GREMLIN Database
HPRL - HGPRTase-like protein
UniProt: Q9HRT1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 188 (164)
Sequences: 4626 (2680)
Seq/√Len: 209.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_R143_D3.2391.00
154_A171_N2.8241.00
56_K115_D2.6751.00
91_G108_I2.4181.00
15_E25_P2.3471.00
95_L135_D2.3421.00
95_L139_Q2.2671.00
43_I74_M2.2061.00
55_D115_D2.1831.00
156_P160_D2.1531.00
137_L142_A2.1171.00
14_I90_P2.1091.00
98_E103_E2.0471.00
48_K167_R1.9821.00
130_L149_A1.9721.00
12_P37_L1.9171.00
39_R74_M1.8931.00
131_R135_D1.8791.00
58_V82_I1.8721.00
152_K159_L1.8671.00
46_I74_M1.8241.00
54_V77_I1.8051.00
82_I133_I1.7731.00
60_P133_I1.7531.00
112_H115_D1.7481.00
15_E27_S1.7321.00
94_A105_E1.6581.00
53_E116_R1.6561.00
47_R50_E1.6481.00
93_V140_T1.5991.00
96_S103_E1.5881.00
113_E141_G1.5471.00
156_P159_L1.5421.00
12_P34_E1.5341.00
58_V137_L1.5201.00
18_G22_F1.5161.00
134_T147_V1.4911.00
38_L69_T1.4891.00
116_R145_A1.4891.00
52_D165_D1.4781.00
72_S79_I1.4721.00
39_R73_L1.4671.00
44_R47_R1.4651.00
155_G159_L1.4581.00
30_V107_Y1.4411.00
147_V164_M1.4281.00
157_N160_D1.4031.00
45_I148_L1.4021.00
130_L147_V1.3991.00
138_E164_M1.3471.00
56_K80_V1.3061.00
49_A148_L1.3021.00
36_E76_D1.2831.00
120_L148_L1.2731.00
111_V142_A1.2711.00
158_E161_D1.2671.00
59_T79_I1.2551.00
49_A118_L1.2541.00
152_K171_N1.2531.00
49_A146_D1.2531.00
46_I71_V1.2481.00
45_I71_V1.2301.00
90_P107_Y1.2251.00
17_D25_P1.2221.00
155_G158_E1.2111.00
123_V151_I1.1941.00
119_V133_I1.1891.00
40_E43_I1.1571.00
46_I75_T1.1561.00
93_V108_I1.1501.00
99_T104_N1.1491.00
157_N161_D1.1301.00
43_I73_L1.1181.00
39_R43_I1.1171.00
68_S79_I1.1121.00
134_T164_M1.1111.00
54_V118_L1.1071.00
39_R76_D1.1011.00
168_T171_N1.1001.00
27_S155_G1.0921.00
41_I150_V1.0871.00
137_L144_V1.0771.00
57_I77_I1.0741.00
56_K78_P1.0711.00
85_R104_N1.0591.00
135_D138_E1.0391.00
48_K146_D1.0191.00
118_L146_D1.0111.00
54_V75_T1.0111.00
118_L145_A0.9851.00
49_A54_V0.9841.00
111_V137_L0.9831.00
44_R169_L0.9821.00
134_T138_E0.9781.00
46_I50_E0.9761.00
44_R48_K0.9641.00
53_E77_I0.9631.00
99_T102_S0.9561.00
93_V139_Q0.9500.99
30_V81_V0.9480.99
42_V71_V0.9470.99
138_E143_D0.9410.99
119_V130_L0.9310.99
144_V164_M0.9260.99
21_Y24_H0.9240.99
38_L70_A0.9220.99
131_R162_T0.9070.99
114_G143_D0.9070.99
55_D114_G0.9040.99
14_I31_P0.8970.99
69_T79_I0.8910.99
71_V120_L0.8850.99
58_V133_I0.8850.99
56_K111_V0.8850.99
13_I170_I0.8830.99
58_V106_M0.8820.99
135_D139_Q0.8680.99
159_L166_V0.8640.99
67_I150_V0.8580.99
66_H81_V0.8460.99
45_I48_K0.8440.99
41_I45_I0.8440.99
134_T144_V0.8430.99
33_L66_H0.8320.99
119_V134_T0.8290.99
40_E44_R0.8260.99
38_L42_V0.8220.99
66_H79_I0.8070.98
42_V70_A0.8010.98
32_M41_I0.7960.98
16_K19_Y0.7950.98
146_D165_D0.7940.98
155_G161_D0.7920.98
138_E162_T0.7910.98
42_V73_L0.7900.98
44_R167_R0.7860.98
10_D172_V0.7780.98
58_V119_V0.7760.98
70_A73_L0.7750.98
13_I109_N0.7730.98
124_L149_A0.7610.98
148_L167_R0.7600.98
119_V147_V0.7590.98
45_I120_L0.7570.97
131_R161_D0.7550.97
131_R158_E0.7490.97
156_P161_D0.7450.97
152_K168_T0.7440.97
117_V137_L0.7420.97
50_E74_M0.7390.97
138_E163_D0.7360.97
93_V106_M0.7340.97
146_D167_R0.7320.97
29_G33_L0.7300.97
85_R94_A0.7220.97
85_R105_E0.7120.96
97_Q100_G0.7090.96
52_D116_R0.7080.96
91_G107_Y0.7030.96
21_Y104_N0.7030.96
54_V57_I0.6900.96
37_L40_E0.6850.95
51_L54_V0.6840.95
55_D77_I0.6820.95
56_K112_H0.6780.95
16_K90_P0.6770.95
66_H69_T0.6760.95
109_N140_T0.6730.95
38_L66_H0.6730.95
31_P123_V0.6680.95
41_I67_I0.6670.95
48_K148_L0.6610.95
49_A52_D0.6600.94
42_V74_M0.6580.94
149_A166_V0.6560.94
9_L13_I0.6510.94
152_K156_P0.6460.94
123_V153_K0.6450.94
16_K107_Y0.6430.94
58_V111_V0.6420.94
34_E37_L0.6390.93
36_E40_E0.6340.93
9_L40_E0.6330.93
151_I172_V0.6310.93
152_K158_E0.6270.93
131_R160_D0.6260.93
83_R88_G0.6200.92
54_V146_D0.6170.92
128_G158_E0.6110.92
149_A168_T0.6080.92
108_I139_Q0.6020.91
9_L170_I0.5990.91
38_L67_I0.5990.91
45_I150_V0.5980.91
90_P108_I0.5980.91
78_P81_V0.5980.91
18_G23_V0.5950.91
35_P73_L0.5940.91
26_I87_Y0.5920.91
115_D142_A0.5890.90
119_V137_L0.5850.90
98_E102_S0.5810.90
49_A57_I0.5810.90
33_L38_L0.5810.90
48_K165_D0.5780.90
56_K117_V0.5770.90
90_P109_N0.5760.89
27_S172_V0.5760.89
29_G67_I0.5760.89
92_E107_Y0.5720.89
94_A100_G0.5710.89
57_I72_S0.5680.89
111_V115_D0.5680.89
29_G150_V0.5580.88
14_I109_N0.5510.87
38_L120_L0.5440.87
86_E105_E0.5440.87
46_I70_A0.5420.86
162_T165_D0.5400.86
87_Y104_N0.5390.86
15_E155_G0.5370.86
67_I120_L0.5320.85
115_D143_D0.5320.85
57_I75_T0.5320.85
46_I118_L0.5310.85
35_P69_T0.5280.85
163_D168_T0.5270.85
163_D166_V0.5270.85
57_I71_V0.5260.85
161_D164_M0.5250.85
29_G151_I0.5210.84
35_P83_R0.5190.84
49_A167_R0.5180.84
11_A37_L0.5160.84
13_I172_V0.5160.84
92_E105_E0.5140.83
68_S75_T0.5130.83
49_A60_P0.5120.83
97_Q128_G0.5120.83
84_K101_Y0.5110.83
60_P130_L0.5110.83
107_Y110_D0.5090.83
160_D166_V0.5070.83
130_L166_V0.5010.82
27_S153_K0.5010.82
41_I44_R0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m0kA 2 0.9096 100 0.379 Contact Map
4lzaA 2 0.8936 100 0.394 Contact Map
1qb7A 2 0.9894 100 0.486 Contact Map
2dy0A 2 0.9255 100 0.509 Contact Map
1l1qA 2 0.9309 100 0.52 Contact Map
1zn8A 2 0.9149 100 0.524 Contact Map
1g2qA 2 0.8989 100 0.534 Contact Map
1o57A 2 0.9309 100 0.55 Contact Map
1y0bA 2 0.9734 99.9 0.563 Contact Map
3qw4B 4 0.9043 99.9 0.57 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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