GREMLIN Database
Q9HRR2 - Cytochrome b6
UniProt: Q9HRR2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (206)
Sequences: 2407 (695)
Seq/√Len: 48.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_V183_T5.2971.00
186_F246_L3.9111.00
104_S232_Q3.1381.00
60_K65_Q3.0741.00
182_L253_V2.9361.00
185_V210_S2.9181.00
50_L65_Q2.8801.00
97_A245_L2.8271.00
89_Y254_I2.8251.00
106_S119_V2.7961.00
128_M139_S2.5421.00
85_S151_A2.4841.00
84_F151_A2.4791.00
174_L178_V2.3391.00
175_I256_I2.2701.00
185_V246_L2.2161.00
62_H258_L2.1631.00
93_A251_T2.0441.00
195_W235_L2.0151.00
86_T258_L1.9580.99
210_S224_M1.9380.99
156_M180_L1.9350.99
183_T250_V1.9340.99
49_T53_R1.9310.99
136_F140_L1.9280.99
105_P236_Q1.8860.99
102_Y126_G1.8370.99
99_L127_I1.8300.99
97_A244_F1.7860.99
175_I253_V1.7680.99
95_S140_L1.7400.99
133_F136_F1.7310.98
182_L250_V1.7130.98
189_T241_L1.6920.98
218_D222_Q1.6900.98
197_Q201_W1.6390.98
172_N264_Q1.6290.98
53_R171_V1.6230.98
174_L177_I1.6180.98
104_S119_V1.6020.97
106_S232_Q1.5590.97
211_L221_A1.5540.97
59_P64_E1.5370.97
246_L249_V1.5190.96
108_A119_V1.5120.96
101_F241_L1.5000.96
221_A225_F1.4950.96
179_L250_V1.4940.96
93_A179_L1.4740.96
150_A202_A1.4720.96
128_M138_R1.4510.95
159_V164_S1.4490.95
100_G240_L1.4320.95
66_Y85_S1.3830.94
98_L101_F1.3820.94
120_A123_A1.3680.94
179_L183_T1.3630.94
91_V140_L1.3610.94
50_L53_R1.3500.93
252_T256_I1.3450.93
163_G179_L1.3370.93
182_L246_L1.3240.93
195_W223_L1.2950.92
83_F87_L1.2870.92
106_S236_Q1.2730.91
80_S84_F1.2630.91
163_G166_K1.2350.90
58_M259_G1.2350.90
52_Y56_L1.2340.90
92_A265_G1.2180.89
126_G130_D1.2110.89
195_W200_Y1.2060.89
166_K170_E1.1900.88
167_E264_Q1.1780.87
90_V251_T1.1740.87
88_S151_A1.1730.87
53_R170_E1.1690.87
93_A97_A1.1650.87
175_I260_L1.1490.86
186_F250_V1.1380.86
192_L203_G1.1330.85
214_P217_G1.1200.85
80_S83_F1.1200.85
220_V224_M1.1140.84
119_V122_C1.1080.84
171_V174_L1.1010.84
241_L246_L1.1010.84
192_L221_A1.1000.83
60_K64_E1.0850.83
230_L233_A1.0730.82
178_V253_V1.0600.81
71_K267_A1.0500.81
80_S266_I1.0470.80
80_S86_T1.0420.80
85_S152_V1.0410.80
95_S229_S1.0360.80
251_T254_I1.0330.79
223_L235_L1.0230.79
100_G239_Y1.0160.78
104_S236_Q1.0130.78
182_L185_V1.0110.78
241_L249_V1.0060.78
196_D199_A1.0030.77
207_V221_A1.0020.77
154_L246_L0.9990.77
170_E174_L0.9910.77
125_A129_T0.9860.76
125_A128_M0.9790.76
181_S185_V0.9630.74
123_A127_I0.9600.74
188_Y206_G0.9570.74
53_R178_V0.9510.73
213_I220_V0.9510.73
54_V259_G0.9500.73
81_L147_V0.9480.73
222_Q263_M0.9430.73
83_F86_T0.9410.73
107_A232_Q0.9380.72
191_Y194_P0.9340.72
79_Y92_A0.9340.72
253_V256_I0.9170.71
97_A152_V0.9160.71
51_Y60_K0.9160.71
171_V178_V0.9140.70
51_Y57_Q0.9070.70
236_Q240_L0.9010.69
196_D223_L0.8970.69
207_V225_F0.8930.69
192_L225_F0.8880.68
147_V150_A0.8870.68
175_I259_G0.8830.68
100_G244_F0.8810.68
104_S108_A0.8750.67
51_Y54_V0.8740.67
260_L264_Q0.8690.67
255_A259_G0.8690.67
106_S166_K0.8630.66
204_Q230_L0.8580.66
119_V232_Q0.8560.65
62_H66_Y0.8510.65
133_F165_Y0.8480.65
54_V263_M0.8470.65
51_Y174_L0.8460.64
53_R174_L0.8420.64
145_A247_P0.8370.64
49_T54_V0.8320.63
49_T170_E0.8320.63
172_N183_T0.8230.62
157_L170_E0.8220.62
87_L250_V0.8170.62
207_V230_L0.8170.62
58_M62_H0.8090.61
224_M231_G0.8040.61
199_A206_G0.7930.59
83_F266_I0.7870.59
200_Y204_Q0.7830.58
232_Q236_Q0.7740.58
197_Q235_L0.7640.57
108_A224_M0.7630.56
53_R166_K0.7590.56
215_L219_W0.7590.56
163_G167_E0.7580.56
201_W235_L0.7550.56
106_S231_G0.7440.55
94_I251_T0.7410.54
105_P154_L0.7410.54
218_D252_T0.7390.54
219_W222_Q0.7340.54
135_F138_R0.7330.53
216_V224_M0.7280.53
198_L203_G0.7250.53
139_S229_S0.7220.52
70_N258_L0.7210.52
54_V57_Q0.7120.51
59_P62_H0.7120.51
130_D245_L0.7110.51
62_H151_A0.7090.51
126_G131_L0.7080.51
88_S233_A0.7070.51
248_F252_T0.7060.51
204_Q207_V0.7030.50
166_K263_M0.7030.50
105_P108_A0.7030.50
89_Y148_M0.6990.50
225_F230_L0.6960.50
177_I183_T0.6910.49
92_A144_A0.6910.49
148_M183_T0.6820.48
176_G257_H0.6810.48
175_I178_V0.6810.48
50_L60_K0.6780.48
53_R163_G0.6780.48
166_K218_D0.6770.48
178_V213_I0.6760.48
185_V189_T0.6730.47
171_V260_L0.6710.47
102_Y131_L0.6700.47
204_Q208_E0.6660.47
105_P119_V0.6640.47
140_L256_I0.6640.47
249_V252_T0.6630.46
167_E202_A0.6570.46
192_L238_M0.6560.46
87_L91_V0.6560.46
66_Y151_A0.6510.45
104_S123_A0.6500.45
125_A139_S0.6490.45
68_L72_F0.6480.45
101_F145_A0.6410.44
83_F151_A0.6390.44
68_L266_I0.6330.43
88_S147_V0.6320.43
207_V211_L0.6300.43
201_W207_V0.6300.43
195_W228_F0.6290.43
124_V220_V0.6270.43
179_L254_I0.6270.43
102_Y265_G0.6260.43
137_L218_D0.6250.43
57_Q64_E0.6230.42
163_G267_A0.6200.42
62_H85_S0.6150.42
223_L228_F0.6140.42
197_Q207_V0.6130.41
225_F229_S0.6120.41
221_A228_F0.6120.41
66_Y223_L0.6080.41
108_A122_C0.6060.41
180_L219_W0.6050.41
192_L195_W0.6020.40
104_S256_I0.6020.40
49_T267_A0.6020.40
189_T224_M0.5980.40
88_S91_V0.5960.40
163_G218_D0.5960.40
172_N260_L0.5940.40
48_E181_S0.5930.40
128_M218_D0.5930.40
150_A231_G0.5920.39
56_L218_D0.5910.39
94_I140_L0.5890.39
127_I137_L0.5880.39
185_V253_V0.5870.39
130_D148_M0.5870.39
158_R188_Y0.5850.39
94_I227_G0.5830.39
166_K231_G0.5830.39
56_L122_C0.5750.38
167_E253_V0.5730.38
174_L181_S0.5720.38
211_L225_F0.5720.38
66_Y266_I0.5700.37
146_Q149_T0.5660.37
66_Y83_F0.5640.37
51_Y170_E0.5630.37
147_V267_A0.5620.37
94_I125_A0.5620.37
127_I156_M0.5600.36
210_S220_V0.5550.36
252_T255_A0.5550.36
100_G137_L0.5540.36
55_N202_A0.5540.36
105_P171_V0.5540.36
48_E152_V0.5530.36
153_F199_A0.5530.36
222_Q249_V0.5510.36
142_R267_A0.5500.35
94_I122_C0.5490.35
244_F248_F0.5480.35
146_Q187_G0.5460.35
178_V181_S0.5440.35
208_E221_A0.5390.34
192_L212_S0.5390.34
150_A252_T0.5380.34
208_E225_F0.5320.34
184_M210_S0.5320.34
108_A166_K0.5310.34
225_F234_T0.5310.34
92_A142_R0.5300.34
94_I265_G0.5300.34
186_F248_F0.5300.34
58_M255_A0.5290.34
149_T268_E0.5270.33
49_T55_N0.5260.33
163_G220_V0.5250.33
136_F166_K0.5250.33
211_L220_V0.5240.33
51_Y55_N0.5220.33
124_V261_V0.5210.33
178_V182_L0.5200.33
204_Q225_F0.5200.33
216_V263_M0.5200.33
59_P150_A0.5190.33
55_N260_L0.5150.32
179_L251_T0.5130.32
197_Q200_Y0.5120.32
150_A154_L0.5120.32
62_H172_N0.5100.32
205_I238_M0.5100.32
81_L267_A0.5080.32
186_F189_T0.5080.32
146_Q206_G0.5080.32
171_V263_M0.5080.32
62_H264_Q0.5050.31
95_S159_V0.5040.31
166_K254_I0.5030.31
179_L182_L0.5020.31
103_Y137_L0.5020.31
107_A120_A0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjyA 2 0.8259 100 0.251 Contact Map
4ogqA 2 0.7926 100 0.267 Contact Map
3cx5C 2 0.7778 100 0.273 Contact Map
1pp9C 2 0.7407 100 0.287 Contact Map
1kqfC 3 0.5593 93.3 0.945 Contact Map
4gd3A 2 0.5963 90.8 0.948 Contact Map
1zcdA 1 0.6333 19.4 0.971 Contact Map
2kdrX 1 0.1037 8.2 0.976 Contact Map
3ff5A 2 0.1185 5.6 0.977 Contact Map
3rjoA 1 0.2333 5 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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