GREMLIN Database
Q9HRS5 - Uncharacterized protein
UniProt: Q9HRS5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 176 (160)
Sequences: 1574 (1099)
Seq/√Len: 86.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_I139_V5.8921.00
136_V142_A5.6091.00
129_H133_E4.5971.00
124_R128_D4.1441.00
94_V98_G3.6981.00
131_Y137_K3.6251.00
101_L105_H3.0671.00
120_S124_R2.9871.00
11_V37_G2.9491.00
36_L60_G2.2911.00
125_Y129_H2.2541.00
90_F93_A2.2481.00
85_L88_P2.1721.00
32_A63_T2.0461.00
17_A30_A2.0261.00
90_F94_V2.0111.00
87_V91_G1.9951.00
134_A142_A1.9571.00
98_G101_L1.9521.00
136_V141_T1.9331.00
14_T63_T1.8271.00
91_G95_V1.7641.00
28_I70_I1.7321.00
129_H132_H1.6911.00
98_G102_T1.6741.00
16_L20_V1.6301.00
9_V13_A1.5321.00
18_T30_A1.5031.00
134_A146_S1.4840.99
23_D76_P1.4530.99
141_T145_A1.3980.99
8_L12_V1.3770.99
93_A96_L1.3740.99
39_A55_A1.3530.99
35_S58_G1.3360.99
6_P9_V1.3270.99
129_H147_Y1.3210.99
26_A153_L1.3200.99
64_V104_V1.3150.99
121_E124_R1.2960.99
53_T138_N1.2930.99
54_E58_G1.2860.98
82_F85_L1.2520.98
134_A144_L1.2510.98
11_V16_L1.2110.98
87_V90_F1.1770.97
21_L26_A1.1580.97
65_L144_L1.1470.97
122_V126_Y1.1430.97
61_V65_L1.1290.97
85_L89_A1.1270.97
8_L11_V1.1260.97
126_Y143_V1.1220.96
8_L15_A1.0970.96
82_F87_V1.0820.96
136_V146_S1.0740.95
153_L157_V1.0430.95
96_L107_L1.0370.94
14_T33_T1.0210.94
134_A137_K1.0160.94
123_T142_A1.0080.94
16_L19_T1.0020.93
29_I61_V0.9980.93
17_A26_A0.9970.93
125_Y149_G0.9940.93
50_V54_E0.9920.93
14_T37_G0.9900.93
53_T141_T0.9880.93
131_Y134_A0.9880.93
42_W60_G0.9840.93
41_V157_V0.9840.93
58_G146_S0.9620.92
107_L153_L0.9620.92
142_A145_A0.9500.91
37_G163_G0.9470.91
84_R88_P0.9390.91
35_S159_V0.9300.91
63_T67_L0.9280.90
11_V15_A0.9280.90
106_A110_I0.9260.90
7_L44_V0.9180.90
102_T106_A0.9090.90
128_D133_E0.9000.89
42_W146_S0.8980.89
76_P169_V0.8910.89
12_V16_L0.8830.88
82_F90_F0.8800.88
32_A44_V0.8800.88
34_Y71_A0.8770.88
46_Q89_A0.8720.87
144_L153_L0.8720.87
26_A29_I0.8670.87
22_R77_G0.8670.87
107_L111_G0.8580.87
149_G163_G0.8580.87
78_D82_F0.8580.87
96_L100_L0.8570.87
39_A165_G0.8550.86
55_A157_V0.8510.86
61_V67_L0.8500.86
15_A34_Y0.8480.86
128_D132_H0.8480.86
56_A67_L0.8460.86
13_A20_V0.8410.86
52_L135_G0.8390.85
50_V140_V0.8380.85
112_D123_T0.8340.85
54_E141_T0.8290.85
27_S64_V0.8250.84
123_T127_I0.8250.84
18_T166_L0.8240.84
61_V81_V0.8180.84
40_V44_V0.8090.83
126_Y147_Y0.8090.83
85_L90_F0.8050.83
98_G124_R0.7930.82
34_Y166_L0.7850.81
163_G170_L0.7830.81
36_L43_V0.7810.81
83_E86_N0.7770.81
126_Y139_V0.7670.80
86_N89_A0.7670.80
13_A82_F0.7650.80
12_V90_F0.7580.79
32_A143_V0.7580.79
67_L166_L0.7460.78
77_G80_A0.7410.77
53_T145_A0.7390.77
23_D77_G0.7360.77
54_E146_S0.7340.77
141_T144_L0.7340.77
100_L103_T0.7330.77
147_Y150_F0.7280.76
5_L87_V0.7270.76
57_V135_G0.7220.76
58_G154_G0.7220.76
84_R87_V0.7210.76
165_G169_V0.7210.76
57_V154_G0.7190.75
55_A144_L0.7170.75
125_Y147_Y0.7150.75
46_Q69_T0.7070.74
43_V46_Q0.7060.74
21_L27_S0.7060.74
17_A20_V0.6990.73
163_G167_L0.6970.73
14_T30_A0.6930.73
41_V45_L0.6910.72
151_D155_E0.6900.72
152_T155_E0.6900.72
8_L57_V0.6890.72
30_A43_V0.6870.72
44_V75_R0.6860.72
61_V108_P0.6860.72
31_F42_W0.6790.71
126_Y130_A0.6770.71
31_F139_V0.6730.70
53_T122_V0.6670.70
46_Q70_I0.6600.69
42_W141_T0.6580.69
105_H127_I0.6570.69
131_Y142_A0.6560.68
9_V85_L0.6540.68
31_F56_A0.6530.68
126_Y135_G0.6510.68
45_L67_L0.6480.68
7_L40_V0.6480.68
153_L161_S0.6440.67
84_R91_G0.6400.67
31_F34_Y0.6380.66
30_A71_A0.6350.66
150_F153_L0.6330.66
50_V164_V0.6290.65
134_A156_A0.6280.65
31_F45_L0.6250.65
122_V142_A0.6140.63
64_V70_I0.6120.63
23_D171_R0.6120.63
16_L30_A0.6110.63
71_A165_G0.6090.63
108_P111_G0.6090.63
91_G102_T0.6080.63
95_V98_G0.6060.62
20_V25_L0.6050.62
102_T168_V0.6050.62
92_A109_T0.6050.62
145_A163_G0.6040.62
133_E147_Y0.5980.61
5_L10_F0.5960.61
92_A132_H0.5950.61
52_L106_A0.5930.61
131_Y144_L0.5930.61
143_V147_Y0.5920.61
56_A150_F0.5900.60
54_E136_V0.5890.60
155_E158_V0.5890.60
9_V78_D0.5870.60
55_A58_G0.5820.59
8_L18_T0.5820.59
103_T110_I0.5810.59
35_S146_S0.5790.59
52_L62_T0.5770.59
50_V141_T0.5760.59
100_L127_I0.5740.58
43_V77_G0.5720.58
54_E145_A0.5710.58
54_E60_G0.5700.58
15_A19_T0.5690.58
142_A149_G0.5630.57
34_Y60_G0.5580.56
60_G146_S0.5560.56
67_L159_V0.5550.56
14_T34_Y0.5550.56
138_N141_T0.5540.56
54_E63_T0.5520.55
25_L29_I0.5490.55
148_R151_D0.5480.55
148_R152_T0.5480.55
134_A147_Y0.5460.55
141_T146_S0.5450.54
136_V144_L0.5410.54
52_L103_T0.5400.54
139_V149_G0.5390.54
35_S168_V0.5390.54
56_A168_V0.5390.54
128_D131_Y0.5380.53
139_V161_S0.5370.53
21_L28_I0.5350.53
21_L78_D0.5330.53
58_G141_T0.5310.53
47_A162_A0.5180.51
7_L170_L0.5150.50
53_T68_L0.5130.50
24_V159_V0.5120.50
68_L74_V0.5100.50
28_I95_V0.5050.49
29_I92_A0.5040.49
130_A142_A0.5030.49
70_I73_T0.5030.49
164_V167_L0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8J 1 0.8977 97.5 0.844 Contact Map
3rkoJ 1 0.8977 95.2 0.878 Contact Map
4r0cA 3 0.4773 11.4 0.947 Contact Map
3dh4A 3 0.6193 10 0.949 Contact Map
3w4tA 1 0.4432 4.2 0.957 Contact Map
2nq2A 2 0.8295 3.5 0.959 Contact Map
2p1gA 1 0.2955 3.2 0.959 Contact Map
4he8K 1 0.4886 2.7 0.961 Contact Map
3mktA 1 0.4886 2.5 0.961 Contact Map
3rkoK 1 0.4886 2.5 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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