GREMLIN Database
Q9HRS6 - Uncharacterized protein
UniProt: Q9HRS6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 155 (132)
Sequences: 1624 (1024)
Seq/√Len: 89.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_G129_G6.6911.00
37_V54_I4.6221.00
112_G115_H4.0391.00
34_G55_V3.5971.00
55_V129_G3.3911.00
38_M126_L3.0231.00
95_A105_F2.7801.00
110_V117_S2.7001.00
112_G117_S2.2951.00
88_V131_I2.2921.00
103_G107_D2.0651.00
104_A107_D1.9851.00
95_A106_L1.7401.00
27_S30_V1.7321.00
97_S120_S1.6451.00
94_V123_I1.6311.00
20_M66_F1.5771.00
34_G51_G1.5381.00
20_M24_R1.5301.00
103_G109_S1.5111.00
67_G70_P1.4831.00
19_I61_M1.4560.99
84_V88_V1.4470.99
97_S123_I1.4140.99
113_G118_K1.3910.99
86_G130_A1.3740.99
87_G127_F1.3490.99
89_T93_A1.3350.99
92_L96_S1.3250.99
35_L39_F1.3110.99
88_V125_E1.2990.99
95_A98_T1.2890.99
83_I134_S1.2890.99
90_A130_A1.2660.98
31_F58_V1.2460.98
78_R81_V1.2430.98
120_S124_I1.2360.98
43_D117_S1.2340.98
31_F55_V1.2090.98
96_S99_V1.1940.98
23_V65_A1.1740.97
27_S93_A1.1680.97
63_G141_I1.1570.97
51_G146_G1.1290.97
118_K122_E1.1260.97
43_D50_Q1.1230.97
36_F39_F1.1150.97
39_F74_W1.1080.96
38_M129_G1.1070.96
120_S123_I1.1070.96
99_V102_G1.0970.96
125_E131_I1.0930.96
113_G117_S1.0720.96
60_L136_I1.0680.96
72_R145_A1.0580.95
30_V58_V1.0550.95
124_I127_F1.0490.95
53_V124_I1.0450.95
78_R82_A1.0450.95
40_H53_V1.0340.95
91_F124_I1.0310.95
110_V119_Y1.0270.95
120_S125_E1.0180.94
75_V79_L1.0160.94
27_S62_L1.0050.94
36_F54_I0.9910.93
115_H119_Y0.9850.93
15_E20_M0.9840.93
97_S109_S0.9830.93
123_I131_I0.9720.93
98_T103_G0.9700.93
97_S101_L0.9570.92
30_V33_Y0.9560.92
15_E57_T0.9500.92
51_G57_T0.9400.92
61_M75_V0.9370.91
60_L143_I0.9330.91
96_S100_L0.9230.91
58_V142_A0.9120.90
86_G90_A0.8970.90
125_E129_G0.8920.89
93_A97_S0.8810.89
98_T107_D0.8770.88
85_V128_I0.8770.88
67_G145_A0.8750.88
71_V76_G0.8680.88
108_V119_Y0.8640.88
52_G88_V0.8580.87
72_R141_I0.8470.87
116_A135_T0.8420.86
37_V56_A0.8400.86
63_G72_R0.8350.86
36_F40_H0.8270.85
94_V97_S0.8210.85
18_I21_G0.8090.84
55_V58_V0.7990.83
45_A132_V0.7980.83
122_E126_L0.7920.83
25_V71_V0.7880.82
110_V121_I0.7830.82
22_T89_T0.7690.81
89_T96_S0.7690.81
93_A98_T0.7650.81
99_V105_F0.7620.80
56_A138_G0.7610.80
90_A93_A0.7600.80
83_I130_A0.7600.80
64_I144_D0.7560.80
34_G54_I0.7540.80
70_P73_E0.7540.80
138_G142_A0.7530.80
34_G68_I0.7440.79
19_I22_T0.7430.79
17_S23_V0.7410.78
71_V141_I0.7410.78
35_L38_M0.7400.78
33_Y137_T0.7360.78
118_K125_E0.7350.78
96_S105_F0.7320.78
96_S107_D0.7130.76
129_G144_D0.7080.75
64_I95_A0.7080.75
59_M71_V0.7070.75
23_V30_V0.7060.75
38_M42_A0.7060.75
84_V135_T0.7050.75
77_E83_I0.7030.75
25_V36_F0.7000.74
40_H124_I0.6990.74
122_E133_A0.6910.73
64_I67_G0.6870.73
19_I83_I0.6840.73
113_G116_A0.6790.72
109_S119_Y0.6720.71
70_P74_W0.6700.71
56_A136_I0.6700.71
108_V121_I0.6690.71
40_H50_Q0.6590.70
55_V65_A0.6580.70
82_A86_G0.6570.70
97_S103_G0.6490.69
101_L109_S0.6450.68
73_E99_V0.6270.66
68_I72_R0.6150.65
44_S60_L0.6140.64
38_M125_E0.6090.64
62_L65_A0.6070.64
57_T81_V0.6030.63
84_V131_I0.5990.63
108_V143_I0.5940.62
135_T139_L0.5900.61
121_I125_E0.5880.61
36_F64_I0.5870.61
98_T105_F0.5870.61
108_V120_S0.5830.60
62_L71_V0.5790.60
40_H44_S0.5780.60
28_P74_W0.5760.60
68_I141_I0.5750.59
23_V58_V0.5720.59
87_G90_A0.5710.59
119_Y122_E0.5710.59
26_V58_V0.5710.59
29_F78_R0.5700.59
32_T78_R0.5700.59
27_S81_V0.5680.58
22_T26_V0.5670.58
27_S77_E0.5630.58
14_I145_A0.5590.57
117_S121_I0.5590.57
57_T64_I0.5540.57
93_A101_L0.5510.56
23_V27_S0.5510.56
139_L142_A0.5510.56
23_V73_E0.5490.56
43_D135_T0.5480.56
94_V110_V0.5460.56
121_I137_T0.5450.55
116_A139_L0.5440.55
34_G125_E0.5420.55
84_V98_T0.5410.55
63_G71_V0.5380.54
96_S136_I0.5350.54
34_G38_M0.5310.54
29_F53_V0.5300.53
51_G135_T0.5250.53
83_I86_G0.5180.52
52_G142_A0.5160.51
110_V123_I0.5100.51
19_I23_V0.5080.50
21_G65_A0.5080.50
38_M51_G0.5080.50
42_A124_I0.5070.50
131_I135_T0.5050.50
68_I136_I0.5020.50
68_I139_L0.5010.49
31_F122_E0.5010.49
61_M122_E0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.8516 22.8 0.931 Contact Map
1pw4A 1 0.871 7.1 0.945 Contact Map
2bg9B 1 0.3355 6.9 0.945 Contact Map
4tphA 2 0.7677 6.5 0.946 Contact Map
3s8fA 1 0.9548 6 0.947 Contact Map
3j1zP 8 0.9419 5.9 0.947 Contact Map
3wdoA 1 0.8516 5 0.949 Contact Map
4o6yA 2 0.8839 4.9 0.949 Contact Map
3pjzA 2 0.8065 4.6 0.95 Contact Map
4fc4A 3 0.8323 4.5 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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