Q9HRQ9 - HALSA - GREMLIN Contacts

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Q9HRQ9 - Uncharacterized protein

UniProt:	Q9HRQ9	Sequences: MKRRDFLKIATGSAGGAAAVGAVGARSSSSSSAVHQQAPGNATGNGTAMDNSTAGNETAAGGDSESGDGGGGATTKTVKVGPNNQNVFDPAEVYVSPGDTVKWVWEGSTGHNVHATSVPDEAGWDAQTEIVSAPHEYSHTFEGPTGEYSYVCDPHKSLGMKGKVIVNENGQAPSGGGGPVERSPHEMGVPIQAHYVGIATILMMILSMVYTFFVLKYGESRNASAPNKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	229 (208)
Sequences:	118 (98)
Seq/√Len:	6.8

HALSA - Q9HRQ9 Q9HRS0 Q9HQF3 Q9HN93

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
103_W	164_V	3.975	0.95
196_V	211_T	2.710	0.75
210_Y	215_L	2.671	0.74
93_V	103_W	2.553	0.70
194_H	202_L	2.404	0.65
124_W	137_Y	2.328	0.63
204_M	213_F	2.157	0.57
202_L	211_T	2.146	0.56
202_L	213_F	2.035	0.52
198_I	212_F	1.955	0.49
194_H	212_F	1.946	0.49
191_I	206_L	1.928	0.48
209_V	212_F	1.920	0.48
196_V	210_Y	1.909	0.47
210_Y	214_V	1.871	0.46
212_F	215_L	1.829	0.44
194_H	210_Y	1.825	0.44
9_I	12_G	1.795	0.43
196_V	202_L	1.786	0.43
195_Y	213_F	1.748	0.41
195_Y	212_F	1.748	0.41
194_H	215_L	1.745	0.41
209_V	215_L	1.718	0.40
210_Y	213_F	1.711	0.40
96_S	167_N	1.705	0.40
192_Q	211_T	1.697	0.39
209_V	214_V	1.687	0.39
194_H	213_F	1.680	0.39
194_H	211_T	1.677	0.39
82_P	87_V	1.676	0.39
194_H	209_V	1.664	0.38
109_T	126_A	1.664	0.38
204_M	214_V	1.663	0.38
202_L	210_Y	1.656	0.38
204_M	210_Y	1.640	0.37
199_A	207_S	1.634	0.37
206_L	209_V	1.608	0.36
202_L	209_V	1.594	0.36
192_Q	196_V	1.575	0.35
198_I	214_V	1.568	0.35
195_Y	202_L	1.558	0.35
101_V	141_F	1.549	0.34
198_I	207_S	1.523	0.33
196_V	215_L	1.515	0.33
188_G	194_H	1.506	0.33
196_V	209_V	1.504	0.33
192_Q	202_L	1.474	0.32
83_N	158_L	1.442	0.31
206_L	214_V	1.435	0.31
201_I	206_L	1.407	0.30
203_M	213_F	1.400	0.29
194_H	214_V	1.390	0.29
209_V	213_F	1.373	0.29
185_H	196_V	1.354	0.28
192_Q	209_V	1.351	0.28
7_L	21_G	1.344	0.28
192_Q	210_Y	1.337	0.27
198_I	209_V	1.325	0.27
195_Y	208_M	1.324	0.27
191_I	209_V	1.320	0.27
192_Q	195_Y	1.317	0.27
103_W	137_Y	1.293	0.26
25_A	28_S	1.289	0.26
202_L	215_L	1.284	0.26
194_H	204_M	1.282	0.26
109_T	138_S	1.277	0.26
200_T	204_M	1.274	0.26
185_H	192_Q	1.265	0.25
202_L	214_V	1.257	0.25
196_V	214_V	1.251	0.25
185_H	211_T	1.243	0.25
188_G	192_Q	1.241	0.25
198_I	215_L	1.240	0.25
195_Y	215_L	1.240	0.25
198_I	204_M	1.228	0.24
203_M	211_T	1.226	0.24
194_H	206_L	1.223	0.24
200_T	205_I	1.222	0.24
192_Q	212_F	1.216	0.24
188_G	211_T	1.208	0.24
109_T	132_S	1.195	0.23
191_I	202_L	1.178	0.23
195_Y	206_L	1.178	0.23
186_E	202_L	1.170	0.23
24_G	29_S	1.168	0.23
150_Y	162_G	1.164	0.23
181_E	185_H	1.164	0.23
187_M	194_H	1.159	0.22
206_L	210_Y	1.154	0.22
195_Y	209_V	1.153	0.22
204_M	211_T	1.143	0.22
199_A	214_V	1.142	0.22
202_L	206_L	1.136	0.22
203_M	207_S	1.133	0.22
211_T	215_L	1.128	0.22
211_T	214_V	1.123	0.22
195_Y	211_T	1.121	0.21
71_G	94_Y	1.119	0.21
191_I	213_F	1.119	0.21
191_I	210_Y	1.109	0.21
81_G	105_W	1.101	0.21
194_H	207_S	1.097	0.21
208_M	214_V	1.097	0.21
188_G	196_V	1.078	0.20
109_T	127_Q	1.069	0.20
207_S	214_V	1.064	0.20
106_E	119_P	1.056	0.20
195_Y	214_V	1.053	0.20
195_Y	204_M	1.053	0.20
208_M	213_F	1.052	0.20
188_G	202_L	1.050	0.20
152_C	155_H	1.047	0.20
198_I	210_Y	1.039	0.19
85_Q	158_L	1.036	0.19
155_H	160_M	1.034	0.19
195_Y	201_I	1.020	0.19
18_A	23_V	1.016	0.19
204_M	215_L	1.012	0.19
202_L	212_F	0.998	0.19
186_E	194_H	0.996	0.18
111_H	155_H	0.994	0.18
24_G	171_Q	0.994	0.18
196_V	213_F	0.993	0.18
24_G	28_S	0.988	0.18
196_V	204_M	0.981	0.18
196_V	206_L	0.977	0.18
204_M	209_V	0.976	0.18
200_T	210_Y	0.972	0.18
191_I	194_H	0.970	0.18
187_M	204_M	0.964	0.18
78_V	103_W	0.956	0.18
188_G	212_F	0.952	0.17
86_N	122_A	0.943	0.17
62_G	92_E	0.941	0.17
107_G	110_G	0.939	0.17
181_E	184_P	0.935	0.17
195_Y	203_M	0.934	0.17
194_H	203_M	0.932	0.17
103_W	124_W	0.931	0.17
201_I	212_F	0.926	0.17
208_M	211_T	0.915	0.17
194_H	201_I	0.911	0.17
78_V	93_V	0.909	0.17
15_G	26_R	0.908	0.17
80_V	112_N	0.907	0.17
80_V	105_W	0.904	0.16
147_E	167_N	0.900	0.16
23_V	27_S	0.896	0.16
186_E	211_T	0.893	0.16
12_G	24_G	0.890	0.16
187_M	212_F	0.887	0.16
105_W	112_N	0.886	0.16
182_R	185_H	0.882	0.16
191_I	196_V	0.880	0.16
108_S	124_W	0.880	0.16
199_A	204_M	0.878	0.16
196_V	203_M	0.875	0.16
28_S	31_S	0.867	0.16
101_V	140_T	0.858	0.16
86_N	165_I	0.858	0.16
119_P	148_Y	0.858	0.16
188_G	191_I	0.857	0.16
184_P	213_F	0.854	0.15
152_C	160_M	0.852	0.15
64_S	93_V	0.850	0.15
106_E	124_W	0.849	0.15
183_S	192_Q	0.847	0.15
84_N	158_L	0.835	0.15
187_M	198_I	0.833	0.15
203_M	209_V	0.831	0.15
186_E	214_V	0.830	0.15
193_A	199_A	0.824	0.15
98_G	146_G	0.822	0.15
195_Y	210_Y	0.819	0.15
111_H	152_C	0.817	0.15
107_G	126_A	0.814	0.15
186_E	213_F	0.813	0.15
82_P	96_S	0.812	0.15
115_A	120_D	0.808	0.15
111_H	160_M	0.803	0.14
29_S	32_S	0.800	0.14
15_G	65_E	0.798	0.14
188_G	213_F	0.797	0.14
149_S	161_K	0.795	0.14
201_I	208_M	0.794	0.14
54_A	157_S	0.787	0.14
195_Y	198_I	0.786	0.14
188_G	195_Y	0.785	0.14
89_D	122_A	0.784	0.14
80_V	113_V	0.783	0.14
206_L	215_L	0.779	0.14
187_M	202_L	0.775	0.14
116_T	156_K	0.774	0.14
206_L	213_F	0.774	0.14
207_S	215_L	0.773	0.14
187_M	192_Q	0.770	0.14
119_P	124_W	0.770	0.14
195_Y	207_S	0.764	0.14
188_G	197_G	0.762	0.14
183_S	187_M	0.759	0.14
196_V	201_I	0.751	0.14
91_A	113_V	0.751	0.14
184_P	187_M	0.749	0.13
191_I	214_V	0.748	0.13
186_E	196_V	0.743	0.13
200_T	214_V	0.739	0.13
76_K	112_N	0.737	0.13
186_E	210_Y	0.734	0.13
119_P	143_G	0.730	0.13
21_G	70_G	0.730	0.13
37_Q	41_N	0.728	0.13
106_E	143_G	0.724	0.13
196_V	207_S	0.720	0.13
78_V	100_T	0.712	0.13
201_I	209_V	0.705	0.13
204_M	212_F	0.705	0.13
5_D	11_T	0.704	0.13
5_D	202_L	0.704	0.13
126_A	143_G	0.701	0.13
3_R	6_F	0.700	0.13
192_Q	213_F	0.699	0.13
191_I	211_T	0.694	0.13
130_I	176_G	0.688	0.12
198_I	205_I	0.679	0.12
70_G	162_G	0.676	0.12
4_R	7_L	0.676	0.12
186_E	203_M	0.674	0.12
92_E	161_K	0.673	0.12
184_P	195_Y	0.671	0.12
192_Q	206_L	0.670	0.12
100_T	140_T	0.669	0.12
196_V	208_M	0.667	0.12
5_D	211_T	0.666	0.12
40_G	46_G	0.665	0.12
91_A	164_V	0.665	0.12
200_T	207_S	0.660	0.12
207_S	210_Y	0.660	0.12
192_Q	215_L	0.658	0.12
207_S	212_F	0.658	0.12
5_D	194_H	0.655	0.12
185_H	191_I	0.654	0.12
105_W	110_G	0.651	0.12
135_H	149_S	0.644	0.12
108_S	158_L	0.638	0.12
64_S	164_V	0.634	0.12
141_F	157_S	0.633	0.12
41_N	121_E	0.633	0.12
185_H	194_H	0.630	0.12
206_L	212_F	0.629	0.12
15_G	18_A	0.624	0.11
191_I	201_I	0.622	0.11
196_V	212_F	0.622	0.11
45_N	180_V	0.621	0.11
205_I	215_L	0.618	0.11
5_D	196_V	0.610	0.11
79_K	106_E	0.608	0.11
39_P	44_G	0.603	0.11
192_Q	204_M	0.603	0.11
200_T	208_M	0.602	0.11
201_I	214_V	0.598	0.11
109_T	115_A	0.594	0.11
195_Y	199_A	0.589	0.11
40_G	44_G	0.587	0.11
54_A	173_P	0.581	0.11
184_P	196_V	0.580	0.11
168_E	188_G	0.575	0.11
182_R	214_V	0.575	0.11
99_D	136_E	0.574	0.11
96_S	104_V	0.572	0.11
191_I	195_Y	0.569	0.11
92_E	203_M	0.566	0.11
191_I	215_L	0.564	0.11
206_L	211_T	0.562	0.11
186_E	207_S	0.561	0.11
185_H	210_Y	0.554	0.10
127_Q	132_S	0.554	0.10
83_N	171_Q	0.554	0.10
21_G	95_V	0.554	0.10
35_H	43_T	0.550	0.10
183_S	214_V	0.547	0.10
81_G	112_N	0.545	0.10
115_A	124_W	0.544	0.10
189_V	193_A	0.541	0.10
183_S	210_Y	0.540	0.10
99_D	110_G	0.538	0.10
203_M	210_Y	0.538	0.10
72_G	105_W	0.537	0.10
72_G	99_D	0.535	0.10
79_K	89_D	0.534	0.10
186_E	209_V	0.532	0.10
127_Q	135_H	0.531	0.10
72_G	80_V	0.528	0.10
186_E	200_T	0.525	0.10
191_I	208_M	0.525	0.10
182_R	195_Y	0.524	0.10
31_S	44_G	0.523	0.10
52_S	85_Q	0.523	0.10
193_A	213_F	0.523	0.10
186_E	192_Q	0.522	0.10
194_H	198_I	0.522	0.10
185_H	214_V	0.519	0.10
88_F	154_P	0.518	0.10
146_G	166_V	0.516	0.10
136_E	150_Y	0.515	0.10
187_M	201_I	0.514	0.10
187_M	209_V	0.512	0.10
193_A	200_T	0.512	0.10
185_H	188_G	0.512	0.10
4_R	9_I	0.511	0.10
192_Q	214_V	0.507	0.10
188_G	215_L	0.506	0.10
132_S	136_E	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3c75A	1	0.4585	99.9	0.67	Contact Map
1iuzA	1	0.4017	99.8	0.725	Contact Map
1kdjA	1	0.393	99.8	0.728	Contact Map
1bypA	1	0.3974	99.8	0.73	Contact Map
2pltA	1	0.4017	99.8	0.732	Contact Map
1b3iA	1	0.4061	99.8	0.733	Contact Map
1bxvA	1	0.393	99.8	0.735	Contact Map
1pcsA	2	0.4061	99.8	0.736	Contact Map
3ef4A	1	0.5153	99.8	0.736	Contact Map
3erxA	3	0.5109	99.8	0.737	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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