A 2 0.9469 100 0.429 Contact Map
3l3bA 2 0.8584 100 0.517 Contact Map
4oggA 3 0.8274 100 0.54 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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