Q9HRR3 - HALSA - GREMLIN Contacts

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Q9HRR3 - Uncharacterized protein

UniProt:	Q9HRR3	Sequences: MSDDQPTDEDARTDGTGIVSPDDETPTWRERKERTTGLSRLTYEYFERSRREDQDLRQESDYVERDVLAFPTWPHELVRNLAITSFFVGMILFLGATLPPHLGQPANPSTTPAVILPDWYLYWSFGLLKLSALNPELAILGGQKLLADRTFGVLANVVVVGFIAIVPFLNKGSARRPVEQPFWASVGVMGVVFAFTISAYSAKTHLPLNPHLSFDLAFLIPPMAGAVAYAILKTMREGYMYDLNKRYYKLRPPK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	254 (194)
Sequences:	100 (57)
Seq/√Len:	4.1

HALSA - Q9HRR3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
192_V	224_A	5.466	0.97
90_M	95_G	3.948	0.83
189_M	222_P	3.246	0.69
155_A	215_D	2.891	0.59
98_L	112_P	2.869	0.58
90_M	219_L	2.762	0.55
139_I	223_M	2.490	0.47
200_Y	213_S	2.303	0.42
51_R	128_L	2.289	0.41
147_A	161_G	2.269	0.41
156_N	201_S	2.200	0.39
162_F	223_M	2.162	0.38
89_G	136_E	2.115	0.37
72_T	199_A	2.023	0.34
89_G	109_S	1.982	0.33
127_L	185_S	1.982	0.33
57_R	112_P	1.894	0.31
89_G	207_P	1.893	0.31
115_I	222_P	1.839	0.29
212_L	216_L	1.813	0.29
150_T	154_L	1.790	0.28
211_H	214_F	1.781	0.28
95_G	185_S	1.755	0.27
157_V	160_V	1.695	0.26
110_T	150_T	1.694	0.26
124_S	199_A	1.664	0.25
192_V	220_I	1.628	0.25
170_N	234_T	1.602	0.24
103_G	195_F	1.537	0.23
166_V	217_A	1.522	0.22
192_V	223_M	1.474	0.21
137_L	144_K	1.466	0.21
149_R	153_V	1.456	0.21
213_S	222_P	1.441	0.21
107_N	128_L	1.438	0.21
140_L	158_V	1.435	0.21
47_E	50_R	1.427	0.20
109_S	139_I	1.419	0.20
82_A	85_S	1.397	0.20
188_V	224_A	1.384	0.20
161_G	223_M	1.373	0.19
90_M	168_F	1.347	0.19
189_M	218_F	1.345	0.19
95_G	196_T	1.330	0.19
109_S	218_F	1.329	0.19
86_F	234_T	1.328	0.19
99_P	209_N	1.325	0.19
189_M	200_Y	1.304	0.18
98_L	199_A	1.301	0.18
139_I	220_I	1.298	0.18
170_N	173_S	1.295	0.18
169_L	193_F	1.290	0.18
115_I	125_F	1.284	0.18
92_L	169_L	1.283	0.18
213_S	216_L	1.270	0.18
131_S	210_P	1.266	0.18
195_F	198_S	1.258	0.17
57_R	179_E	1.257	0.17
157_V	186_V	1.248	0.17
125_F	201_S	1.245	0.17
76_E	209_N	1.242	0.17
215_D	219_L	1.235	0.17
48_R	76_E	1.233	0.17
96_A	224_A	1.225	0.17
68_L	196_T	1.220	0.17
227_V	231_I	1.219	0.17
121_L	168_F	1.217	0.17
157_V	199_A	1.208	0.17
97_T	112_P	1.185	0.16
54_Q	58_Q	1.184	0.16
51_R	64_E	1.182	0.16
90_M	197_I	1.173	0.16
203_K	210_P	1.172	0.16
166_V	211_H	1.169	0.16
110_T	195_F	1.156	0.16
134_N	225_G	1.145	0.16
130_L	190_G	1.131	0.15
47_E	51_R	1.129	0.15
152_G	164_A	1.122	0.15
48_R	152_G	1.121	0.15
51_R	202_A	1.118	0.15
185_S	228_A	1.117	0.15
109_S	135_P	1.109	0.15
156_N	190_G	1.100	0.15
92_L	121_L	1.096	0.15
81_L	84_T	1.087	0.15
62_Y	100_P	1.085	0.15
194_A	218_F	1.079	0.15
164_A	168_F	1.072	0.14
55_D	59_E	1.069	0.14
128_L	137_L	1.060	0.14
128_L	200_Y	1.054	0.14
114_V	175_R	1.052	0.14
71_P	189_M	1.051	0.14
86_F	107_N	1.047	0.14
131_S	206_L	1.033	0.14
200_Y	220_I	1.029	0.14
95_G	142_G	1.026	0.14
179_E	192_V	1.016	0.14
78_V	88_V	1.012	0.14
77_L	165_I	1.010	0.14
69_A	194_A	1.009	0.14
144_K	162_F	1.007	0.14
48_R	52_E	1.006	0.14
161_G	206_L	1.006	0.14
156_N	159_V	0.999	0.13
50_R	76_E	0.989	0.13
112_P	234_T	0.980	0.13
171_K	193_F	0.971	0.13
169_L	196_T	0.969	0.13
215_D	223_M	0.968	0.13
150_T	223_M	0.967	0.13
158_V	169_L	0.962	0.13
143_Q	218_F	0.961	0.13
71_P	185_S	0.957	0.13
139_I	195_F	0.957	0.13
78_V	202_A	0.955	0.13
162_F	165_I	0.953	0.13
192_V	216_L	0.951	0.13
150_T	197_I	0.947	0.13
112_P	119_W	0.945	0.13
95_G	164_A	0.931	0.13
152_G	218_F	0.927	0.13
92_L	188_V	0.917	0.12
159_V	209_N	0.916	0.12
52_E	140_L	0.916	0.12
153_V	179_E	0.910	0.12
166_V	187_G	0.907	0.12
166_V	186_V	0.904	0.12
73_W	223_M	0.903	0.12
146_L	165_I	0.901	0.12
158_V	191_V	0.893	0.12
107_N	200_Y	0.892	0.12
139_I	169_L	0.892	0.12
122_Y	194_A	0.891	0.12
157_V	226_A	0.891	0.12
112_P	163_I	0.889	0.12
109_S	154_L	0.888	0.12
103_G	225_G	0.886	0.12
153_V	171_K	0.884	0.12
129_K	176_R	0.882	0.12
175_R	180_Q	0.878	0.12
98_L	142_G	0.878	0.12
158_V	220_I	0.877	0.12
58_Q	237_E	0.875	0.12
71_P	227_V	0.872	0.12
166_V	235_M	0.872	0.12
45_Y	55_D	0.867	0.12
99_P	166_V	0.866	0.12
141_G	191_V	0.859	0.12
62_Y	113_A	0.857	0.12
154_L	171_K	0.850	0.12
141_G	220_I	0.845	0.11
186_V	224_A	0.840	0.11
115_I	123_W	0.839	0.11
200_Y	212_L	0.819	0.11
164_A	225_G	0.817	0.11
155_A	211_H	0.816	0.11
193_F	197_I	0.815	0.11
121_L	134_N	0.815	0.11
81_L	223_M	0.812	0.11
59_E	210_P	0.811	0.11
83_I	234_T	0.803	0.11
72_T	165_I	0.789	0.11
113_A	125_F	0.787	0.11
111_T	162_F	0.785	0.11
196_T	201_S	0.785	0.11
103_G	201_S	0.782	0.11
95_G	112_P	0.781	0.11
207_P	236_R	0.771	0.11
67_V	74_P	0.769	0.11
66_D	104_Q	0.767	0.11
129_K	204_T	0.766	0.11
110_T	154_L	0.766	0.11
102_L	217_A	0.764	0.11
55_D	76_E	0.755	0.10
205_H	227_V	0.743	0.10
93_F	192_V	0.742	0.10
93_F	215_D	0.736	0.10
76_E	87_F	0.736	0.10
51_R	201_S	0.733	0.10
163_I	206_L	0.728	0.10
153_V	173_S	0.728	0.10
95_G	168_F	0.721	0.10
70_F	90_M	0.719	0.10
74_P	176_R	0.717	0.10
73_W	191_V	0.716	0.10
108_P	146_L	0.712	0.10
72_T	77_L	0.707	0.10
79_R	176_R	0.703	0.10
163_I	199_A	0.700	0.10
150_T	186_V	0.698	0.10
169_L	191_V	0.697	0.10
110_T	222_P	0.697	0.10
193_F	217_A	0.695	0.10
108_P	153_V	0.691	0.10
121_L	229_Y	0.689	0.10
67_V	105_P	0.686	0.10
159_V	188_V	0.682	0.10
131_S	151_F	0.681	0.10
52_E	76_E	0.680	0.10
98_L	218_F	0.679	0.10
173_S	195_F	0.677	0.10
110_T	192_V	0.676	0.10
139_I	209_N	0.675	0.10
119_W	168_F	0.674	0.10
176_R	187_G	0.673	0.10
66_D	87_F	0.670	0.10
108_P	157_V	0.667	0.10
109_S	197_I	0.666	0.10
64_E	215_D	0.664	0.09
192_V	195_F	0.663	0.09
142_G	169_L	0.662	0.09
89_G	218_F	0.658	0.09
143_Q	146_L	0.658	0.09
119_W	163_I	0.658	0.09
178_V	230_A	0.655	0.09
154_L	186_V	0.654	0.09
134_N	218_F	0.654	0.09
110_T	216_L	0.654	0.09
97_T	198_S	0.653	0.09
92_L	140_L	0.650	0.09
169_L	172_G	0.647	0.09
159_V	162_F	0.640	0.09
195_F	220_I	0.640	0.09
134_N	171_K	0.639	0.09
164_A	193_F	0.634	0.09
65_R	121_L	0.633	0.09
117_P	120_Y	0.629	0.09
117_P	126_G	0.629	0.09
117_P	167_P	0.629	0.09
118_D	126_G	0.629	0.09
126_G	167_P	0.629	0.09
120_Y	126_G	0.629	0.09
118_D	167_P	0.629	0.09
120_Y	167_P	0.629	0.09
135_P	208_L	0.626	0.09
63_V	76_E	0.623	0.09
86_F	91_I	0.618	0.09
148_D	214_F	0.618	0.09
124_S	201_S	0.617	0.09
74_P	168_F	0.613	0.09
47_E	103_G	0.609	0.09
61_D	66_D	0.607	0.09
119_W	137_L	0.606	0.09
95_G	208_L	0.602	0.09
108_P	139_I	0.601	0.09
139_I	179_E	0.601	0.09
80_N	225_G	0.591	0.09
171_K	199_A	0.589	0.09
225_G	232_L	0.584	0.09
200_Y	216_L	0.583	0.09
159_V	165_I	0.582	0.09
152_G	213_S	0.580	0.09
112_P	139_I	0.579	0.09
51_R	73_W	0.578	0.09
112_P	142_G	0.577	0.09
163_I	193_F	0.576	0.09
73_W	128_L	0.573	0.09
144_K	164_A	0.571	0.09
216_L	222_P	0.569	0.09
171_K	228_A	0.567	0.09
73_W	169_L	0.566	0.09
90_M	154_L	0.565	0.09
105_P	176_R	0.563	0.09
110_T	202_A	0.559	0.08
64_E	217_A	0.556	0.08
206_L	217_A	0.554	0.08
163_I	168_F	0.552	0.08
79_R	178_V	0.552	0.08
197_I	217_A	0.551	0.08
84_T	184_A	0.549	0.08
46_F	76_E	0.548	0.08
137_L	196_T	0.547	0.08
146_L	180_Q	0.547	0.08
159_V	186_V	0.534	0.08
99_P	202_A	0.533	0.08
127_L	152_G	0.531	0.08
132_A	177_P	0.523	0.08
56_L	59_E	0.522	0.08
158_V	185_S	0.522	0.08
127_L	199_A	0.519	0.08
52_E	157_V	0.518	0.08
101_H	236_R	0.518	0.08
69_A	165_I	0.513	0.08
97_T	125_F	0.509	0.08
150_T	217_A	0.509	0.08
51_R	123_W	0.509	0.08
203_K	214_F	0.506	0.08
115_I	136_E	0.504	0.08
72_T	110_T	0.500	0.08

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qjyA	2	0.9213	99.9	0.814	Contact Map
3cx5C	2	0.8189	99.7	0.846	Contact Map
1pp9C	2	0.8031	99.6	0.851	Contact Map
4ogqB	1	0.5984	99.5	0.861	Contact Map
1rk8C	1	0.0709	9.7	0.977	Contact Map
3rlbA	1	0.626	8.8	0.978	Contact Map
2rm9A	1	0.1063	6.2	0.979	Contact Map
1sauA	1	0.3465	5.7	0.98	Contact Map
4z7fA	2	0.6142	5.2	0.98	Contact Map
4dveA	3	0.6575	4.1	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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