HPRL - HALSA - GREMLIN Contacts

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HPRL - HGPRTase-like protein

UniProt:	Q9HRT1	Sequences: MDRLKQSLLDAPIIEKDGYHYFVHPISDGVPMLEPELLREIVIRIIRKAELDEVDKIVTPAAMGIHISTAVSLMTDIPIVVIRKREYGLPGEVALSQETGYSENEMYINDVHEGDRVLVLDDVLSTGGTLRAITDALEQTGADVADVLAVIKKAGPNELDDTDMDVRTLINVDVADGEVVVVDDQGDH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	188 (164)
Sequences:	4626 (2680)
Seq/√Len:	209.2

ECOLI - APT
BACSU - APT XPT PURR
HALSA - HPRL Q9HNG3
SULSO - Q980Q2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
116_R	143_D	3.239	1.00
154_A	171_N	2.824	1.00
56_K	115_D	2.675	1.00
91_G	108_I	2.418	1.00
15_E	25_P	2.347	1.00
95_L	135_D	2.342	1.00
95_L	139_Q	2.267	1.00
43_I	74_M	2.206	1.00
55_D	115_D	2.183	1.00
156_P	160_D	2.153	1.00
137_L	142_A	2.117	1.00
14_I	90_P	2.109	1.00
98_E	103_E	2.047	1.00
48_K	167_R	1.982	1.00
130_L	149_A	1.972	1.00
12_P	37_L	1.917	1.00
39_R	74_M	1.893	1.00
131_R	135_D	1.879	1.00
58_V	82_I	1.872	1.00
152_K	159_L	1.867	1.00
46_I	74_M	1.824	1.00
54_V	77_I	1.805	1.00
82_I	133_I	1.773	1.00
60_P	133_I	1.753	1.00
112_H	115_D	1.748	1.00
15_E	27_S	1.732	1.00
94_A	105_E	1.658	1.00
53_E	116_R	1.656	1.00
47_R	50_E	1.648	1.00
93_V	140_T	1.599	1.00
96_S	103_E	1.588	1.00
113_E	141_G	1.547	1.00
156_P	159_L	1.542	1.00
12_P	34_E	1.534	1.00
58_V	137_L	1.520	1.00
18_G	22_F	1.516	1.00
134_T	147_V	1.491	1.00
38_L	69_T	1.489	1.00
116_R	145_A	1.489	1.00
52_D	165_D	1.478	1.00
72_S	79_I	1.472	1.00
39_R	73_L	1.467	1.00
44_R	47_R	1.465	1.00
155_G	159_L	1.458	1.00
30_V	107_Y	1.441	1.00
147_V	164_M	1.428	1.00
157_N	160_D	1.403	1.00
45_I	148_L	1.402	1.00
130_L	147_V	1.399	1.00
138_E	164_M	1.347	1.00
56_K	80_V	1.306	1.00
49_A	148_L	1.302	1.00
36_E	76_D	1.283	1.00
120_L	148_L	1.273	1.00
111_V	142_A	1.271	1.00
158_E	161_D	1.267	1.00
59_T	79_I	1.255	1.00
49_A	118_L	1.254	1.00
152_K	171_N	1.253	1.00
49_A	146_D	1.253	1.00
46_I	71_V	1.248	1.00
45_I	71_V	1.230	1.00
90_P	107_Y	1.225	1.00
17_D	25_P	1.222	1.00
155_G	158_E	1.211	1.00
123_V	151_I	1.194	1.00
119_V	133_I	1.189	1.00
40_E	43_I	1.157	1.00
46_I	75_T	1.156	1.00
93_V	108_I	1.150	1.00
99_T	104_N	1.149	1.00
157_N	161_D	1.130	1.00
43_I	73_L	1.118	1.00
39_R	43_I	1.117	1.00
68_S	79_I	1.112	1.00
134_T	164_M	1.111	1.00
54_V	118_L	1.107	1.00
39_R	76_D	1.101	1.00
168_T	171_N	1.100	1.00
27_S	155_G	1.092	1.00
41_I	150_V	1.087	1.00
137_L	144_V	1.077	1.00
57_I	77_I	1.074	1.00
56_K	78_P	1.071	1.00
85_R	104_N	1.059	1.00
135_D	138_E	1.039	1.00
48_K	146_D	1.019	1.00
118_L	146_D	1.011	1.00
54_V	75_T	1.011	1.00
118_L	145_A	0.985	1.00
49_A	54_V	0.984	1.00
111_V	137_L	0.983	1.00
44_R	169_L	0.982	1.00
134_T	138_E	0.978	1.00
46_I	50_E	0.976	1.00
44_R	48_K	0.964	1.00
53_E	77_I	0.963	1.00
99_T	102_S	0.956	1.00
93_V	139_Q	0.950	0.99
30_V	81_V	0.948	0.99
42_V	71_V	0.947	0.99
138_E	143_D	0.941	0.99
119_V	130_L	0.931	0.99
144_V	164_M	0.926	0.99
21_Y	24_H	0.924	0.99
38_L	70_A	0.922	0.99
131_R	162_T	0.907	0.99
114_G	143_D	0.907	0.99
55_D	114_G	0.904	0.99
14_I	31_P	0.897	0.99
69_T	79_I	0.891	0.99
71_V	120_L	0.885	0.99
58_V	133_I	0.885	0.99
56_K	111_V	0.885	0.99
13_I	170_I	0.883	0.99
58_V	106_M	0.882	0.99
135_D	139_Q	0.868	0.99
159_L	166_V	0.864	0.99
67_I	150_V	0.858	0.99
66_H	81_V	0.846	0.99
45_I	48_K	0.844	0.99
41_I	45_I	0.844	0.99
134_T	144_V	0.843	0.99
33_L	66_H	0.832	0.99
119_V	134_T	0.829	0.99
40_E	44_R	0.826	0.99
38_L	42_V	0.822	0.99
66_H	79_I	0.807	0.98
42_V	70_A	0.801	0.98
32_M	41_I	0.796	0.98
16_K	19_Y	0.795	0.98
146_D	165_D	0.794	0.98
155_G	161_D	0.792	0.98
138_E	162_T	0.791	0.98
42_V	73_L	0.790	0.98
44_R	167_R	0.786	0.98
10_D	172_V	0.778	0.98
58_V	119_V	0.776	0.98
70_A	73_L	0.775	0.98
13_I	109_N	0.773	0.98
124_L	149_A	0.761	0.98
148_L	167_R	0.760	0.98
119_V	147_V	0.759	0.98
45_I	120_L	0.757	0.97
131_R	161_D	0.755	0.97
131_R	158_E	0.749	0.97
156_P	161_D	0.745	0.97
152_K	168_T	0.744	0.97
117_V	137_L	0.742	0.97
50_E	74_M	0.739	0.97
138_E	163_D	0.736	0.97
93_V	106_M	0.734	0.97
146_D	167_R	0.732	0.97
29_G	33_L	0.730	0.97
85_R	94_A	0.722	0.97
85_R	105_E	0.712	0.96
97_Q	100_G	0.709	0.96
52_D	116_R	0.708	0.96
91_G	107_Y	0.703	0.96
21_Y	104_N	0.703	0.96
54_V	57_I	0.690	0.96
37_L	40_E	0.685	0.95
51_L	54_V	0.684	0.95
55_D	77_I	0.682	0.95
56_K	112_H	0.678	0.95
16_K	90_P	0.677	0.95
66_H	69_T	0.676	0.95
109_N	140_T	0.673	0.95
38_L	66_H	0.673	0.95
31_P	123_V	0.668	0.95
41_I	67_I	0.667	0.95
48_K	148_L	0.661	0.95
49_A	52_D	0.660	0.94
42_V	74_M	0.658	0.94
149_A	166_V	0.656	0.94
9_L	13_I	0.651	0.94
152_K	156_P	0.646	0.94
123_V	153_K	0.645	0.94
16_K	107_Y	0.643	0.94
58_V	111_V	0.642	0.94
34_E	37_L	0.639	0.93
36_E	40_E	0.634	0.93
9_L	40_E	0.633	0.93
151_I	172_V	0.631	0.93
152_K	158_E	0.627	0.93
131_R	160_D	0.626	0.93
83_R	88_G	0.620	0.92
54_V	146_D	0.617	0.92
128_G	158_E	0.611	0.92
149_A	168_T	0.608	0.92
108_I	139_Q	0.602	0.91
9_L	170_I	0.599	0.91
38_L	67_I	0.599	0.91
45_I	150_V	0.598	0.91
90_P	108_I	0.598	0.91
78_P	81_V	0.598	0.91
18_G	23_V	0.595	0.91
35_P	73_L	0.594	0.91
26_I	87_Y	0.592	0.91
115_D	142_A	0.589	0.90
119_V	137_L	0.585	0.90
98_E	102_S	0.581	0.90
49_A	57_I	0.581	0.90
33_L	38_L	0.581	0.90
48_K	165_D	0.578	0.90
56_K	117_V	0.577	0.90
90_P	109_N	0.576	0.89
27_S	172_V	0.576	0.89
29_G	67_I	0.576	0.89
92_E	107_Y	0.572	0.89
94_A	100_G	0.571	0.89
57_I	72_S	0.568	0.89
111_V	115_D	0.568	0.89
29_G	150_V	0.558	0.88
14_I	109_N	0.551	0.87
38_L	120_L	0.544	0.87
86_E	105_E	0.544	0.87
46_I	70_A	0.542	0.86
162_T	165_D	0.540	0.86
87_Y	104_N	0.539	0.86
15_E	155_G	0.537	0.86
67_I	120_L	0.532	0.85
115_D	143_D	0.532	0.85
57_I	75_T	0.532	0.85
46_I	118_L	0.531	0.85
35_P	69_T	0.528	0.85
163_D	168_T	0.527	0.85
163_D	166_V	0.527	0.85
57_I	71_V	0.526	0.85
161_D	164_M	0.525	0.85
29_G	151_I	0.521	0.84
35_P	83_R	0.519	0.84
49_A	167_R	0.518	0.84
11_A	37_L	0.516	0.84
13_I	172_V	0.516	0.84
92_E	105_E	0.514	0.83
68_S	75_T	0.513	0.83
49_A	60_P	0.512	0.83
97_Q	128_G	0.512	0.83
84_K	101_Y	0.511	0.83
60_P	130_L	0.511	0.83
107_Y	110_D	0.509	0.83
160_D	166_V	0.507	0.83
130_L	166_V	0.501	0.82
27_S	153_K	0.501	0.82
41_I	44_R	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4m0kA	2	0.9096	100	0.379	Contact Map
4lzaA	2	0.8936	100	0.394	Contact Map
1qb7A	2	0.9894	100	0.486	Contact Map
2dy0A	2	0.9255	100	0.509	Contact Map
1l1qA	2	0.9309	100	0.52	Contact Map
1zn8A	2	0.9149	100	0.524	Contact Map
1g2qA	2	0.8989	100	0.534	Contact Map
1o57A	2	0.9309	100	0.55	Contact Map
1y0bA	2	0.9734	99.9	0.563	Contact Map
3qw4B	4	0.9043	99.9	0.57	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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