GREMLIN Database
Q9HRS8 - NADH dehydrogenase/oxidoreductase
UniProt: Q9HRS8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (340)
Sequences: 24315 (12694)
Seq/√Len: 688.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_G266_L4.8221.00
9_G22_F4.5071.00
75_N78_D3.8051.00
35_A46_A3.5311.00
48_K117_D3.2951.00
185_E244_R3.0991.00
222_G277_V2.9731.00
169_A206_A2.8781.00
173_I304_S2.8751.00
219_H281_G2.8081.00
243_A248_E2.7341.00
184_S247_D2.6081.00
264_G316_V2.5991.00
204_A285_I2.5721.00
73_T78_D2.5631.00
6_G25_I2.5451.00
245_T248_E2.5281.00
203_A301_I2.5061.00
63_G97_L2.4151.00
108_V202_L2.4041.00
267_A312_F2.3071.00
103_F108_V2.2991.00
190_L234_A2.2821.00
174_V304_S2.0371.00
107_A115_Q2.0121.00
181_V310_A1.9891.00
163_A167_G1.9621.00
99_V103_F1.9061.00
78_D81_A1.8931.00
189_V246_I1.8901.00
103_F168_G1.8691.00
119_Y127_S1.8401.00
119_Y135_S1.8251.00
183_Q188_R1.8031.00
359_A362_F1.7921.00
230_L266_L1.7921.00
193_S311_Y1.7851.00
63_G101_G1.7731.00
184_S245_T1.7561.00
207_I212_A1.7441.00
215_G288_G1.7401.00
314_R318_R1.7111.00
256_S259_A1.7081.00
14_A77_A1.7011.00
135_S194_S1.6991.00
351_V355_V1.6951.00
345_G348_A1.6661.00
160_V163_A1.6551.00
340_A344_T1.6441.00
287_I291_E1.6411.00
167_G171_V1.6231.00
289_A298_L1.6051.00
13_T18_N1.6041.00
109_F171_V1.5991.00
166_I206_A1.5861.00
60_F101_G1.5631.00
136_T140_Y1.5631.00
170_V300_V1.5621.00
177_S196_S1.5571.00
186_I315_L1.5491.00
340_A343_S1.5331.00
286_A301_I1.5161.00
117_D188_R1.5141.00
218_I281_G1.4991.00
66_Y94_A1.4961.00
162_R166_I1.4961.00
63_G94_A1.4911.00
201_I216_A1.4901.00
16_L79_L1.4861.00
295_W299_A1.4831.00
6_G22_F1.4721.00
44_V48_K1.4661.00
78_D82_K1.4661.00
108_V168_G1.4601.00
166_I297_L1.4571.00
263_F315_L1.4541.00
203_A289_A1.4521.00
352_G356_C1.4481.00
177_S304_S1.4421.00
7_L134_V1.4411.00
205_I216_A1.4361.00
263_F267_A1.4181.00
169_A203_A1.4071.00
348_A352_G1.4051.00
63_G98_I1.3931.00
175_A179_L1.3841.00
296_A299_A1.3741.00
196_S308_T1.3671.00
60_F64_I1.3621.00
99_V165_L1.3581.00
253_A260_A1.3551.00
169_A199_G1.3531.00
283_W287_I1.3521.00
68_Y74_L1.3501.00
45_A121_G1.3311.00
119_Y132_A1.3301.00
173_I199_G1.3291.00
15_D74_L1.3291.00
56_G104_I1.3281.00
350_V354_T1.3161.00
259_A337_E1.3151.00
116_P192_Y1.3141.00
89_V93_A1.3001.00
180_A311_Y1.2991.00
33_L126_V1.2921.00
270_M312_F1.2851.00
233_T263_F1.2801.00
15_D75_N1.2721.00
299_A303_A1.2721.00
264_G320_F1.2681.00
70_G94_A1.2681.00
19_M141_A1.2611.00
133_L136_T1.2581.00
104_I111_L1.2521.00
165_L206_A1.2491.00
258_V261_G1.2391.00
176_G199_G1.2261.00
226_M269_S1.2181.00
66_Y70_G1.2181.00
125_T128_A1.2131.00
6_G29_T1.2061.00
225_V352_G1.2021.00
96_A100_V1.1911.00
260_A316_V1.1901.00
267_A316_V1.1881.00
176_G179_L1.1771.00
238_A244_R1.1711.00
65_G69_V1.1631.00
39_D42_S1.1601.00
290_A298_L1.1581.00
339_P342_S1.1481.00
265_V350_V1.1471.00
163_A166_I1.1431.00
19_M142_L1.1421.00
136_T139_A1.1271.00
204_A216_A1.1271.00
59_L97_L1.1251.00
352_G357_A1.1241.00
77_A81_A1.1151.00
355_V359_A1.1151.00
8_S12_V1.1131.00
353_A357_A1.1131.00
123_P131_S1.1121.00
204_A212_A1.1071.00
120_A185_E1.1031.00
64_I98_I1.0991.00
52_V113_T1.0971.00
212_A288_G1.0961.00
271_V309_L1.0911.00
19_M76_M1.0851.00
347_Y351_V1.0821.00
218_I222_G1.0741.00
31_Y46_A1.0731.00
260_A321_F1.0671.00
186_I234_A1.0651.00
197_Q219_H1.0641.00
135_S139_A1.0601.00
17_F74_L1.0591.00
109_F175_A1.0561.00
185_E245_T1.0561.00
41_R44_V1.0551.00
66_Y90_L1.0521.00
207_I289_A1.0511.00
70_G90_L1.0471.00
93_A97_L1.0451.00
250_D318_R1.0371.00
92_Q161_A1.0371.00
284_Y287_I1.0311.00
308_T311_Y1.0271.00
349_T352_G1.0201.00
258_V262_A1.0171.00
222_G281_G1.0161.00
327_V330_D1.0081.00
354_T357_A1.0051.00
10_M19_M1.0031.00
143_L205_I1.0011.00
336_A339_P0.9951.00
177_S311_Y0.9941.00
144_R216_A0.9861.00
92_Q160_V0.9851.00
73_T79_L0.9851.00
223_H227_K0.9831.00
119_Y131_S0.9811.00
262_A266_L0.9801.00
43_T46_A0.9791.00
173_I301_I0.9791.00
89_V92_Q0.9781.00
159_P162_R0.9761.00
341_S345_G0.9721.00
241_T249_F0.9721.00
115_Q119_Y0.9701.00
266_L350_V0.9681.00
215_G284_Y0.9621.00
171_V175_A0.9541.00
16_L64_I0.9511.00
124_D127_S0.9451.00
166_I169_A0.9451.00
262_A350_V0.9361.00
135_S140_Y0.9351.00
141_A145_V0.9321.00
226_M278_G0.9301.00
20_Y61_L0.9261.00
14_A75_N0.9251.00
300_V304_S0.9231.00
338_T341_S0.9221.00
233_T346_M0.9211.00
246_I319_M0.9201.00
286_A298_L0.9161.00
258_V347_Y0.9141.00
178_L307_L0.9131.00
176_G196_S0.9111.00
240_E256_S0.9101.00
272_G282_K0.8961.00
260_A320_F0.8941.00
102_L141_A0.8911.00
228_G232_L0.8871.00
166_I170_V0.8861.00
106_V139_A0.8861.00
325_A328_P0.8851.00
338_T343_S0.8851.00
74_L78_D0.8831.00
15_D18_N0.8831.00
94_A98_I0.8791.00
197_Q311_Y0.8781.00
132_A136_T0.8771.00
20_Y24_E0.8761.00
10_M137_V0.8741.00
124_D187_K0.8711.00
20_Y64_I0.8701.00
250_D325_A0.8701.00
127_S130_I0.8671.00
3_L7_L0.8651.00
139_A220_L0.8651.00
124_D131_S0.8641.00
186_I249_F0.8631.00
350_V353_A0.8631.00
267_A315_L0.8571.00
174_V178_L0.8501.00
124_D235_G0.8501.00
164_I167_G0.8491.00
173_I203_A0.8491.00
288_G292_A0.8491.00
346_M357_A0.8461.00
312_F315_L0.8391.00
200_L285_I0.8371.00
237_V252_L0.8371.00
179_L192_Y0.8361.00
124_D128_A0.8341.00
23_L60_F0.8311.00
354_T358_V0.8301.00
13_T22_F0.8291.00
344_T347_Y0.8281.00
169_A202_L0.8261.00
261_G265_V0.8251.00
7_L138_A0.8211.00
140_Y144_R0.8201.00
236_V259_A0.8201.00
76_M80_A0.8191.00
341_S344_T0.8191.00
11_T141_A0.8191.00
4_V8_S0.8181.00
304_S307_L0.8121.00
288_G291_E0.8111.00
262_A347_Y0.8101.00
197_Q308_T0.8091.00
316_V321_F0.8061.00
243_A249_F0.8051.00
11_T137_V0.8031.00
120_A188_R0.8011.00
71_T79_L0.8001.00
277_V356_C0.7981.00
116_P195_V0.7971.00
92_Q96_A0.7971.00
256_S337_E0.7941.00
219_H226_M0.7941.00
7_L26_T0.7911.00
201_I220_L0.7901.00
16_L146_V0.7901.00
355_V362_F0.7891.00
194_S223_H0.7891.00
338_T342_S0.7891.00
174_V300_V0.7871.00
108_V198_F0.7861.00
219_H222_G0.7851.00
316_V320_F0.7841.00
63_G67_A0.7831.00
67_A94_A0.7821.00
113_T116_P0.7821.00
166_I203_A0.7731.00
128_A232_L0.7701.00
342_S345_G0.7691.00
327_V331_G0.7671.00
337_E343_S0.7661.00
93_A96_A0.7651.00
269_S278_G0.7621.00
128_A231_F0.7611.00
47_L51_L0.7601.00
240_E342_S0.7591.00
349_T353_A0.7561.00
347_Y350_V0.7541.00
262_A346_M0.7531.00
6_G10_M0.7531.00
164_I168_G0.7481.00
134_V138_A0.7461.00
190_L230_L0.7451.00
34_V118_A0.7411.00
177_S308_T0.7401.00
343_S347_Y0.7371.00
274_P279_F0.7361.00
309_L313_L0.7351.00
26_T135_S0.7341.00
59_L100_V0.7301.00
77_A80_A0.7301.00
268_V273_V0.7291.00
236_V338_T0.7291.00
34_V123_P0.7251.00
313_L317_E0.7251.00
346_M350_V0.7231.00
148_T151_G0.7221.00
37_G40_S0.7221.00
229_G349_T0.7191.00
127_S131_S0.7161.00
291_E294_S0.7141.00
131_S223_H0.7111.00
41_R121_G0.7071.00
56_G101_G0.7071.00
160_V164_I0.7061.00
123_P128_A0.7051.00
170_V174_V0.7031.00
215_G285_I0.7021.00
259_A338_T0.6981.00
336_A340_A0.6971.00
109_F176_G0.6931.00
212_A216_A0.6921.00
80_A148_T0.6921.00
178_L182_S0.6911.00
269_S276_T0.6911.00
226_M270_M0.6911.00
170_V297_L0.6901.00
197_Q227_K0.6891.00
261_G320_F0.6881.00
170_V203_A0.6851.00
95_F99_V0.6821.00
204_A215_G0.6801.00
276_T280_A0.6791.00
286_A302_V0.6791.00
306_L310_A0.6771.00
224_A228_G0.6751.00
179_L182_S0.6741.00
3_L129_L0.6741.00
131_S194_S0.6731.00
275_P358_V0.6721.00
73_T76_M0.6701.00
139_A145_V0.6701.00
40_S120_A0.6701.00
14_A18_N0.6671.00
189_V315_L0.6671.00
68_Y71_T0.6661.00
356_C360_L0.6641.00
167_G170_V0.6641.00
255_R324_P0.6641.00
277_V353_A0.6631.00
10_M22_F0.6631.00
183_Q189_V0.6621.00
27_G57_A0.6621.00
119_Y128_A0.6621.00
144_R205_I0.6611.00
272_G276_T0.6601.00
67_A79_L0.6591.00
272_G278_G0.6571.00
123_P126_V0.6561.00
60_F102_L0.6561.00
95_F161_A0.6541.00
183_Q192_Y0.6541.00
54_T57_A0.6521.00
220_L224_A0.6511.00
31_Y53_G0.6491.00
356_C359_A0.6491.00
60_F98_I0.6491.00
263_F320_F0.6471.00
246_I315_L0.6471.00
197_Q270_M0.6461.00
126_V235_G0.6431.00
67_A70_G0.6431.00
132_A228_G0.6411.00
152_A159_P0.6401.00
139_A201_I0.6391.00
260_A264_G0.6391.00
90_L93_A0.6391.00
236_V240_E0.6371.00
169_A173_I0.6301.00
119_Y194_S0.6301.00
314_R317_E0.6301.00
119_Y191_A0.6261.00
337_E340_A0.6241.00
9_G12_V0.6201.00
132_A231_F0.6201.00
246_I318_R0.6201.00
227_K231_F0.6181.00
109_F112_H0.6181.00
261_G264_G0.6131.00
207_I292_A0.6131.00
91_A94_A0.6121.00
177_S193_S0.6101.00
3_L30_A0.6091.00
140_Y145_V0.6091.00
145_V149_V0.6081.00
331_G336_A0.6081.00
193_S223_H0.6061.00
299_A302_V0.6051.00
25_I29_T0.6041.00
177_S307_L0.6031.00
254_D257_P0.6031.00
302_V305_T0.6021.00
267_A271_V0.6011.00
204_A208_G0.6001.00
42_S120_A0.6001.00
10_M27_G0.5981.00
282_K305_T0.5921.00
200_L304_S0.5901.00
159_P163_A0.5901.00
204_A288_G0.5891.00
346_M349_T0.5891.00
346_M352_G0.5881.00
34_V130_I0.5881.00
233_T266_L0.5771.00
212_A215_G0.5761.00
213_L216_A0.5751.00
193_S197_Q0.5691.00
27_G53_G0.5691.00
61_L65_G0.5681.00
95_F149_V0.5671.00
166_I207_I0.5651.00
170_V173_I0.5651.00
262_A343_S0.5651.00
239_T336_A0.5641.00
239_T342_S0.5631.00
138_A141_A0.5631.00
99_V142_L0.5611.00
253_A320_F0.5611.00
280_A284_Y0.5601.00
24_E105_K0.5591.00
326_T329_A0.5591.00
323_A326_T0.5571.00
301_I305_T0.5541.00
225_V277_V0.5511.00
226_M353_A0.5511.00
135_S198_F0.5501.00
126_V131_S0.5501.00
16_L76_M0.5501.00
251_G254_D0.5481.00
290_A293_G0.5461.00
250_D322_R0.5451.00
286_A305_T0.5451.00
143_L213_L0.5451.00
357_A360_L0.5441.00
20_Y31_Y0.5441.00
99_V168_G0.5421.00
254_D323_A0.5421.00
112_H116_P0.5401.00
20_Y57_A0.5391.00
258_V343_S0.5381.00
136_T141_A0.5371.00
52_V104_I0.5361.00
176_G195_V0.5351.00
344_T348_A0.5351.00
95_F146_V0.5351.00
352_G355_V0.5351.00
26_T137_V0.5341.00
221_V224_A0.5341.00
240_E255_R0.5331.00
179_L183_Q0.5331.00
71_T75_N0.5321.00
184_S193_S0.5311.00
348_A351_V0.5301.00
67_A98_I0.5301.00
45_A118_A0.5291.00
173_I200_L0.5291.00
126_V130_I0.5281.00
23_L26_T0.5271.00
124_D129_L0.5241.00
252_L257_P0.5231.00
236_V342_S0.5221.00
79_L82_K0.5211.00
319_M322_R0.5211.00
134_V141_A0.5201.00
257_P260_A0.5191.00
23_L137_V0.5191.00
18_N21_V0.5191.00
310_A314_R0.5180.99
125_T131_S0.5170.99
236_V346_M0.5160.99
131_S135_S0.5160.99
127_S187_K0.5150.99
350_V356_C0.5140.99
19_M60_F0.5130.99
326_T330_D0.5130.99
192_Y195_V0.5120.99
121_G188_R0.5100.99
30_A134_V0.5080.99
279_F283_W0.5070.99
136_T198_F0.5070.99
147_Y151_G0.5060.99
230_L263_F0.5050.99
16_L67_A0.5050.99
137_V140_Y0.5050.99
264_G268_V0.5050.99
48_K51_L0.5040.99
347_Y357_A0.5000.99
233_T262_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoM 1 0.9763 100 0.076 Contact Map
4he8M 1 0.9632 100 0.086 Contact Map
3rkoN 1 0.9395 100 0.102 Contact Map
4he8L 1 0.9605 100 0.138 Contact Map
3rkoL 1 0.9579 100 0.138 Contact Map
4he8N 1 0.8921 100 0.169 Contact Map
3rkoK 1 0.2211 48.2 0.951 Contact Map
4he8K 1 0.2211 40.1 0.954 Contact Map
3wdoA 1 0.8921 2.6 0.974 Contact Map
2yevB 1 0.2711 2.4 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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