GREMLIN Database
Q9HRS1 - Pantothenate metabolism flavoprotein
UniProt: Q9HRS1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (374)
Sequences: 3571 (2466)
Seq/√Len: 127.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
194_A246_S3.4231.00
251_T302_A3.4151.00
183_H223_R3.3811.00
208_R358_D2.9211.00
211_R228_H2.8171.00
6_N33_C2.7641.00
136_D144_W2.7251.00
337_S341_R2.6411.00
178_P220_R2.6401.00
280_E320_P2.6381.00
362_A380_L2.5331.00
320_P330_S2.5181.00
330_S333_A2.4871.00
43_Q61_T2.3681.00
24_V55_T2.3521.00
136_D140_R2.3361.00
220_R386_E2.3351.00
12_T91_T2.3151.00
217_C385_A2.2981.00
274_T294_E2.2701.00
10_G104_V2.2691.00
220_R385_A2.2411.00
183_H225_T2.2011.00
9_V24_V2.1801.00
248_A252_A2.1751.00
35_R57_N2.1511.00
152_R165_T2.1331.00
332_V365_V2.1121.00
348_V362_A2.0711.00
26_E29_R2.0671.00
187_T254_T2.0631.00
77_G154_E2.0291.00
83_V170_T1.9901.00
21_V54_A1.9811.00
184_V263_A1.9651.00
215_A378_R1.9621.00
4_G32_A1.9581.00
95_I120_V1.9491.00
240_D257_A1.9331.00
185_V261_A1.9311.00
81_V170_T1.9281.00
235_A241_V1.9271.00
149_V161_P1.9051.00
93_G134_V1.8881.00
21_V50_A1.8841.00
11_V51_V1.8511.00
37_V107_C1.8491.00
186_V213_V1.8461.00
371_S387_R1.8161.00
190_A230_A1.8131.00
223_R240_D1.7981.00
251_T255_L1.7551.00
255_L302_A1.7541.00
274_T296_T1.7511.00
225_T242_R1.7471.00
33_C57_N1.7421.00
319_T352_A1.7341.00
82_F114_A1.7251.00
35_R78_W1.7131.00
218_Y239_A1.7131.00
40_E44_G1.7121.00
364_F387_R1.7031.00
130_D157_K1.7031.00
301_G305_D1.6941.00
335_A349_A1.6821.00
187_T227_V1.6661.00
194_A204_R1.6501.00
30_R171_A1.6271.00
138_I148_V1.6071.00
216_A382_A1.6061.00
195_I201_L1.5931.00
254_T303_V1.5871.00
190_A229_D1.5821.00
213_V384_I1.5711.00
211_R233_G1.5691.00
235_A243_D1.5631.00
253_A256_T1.5431.00
14_S88_T1.5351.00
119_V173_A1.5131.00
92_V120_V1.5121.00
139_D143_S1.5101.00
129_Y138_I1.5091.00
248_A297_R1.5041.00
263_A388_L1.4951.00
331_M349_A1.4761.00
244_V250_M1.4751.00
359_E375_G1.4651.00
206_S356_G1.4641.00
242_R257_A1.4641.00
182_T262_D1.4591.00
346_F366_T1.4511.00
38_M42_A1.4491.00
95_I111_A1.4401.00
288_D292_S1.4391.00
150_D157_K1.4381.00
46_I51_V1.4381.00
150_D161_P1.4261.00
91_T105_T1.4161.00
91_T102_S1.3861.00
82_F111_A1.3761.00
136_D143_S1.3691.00
194_A245_S1.3641.00
184_V217_C1.3551.00
211_R231_S1.3521.00
22_E26_E1.3461.00
287_E295_P1.3421.00
120_V146_V1.3391.00
192_S202_T1.3381.00
264_L303_V1.3321.00
121_V149_V1.3311.00
133_G144_W1.3201.00
314_G344_L1.3201.00
248_A274_T1.3191.00
84_V111_A1.3191.00
265_V385_A1.3181.00
304_R312_I1.3121.00
348_V384_I1.3071.00
94_K99_V1.3041.00
383_R386_E1.2991.00
195_I275_V1.2961.00
93_G112_V1.2951.00
192_S245_S1.2921.00
211_R235_A1.2901.00
177_Q180_A1.2881.00
139_D142_S1.2841.00
23_F167_V1.2811.00
188_S211_R1.2701.00
9_V20_V1.2621.00
81_V119_V1.2581.00
37_V104_V1.2531.00
21_V46_I1.2531.00
96_A140_R1.2491.00
197_P280_E1.2491.00
334_A337_S1.2451.00
336_R340_Q1.2431.00
333_A337_S1.2391.00
245_S249_E1.2271.00
303_V312_I1.2180.99
266_S300_V1.2110.99
36_A55_T1.2080.99
115_D127_P1.2080.99
213_V265_V1.2070.99
129_Y151_P1.2020.99
94_K101_D1.2000.99
247_A270_I1.1960.99
140_R144_W1.1920.99
228_H241_V1.1810.99
22_E164_S1.1740.99
218_Y238_Y1.1630.99
90_N101_D1.1600.99
227_V254_T1.1520.99
366_T370_V1.1440.99
7_V81_V1.1420.99
26_E167_V1.1400.99
152_R161_P1.1350.99
39_T104_V1.1350.99
361_R375_G1.1350.99
248_A251_T1.1310.99
127_P154_E1.1310.99
340_Q367_A1.1180.99
185_V257_A1.1150.99
121_V161_P1.1140.99
93_G99_V1.1100.99
300_V314_G1.1080.99
38_M43_Q1.1050.99
102_S105_T1.1040.99
44_G64_T1.1020.99
219_V382_A1.1010.99
302_A305_D1.0990.99
258_C264_L1.0990.99
95_I146_V1.0950.99
225_T257_A1.0920.99
306_D310_L1.0860.99
185_V227_V1.0830.99
24_V51_V1.0830.99
225_T240_D1.0810.99
178_P386_E1.0770.99
246_S249_E1.0740.99
258_C310_L1.0710.99
97_A140_R1.0610.99
253_A257_A1.0570.98
362_A384_I1.0540.98
152_R162_R1.0470.98
148_V161_P1.0450.98
204_R356_G1.0430.98
248_A296_T1.0390.98
142_S150_D1.0370.98
204_R245_S1.0310.98
249_E252_A1.0310.98
121_V160_L1.0260.98
288_D295_P1.0190.98
361_R372_E1.0050.98
160_L163_E1.0040.98
90_N99_V1.0010.98
251_T297_R0.9970.98
192_S200_V0.9950.98
275_V291_L0.9930.98
7_V32_A0.9930.98
178_P389_A0.9930.98
131_H146_V0.9920.98
147_S173_A0.9910.98
354_V360_T0.9900.98
41_S90_N0.9890.98
217_C265_V0.9880.98
10_G82_F0.9870.98
307_N310_L0.9850.98
339_L367_A0.9830.98
250_M299_L0.9830.98
93_G97_A0.9810.98
87_A92_V0.9790.98
6_N78_W0.9770.97
5_V80_D0.9760.97
311_P388_L0.9740.97
149_V169_E0.9720.97
27_L167_V0.9690.97
195_I291_L0.9640.97
225_T261_A0.9640.97
184_V265_V0.9620.97
5_V32_A0.9610.97
111_A118_V0.9600.97
228_H231_S0.9600.97
186_V217_C0.9590.97
301_G341_R0.9580.97
30_R167_V0.9560.97
60_V103_P0.9560.97
376_H379_G0.9540.97
161_P165_T0.9500.97
216_A219_V0.9490.97
264_L312_I0.9480.97
40_E62_E0.9480.97
119_V149_V0.9470.97
311_P346_F0.9460.97
201_L293_L0.9450.97
112_V134_V0.9420.97
220_R382_A0.9420.97
40_E43_Q0.9420.97
304_R343_G0.9420.97
120_V148_V0.9400.97
344_L347_V0.9340.97
346_F364_F0.9340.97
216_A220_R0.9330.97
332_V336_R0.9290.97
26_E163_E0.9270.97
313_V388_L0.9260.97
84_V95_I0.9220.96
304_R344_L0.9170.96
211_R241_V0.9170.96
183_H261_A0.9100.96
188_S226_L0.9060.96
23_F85_A0.9030.96
330_S334_A0.8960.96
366_T369_S0.8950.96
242_R253_A0.8940.96
21_V51_V0.8920.96
236_V239_A0.8910.96
53_F70_V0.8870.96
178_P382_A0.8850.96
317_A352_A0.8820.95
252_A256_T0.8810.95
121_V166_I0.8790.95
258_C303_V0.8720.95
276_E292_S0.8720.95
320_P334_A0.8710.95
126_E130_D0.8660.95
24_V36_A0.8610.95
28_R56_E0.8550.95
266_S303_V0.8540.95
6_N35_R0.8530.95
118_V146_V0.8510.94
119_V170_T0.8490.94
211_R243_D0.8440.94
111_A131_H0.8420.94
273_Y289_V0.8420.94
153_I157_K0.8380.94
33_C78_W0.8350.94
23_F83_V0.8320.94
43_Q48_P0.8300.94
228_H233_G0.8280.94
186_V265_V0.8270.94
142_S148_V0.8250.93
337_S340_Q0.8240.93
8_A79_A0.8240.93
74_G78_W0.8190.93
10_G84_V0.8180.93
150_D160_L0.8180.93
26_E30_R0.8120.93
22_E163_E0.8090.93
11_V17_A0.8070.93
316_K335_A0.8030.93
283_R318_E0.8020.93
94_K105_T0.8020.93
373_Y383_R0.7990.92
354_V357_N0.7990.92
184_V385_A0.7950.92
278_A282_L0.7900.92
190_A202_T0.7890.92
336_R365_V0.7880.92
77_G127_P0.7860.92
140_R143_S0.7860.92
188_S210_G0.7800.91
27_L170_T0.7800.91
20_V23_F0.7790.91
197_P319_T0.7780.91
179_L389_A0.7760.91
21_V24_V0.7760.91
152_R159_K0.7750.91
27_L83_V0.7740.91
336_R370_V0.7710.91
20_V160_L0.7700.91
83_V166_I0.7640.91
332_V363_L0.7640.91
185_V254_T0.7640.91
220_R389_A0.7610.90
213_V381_G0.7600.90
263_A311_P0.7600.90
49_W53_F0.7590.90
161_P169_E0.7570.90
347_V365_V0.7570.90
126_E154_E0.7560.90
336_R339_L0.7550.90
383_R387_R0.7510.90
96_A136_D0.7500.90
9_V85_A0.7480.90
111_A146_V0.7460.90
118_V131_H0.7440.89
228_H243_D0.7440.89
97_A137_A0.7440.89
300_V344_L0.7430.89
168_H172_R0.7400.89
366_T387_R0.7390.89
348_V364_F0.7390.89
212_A215_A0.7380.89
187_T266_S0.7380.89
254_T266_S0.7370.89
114_A118_V0.7350.89
363_L372_E0.7320.89
179_L182_T0.7300.89
211_R226_L0.7290.88
317_A351_D0.7230.88
92_V138_I0.7230.88
274_T297_R0.7210.88
228_H235_A0.7210.88
219_V378_R0.7190.88
32_A171_A0.7190.88
117_P147_S0.7150.87
87_A141_V0.7140.87
312_I344_L0.7100.87
385_A388_L0.7100.87
40_E102_S0.7090.87
378_R382_A0.7070.87
371_S383_R0.7060.87
36_A51_V0.7040.87
161_P166_I0.7030.87
41_S44_G0.7030.87
95_I131_H0.6990.86
168_H171_A0.6970.86
63_I103_P0.6960.86
332_V372_E0.6950.86
119_V147_S0.6940.86
380_L383_R0.6920.86
283_R334_A0.6900.86
76_D116_V0.6880.85
125_H154_E0.6870.85
266_S312_I0.6860.85
280_E330_S0.6820.85
20_V51_V0.6820.85
185_V264_L0.6790.85
8_A75_R0.6780.85
363_L370_V0.6770.84
218_Y235_A0.6760.84
306_D309_D0.6760.84
215_A219_V0.6760.84
11_V20_V0.6750.84
255_L303_V0.6740.84
28_R33_C0.6710.84
12_T88_T0.6700.84
67_V71_E0.6670.84
227_V250_M0.6670.84
244_V249_E0.6670.84
85_A160_L0.6670.84
284_S300_V0.6660.84
93_G137_A0.6650.83
26_E164_S0.6640.83
12_T84_V0.6640.83
119_V169_E0.6620.83
379_G382_A0.6560.83
47_H50_A0.6560.83
258_C261_A0.6550.83
25_H29_R0.6530.82
24_V28_R0.6530.82
183_H260_D0.6500.82
38_M48_P0.6490.82
76_D127_P0.6480.82
359_E376_H0.6480.82
73_C125_H0.6470.82
284_S295_P0.6440.81
335_A347_V0.6430.81
206_S267_A0.6430.81
15_I50_A0.6410.81
38_M59_V0.6400.81
247_A296_T0.6390.81
257_A260_D0.6390.81
298_K342_D0.6370.81
213_V385_A0.6370.81
119_V174_A0.6360.81
192_S230_A0.6350.81
258_C306_D0.6340.80
27_L32_A0.6320.80
68_P74_G0.6300.80
192_S204_R0.6290.80
247_A271_S0.6280.80
259_A308_P0.6280.80
360_T380_L0.6270.80
252_A255_L0.6270.80
211_R232_D0.6250.79
229_D250_M0.6240.79
304_R310_L0.6240.79
111_A114_A0.6230.79
135_R139_D0.6220.79
38_M46_I0.6210.79
10_G39_T0.6200.79
364_F384_I0.6170.79
37_V103_P0.6160.79
365_V370_V0.6150.78
47_H51_V0.6130.78
115_D130_D0.6130.78
38_M51_V0.6110.78
5_V174_A0.6100.78
361_R380_L0.6090.78
13_G41_S0.6080.78
190_A231_S0.6080.78
165_T237_P0.6080.78
129_Y150_D0.6070.78
244_V253_A0.6060.77
197_P278_A0.6060.77
113_G125_H0.6050.77
274_T277_A0.6050.77
193_E296_T0.6010.77
117_P173_A0.5980.76
91_T111_A0.5980.76
23_F160_L0.5970.76
193_E247_A0.5970.76
35_R60_V0.5960.76
126_E157_K0.5950.76
183_H257_A0.5950.76
261_A264_L0.5950.76
83_V121_V0.5950.76
169_E172_R0.5940.76
8_A82_F0.5930.76
82_F107_C0.5930.76
23_F26_E0.5930.76
355_M360_T0.5920.76
138_I142_S0.5920.76
133_G140_R0.5920.76
23_F166_I0.5890.75
94_K102_S0.5880.75
331_M334_A0.5880.75
230_A233_G0.5850.75
286_R295_P0.5840.75
242_R256_T0.5840.75
374_A380_L0.5840.75
216_A385_A0.5830.75
69_H74_G0.5830.75
43_Q47_H0.5820.75
89_A112_V0.5820.75
382_A386_E0.5790.74
352_A355_M0.5770.74
87_A120_V0.5770.74
179_L385_A0.5760.74
179_L184_V0.5760.74
254_T299_L0.5740.74
316_K338_L0.5740.74
90_N94_K0.5740.74
190_A228_H0.5740.74
13_G42_A0.5720.73
297_R302_A0.5720.73
28_R55_T0.5720.73
159_K162_R0.5710.73
313_V346_F0.5710.73
226_L233_G0.5690.73
85_A166_I0.5690.73
258_C307_N0.5690.73
18_V22_E0.5680.73
28_R57_N0.5680.73
81_V174_A0.5680.73
258_C312_I0.5660.72
97_A136_D0.5660.72
21_V38_M0.5650.72
91_T104_V0.5630.72
179_L217_C0.5620.72
13_G17_A0.5610.72
71_E74_G0.5610.72
339_L347_V0.5610.72
136_D139_D0.5580.71
77_G126_E0.5560.71
346_F387_R0.5530.71
163_E167_V0.5520.71
44_G49_W0.5520.71
357_N375_G0.5520.71
22_E29_R0.5520.71
362_A373_Y0.5510.70
22_E162_R0.5500.70
192_S356_G0.5490.70
343_G367_A0.5490.70
190_A233_G0.5480.70
99_V106_T0.5480.70
194_A277_A0.5470.70
184_V213_V0.5440.70
24_V54_A0.5440.70
231_S235_A0.5440.70
70_V77_G0.5440.70
257_A261_A0.5420.69
11_V24_V0.5410.69
332_V370_V0.5410.69
233_G241_V0.5400.69
216_A378_R0.5390.69
13_G45_I0.5390.69
102_S106_T0.5340.68
215_A239_A0.5330.68
276_E279_D0.5330.68
25_H28_R0.5310.68
121_V148_V0.5300.68
333_A336_R0.5300.68
76_D107_C0.5290.67
265_V388_L0.5290.67
17_A46_I0.5290.67
126_E159_K0.5280.67
6_N80_D0.5280.67
89_A124_M0.5270.67
132_P144_W0.5260.67
17_A51_V0.5260.67
354_V375_G0.5250.67
148_V166_I0.5250.67
11_V36_A0.5230.67
251_T254_T0.5220.66
348_V380_L0.5210.66
208_R212_A0.5210.66
227_V244_V0.5210.66
84_V91_T0.5210.66
120_V138_I0.5210.66
254_T261_A0.5200.66
41_S101_D0.5190.66
233_G236_V0.5190.66
83_V119_V0.5170.66
267_A355_M0.5160.65
10_G37_V0.5160.65
147_S169_E0.5150.65
263_A385_A0.5150.65
179_L222_A0.5150.65
95_I118_V0.5100.65
282_L289_V0.5100.65
85_A121_V0.5100.65
95_I105_T0.5080.64
73_C113_G0.5060.64
270_I300_V0.5060.64
379_G383_R0.5050.64
280_E353_G0.5040.64
331_M351_D0.5020.63
23_F346_F0.5020.63
339_L344_L0.5000.63
359_E379_G0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qjiA 2 0.5153 100 0.535 Contact Map
1p9oA 2 0.5434 100 0.579 Contact Map
2gk4A 2 0.5281 100 0.618 Contact Map
1p3y1 6 0.4286 100 0.646 Contact Map
1mvlA 3 0.4209 100 0.655 Contact Map
3qjgA 5 0.4082 100 0.656 Contact Map
1u7zA 2 0.5306 100 0.657 Contact Map
1qzuA 3 0.3852 100 0.657 Contact Map
3mcuA 5 0.4541 100 0.667 Contact Map
1g63A 6 0.4184 100 0.67 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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