GREMLIN Database
Q9HRQ9 - Uncharacterized protein
UniProt: Q9HRQ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (208)
Sequences: 118 (98)
Seq/√Len: 6.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_W164_V3.9750.95
196_V211_T2.7100.75
210_Y215_L2.6710.74
93_V103_W2.5530.70
194_H202_L2.4040.65
124_W137_Y2.3280.63
204_M213_F2.1570.57
202_L211_T2.1460.56
202_L213_F2.0350.52
198_I212_F1.9550.49
194_H212_F1.9460.49
191_I206_L1.9280.48
209_V212_F1.9200.48
196_V210_Y1.9090.47
210_Y214_V1.8710.46
212_F215_L1.8290.44
194_H210_Y1.8250.44
9_I12_G1.7950.43
196_V202_L1.7860.43
195_Y213_F1.7480.41
195_Y212_F1.7480.41
194_H215_L1.7450.41
209_V215_L1.7180.40
210_Y213_F1.7110.40
96_S167_N1.7050.40
192_Q211_T1.6970.39
209_V214_V1.6870.39
194_H213_F1.6800.39
194_H211_T1.6770.39
82_P87_V1.6760.39
194_H209_V1.6640.38
109_T126_A1.6640.38
204_M214_V1.6630.38
202_L210_Y1.6560.38
204_M210_Y1.6400.37
199_A207_S1.6340.37
206_L209_V1.6080.36
202_L209_V1.5940.36
192_Q196_V1.5750.35
198_I214_V1.5680.35
195_Y202_L1.5580.35
101_V141_F1.5490.34
198_I207_S1.5230.33
196_V215_L1.5150.33
188_G194_H1.5060.33
196_V209_V1.5040.33
192_Q202_L1.4740.32
83_N158_L1.4420.31
206_L214_V1.4350.31
201_I206_L1.4070.30
203_M213_F1.4000.29
194_H214_V1.3900.29
209_V213_F1.3730.29
185_H196_V1.3540.28
192_Q209_V1.3510.28
7_L21_G1.3440.28
192_Q210_Y1.3370.27
198_I209_V1.3250.27
195_Y208_M1.3240.27
191_I209_V1.3200.27
192_Q195_Y1.3170.27
103_W137_Y1.2930.26
25_A28_S1.2890.26
202_L215_L1.2840.26
194_H204_M1.2820.26
109_T138_S1.2770.26
200_T204_M1.2740.26
185_H192_Q1.2650.25
202_L214_V1.2570.25
196_V214_V1.2510.25
185_H211_T1.2430.25
188_G192_Q1.2410.25
198_I215_L1.2400.25
195_Y215_L1.2400.25
198_I204_M1.2280.24
203_M211_T1.2260.24
194_H206_L1.2230.24
200_T205_I1.2220.24
192_Q212_F1.2160.24
188_G211_T1.2080.24
109_T132_S1.1950.23
191_I202_L1.1780.23
195_Y206_L1.1780.23
186_E202_L1.1700.23
24_G29_S1.1680.23
150_Y162_G1.1640.23
181_E185_H1.1640.23
187_M194_H1.1590.22
206_L210_Y1.1540.22
195_Y209_V1.1530.22
204_M211_T1.1430.22
199_A214_V1.1420.22
202_L206_L1.1360.22
203_M207_S1.1330.22
211_T215_L1.1280.22
211_T214_V1.1230.22
195_Y211_T1.1210.21
71_G94_Y1.1190.21
191_I213_F1.1190.21
191_I210_Y1.1090.21
81_G105_W1.1010.21
194_H207_S1.0970.21
208_M214_V1.0970.21
188_G196_V1.0780.20
109_T127_Q1.0690.20
207_S214_V1.0640.20
106_E119_P1.0560.20
195_Y214_V1.0530.20
195_Y204_M1.0530.20
208_M213_F1.0520.20
188_G202_L1.0500.20
152_C155_H1.0470.20
198_I210_Y1.0390.19
85_Q158_L1.0360.19
155_H160_M1.0340.19
195_Y201_I1.0200.19
18_A23_V1.0160.19
204_M215_L1.0120.19
202_L212_F0.9980.19
186_E194_H0.9960.18
111_H155_H0.9940.18
24_G171_Q0.9940.18
196_V213_F0.9930.18
24_G28_S0.9880.18
196_V204_M0.9810.18
196_V206_L0.9770.18
204_M209_V0.9760.18
200_T210_Y0.9720.18
191_I194_H0.9700.18
187_M204_M0.9640.18
78_V103_W0.9560.18
188_G212_F0.9520.17
86_N122_A0.9430.17
62_G92_E0.9410.17
107_G110_G0.9390.17
181_E184_P0.9350.17
195_Y203_M0.9340.17
194_H203_M0.9320.17
103_W124_W0.9310.17
201_I212_F0.9260.17
208_M211_T0.9150.17
194_H201_I0.9110.17
78_V93_V0.9090.17
15_G26_R0.9080.17
80_V112_N0.9070.17
80_V105_W0.9040.16
147_E167_N0.9000.16
23_V27_S0.8960.16
186_E211_T0.8930.16
12_G24_G0.8900.16
187_M212_F0.8870.16
105_W112_N0.8860.16
182_R185_H0.8820.16
191_I196_V0.8800.16
108_S124_W0.8800.16
199_A204_M0.8780.16
196_V203_M0.8750.16
28_S31_S0.8670.16
101_V140_T0.8580.16
86_N165_I0.8580.16
119_P148_Y0.8580.16
188_G191_I0.8570.16
184_P213_F0.8540.15
152_C160_M0.8520.15
64_S93_V0.8500.15
106_E124_W0.8490.15
183_S192_Q0.8470.15
84_N158_L0.8350.15
187_M198_I0.8330.15
203_M209_V0.8310.15
186_E214_V0.8300.15
193_A199_A0.8240.15
98_G146_G0.8220.15
195_Y210_Y0.8190.15
111_H152_C0.8170.15
107_G126_A0.8140.15
186_E213_F0.8130.15
82_P96_S0.8120.15
115_A120_D0.8080.15
111_H160_M0.8030.14
29_S32_S0.8000.14
15_G65_E0.7980.14
188_G213_F0.7970.14
149_S161_K0.7950.14
201_I208_M0.7940.14
54_A157_S0.7870.14
195_Y198_I0.7860.14
188_G195_Y0.7850.14
89_D122_A0.7840.14
80_V113_V0.7830.14
206_L215_L0.7790.14
187_M202_L0.7750.14
116_T156_K0.7740.14
206_L213_F0.7740.14
207_S215_L0.7730.14
187_M192_Q0.7700.14
119_P124_W0.7700.14
195_Y207_S0.7640.14
188_G197_G0.7620.14
183_S187_M0.7590.14
196_V201_I0.7510.14
91_A113_V0.7510.14
184_P187_M0.7490.13
191_I214_V0.7480.13
186_E196_V0.7430.13
200_T214_V0.7390.13
76_K112_N0.7370.13
186_E210_Y0.7340.13
119_P143_G0.7300.13
21_G70_G0.7300.13
37_Q41_N0.7280.13
106_E143_G0.7240.13
196_V207_S0.7200.13
78_V100_T0.7120.13
201_I209_V0.7050.13
204_M212_F0.7050.13
5_D11_T0.7040.13
5_D202_L0.7040.13
126_A143_G0.7010.13
3_R6_F0.7000.13
192_Q213_F0.6990.13
191_I211_T0.6940.13
130_I176_G0.6880.12
198_I205_I0.6790.12
70_G162_G0.6760.12
4_R7_L0.6760.12
186_E203_M0.6740.12
92_E161_K0.6730.12
184_P195_Y0.6710.12
192_Q206_L0.6700.12
100_T140_T0.6690.12
196_V208_M0.6670.12
5_D211_T0.6660.12
40_G46_G0.6650.12
91_A164_V0.6650.12
200_T207_S0.6600.12
207_S210_Y0.6600.12
192_Q215_L0.6580.12
207_S212_F0.6580.12
5_D194_H0.6550.12
185_H191_I0.6540.12
105_W110_G0.6510.12
135_H149_S0.6440.12
108_S158_L0.6380.12
64_S164_V0.6340.12
141_F157_S0.6330.12
41_N121_E0.6330.12
185_H194_H0.6300.12
206_L212_F0.6290.12
15_G18_A0.6240.11
191_I201_I0.6220.11
196_V212_F0.6220.11
45_N180_V0.6210.11
205_I215_L0.6180.11
5_D196_V0.6100.11
79_K106_E0.6080.11
39_P44_G0.6030.11
192_Q204_M0.6030.11
200_T208_M0.6020.11
201_I214_V0.5980.11
109_T115_A0.5940.11
195_Y199_A0.5890.11
40_G44_G0.5870.11
54_A173_P0.5810.11
184_P196_V0.5800.11
168_E188_G0.5750.11
182_R214_V0.5750.11
99_D136_E0.5740.11
96_S104_V0.5720.11
191_I195_Y0.5690.11
92_E203_M0.5660.11
191_I215_L0.5640.11
206_L211_T0.5620.11
186_E207_S0.5610.11
185_H210_Y0.5540.10
127_Q132_S0.5540.10
83_N171_Q0.5540.10
21_G95_V0.5540.10
35_H43_T0.5500.10
183_S214_V0.5470.10
81_G112_N0.5450.10
115_A124_W0.5440.10
189_V193_A0.5410.10
183_S210_Y0.5400.10
99_D110_G0.5380.10
203_M210_Y0.5380.10
72_G105_W0.5370.10
72_G99_D0.5350.10
79_K89_D0.5340.10
186_E209_V0.5320.10
127_Q135_H0.5310.10
72_G80_V0.5280.10
186_E200_T0.5250.10
191_I208_M0.5250.10
182_R195_Y0.5240.10
31_S44_G0.5230.10
52_S85_Q0.5230.10
193_A213_F0.5230.10
186_E192_Q0.5220.10
194_H198_I0.5220.10
185_H214_V0.5190.10
88_F154_P0.5180.10
146_G166_V0.5160.10
136_E150_Y0.5150.10
187_M201_I0.5140.10
187_M209_V0.5120.10
193_A200_T0.5120.10
185_H188_G0.5120.10
4_R9_I0.5110.10
192_Q214_V0.5070.10
188_G215_L0.5060.10
132_S136_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c75A 1 0.4585 99.9 0.67 Contact Map
1iuzA 1 0.4017 99.8 0.725 Contact Map
1kdjA 1 0.393 99.8 0.728 Contact Map
1bypA 1 0.3974 99.8 0.73 Contact Map
2pltA 1 0.4017 99.8 0.732 Contact Map
1b3iA 1 0.4061 99.8 0.733 Contact Map
1bxvA 1 0.393 99.8 0.735 Contact Map
1pcsA 2 0.4061 99.8 0.736 Contact Map
3ef4A 1 0.5153 99.8 0.736 Contact Map
3erxA 3 0.5109 99.8 0.737 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0069 seconds.