GREMLIN Database
Q9HRR3 - Uncharacterized protein
UniProt: Q9HRR3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (194)
Sequences: 100 (57)
Seq/√Len: 4.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_V224_A5.4660.97
90_M95_G3.9480.83
189_M222_P3.2460.69
155_A215_D2.8910.59
98_L112_P2.8690.58
90_M219_L2.7620.55
139_I223_M2.4900.47
200_Y213_S2.3030.42
51_R128_L2.2890.41
147_A161_G2.2690.41
156_N201_S2.2000.39
162_F223_M2.1620.38
89_G136_E2.1150.37
72_T199_A2.0230.34
89_G109_S1.9820.33
127_L185_S1.9820.33
57_R112_P1.8940.31
89_G207_P1.8930.31
115_I222_P1.8390.29
212_L216_L1.8130.29
150_T154_L1.7900.28
211_H214_F1.7810.28
95_G185_S1.7550.27
157_V160_V1.6950.26
110_T150_T1.6940.26
124_S199_A1.6640.25
192_V220_I1.6280.25
170_N234_T1.6020.24
103_G195_F1.5370.23
166_V217_A1.5220.22
192_V223_M1.4740.21
137_L144_K1.4660.21
149_R153_V1.4560.21
213_S222_P1.4410.21
107_N128_L1.4380.21
140_L158_V1.4350.21
47_E50_R1.4270.20
109_S139_I1.4190.20
82_A85_S1.3970.20
188_V224_A1.3840.20
161_G223_M1.3730.19
90_M168_F1.3470.19
189_M218_F1.3450.19
95_G196_T1.3300.19
109_S218_F1.3290.19
86_F234_T1.3280.19
99_P209_N1.3250.19
189_M200_Y1.3040.18
98_L199_A1.3010.18
139_I220_I1.2980.18
170_N173_S1.2950.18
169_L193_F1.2900.18
115_I125_F1.2840.18
92_L169_L1.2830.18
213_S216_L1.2700.18
131_S210_P1.2660.18
195_F198_S1.2580.17
57_R179_E1.2570.17
157_V186_V1.2480.17
125_F201_S1.2450.17
76_E209_N1.2420.17
215_D219_L1.2350.17
48_R76_E1.2330.17
96_A224_A1.2250.17
68_L196_T1.2200.17
227_V231_I1.2190.17
121_L168_F1.2170.17
157_V199_A1.2080.17
97_T112_P1.1850.16
54_Q58_Q1.1840.16
51_R64_E1.1820.16
90_M197_I1.1730.16
203_K210_P1.1720.16
166_V211_H1.1690.16
110_T195_F1.1560.16
134_N225_G1.1450.16
130_L190_G1.1310.15
47_E51_R1.1290.15
152_G164_A1.1220.15
48_R152_G1.1210.15
51_R202_A1.1180.15
185_S228_A1.1170.15
109_S135_P1.1090.15
156_N190_G1.1000.15
92_L121_L1.0960.15
81_L84_T1.0870.15
62_Y100_P1.0850.15
194_A218_F1.0790.15
164_A168_F1.0720.14
55_D59_E1.0690.14
128_L137_L1.0600.14
128_L200_Y1.0540.14
114_V175_R1.0520.14
71_P189_M1.0510.14
86_F107_N1.0470.14
131_S206_L1.0330.14
200_Y220_I1.0290.14
95_G142_G1.0260.14
179_E192_V1.0160.14
78_V88_V1.0120.14
77_L165_I1.0100.14
69_A194_A1.0090.14
144_K162_F1.0070.14
48_R52_E1.0060.14
161_G206_L1.0060.14
156_N159_V0.9990.13
50_R76_E0.9890.13
112_P234_T0.9800.13
171_K193_F0.9710.13
169_L196_T0.9690.13
215_D223_M0.9680.13
150_T223_M0.9670.13
158_V169_L0.9620.13
143_Q218_F0.9610.13
71_P185_S0.9570.13
139_I195_F0.9570.13
78_V202_A0.9550.13
162_F165_I0.9530.13
192_V216_L0.9510.13
150_T197_I0.9470.13
112_P119_W0.9450.13
95_G164_A0.9310.13
152_G218_F0.9270.13
92_L188_V0.9170.12
159_V209_N0.9160.12
52_E140_L0.9160.12
153_V179_E0.9100.12
166_V187_G0.9070.12
166_V186_V0.9040.12
73_W223_M0.9030.12
146_L165_I0.9010.12
158_V191_V0.8930.12
107_N200_Y0.8920.12
139_I169_L0.8920.12
122_Y194_A0.8910.12
157_V226_A0.8910.12
112_P163_I0.8890.12
109_S154_L0.8880.12
103_G225_G0.8860.12
153_V171_K0.8840.12
129_K176_R0.8820.12
175_R180_Q0.8780.12
98_L142_G0.8780.12
158_V220_I0.8770.12
58_Q237_E0.8750.12
71_P227_V0.8720.12
166_V235_M0.8720.12
45_Y55_D0.8670.12
99_P166_V0.8660.12
141_G191_V0.8590.12
62_Y113_A0.8570.12
154_L171_K0.8500.12
141_G220_I0.8450.11
186_V224_A0.8400.11
115_I123_W0.8390.11
200_Y212_L0.8190.11
164_A225_G0.8170.11
155_A211_H0.8160.11
193_F197_I0.8150.11
121_L134_N0.8150.11
81_L223_M0.8120.11
59_E210_P0.8110.11
83_I234_T0.8030.11
72_T165_I0.7890.11
113_A125_F0.7870.11
111_T162_F0.7850.11
196_T201_S0.7850.11
103_G201_S0.7820.11
95_G112_P0.7810.11
207_P236_R0.7710.11
67_V74_P0.7690.11
66_D104_Q0.7670.11
129_K204_T0.7660.11
110_T154_L0.7660.11
102_L217_A0.7640.11
55_D76_E0.7550.10
205_H227_V0.7430.10
93_F192_V0.7420.10
93_F215_D0.7360.10
76_E87_F0.7360.10
51_R201_S0.7330.10
163_I206_L0.7280.10
153_V173_S0.7280.10
95_G168_F0.7210.10
70_F90_M0.7190.10
74_P176_R0.7170.10
73_W191_V0.7160.10
108_P146_L0.7120.10
72_T77_L0.7070.10
79_R176_R0.7030.10
163_I199_A0.7000.10
150_T186_V0.6980.10
169_L191_V0.6970.10
110_T222_P0.6970.10
193_F217_A0.6950.10
108_P153_V0.6910.10
121_L229_Y0.6890.10
67_V105_P0.6860.10
159_V188_V0.6820.10
131_S151_F0.6810.10
52_E76_E0.6800.10
98_L218_F0.6790.10
173_S195_F0.6770.10
110_T192_V0.6760.10
139_I209_N0.6750.10
119_W168_F0.6740.10
176_R187_G0.6730.10
66_D87_F0.6700.10
108_P157_V0.6670.10
109_S197_I0.6660.10
64_E215_D0.6640.09
192_V195_F0.6630.09
142_G169_L0.6620.09
89_G218_F0.6580.09
143_Q146_L0.6580.09
119_W163_I0.6580.09
178_V230_A0.6550.09
154_L186_V0.6540.09
134_N218_F0.6540.09
110_T216_L0.6540.09
97_T198_S0.6530.09
92_L140_L0.6500.09
169_L172_G0.6470.09
159_V162_F0.6400.09
195_F220_I0.6400.09
134_N171_K0.6390.09
164_A193_F0.6340.09
65_R121_L0.6330.09
117_P120_Y0.6290.09
117_P126_G0.6290.09
117_P167_P0.6290.09
118_D126_G0.6290.09
126_G167_P0.6290.09
120_Y126_G0.6290.09
118_D167_P0.6290.09
120_Y167_P0.6290.09
135_P208_L0.6260.09
63_V76_E0.6230.09
86_F91_I0.6180.09
148_D214_F0.6180.09
124_S201_S0.6170.09
74_P168_F0.6130.09
47_E103_G0.6090.09
61_D66_D0.6070.09
119_W137_L0.6060.09
95_G208_L0.6020.09
108_P139_I0.6010.09
139_I179_E0.6010.09
80_N225_G0.5910.09
171_K199_A0.5890.09
225_G232_L0.5840.09
200_Y216_L0.5830.09
159_V165_I0.5820.09
152_G213_S0.5800.09
112_P139_I0.5790.09
51_R73_W0.5780.09
112_P142_G0.5770.09
163_I193_F0.5760.09
73_W128_L0.5730.09
144_K164_A0.5710.09
216_L222_P0.5690.09
171_K228_A0.5670.09
73_W169_L0.5660.09
90_M154_L0.5650.09
105_P176_R0.5630.09
110_T202_A0.5590.08
64_E217_A0.5560.08
206_L217_A0.5540.08
163_I168_F0.5520.08
79_R178_V0.5520.08
197_I217_A0.5510.08
84_T184_A0.5490.08
46_F76_E0.5480.08
137_L196_T0.5470.08
146_L180_Q0.5470.08
159_V186_V0.5340.08
99_P202_A0.5330.08
127_L152_G0.5310.08
132_A177_P0.5230.08
56_L59_E0.5220.08
158_V185_S0.5220.08
127_L199_A0.5190.08
52_E157_V0.5180.08
101_H236_R0.5180.08
69_A165_I0.5130.08
97_T125_F0.5090.08
150_T217_A0.5090.08
51_R123_W0.5090.08
203_K214_F0.5060.08
115_I136_E0.5040.08
72_T110_T0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjyA 2 0.9213 99.9 0.814 Contact Map
3cx5C 2 0.8189 99.7 0.846 Contact Map
1pp9C 2 0.8031 99.6 0.851 Contact Map
4ogqB 1 0.5984 99.5 0.861 Contact Map
1rk8C 1 0.0709 9.7 0.977 Contact Map
3rlbA 1 0.626 8.8 0.978 Contact Map
2rm9A 1 0.1063 6.2 0.979 Contact Map
1sauA 1 0.3465 5.7 0.98 Contact Map
4z7fA 2 0.6142 5.2 0.98 Contact Map
4dveA 3 0.6575 4.1 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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