GREMLIN Database
Q9HRS9 - Uncharacterized protein
UniProt: Q9HRS9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 489 (383)
Sequences: 16380 (8449)
Seq/√Len: 431.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_D214_R4.5591.00
306_T343_A4.4741.00
78_A91_A4.2021.00
36_A81_F3.6921.00
144_A147_P3.6211.00
104_V115_G3.4331.00
299_A354_A3.2621.00
43_W73_I3.1911.00
254_N321_D3.1801.00
142_T147_P3.0721.00
117_K187_D2.9721.00
242_L381_S2.7991.00
296_H358_S2.6711.00
39_A80_A2.6621.00
320_T325_D2.6601.00
253_D324_S2.6591.00
341_A393_V2.5041.00
36_A77_I2.4881.00
259_L311_A2.4321.00
258_R323_I2.4311.00
238_A275_A2.4291.00
322_D325_D2.4261.00
344_A389_F2.4081.00
132_G167_L2.3371.00
75_S94_L2.3101.00
50_S65_Y2.2741.00
272_L378_L2.2691.00
178_L271_V2.2181.00
40_S77_I2.1981.00
189_M205_V2.1741.00
250_L387_A2.1421.00
243_I381_S1.9921.00
295_L358_S1.9791.00
189_M196_S1.9651.00
38_L301_A1.9561.00
333_M336_T1.9551.00
363_L378_L1.9501.00
232_M236_V1.9151.00
27_R83_A1.9071.00
262_S388_Y1.8671.00
139_A164_A1.8531.00
246_S265_S1.8081.00
253_D322_D1.7981.00
292_G365_G1.7731.00
179_M240_I1.7641.00
82_A87_V1.7601.00
235_A275_A1.7511.00
273_G362_L1.7411.00
85_L148_G1.7341.00
85_L215_V1.7131.00
239_A377_A1.7031.00
330_G337_M1.6781.00
169_I173_G1.6551.00
391_P395_T1.6541.00
29_D32_G1.6501.00
364_I368_T1.6471.00
177_A185_L1.6451.00
88_L211_G1.6411.00
83_A146_A1.6381.00
205_V263_T1.6331.00
372_L376_A1.6171.00
34_L298_P1.6101.00
213_A274_L1.6041.00
366_T375_T1.5781.00
234_V275_A1.5711.00
255_L392_V1.5691.00
235_A374_F1.5591.00
32_G210_F1.5531.00
173_G178_L1.5121.00
252_Q257_R1.5071.00
135_L164_A1.5041.00
340_F392_V1.5011.00
276_V289_A1.5001.00
68_A101_P1.4861.00
337_M393_V1.4851.00
229_N232_M1.4801.00
79_V207_S1.4761.00
274_L293_G1.4731.00
84_N144_A1.4621.00
337_M398_F1.4551.00
25_A83_A1.4531.00
340_F344_A1.4521.00
28_A81_F1.4471.00
246_S381_S1.4461.00
276_V366_T1.4331.00
47_S69_F1.4331.00
323_I396_A1.4321.00
102_L195_V1.4241.00
114_A190_V1.4161.00
132_G171_G1.4001.00
110_A190_V1.3901.00
303_M346_G1.3891.00
84_N143_T1.3791.00
47_S66_F1.3771.00
213_A293_G1.3711.00
172_F211_G1.3711.00
42_L305_L1.3561.00
273_G289_A1.3541.00
61_S64_R1.3481.00
17_T23_S1.3461.00
121_Y183_S1.3421.00
178_L237_V1.3391.00
347_M389_F1.3351.00
27_R30_A1.3311.00
49_Y309_F1.3301.00
88_L145_F1.3231.00
159_T163_A1.3151.00
265_S385_N1.3031.00
169_I234_V1.3021.00
270_I293_G1.2911.00
212_I271_V1.2861.00
231_G235_A1.2821.00
134_V138_H1.2771.00
307_L343_A1.2751.00
42_L301_A1.2621.00
238_A272_L1.2441.00
361_F364_I1.2381.00
135_L160_L1.2201.00
236_V240_I1.2171.00
345_A350_I1.2151.00
17_T20_P1.2111.00
70_A74_A1.2091.00
179_M244_V1.1991.00
244_V248_I1.1981.00
238_A268_S1.1931.00
315_H321_D1.1911.00
323_I395_T1.1841.00
86_V143_T1.1801.00
317_E333_M1.1721.00
40_S44_L1.1701.00
15_L23_S1.1661.00
132_G168_L1.1661.00
44_L48_F1.1641.00
39_A73_I1.1591.00
85_L133_V1.1581.00
341_A397_F1.1521.00
373_V376_A1.1501.00
314_L329_I1.1471.00
310_C340_F1.1471.00
191_A200_H1.1411.00
142_T148_G1.1401.00
139_A160_L1.1371.00
140_T148_G1.1311.00
128_A167_L1.1301.00
132_G164_A1.1291.00
340_F397_F1.1281.00
292_G361_F1.1251.00
313_A336_T1.1251.00
187_D257_R1.1221.00
367_V375_T1.1181.00
41_T45_A1.1171.00
273_G293_G1.1161.00
133_V168_L1.1071.00
137_Y143_T1.1061.00
35_F297_I1.1051.00
162_R229_N1.0971.00
69_F198_L1.0961.00
174_V181_L1.0951.00
15_L19_V1.0941.00
327_A395_T1.0931.00
129_V133_V1.0811.00
206_K210_F1.0791.00
128_A170_T1.0781.00
135_L139_A1.0771.00
209_V271_V1.0771.00
338_T342_V1.0761.00
344_A393_V1.0731.00
299_A358_S1.0681.00
113_A117_K1.0671.00
32_G36_A1.0661.00
89_Y130_L1.0661.00
108_T111_A1.0651.00
136_V164_A1.0641.00
278_A289_A1.0601.00
158_P162_R1.0551.00
210_F214_R1.0541.00
83_A144_A1.0501.00
164_A168_L1.0491.00
28_A33_V1.0481.00
42_L201_A1.0471.00
360_Y364_I1.0431.00
376_A380_V1.0381.00
52_G55_R1.0371.00
129_V171_G1.0361.00
31_L294_L1.0351.00
289_A365_G1.0331.00
125_G174_V1.0321.00
327_A402_G1.0311.00
162_R230_V1.0221.00
272_L366_T1.0201.00
404_S407_K1.0061.00
173_G237_V1.0051.00
303_M355_G1.0011.00
409_L412_G0.9991.00
189_M200_H0.9971.00
34_L294_L0.9961.00
406_E409_L0.9961.00
71_G98_A0.9961.00
247_V384_L0.9911.00
254_N322_D0.9901.00
14_T17_T0.9881.00
266_Q388_Y0.9861.00
109_D113_A0.9861.00
145_F149_G0.9851.00
335_L339_A0.9841.00
112_R115_G0.9841.00
335_L338_T0.9811.00
246_S388_Y0.9801.00
137_Y140_T0.9801.00
209_V270_I0.9721.00
153_L156_A0.9701.00
242_L272_L0.9691.00
39_A76_A0.9691.00
22_V86_V0.9671.00
193_T256_K0.9651.00
185_L189_M0.9641.00
159_T162_R0.9641.00
31_L213_A0.9621.00
363_L375_T0.9541.00
143_T147_P0.9511.00
300_H304_K0.9501.00
176_A209_V0.9501.00
157_D161_A0.9491.00
266_Q385_N0.9441.00
111_A190_V0.9431.00
196_S200_H0.9421.00
46_A309_F0.9411.00
149_G218_D0.9391.00
166_G170_T0.9351.00
38_L298_P0.9351.00
239_A374_F0.9321.00
270_I297_I0.9281.00
26_L81_F0.9191.00
240_I244_V0.9191.00
142_T145_F0.9191.00
77_I81_F0.9171.00
245_A268_S0.9151.00
338_T397_F0.9141.00
407_K410_V0.9121.00
103_V188_A0.9101.00
266_Q296_H0.9101.00
162_R166_G0.9091.00
327_A399_E0.9091.00
332_R401_Q0.9091.00
239_A272_L0.9081.00
402_G405_D0.9081.00
258_R392_V0.9071.00
295_L299_A0.9031.00
246_S384_L0.9021.00
205_V210_F0.9021.00
197_G309_F0.9001.00
215_V219_V0.8971.00
32_G214_R0.8931.00
310_C339_A0.8921.00
165_F230_V0.8891.00
63_T67_A0.8881.00
151_G154_A0.8851.00
337_M341_A0.8851.00
263_T300_H0.8811.00
72_S76_A0.8801.00
13_T25_A0.8771.00
235_A239_A0.8761.00
279_A288_W0.8741.00
37_L41_T0.8731.00
99_T204_V0.8721.00
185_L188_A0.8701.00
110_A113_A0.8691.00
393_V398_F0.8681.00
100_Y122_T0.8661.00
235_A238_A0.8611.00
89_Y93_E0.8591.00
405_D408_P0.8591.00
89_Y133_V0.8591.00
232_M235_A0.8581.00
200_H304_K0.8571.00
25_A144_A0.8571.00
278_A365_G0.8551.00
318_T326_M0.8521.00
49_Y312_G0.8511.00
35_F210_F0.8511.00
169_I212_I0.8491.00
65_Y194_P0.8491.00
157_D160_L0.8481.00
296_H303_M0.8471.00
385_N388_Y0.8461.00
302_F354_A0.8451.00
76_A95_L0.8441.00
189_M263_T0.8431.00
265_S388_Y0.8421.00
76_A202_V0.8401.00
156_A159_T0.8401.00
163_A166_G0.8391.00
331_K334_P0.8381.00
249_A388_Y0.8381.00
95_L204_V0.8361.00
408_P411_S0.8321.00
100_Y115_G0.8321.00
259_L307_L0.8281.00
43_W69_F0.8261.00
136_V148_G0.8221.00
213_A290_L0.8221.00
40_S73_I0.8221.00
243_I247_V0.8181.00
233_A236_V0.8171.00
62_Q66_F0.8151.00
218_D221_G0.8141.00
186_P261_F0.8101.00
255_L311_A0.8051.00
273_G292_G0.8041.00
46_A197_G0.8001.00
151_G155_T0.7981.00
235_A272_L0.7971.00
212_I274_L0.7961.00
349_G359_K0.7941.00
42_L198_L0.7921.00
344_A392_V0.7901.00
246_S262_S0.7891.00
92_Y129_V0.7871.00
269_Y378_L0.7871.00
255_L326_M0.7801.00
363_L382_G0.7791.00
155_T158_P0.7771.00
243_I377_A0.7731.00
248_I251_R0.7721.00
158_P161_A0.7641.00
191_A196_S0.7601.00
404_S408_P0.7581.00
346_G355_G0.7531.00
75_S98_A0.7521.00
238_A271_V0.7501.00
37_L40_S0.7491.00
103_V191_A0.7481.00
72_S204_V0.7471.00
161_A223_D0.7471.00
269_Y381_S0.7451.00
255_L396_A0.7451.00
152_G156_A0.7431.00
269_Y362_L0.7421.00
323_I326_M0.7401.00
295_L361_F0.7361.00
89_Y126_G0.7341.00
209_V267_L0.7331.00
130_L134_V0.7331.00
348_A386_I0.7311.00
279_A291_I0.7301.00
313_A317_E0.7301.00
45_A305_L0.7301.00
39_A77_I0.7251.00
50_S53_Y0.7241.00
13_T16_S0.7241.00
72_S198_L0.7231.00
25_A84_N0.7201.00
389_F392_V0.7171.00
390_W394_Y0.7161.00
200_H263_T0.7161.00
377_A381_S0.7151.00
28_A32_G0.7151.00
337_M397_F0.7151.00
95_L207_S0.7111.00
17_T21_G0.7111.00
136_V168_L0.7111.00
163_A167_L0.7101.00
346_G353_V0.7081.00
72_S99_T0.7081.00
393_V397_F0.7071.00
340_F389_F0.7061.00
65_Y102_L0.7051.00
320_T326_M0.6981.00
16_S19_V0.6971.00
406_E411_S0.6961.00
153_L157_D0.6961.00
209_V297_I0.6961.00
13_T19_V0.6961.00
288_W368_T0.6921.00
186_P264_V0.6921.00
252_Q261_F0.6921.00
176_A212_I0.6901.00
14_T19_V0.6871.00
196_S205_V0.6831.00
165_F169_I0.6811.00
325_D404_S0.6801.00
65_Y195_V0.6791.00
193_T200_H0.6791.00
76_A204_V0.6771.00
408_P412_G0.6761.00
326_M396_A0.6761.00
381_S384_L0.6761.00
193_T196_S0.6751.00
152_G155_T0.6751.00
212_I220_Y0.6741.00
108_T190_V0.6721.00
33_V37_L0.6721.00
349_G355_G0.6701.00
165_F220_Y0.6701.00
329_I333_M0.6691.00
262_S266_Q0.6661.00
87_V90_L0.6651.00
353_V357_V0.6631.00
262_S300_H0.6601.00
43_W198_L0.6601.00
200_H205_V0.6591.00
248_I261_F0.6580.99
80_A210_F0.6550.99
238_A242_L0.6550.99
338_T341_A0.6550.99
160_L163_A0.6540.99
344_A348_A0.6540.99
167_L171_G0.6530.99
266_Q304_K0.6520.99
92_Y207_S0.6520.99
263_T267_L0.6510.99
253_D262_S0.6490.99
192_P200_H0.6490.99
348_A390_W0.6480.99
79_V95_L0.6470.99
386_I390_W0.6460.99
407_K412_G0.6460.99
224_L229_N0.6440.99
46_A69_F0.6440.99
248_I252_Q0.6430.99
175_K256_K0.6400.99
300_H308_F0.6400.99
160_L164_A0.6390.99
247_V251_R0.6390.99
324_S395_T0.6360.99
177_A205_V0.6330.99
289_A293_G0.6310.99
330_G397_F0.6310.99
222_I229_N0.6310.99
19_V22_V0.6300.99
200_H300_H0.6290.99
383_V387_A0.6280.99
276_V369_G0.6270.99
246_S385_N0.6270.99
32_G80_A0.6200.99
176_A208_G0.6160.99
261_F264_V0.6160.99
35_F80_A0.6150.99
349_G353_V0.6130.99
239_A243_I0.6120.99
365_G369_G0.6110.99
391_P394_Y0.6100.99
328_G334_P0.6090.99
135_L163_A0.6080.99
35_F39_A0.6060.99
331_K400_S0.6050.99
196_S300_H0.6050.99
185_L205_V0.6040.99
337_M396_A0.6030.99
123_F126_G0.6030.99
303_M347_M0.6030.99
42_L202_V0.6000.99
405_D409_L0.6000.99
389_F393_V0.6000.99
46_A194_P0.6000.99
342_V346_G0.5990.99
79_V92_Y0.5980.99
13_T17_T0.5970.99
179_M245_A0.5960.99
345_A390_W0.5950.99
53_Y194_P0.5950.99
88_L129_V0.5950.99
403_D406_E0.5910.99
195_V198_L0.5910.99
196_S199_L0.5900.99
103_V199_L0.5850.99
399_E402_G0.5840.99
27_R146_A0.5830.99
242_L269_Y0.5830.99
31_L35_F0.5810.99
83_A87_V0.5810.99
161_A164_A0.5810.99
379_L382_G0.5810.99
357_V361_F0.5800.99
116_R120_A0.5800.99
146_A149_G0.5760.99
387_A391_P0.5750.99
85_L136_V0.5750.99
39_A206_K0.5740.99
39_A259_L0.5700.99
328_G401_Q0.5700.99
48_F51_I0.5700.99
96_T99_T0.5690.99
262_S304_K0.5680.99
196_S202_V0.5680.99
314_L326_M0.5670.99
205_V208_G0.5670.99
395_T399_E0.5660.98
310_C336_T0.5650.98
189_M260_A0.5650.98
323_I392_V0.5650.98
144_A149_G0.5640.98
129_V211_G0.5610.98
65_Y105_H0.5610.98
198_L202_V0.5610.98
38_L297_I0.5600.98
255_L314_L0.5590.98
206_K209_V0.5590.98
49_Y53_Y0.5580.98
206_K267_L0.5580.98
328_G331_K0.5580.98
70_A73_I0.5550.98
39_A43_W0.5550.98
342_V353_V0.5540.98
334_P337_M0.5530.98
125_G171_G0.5520.98
332_R405_D0.5520.98
99_T103_V0.5500.98
236_V239_A0.5500.98
252_Q258_R0.5500.98
189_M201_A0.5450.98
348_A389_F0.5450.98
340_F393_V0.5450.98
178_L267_L0.5440.98
341_A398_F0.5440.98
260_A263_T0.5400.98
314_L336_T0.5400.98
245_A248_I0.5380.98
59_E106_D0.5380.98
205_V209_V0.5370.98
273_G277_G0.5370.98
64_R68_A0.5370.98
231_G277_G0.5370.98
99_T102_L0.5370.98
328_G399_E0.5360.98
179_M182_H0.5350.98
188_A260_A0.5330.98
307_L311_A0.5310.98
53_Y192_P0.5300.98
314_L397_F0.5300.98
341_A344_A0.5300.98
68_A98_A0.5290.98
191_A198_L0.5290.98
223_D229_N0.5290.98
112_R116_R0.5280.98
195_V200_H0.5270.98
205_V267_L0.5240.98
403_D407_K0.5240.98
166_G230_V0.5240.98
49_Y197_G0.5220.97
293_G299_A0.5220.97
214_R218_D0.5220.97
165_F219_V0.5220.97
330_G341_A0.5210.97
241_T271_V0.5210.97
246_S266_Q0.5200.97
242_L374_F0.5200.97
85_L145_F0.5200.97
155_T159_T0.5190.97
73_I77_I0.5180.97
131_A135_L0.5180.97
381_S385_N0.5180.97
220_Y223_D0.5170.97
229_N233_A0.5140.97
403_D409_L0.5140.97
190_V257_R0.5100.97
339_A343_A0.5090.97
133_V143_T0.5080.97
304_K308_F0.5070.97
169_I237_V0.5070.97
168_L212_I0.5060.97
157_D162_R0.5060.97
296_H299_A0.5050.97
31_L210_F0.5040.97
311_A326_M0.5040.97
92_Y211_G0.5030.97
221_G224_L0.5030.97
196_S256_K0.5030.97
315_H319_H0.5030.97
44_L47_S0.5030.97
291_I294_L0.5020.97
201_A305_L0.5010.97
266_Q269_Y0.5000.97
154_A158_P0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoL 1 0.9571 100 0.209 Contact Map
4he8L 1 0.955 100 0.218 Contact Map
3rkoM 1 0.8875 100 0.243 Contact Map
3rkoN 1 0.8671 100 0.265 Contact Map
4he8M 1 0.8589 100 0.27 Contact Map
4he8N 1 0.816 100 0.319 Contact Map
4he8K 1 0.1881 61.2 0.961 Contact Map
3rkoK 1 0.1963 59.2 0.962 Contact Map
3wdoA 1 0.8323 14.1 0.972 Contact Map
1pw4A 1 0.7301 10.6 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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