GREMLIN Database
Q9HRR8 - Aminopeptidase
UniProt: Q9HRR8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (389)
Sequences: 4045 (3030)
Seq/√Len: 153.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_A47_Q4.0011.00
42_R46_A3.8811.00
367_W372_A3.7561.00
42_R54_L3.7031.00
110_L115_V3.5841.00
117_V146_F3.4481.00
217_D262_D3.3581.00
45_L269_C3.3271.00
224_V394_A3.1221.00
91_A195_T3.0671.00
93_E113_A3.0641.00
249_E252_R2.8821.00
54_L208_Q2.8221.00
56_T206_T2.7781.00
97_L117_V2.6511.00
294_A397_L2.6461.00
114_I145_G2.6411.00
17_H40_A2.6361.00
225_T295_V2.5611.00
282_H286_Q2.4831.00
38_A210_V2.3881.00
213_T266_H2.3851.00
92_G144_A2.3711.00
216_P262_D2.3471.00
34_E271_G2.3231.00
57_F271_G2.2831.00
32_D36_E2.2381.00
112_G144_A2.2361.00
39_A42_R2.2251.00
384_R388_I2.2131.00
35_R39_A2.1861.00
41_T228_V2.1521.00
115_V143_A2.1091.00
221_E266_H2.0971.00
219_D291_D2.0701.00
220_A263_T2.0591.00
89_T197_T2.0271.00
136_A140_A2.0231.00
247_A269_C2.0091.00
280_S346_A2.0041.00
221_E264_R1.9971.00
211_H268_V1.9291.00
34_E228_V1.9271.00
244_T269_C1.9221.00
89_T195_T1.8761.00
289_L352_V1.8701.00
94_F116_M1.8681.00
18_L241_G1.8601.00
41_T269_C1.8511.00
39_A43_D1.8511.00
246_M301_V1.8271.00
137_H140_A1.8261.00
137_H141_A1.8151.00
10_T13_T1.8041.00
19_Q375_L1.7621.00
29_A272_A1.7561.00
45_L212_A1.7441.00
42_R52_A1.6981.00
270_F295_V1.6931.00
70_E195_T1.6931.00
246_M387_A1.6861.00
58_P206_T1.6851.00
147_V175_V1.6811.00
74_D77_A1.6791.00
225_T270_F1.6731.00
94_F194_V1.6711.00
147_V177_V1.6661.00
20_R24_T1.6281.00
284_A346_A1.6251.00
43_D47_Q1.6091.00
283_D292_V1.6081.00
105_F137_H1.5911.00
95_V110_L1.5881.00
82_L85_S1.5771.00
15_W380_L1.5711.00
179_T183_T1.5671.00
177_V181_T1.5431.00
86_P89_T1.5391.00
207_S271_G1.5261.00
11_S384_R1.5081.00
58_P204_D1.5051.00
38_A54_L1.4881.00
103_G106_E1.4821.00
213_T264_R1.4761.00
273_E369_H1.4691.00
38_A228_V1.4641.00
298_L390_L1.4491.00
239_D273_E1.4481.00
213_T221_E1.4381.00
13_T249_E1.4301.00
281_H285_A1.4281.00
101_L104_D1.4191.00
395_A399_D1.4181.00
323_A396_R1.4151.00
72_P77_A1.4071.00
274_E369_H1.4031.00
226_S244_T1.3991.00
226_S247_A1.3981.00
254_L265_V1.3961.00
48_H212_A1.3961.00
120_D134_K1.3961.00
56_T208_Q1.3831.00
65_G199_D1.3831.00
273_E368_G1.3791.00
228_V269_C1.3771.00
97_L108_A1.3761.00
110_L143_A1.3761.00
72_P76_T1.3711.00
45_L248_V1.3711.00
48_H248_V1.3691.00
100_G105_F1.3641.00
45_L251_A1.3551.00
17_H44_A1.3521.00
109_D113_A1.3431.00
183_T187_R1.3421.00
65_G201_D1.3391.00
239_D369_H1.3361.00
105_F141_A1.3331.00
54_L210_V1.3311.00
15_W19_Q1.3271.00
227_H239_D1.3261.00
44_A252_R1.3081.00
43_D46_A1.3081.00
252_R256_A1.2991.00
21_L244_T1.2951.00
105_F138_A1.2941.00
51_D213_T1.2911.00
266_H283_D1.2841.00
81_A85_S1.2801.00
28_M31_S1.2741.00
223_L268_V1.2681.00
14_G387_A1.2671.00
181_T184_R1.2641.00
55_D282_H1.2631.00
272_A278_V1.2611.00
35_R208_Q1.2561.00
230_A236_G1.2521.00
235_D374_T1.2101.00
284_A350_H1.1951.00
92_G114_I1.1891.00
323_A326_D1.1851.00
151_H154_G1.1721.00
227_H273_E1.1671.00
15_W379_E1.1641.00
97_L115_V1.1621.00
296_L394_A1.1521.00
139_V171_E1.1511.00
13_T252_R1.1501.00
147_V194_V1.1461.00
325_S332_I1.1401.00
37_A228_V1.1371.00
215_G218_T1.1361.00
196_L200_A1.1341.00
15_W375_L1.1341.00
240_N297_N1.1331.00
261_L265_V1.1321.00
182_G186_S1.1281.00
87_A199_D1.1271.00
184_R187_R1.1211.00
55_D209_N1.1181.00
289_L350_H1.1161.00
17_H248_V1.1110.99
25_P32_D1.1100.99
18_L245_A1.1090.99
135_Y146_F1.1060.99
274_E368_G1.1050.99
251_A267_F1.1040.99
295_V354_G1.1040.99
53_W213_T1.1020.99
184_R188_R1.1010.99
81_A84_R1.0950.99
50_D214_L1.0920.99
320_A397_L1.0910.99
61_G203_H1.0890.99
257_R395_A1.0780.99
319_D323_A1.0640.99
145_G196_L1.0630.99
282_H285_A1.0620.99
55_D286_Q1.0550.99
250_L394_A1.0530.99
44_A48_H1.0500.99
38_A208_Q1.0490.99
94_F185_L1.0470.99
138_A143_A1.0400.99
45_L267_F1.0400.99
17_H249_E1.0260.99
28_M275_V1.0250.99
119_A131_R1.0240.99
254_L267_F1.0230.99
374_T377_K1.0200.99
20_R23_D1.0190.99
72_P75_T1.0180.99
265_V398_A1.0170.99
114_I194_V1.0130.99
22_V237_A1.0080.99
19_Q23_D1.0060.99
102_P141_A1.0060.99
118_A186_S1.0050.99
225_T268_V0.9980.99
325_S389_L0.9980.99
215_G264_R0.9940.99
9_F253_I0.9880.99
69_I196_L0.9870.99
270_F347_Y0.9860.99
177_V182_G0.9830.99
25_P33_G0.9780.99
214_L261_L0.9770.99
48_H255_A0.9760.99
79_T82_L0.9750.99
33_G36_E0.9680.99
324_V393_L0.9670.99
78_D81_A0.9640.99
94_F147_V0.9580.98
218_T264_R0.9560.98
131_R148_Y0.9560.98
319_D322_N0.9550.98
97_L146_F0.9510.98
281_H346_A0.9510.98
17_H48_H0.9470.98
284_A347_Y0.9460.98
63_T201_D0.9450.98
250_L391_A0.9440.98
375_L380_L0.9430.98
227_H274_E0.9410.98
224_V267_F0.9380.98
82_L174_A0.9380.98
227_H299_D0.9330.98
367_W377_K0.9320.98
96_D189_F0.9300.98
232_D235_D0.9260.98
261_L264_R0.9190.98
85_S89_T0.9150.98
273_E277_L0.9150.98
31_S61_G0.9100.98
322_N326_D0.9090.98
318_G322_N0.9080.98
93_E193_T0.9070.98
32_D35_R0.9060.98
239_D368_G0.9030.98
295_V347_Y0.9030.98
135_Y162_V0.9020.98
61_G205_A0.9010.98
96_D118_A0.8980.98
71_T194_V0.8980.98
135_Y174_A0.8910.98
333_T337_A0.8850.97
175_V198_V0.8840.97
16_T19_Q0.8810.97
102_P106_E0.8800.97
68_A197_T0.8780.97
359_S386_H0.8750.97
292_V352_V0.8730.97
239_D343_D0.8720.97
320_A324_V0.8710.97
66_D199_D0.8650.97
215_G263_T0.8630.97
138_A142_G0.8590.97
18_L22_V0.8570.97
211_H266_H0.8550.97
22_V375_L0.8530.97
285_A350_H0.8490.97
328_F331_P0.8460.97
224_V247_A0.8440.97
13_T16_T0.8440.97
254_L391_A0.8440.97
344_H356_H0.8430.97
11_S15_W0.8430.97
50_D212_A0.8390.96
214_L255_A0.8380.96
238_M367_W0.8370.96
319_D406_H0.8330.96
367_W370_T0.8330.96
105_F110_L0.8320.96
20_R36_E0.8310.96
249_E253_I0.8310.96
20_R40_A0.8280.96
227_H369_H0.8270.96
209_N279_G0.8230.96
222_L397_L0.8230.96
288_D291_D0.8210.96
238_M300_G0.8200.96
190_E193_T0.8190.96
100_G138_A0.8190.96
110_L141_A0.8170.96
223_L295_V0.8160.96
134_K138_A0.8150.96
34_E41_T0.8130.96
96_D186_S0.8110.96
118_A149_M0.8110.96
277_L342_S0.8100.96
348_V354_G0.8070.96
39_A54_L0.8050.96
21_L241_G0.8050.96
278_V282_H0.8030.95
273_E342_S0.8010.95
258_E261_L0.7990.95
323_A327_T0.7920.95
29_A275_V0.7900.95
27_R241_G0.7870.95
50_D255_A0.7840.95
178_S181_T0.7820.95
280_S343_D0.7790.95
12_T381_R0.7750.95
307_L310_Y0.7750.95
227_H368_G0.7730.94
300_G368_G0.7700.94
243_G299_D0.7690.94
380_L383_F0.7690.94
238_M303_R0.7680.94
331_P334_V0.7660.94
227_H343_D0.7640.94
273_E297_N0.7620.94
157_P160_G0.7590.94
111_D142_G0.7590.94
300_G342_S0.7590.94
254_L394_A0.7580.94
223_L292_V0.7520.94
357_A390_L0.7500.94
342_S368_G0.7490.93
16_T20_R0.7450.93
222_L398_A0.7440.93
50_D267_F0.7400.93
327_T392_A0.7370.93
315_D318_G0.7360.93
226_S240_N0.7320.93
53_W211_H0.7310.93
238_M365_R0.7300.93
138_A172_I0.7300.93
255_A260_A0.7300.93
369_H373_D0.7270.92
242_A378_L0.7210.92
99_Y118_A0.7210.92
214_L267_F0.7200.92
283_D287_R0.7200.92
270_F280_S0.7170.92
100_G117_V0.7110.92
214_L254_L0.7110.92
24_T36_E0.7090.91
106_E141_A0.7070.91
274_E277_L0.7060.91
330_H333_T0.7040.91
215_G261_L0.7020.91
100_G104_D0.7010.91
42_R210_V0.7010.91
55_D283_D0.7000.91
288_D292_V0.6950.91
91_A193_T0.6940.91
301_V304_E0.6930.91
328_F392_A0.6910.90
329_A337_A0.6910.90
101_L105_F0.6900.90
159_T164_T0.6890.90
324_V328_F0.6890.90
103_G107_D0.6870.90
216_P260_A0.6870.90
250_L254_L0.6870.90
116_M186_S0.6850.90
27_R240_N0.6840.90
268_V283_D0.6830.90
186_S189_F0.6830.90
17_H252_R0.6800.90
228_V244_T0.6800.90
221_E292_V0.6790.90
253_I391_A0.6790.90
40_A44_A0.6780.90
41_T244_T0.6780.90
324_V327_T0.6770.90
334_V337_A0.6760.89
71_T74_D0.6760.89
266_H287_R0.6750.89
332_I335_A0.6740.89
28_M33_G0.6740.89
235_D238_M0.6720.89
20_R47_Q0.6710.89
60_Q204_D0.6700.89
341_H345_W0.6690.89
296_L390_L0.6660.89
161_S164_T0.6660.89
239_D299_D0.6650.89
381_R384_R0.6640.89
273_E299_D0.6640.89
241_G245_A0.6630.89
35_R54_L0.6610.88
68_A199_D0.6570.88
11_S381_R0.6570.88
317_L321_A0.6570.88
227_H240_N0.6560.88
237_A373_D0.6540.88
331_P335_A0.6520.88
37_A41_T0.6520.88
216_P261_L0.6490.87
94_F145_G0.6480.87
101_L122_P0.6480.87
105_F115_V0.6480.87
177_V185_L0.6440.87
227_H297_N0.6440.87
45_L50_D0.6420.87
153_A179_T0.6420.87
391_A395_A0.6400.87
34_E208_Q0.6400.87
345_W349_K0.6400.87
239_D274_E0.6390.87
320_A323_A0.6390.87
255_A259_S0.6380.87
212_A267_F0.6370.86
88_G199_D0.6360.86
238_M302_V0.6360.86
153_A180_E0.6350.86
224_V390_L0.6340.86
317_L353_P0.6330.86
300_G303_R0.6310.86
222_L293_R0.6290.86
55_D211_H0.6290.86
316_A319_D0.6280.86
313_R318_G0.6270.86
397_L400_D0.6270.86
207_S272_A0.6260.86
299_D342_S0.6260.86
221_E287_R0.6260.86
254_L261_L0.6250.85
214_L265_V0.6250.85
305_R308_K0.6250.85
328_F385_E0.6240.85
157_P161_S0.6240.85
79_T83_P0.6230.85
321_A325_S0.6220.85
14_G246_M0.6220.85
114_I196_L0.6200.85
272_A275_V0.6190.85
236_G373_D0.6190.85
222_L294_A0.6160.85
119_A150_N0.6160.85
277_L280_S0.6120.84
57_F286_Q0.6100.84
396_R400_D0.6100.84
351_G354_G0.6100.84
276_G284_A0.6090.84
12_T16_T0.6080.84
212_A269_C0.6080.84
61_G64_R0.6070.84
239_D297_N0.6060.84
274_E280_S0.6050.84
162_V165_G0.6040.83
331_P385_E0.6030.83
133_E136_A0.6030.83
160_G163_G0.6010.83
340_P348_V0.6010.83
163_G166_D0.6010.83
330_H335_A0.5990.83
333_T336_P0.5990.83
346_A349_K0.5990.83
341_H368_G0.5980.83
151_H179_T0.5980.83
315_D332_I0.5970.83
316_A405_A0.5950.83
93_E191_H0.5940.82
78_D83_P0.5930.82
158_A164_T0.5870.82
297_N343_D0.5870.82
50_D251_A0.5870.82
306_T309_L0.5870.82
116_M147_V0.5860.82
159_T162_V0.5860.82
17_H20_R0.5850.81
79_T84_R0.5850.81
99_Y104_D0.5840.81
158_A162_V0.5840.81
116_M189_F0.5840.81
97_L105_F0.5840.81
23_D187_R0.5820.81
31_S63_T0.5820.81
297_N342_S0.5820.81
343_D368_G0.5820.81
117_V148_Y0.5790.81
170_G173_P0.5780.81
400_D404_V0.5770.81
302_V383_F0.5770.81
34_E38_A0.5760.81
69_I175_V0.5750.80
224_V265_V0.5750.80
220_A291_D0.5720.80
157_P162_V0.5720.80
378_L383_F0.5720.80
92_G113_A0.5700.80
19_Q380_L0.5680.80
21_L37_A0.5660.79
72_P188_R0.5660.79
236_G239_D0.5650.79
315_D322_N0.5630.79
316_A320_A0.5620.79
139_V172_I0.5620.79
321_A393_L0.5620.79
26_T233_I0.5610.79
294_A355_Y0.5600.79
250_L253_I0.5600.79
160_G164_T0.5590.79
340_P345_W0.5590.79
317_L324_V0.5570.78
97_L100_G0.5570.78
162_V166_D0.5560.78
217_D264_R0.5560.78
29_A34_E0.5550.78
81_A275_V0.5550.78
138_A148_Y0.5550.78
273_E343_D0.5550.78
293_R403_A0.5540.78
159_T163_G0.5540.78
136_A139_V0.5540.78
131_R273_E0.5530.78
14_G245_A0.5510.78
382_T386_H0.5500.77
97_L143_A0.5470.77
131_R150_N0.5470.77
196_L199_D0.5460.77
80_I84_R0.5460.77
142_G145_G0.5460.77
160_G166_D0.5460.77
322_N334_V0.5460.77
27_R37_A0.5460.77
64_R232_D0.5440.77
388_I392_A0.5440.77
112_G143_A0.5430.77
287_R292_V0.5430.77
105_F134_K0.5430.77
17_H245_A0.5430.77
13_T17_H0.5420.76
66_D197_T0.5420.76
322_N325_S0.5420.76
100_G134_K0.5410.76
320_A396_R0.5410.76
104_D107_D0.5410.76
318_G321_A0.5370.76
289_L292_V0.5350.75
313_R317_L0.5340.75
34_E37_A0.5340.75
242_A302_V0.5340.75
160_G165_G0.5330.75
331_P336_P0.5330.75
223_L347_Y0.5300.75
295_V346_A0.5300.75
155_C158_A0.5290.75
274_E343_D0.5290.75
222_L394_A0.5280.75
27_R230_A0.5270.74
331_P337_A0.5270.74
73_A193_T0.5260.74
9_F387_A0.5260.74
277_L299_D0.5240.74
161_S165_G0.5240.74
270_F338_L0.5230.74
214_L264_R0.5230.74
294_A317_L0.5230.74
84_R87_A0.5220.74
24_T40_A0.5210.74
262_D401_G0.5210.74
77_A256_A0.5210.74
304_E307_L0.5210.74
34_E207_S0.5200.73
210_V289_L0.5200.73
315_D321_A0.5190.73
73_A77_A0.5180.73
280_S284_A0.5160.73
20_R44_A0.5160.73
9_F388_I0.5160.73
343_D369_H0.5150.73
104_D108_A0.5150.73
238_M242_A0.5150.73
223_L266_H0.5150.73
276_G343_D0.5130.72
95_V115_V0.5120.72
26_T33_G0.5110.72
355_Y393_L0.5110.72
332_I337_A0.5110.72
246_M250_L0.5100.72
281_H349_K0.5100.72
307_L325_S0.5100.72
59_V272_A0.5090.72
101_L121_V0.5090.72
119_A148_Y0.5080.72
85_S88_G0.5030.71
296_L397_L0.5010.71
229_D276_G0.5010.71
330_H334_V0.5000.71
80_I83_P0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tweA 2 0.9746 100 0.286 Contact Map
3kasA 2 0.9769 100 0.289 Contact Map
3fedA 2 0.9746 100 0.294 Contact Map
2ek8A 2 0.9099 100 0.302 Contact Map
3iibA 2 0.9353 100 0.338 Contact Map
4r12A 1 0.8337 100 0.518 Contact Map
3k9tA 3 0.8268 100 0.552 Contact Map
1tkjA 1 0.5797 100 0.591 Contact Map
5a63A 1 0.8522 100 0.609 Contact Map
3guxA 1 0.5381 100 0.617 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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