GREMLIN Database
Q9HRS7 - Uncharacterized protein
UniProt: Q9HRS7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 118 (104)
Sequences: 1624 (932)
Seq/√Len: 91.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_I44_G5.1991.00
24_V37_G4.5941.00
29_G107_D2.9341.00
99_I111_L2.7581.00
30_N106_L2.7341.00
46_F78_I2.5041.00
39_N89_T2.4211.00
105_T110_T2.1821.00
74_P77_L2.1761.00
21_G41_F1.9841.00
91_V95_M1.9701.00
99_I103_Y1.9281.00
107_D110_T1.9191.00
42_Q81_A1.9021.00
49_F53_A1.8851.00
15_F19_G1.8741.00
18_I45_I1.8071.00
35_V89_T1.6551.00
28_A33_K1.5551.00
49_F78_I1.5541.00
32_V96_I1.5451.00
89_T93_L1.4931.00
24_V28_A1.4881.00
18_I41_F1.4270.99
64_T68_P1.3500.99
31_L107_D1.3380.99
22_T27_A1.2860.99
35_V96_I1.2740.99
42_Q84_V1.2580.99
46_F49_F1.2410.98
46_F84_V1.2330.98
35_V92_A1.2300.98
21_G94_G1.2230.98
98_R101_D1.2010.98
46_F81_A1.1960.98
76_V84_V1.1870.98
95_M98_R1.1770.98
25_M38_M1.1500.97
46_F53_A1.1350.97
45_I62_L1.1280.97
19_G27_A1.1160.97
71_S89_T1.0750.96
38_M47_L1.0600.96
34_K108_E1.0530.96
88_L95_M1.0400.95
10_Y51_A1.0370.95
19_G23_Y1.0360.95
33_K48_F1.0080.94
16_L70_V0.9940.94
104_G108_E0.9900.94
79_L82_I0.9870.94
85_G94_G0.9840.94
70_V75_H0.9840.94
71_S75_H0.9740.93
20_I40_I0.9690.93
37_G40_I0.9460.92
53_A74_P0.9080.91
60_P88_L0.8850.89
39_N45_I0.8830.89
29_G98_R0.8760.89
43_T48_F0.8720.89
10_Y13_A0.8640.88
35_V49_F0.8620.88
34_K84_V0.8590.88
32_V78_I0.8550.88
59_T68_P0.8530.88
23_Y95_M0.8440.87
25_M39_N0.8370.87
41_F76_V0.8350.87
30_N99_I0.8290.86
42_Q85_G0.8240.86
99_I106_L0.8200.86
96_I106_L0.8160.85
14_S44_G0.8010.84
11_Y31_L0.7940.84
71_S88_L0.7890.83
25_M90_A0.7780.82
71_S84_V0.7660.81
25_M104_G0.7640.81
76_V86_V0.7590.81
47_L70_V0.7580.81
62_L72_P0.7540.80
54_Y106_L0.7430.79
53_A75_H0.7420.79
104_G107_D0.7380.79
92_A99_I0.7310.78
56_E70_V0.7300.78
81_A85_G0.7270.78
25_M41_F0.7250.78
54_Y70_V0.7170.77
91_V98_R0.7130.77
50_I86_V0.6960.75
21_G44_G0.6940.75
68_P92_A0.6850.74
37_G79_L0.6800.73
25_M70_V0.6770.73
64_T69_H0.6720.72
42_Q69_H0.6680.72
50_I78_I0.6680.72
25_M47_L0.6650.72
23_Y77_L0.6610.71
9_D68_P0.6550.70
43_T91_V0.6540.70
95_M105_T0.6500.70
15_F86_V0.6480.70
100_Y107_D0.6450.69
77_L107_D0.6450.69
79_L95_M0.6430.69
13_A57_G0.6260.67
24_V40_I0.6220.66
54_Y58_G0.6210.66
35_V98_R0.6200.66
42_Q90_A0.6190.66
8_K12_I0.6180.66
75_H84_V0.6150.66
40_I52_S0.6130.65
16_L20_I0.6120.65
31_L96_I0.6110.65
17_L95_M0.6040.64
12_I19_G0.6030.64
56_E63_L0.6020.64
61_P91_V0.6010.64
58_G90_A0.5980.63
13_A51_A0.5960.63
29_G56_E0.5940.63
36_I85_G0.5940.63
23_Y27_A0.5930.63
42_Q95_M0.5820.61
33_K93_L0.5810.61
27_A42_Q0.5780.61
71_S106_L0.5780.61
43_T97_V0.5770.61
54_Y86_V0.5770.61
91_V94_G0.5750.60
34_K103_Y0.5740.60
12_I15_F0.5660.59
29_G94_G0.5640.59
33_K97_V0.5630.59
9_D64_T0.5610.59
59_T87_A0.5530.57
59_T67_T0.5460.57
35_V43_T0.5390.56
13_A96_I0.5380.55
13_A17_L0.5380.55
54_Y97_V0.5230.53
57_G61_P0.5190.53
53_A77_L0.5180.53
60_P90_A0.5160.52
86_V94_G0.5140.52
12_I16_L0.5140.52
81_A84_V0.5120.52
24_V36_I0.5120.52
8_K21_G0.5110.52
38_M45_I0.5080.51
11_Y42_Q0.5030.51
87_A100_Y0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoK 1 0.8475 99.6 0.568 Contact Map
4he8K 1 0.8051 99.6 0.589 Contact Map
2kncB 1 0.4322 8 0.936 Contact Map
3rkoL 1 0.8305 7.2 0.937 Contact Map
1lnqA 6 0.6356 7.2 0.937 Contact Map
3rkoM 1 0.8475 7.1 0.937 Contact Map
2kluA 1 0.4068 6.6 0.938 Contact Map
3rkoN 1 0.839 6.4 0.939 Contact Map
2kncA 1 0.4322 5.7 0.94 Contact Map
4he8M 1 0.8475 5.5 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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