GREMLIN Database
Q9HRR7 - Uncharacterized protein
UniProt: Q9HRR7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 126 (117)
Sequences: 3348 (2147)
Seq/√Len: 198.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_S108_S3.7171.00
79_T104_P3.6741.00
16_P76_V3.5911.00
53_S74_P3.3351.00
40_A58_V3.2011.00
79_T106_T2.9531.00
12_T81_A2.8171.00
81_A104_P2.7241.00
11_Y80_V2.6901.00
77_S106_T2.4631.00
48_L56_A2.2801.00
57_V72_V2.2001.00
14_S19_T2.0931.00
14_S81_A2.0591.00
17_D79_T2.0551.00
13_V57_V1.9721.00
43_A58_V1.9341.00
9_S87_V1.8851.00
14_S79_T1.8091.00
37_H47_H1.7871.00
100_P103_S1.6691.00
15_T78_V1.6691.00
18_R122_G1.6531.00
46_P56_A1.6211.00
19_T22_S1.5961.00
43_A61_S1.5841.00
17_D77_S1.5551.00
48_L54_A1.5471.00
65_V68_T1.5351.00
29_V43_A1.4861.00
31_A56_A1.4291.00
15_T76_V1.3581.00
12_T22_S1.3151.00
46_P71_V1.2741.00
53_S109_W1.2731.00
49_A73_C1.2441.00
30_A107_L1.2041.00
41_A63_F1.1971.00
48_L71_V1.1951.00
86_T100_P1.1911.00
41_A65_V1.1761.00
30_A80_V1.1731.00
10_E24_R1.1681.00
15_T72_V1.1561.00
30_A55_A1.1501.00
28_I57_V1.1251.00
7_K93_G1.1241.00
53_S112_P1.1111.00
88_E96_H1.0841.00
86_T98_R1.0601.00
15_T20_V1.0271.00
13_V28_I1.0171.00
11_Y25_A1.0161.00
49_A76_V1.0141.00
34_L50_P0.9791.00
72_V78_V0.9650.99
51_G73_C0.9630.99
74_P109_W0.9570.99
88_E98_R0.9490.99
23_V47_H0.9370.99
27_G60_V0.9180.99
16_P77_S0.9100.99
53_S75_P0.9060.99
109_W112_P0.8970.99
56_A71_V0.8950.99
14_S17_D0.8900.99
64_R93_G0.8750.99
89_L99_V0.8700.99
12_T19_T0.8640.99
30_A57_V0.8590.99
7_K94_H0.8520.99
13_V80_V0.8410.98
55_A78_V0.8350.98
6_A61_S0.8290.98
23_V67_R0.8270.98
62_P68_T0.8240.98
72_V76_V0.8190.98
99_V105_V0.8020.98
41_A46_P0.7890.98
90_H96_H0.7680.97
51_G95_A0.7660.97
10_E22_S0.7650.97
58_V69_N0.7520.97
41_A47_H0.7490.97
82_R86_T0.7380.97
25_A64_R0.7320.96
29_V59_P0.7310.96
40_A56_A0.7240.96
13_V23_V0.7220.96
43_A60_V0.7210.96
21_A63_F0.7170.96
75_P114_P0.7100.96
42_D111_T0.7080.96
42_D45_G0.6970.95
54_A71_V0.6960.95
17_D106_T0.6960.95
20_V72_V0.6930.95
118_V121_A0.6920.95
82_R99_V0.6850.95
80_V107_L0.6830.95
86_T95_A0.6790.95
75_P109_W0.6780.94
106_T109_W0.6690.94
44_G92_D0.6690.94
7_K90_H0.6670.94
42_D67_R0.6640.94
66_D69_N0.6630.94
8_I11_Y0.6610.94
63_F118_V0.6600.94
21_A38_G0.6590.94
83_D86_T0.6550.93
26_D39_Y0.6510.93
57_V70_W0.6500.93
9_S28_I0.6390.93
36_S56_A0.6300.92
23_V59_P0.6280.92
20_V23_V0.6260.92
55_A76_V0.6260.92
54_A69_N0.6230.92
41_A68_T0.6100.91
51_G75_P0.5940.90
39_Y60_V0.5930.90
30_A78_V0.5930.90
84_E101_V0.5910.89
34_L37_H0.5910.89
34_L90_H0.5900.89
52_V55_A0.5860.89
60_V68_T0.5820.89
28_I80_V0.5810.89
94_H103_S0.5800.88
82_R85_T0.5800.88
90_H93_G0.5800.88
8_I63_F0.5710.88
13_V72_V0.5700.88
24_R118_V0.5690.88
23_V63_F0.5690.88
85_T88_E0.5650.87
11_Y87_V0.5640.87
39_Y89_L0.5630.87
59_P62_P0.5620.87
64_R68_T0.5610.87
11_Y28_I0.5590.87
106_T111_T0.5510.86
60_V90_H0.5490.86
49_A66_D0.5480.86
75_P108_S0.5450.85
88_E95_A0.5450.85
24_R63_F0.5440.85
98_R101_V0.5400.85
116_A121_A0.5360.84
62_P70_W0.5350.84
60_V96_H0.5320.84
39_Y78_V0.5290.83
63_F68_T0.5290.83
64_R107_L0.5280.83
73_C76_V0.5270.83
64_R67_R0.5260.83
47_H65_V0.5250.83
42_D76_V0.5230.83
38_G41_A0.5230.83
42_D63_F0.5220.83
7_K95_A0.5220.83
77_S86_T0.5210.83
63_F105_V0.5200.82
111_T120_H0.5190.82
83_D101_V0.5180.82
7_K20_V0.5180.82
117_V121_A0.5170.82
46_P109_W0.5150.82
89_L103_S0.5130.82
81_A106_T0.5110.81
116_A119_S0.5090.81
61_S87_V0.5080.81
99_V103_S0.5080.81
103_S106_T0.5070.81
32_T88_E0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfnA 4 1 100 0.125 Contact Map
3afoA 4 0.9921 100 0.192 Contact Map
2an1A 4 1 100 0.33 Contact Map
1u0tA 4 1 100 0.334 Contact Map
1yt5A 4 0.9524 100 0.379 Contact Map
1z0sA 4 0.9524 100 0.388 Contact Map
2i2cA 3 0.9921 99.9 0.399 Contact Map
2qv7A 2 0.9048 99.2 0.703 Contact Map
3s40A 3 0.8651 98.9 0.738 Contact Map
4werA 2 0.8651 98.5 0.769 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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