GREMLIN Database
Q9HRT0 - Uncharacterized protein
UniProt: Q9HRT0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 594 (450)
Sequences: 14680 (8524)
Seq/√Len: 401.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_G122_F4.5341.00
66_D242_R4.4411.00
174_L177_S4.0991.00
73_G112_F3.5851.00
309_N364_N3.4271.00
316_L353_A3.3971.00
135_W145_G3.1621.00
172_T177_S3.0271.00
80_G104_V2.8901.00
14_V34_A2.8541.00
147_R215_D2.7911.00
272_D331_E2.7391.00
330_E335_K2.7111.00
12_V105_G2.7041.00
271_N334_P2.7021.00
351_T411_G2.6771.00
276_L333_L2.6061.00
256_G293_G2.5851.00
306_H368_S2.5751.00
73_G108_L2.5141.00
332_R335_K2.5081.00
76_F111_V2.4141.00
39_V43_W2.3201.00
354_A407_F2.2691.00
36_A81_A2.2691.00
290_A396_L2.2181.00
264_A283_S2.2091.00
429_R433_A2.1921.00
162_A195_L2.1881.00
217_Y225_S2.1181.00
39_V78_L2.1121.00
260_A399_G2.0581.00
277_L321_A2.0441.00
257_G395_L2.0131.00
116_W243_V2.0081.00
346_T426_D2.0011.00
8_P11_P1.9861.00
206_F289_V1.9781.00
217_Y233_T1.9701.00
97_T100_A1.9581.00
268_L405_M1.9421.00
165_W192_A1.9321.00
294_I376_S1.9171.00
343_M346_T1.8801.00
340_A347_A1.8781.00
233_T281_I1.8771.00
280_H406_S1.8701.00
207_V258_A1.8661.00
333_L414_A1.8621.00
75_I311_I1.8601.00
252_V293_G1.8481.00
113_A118_T1.8471.00
77_G108_L1.8391.00
116_W178_V1.8321.00
71_L308_F1.8121.00
69_S238_Y1.8091.00
197_A252_V1.8021.00
350_F410_F1.7941.00
197_A201_G1.7821.00
241_Y292_V1.7781.00
250_M254_Y1.7731.00
440_A444_G1.7691.00
347_A416_F1.7521.00
106_T125_L1.7271.00
25_R28_H1.7251.00
273_M410_F1.7191.00
271_N332_R1.7151.00
253_A293_G1.7061.00
292_V303_A1.6951.00
305_A368_S1.6941.00
457_P461_T1.6911.00
94_N97_T1.6861.00
62_L114_G1.6861.00
347_A411_G1.6841.00
373_I396_L1.6831.00
454_G457_P1.6811.00
169_E192_A1.6781.00
185_A188_A1.6681.00
352_V439_A1.6651.00
64_N114_G1.6491.00
186_G189_G1.6351.00
302_G375_A1.6301.00
54_K60_A1.6201.00
350_F354_A1.6141.00
409_K413_Y1.6081.00
42_V77_G1.5951.00
177_S180_G1.5861.00
33_V37_A1.5771.00
40_P44_L1.5771.00
87_S98_A1.5761.00
162_A199_G1.5651.00
114_G176_G1.5631.00
65_V112_F1.5471.00
54_K57_G1.5331.00
390_T394_V1.5301.00
177_S181_G1.5151.00
448_Y451_G1.4981.00
312_L441_L1.4931.00
151_A211_A1.4761.00
119_L239_G1.4751.00
241_Y303_A1.4721.00
201_G206_F1.4661.00
253_A392_L1.4591.00
301_A457_P1.4461.00
36_A40_P1.4451.00
240_L289_V1.4431.00
64_N67_P1.4421.00
96_Q100_A1.4341.00
270_Q275_R1.4331.00
185_A189_G1.4261.00
79_I315_G1.4091.00
56_F59_H1.4091.00
66_D69_S1.4091.00
374_S378_Y1.4011.00
95_I99_F1.4001.00
8_P105_G1.3851.00
291_G372_I1.3841.00
256_G290_A1.3831.00
354_A411_G1.3811.00
140_K143_R1.3731.00
349_A439_A1.3601.00
429_R432_A1.3571.00
170_T178_V1.3491.00
376_S393_Q1.3401.00
434_A437_A1.3391.00
162_A192_A1.3381.00
183_E186_G1.3371.00
172_T178_V1.3321.00
355_L360_F1.3191.00
110_A235_T1.3181.00
206_F255_M1.3181.00
52_P56_F1.3151.00
164_I168_A1.3111.00
35_S39_V1.3071.00
254_Y258_A1.3051.00
238_Y242_R1.2811.00
28_H32_A1.2801.00
428_N431_Q1.2681.00
350_F415_F1.2641.00
79_I230_V1.2641.00
167_F170_T1.2631.00
181_G184_T1.2571.00
82_A437_A1.2381.00
54_K62_L1.2361.00
201_G255_M1.2311.00
437_A441_L1.2301.00
325_V331_E1.2271.00
264_A399_G1.2211.00
327_R343_M1.2171.00
62_L174_L1.2161.00
256_G286_G1.2101.00
117_L173_F1.2101.00
202_V209_L1.2061.00
158_L198_L1.2051.00
81_A85_V1.2021.00
86_Y319_M1.1991.00
15_A19_V1.1951.00
133_L224_A1.1901.00
394_V398_L1.1891.00
345_I436_V1.1871.00
71_L304_F1.1811.00
86_Y322_G1.1711.00
115_D174_L1.1711.00
451_G454_G1.1701.00
47_T50_H1.1691.00
167_F173_F1.1681.00
82_A434_A1.1521.00
34_A38_V1.1511.00
5_F8_P1.1451.00
349_A436_V1.1441.00
175_F179_P1.1391.00
237_V289_V1.1391.00
200_I239_G1.1381.00
357_I407_F1.1341.00
288_M303_A1.1331.00
261_V399_G1.1321.00
391_G394_V1.1321.00
364_N442_C1.1291.00
349_A435_M1.1291.00
262_F266_M1.1281.00
45_V49_A1.1261.00
39_V42_V1.1221.00
326_Y425_K1.1191.00
74_L78_L1.1181.00
191_I195_L1.1141.00
207_V262_F1.1091.00
158_L195_L1.1081.00
291_G303_A1.1051.00
313_Y356_S1.1011.00
263_G286_G1.0941.00
430_G434_A1.0941.00
120_I160_L1.0901.00
55_L58_F1.0891.00
83_G319_M1.0891.00
77_G81_A1.0831.00
26_T29_A1.0831.00
450_E454_G1.0791.00
194_V198_L1.0761.00
243_V246_E1.0751.00
284_Q403_T1.0741.00
324_I339_L1.0701.00
72_M307_V1.0661.00
38_V42_V1.0661.00
345_I349_A1.0601.00
162_A196_A1.0571.00
50_H53_V1.0571.00
333_L413_Y1.0471.00
257_G392_L1.0471.00
283_S403_T1.0431.00
309_N368_S1.0391.00
256_G289_V1.0391.00
316_L438_I1.0371.00
184_T189_G1.0371.00
6_V10_V1.0341.00
411_G416_F1.0331.00
102_G129_T1.0321.00
179_P245_P1.0311.00
30_L34_A1.0301.00
377_H393_Q1.0301.00
348_G352_V1.0301.00
310_H314_K1.0291.00
165_W169_E1.0281.00
320_T350_F1.0231.00
444_G448_Y1.0201.00
141_A218_P1.0161.00
103_Y107_S1.0141.00
182_P185_A1.0131.00
221_H224_A1.0101.00
220_P223_A1.0091.00
46_A49_A1.0081.00
454_G458_I1.0081.00
50_H57_G1.0081.00
345_I432_A1.0061.00
126_M232_T1.0051.00
190_S194_V1.0031.00
441_L445_Y1.0031.00
16_A19_V1.0021.00
343_M426_D1.0011.00
46_A50_H1.0011.00
52_P62_L0.9971.00
114_G174_L0.9961.00
180_G183_E0.9941.00
320_T435_M0.9921.00
35_S38_V0.9901.00
436_V440_A0.9901.00
50_H54_K0.9881.00
184_T187_L0.9851.00
371_I374_S0.9821.00
144_A219_R0.9821.00
192_A196_A0.9761.00
284_Q406_S0.9651.00
74_L77_G0.9641.00
35_S42_V0.9621.00
215_D275_R0.9591.00
433_A437_A0.9561.00
8_P63_L0.9551.00
65_V70_T0.9551.00
78_L82_A0.9521.00
240_L247_H0.9521.00
32_A36_A0.9521.00
27_G31_G0.9511.00
96_Q99_F0.9501.00
323_V427_A0.9501.00
217_Y220_P0.9471.00
116_W163_I0.9471.00
37_A41_Y0.9471.00
373_I400_G0.9431.00
253_A290_A0.9431.00
313_Y365_G0.9431.00
101_L105_G0.9371.00
458_I461_T0.9351.00
364_N445_Y0.9341.00
328_T336_L0.9341.00
39_V77_G0.9331.00
265_M402_G0.9311.00
323_V346_T0.9311.00
301_A456_L0.9281.00
264_A280_H0.9251.00
296_S375_A0.9251.00
76_F108_L0.9231.00
258_A262_F0.9231.00
297_A301_A0.9231.00
260_A290_A0.9201.00
32_A35_S0.9171.00
257_G290_A0.9161.00
130_S232_T0.9111.00
281_I310_H0.9051.00
226_V319_M0.9041.00
69_S242_R0.9041.00
91_D95_I0.9031.00
399_G402_G0.9021.00
432_A436_V0.9001.00
34_A40_P0.8991.00
11_P15_A0.8951.00
68_F304_F0.8931.00
63_L112_F0.8931.00
115_D118_T0.8921.00
342_E419_S0.8921.00
75_I308_F0.8891.00
166_Q178_V0.8891.00
142_V145_G0.8871.00
19_V22_L0.8861.00
237_V285_V0.8831.00
433_A436_V0.8801.00
126_M235_T0.8791.00
427_A432_A0.8791.00
191_I194_V0.8761.00
31_G35_S0.8751.00
95_I98_A0.8741.00
5_F53_V0.8671.00
342_E422_G0.8611.00
408_I412_Y0.8601.00
25_R29_A0.8591.00
78_L441_L0.8591.00
218_P275_R0.8581.00
351_T416_F0.8581.00
347_A351_T0.8561.00
106_T129_T0.8551.00
373_I393_Q0.8521.00
35_S41_Y0.8521.00
306_H313_Y0.8521.00
54_K59_H0.8511.00
426_D432_A0.8501.00
68_F241_Y0.8491.00
273_M414_A0.8481.00
5_F61_I0.8441.00
213_L216_T0.8431.00
213_L217_Y0.8411.00
456_L459_D0.8371.00
176_G180_G0.8351.00
251_A254_Y0.8351.00
62_L115_D0.8351.00
123_W235_T0.8341.00
172_T175_F0.8331.00
69_S73_G0.8321.00
38_V77_G0.8301.00
4_T63_L0.8301.00
362_G447_L0.8291.00
179_P183_E0.8291.00
143_R147_R0.8291.00
280_H310_H0.8251.00
339_L343_M0.8241.00
53_V56_F0.8211.00
264_A406_S0.8201.00
46_A51_L0.8191.00
27_G30_L0.8141.00
352_V443_L0.8121.00
316_L435_M0.8121.00
345_I348_G0.8101.00
119_L175_F0.8081.00
317_L353_A0.8061.00
180_G184_T0.8061.00
12_V16_A0.8051.00
31_G84_V0.8051.00
439_A442_C0.8031.00
31_G34_A0.8011.00
320_T349_A0.7991.00
370_G374_S0.7961.00
403_T406_S0.7921.00
103_Y232_T0.7921.00
324_I336_L0.7891.00
326_Y431_Q0.7881.00
7_P41_Y0.7881.00
323_V435_M0.7871.00
443_L447_L0.7871.00
348_G351_T0.7861.00
108_L112_F0.7821.00
173_F177_S0.7811.00
35_S84_V0.7801.00
297_A461_T0.7791.00
155_G202_V0.7781.00
11_P14_V0.7781.00
15_A18_L0.7781.00
197_A240_L0.7711.00
283_S406_S0.7701.00
45_V50_H0.7691.00
261_V265_M0.7681.00
140_K219_R0.7671.00
260_A287_Y0.7661.00
146_F150_L0.7651.00
267_A406_S0.7651.00
273_M321_A0.7641.00
253_A257_G0.7581.00
347_A415_F0.7581.00
166_Q192_A0.7581.00
10_V14_V0.7571.00
153_G156_G0.7551.00
39_V81_A0.7541.00
34_A37_A0.7541.00
10_V34_A0.7531.00
312_L364_N0.7501.00
159_L196_A0.7491.00
272_D332_R0.7491.00
53_V57_G0.7461.00
38_V41_Y0.7461.00
159_L163_I0.7431.00
29_A33_V0.7421.00
36_A42_V0.7401.00
47_T51_L0.7401.00
445_Y452_L0.7371.00
354_A358_S0.7361.00
353_A439_A0.7351.00
107_S232_T0.7311.00
28_H42_V0.7311.00
29_A32_A0.7311.00
134_V216_T0.7301.00
82_A438_I0.7291.00
14_V101_L0.7281.00
193_P246_E0.7261.00
452_L456_L0.7251.00
75_I307_V0.7241.00
14_V18_L0.7231.00
170_T185_A0.7231.00
205_G213_L0.7221.00
337_G420_Y0.7211.00
64_N176_G0.7211.00
93_E96_Q0.7201.00
163_I196_A0.7201.00
250_M253_A0.7181.00
273_M324_I0.7181.00
80_G227_F0.7171.00
266_M279_Y0.7131.00
160_L164_I0.7111.00
373_I397_L0.7111.00
222_I274_R0.7071.00
237_V288_M0.7051.00
15_A102_G0.7041.00
359_G369_K0.7031.00
280_H409_K0.7021.00
120_I163_I0.7021.00
398_L402_G0.7011.00
411_G415_F0.7001.00
456_L460_V0.7001.00
363_F443_L0.6981.00
116_W166_Q0.6971.00
349_A432_A0.6951.00
4_T65_V0.6921.00
305_A309_N0.6921.00
341_R344_P0.6921.00
287_Y396_L0.6861.00
276_L410_F0.6851.00
27_G34_A0.6841.00
337_G417_H0.6841.00
461_T464_P0.6820.99
179_P182_P0.6810.99
225_S228_L0.6810.99
35_S43_W0.6770.99
287_Y399_G0.6770.99
460_V464_P0.6750.99
407_F410_F0.6740.99
40_P43_W0.6720.99
13_L16_A0.6720.99
220_P224_A0.6720.99
175_F243_V0.6720.99
51_L57_G0.6710.99
56_F60_A0.6710.99
103_Y130_S0.6700.99
82_A315_G0.6670.99
181_G185_A0.6660.99
304_F456_L0.6630.99
217_Y228_L0.6620.99
161_A195_L0.6620.99
7_P19_V0.6620.99
70_T74_L0.6610.99
85_V433_A0.6610.99
401_V405_M0.6600.99
213_L233_T0.6590.99
15_A100_A0.6570.99
271_N280_H0.6560.99
170_T181_G0.6560.99
254_Y257_G0.6540.99
79_I311_I0.6520.99
204_V237_V0.6500.99
217_Y281_I0.6490.99
229_C310_H0.6470.99
336_L414_A0.6460.99
37_A40_P0.6460.99
302_G371_I0.6450.99
107_S126_M0.6450.99
193_P247_H0.6450.99
110_A126_M0.6450.99
280_H314_K0.6450.99
134_V228_L0.6440.99
28_H39_V0.6430.99
13_L17_L0.6420.99
32_A85_V0.6420.99
165_W191_I0.6420.99
313_Y442_C0.6410.99
38_V108_L0.6410.99
28_H35_S0.6340.99
284_Q314_K0.6330.99
244_F248_G0.6310.99
356_S365_G0.6300.99
351_T415_F0.6290.99
241_Y304_F0.6290.99
42_V73_G0.6290.99
264_A402_G0.6270.99
15_A105_G0.6270.99
458_I462_T0.6270.99
220_P228_L0.6270.99
163_I173_F0.6260.99
455_I459_D0.6250.99
8_P112_F0.6230.99
92_A137_Y0.6230.99
455_I463_N0.6230.99
194_V251_A0.6220.99
178_V181_G0.6210.99
301_A453_F0.6180.99
316_L439_A0.6180.99
10_V37_A0.6180.99
76_F80_G0.6180.99
309_N442_C0.6170.99
49_A52_P0.6150.99
340_A351_T0.6150.99
352_V356_S0.6150.99
27_G38_V0.6140.99
65_V73_G0.6130.99
417_H420_Y0.6130.99
52_P55_L0.6120.99
55_L59_H0.6120.99
49_A53_V0.6110.99
90_S95_I0.6110.99
351_T354_A0.6100.99
359_G365_G0.6090.99
253_A256_G0.6090.99
166_Q196_A0.6090.99
33_V40_P0.6080.99
43_W78_L0.6060.99
4_T11_P0.6050.99
333_L336_L0.6050.99
330_E336_L0.6050.99
266_M269_F0.6050.99
323_V327_R0.6040.99
32_A81_A0.6040.99
217_Y226_V0.6020.99
287_Y372_I0.6020.99
159_L239_G0.6020.99
371_I375_A0.5980.99
323_V431_Q0.5970.99
83_G223_A0.5950.99
216_T278_S0.5940.99
451_G455_I0.5930.99
119_L159_L0.5930.99
207_V263_G0.5900.99
36_A39_V0.5900.99
429_R434_A0.5890.99
34_A101_L0.5880.99
217_Y224_A0.5880.99
35_S80_G0.5880.99
290_A392_L0.5870.98
220_P225_S0.5870.98
30_L33_V0.5870.98
89_A92_A0.5860.98
362_G367_V0.5850.98
130_S229_C0.5830.98
25_R43_W0.5830.98
333_L410_F0.5820.98
395_L399_G0.5810.98
251_A255_M0.5790.98
284_Q287_Y0.5780.98
325_V336_L0.5770.98
214_P282_Q0.5770.98
281_I314_K0.5750.98
257_G261_V0.5740.98
264_A403_T0.5730.98
12_V15_A0.5730.98
338_G417_H0.5730.98
266_M270_Q0.5730.98
11_P16_A0.5730.98
34_A39_V0.5720.98
280_H284_Q0.5710.98
214_P279_Y0.5700.98
91_D94_N0.5690.98
455_I458_I0.5680.98
38_V44_L0.5670.98
338_G344_P0.5660.98
45_V51_L0.5650.98
217_Y274_R0.5650.98
152_H232_T0.5640.98
278_S281_I0.5640.98
263_G282_Q0.5640.98
308_F445_Y0.5630.98
8_P22_L0.5630.98
107_S231_F0.5620.98
131_T152_H0.5620.98
163_I199_G0.5600.98
110_A123_W0.5600.98
77_G104_V0.5590.98
350_F407_F0.5580.98
8_P15_A0.5570.98
131_T145_G0.5570.98
346_T435_M0.5560.98
76_F107_S0.5560.98
273_M336_L0.5550.98
410_F414_A0.5550.98
31_G101_L0.5540.98
371_I453_F0.5540.98
459_D463_N0.5510.98
294_I375_A0.5490.98
45_V48_G0.5480.98
310_H318_F0.5470.98
261_V395_L0.5470.98
319_M438_I0.5450.98
5_F9_F0.5450.98
120_I131_T0.5450.98
42_V74_L0.5440.98
79_I227_F0.5420.97
277_L407_F0.5420.97
229_C318_F0.5410.97
85_V430_G0.5390.97
270_Q279_Y0.5380.97
376_S396_L0.5370.97
346_T427_A0.5350.97
284_Q306_H0.5340.97
139_G219_R0.5340.97
27_G41_Y0.5330.97
69_S111_V0.5320.97
234_K285_V0.5300.97
26_T30_L0.5300.97
51_L54_K0.5290.97
402_G406_S0.5290.97
9_F105_G0.5280.97
288_M307_V0.5280.97
327_R427_A0.5280.97
107_S111_V0.5270.97
358_S408_I0.5270.97
15_A23_S0.5260.97
353_A442_C0.5250.97
127_A152_H0.5250.97
245_P248_G0.5250.97
158_L199_G0.5240.97
217_Y221_H0.5240.97
217_Y222_I0.5230.97
16_A22_L0.5230.97
123_W159_L0.5220.97
225_S233_T0.5220.97
130_S217_Y0.5210.97
218_P229_C0.5210.97
290_A376_S0.5210.97
277_L317_L0.5200.97
85_V434_A0.5200.97
7_P11_P0.5190.97
33_V36_A0.5190.97
28_H40_P0.5180.97
327_R425_K0.5180.97
397_L400_G0.5180.97
313_Y357_I0.5180.97
244_F292_V0.5170.97
355_L408_I0.5160.97
358_S407_F0.5150.97
375_A378_Y0.5150.97
65_V69_S0.5150.97
338_G419_S0.5150.97
83_G230_V0.5130.97
5_F55_L0.5130.97
233_T285_V0.5120.96
315_G438_I0.5120.96
9_F12_V0.5110.96
114_G242_R0.5100.96
76_F104_V0.5100.96
308_F449_P0.5090.96
31_G99_F0.5080.96
48_G52_P0.5080.96
294_I379_M0.5080.96
230_V315_G0.5070.96
305_A367_V0.5070.96
276_L413_Y0.5060.96
217_Y230_V0.5060.96
306_H309_N0.5050.96
50_H64_N0.5050.96
316_L442_C0.5050.96
61_I118_T0.5040.96
291_G302_G0.5040.96
17_L20_P0.5010.96
326_Y428_N0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8L 1 0.963 100 0.222 Contact Map
3rkoL 1 0.9512 100 0.23 Contact Map
3rkoM 1 0.7744 100 0.326 Contact Map
4he8M 1 0.7508 100 0.35 Contact Map
3rkoN 1 0.7374 100 0.37 Contact Map
4he8N 1 0.7104 100 0.391 Contact Map
3rkoK 1 0.1599 39.5 0.972 Contact Map
4he8K 1 0.1532 35 0.972 Contact Map
1nkzA 4 0.0892 5.1 0.981 Contact Map
4tnwA 3 0.1549 4 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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