Q9HRQ6 - HALSA - GREMLIN Contacts

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Q9HRQ6 - Uncharacterized protein

UniProt:	Q9HRQ6	Sequences: MTANRLLPGSVSVDGGDGSEVVHIREDAADDVFDALGSRTAREILSALYEEPDTASSVADRVDTSLQNASYHIENLVEADLLEVADTWYSAQGREMSVYAPASDTLVLFAADSGQSPSLRSRLAGLLGVLGALGVVSVAVQRLLTGGTPRPGARMRVASERVTQAAENTTEPGVIDRIGHAVTATLQTLPPGVVFFAGGVFVLAMVGAYAWYQS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	214 (190)
Sequences:	146 (127)
Seq/√Len:	9.2

HALSA - Q9HRQ6 Q9HMP5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
195_F	198_G	3.865	0.98
88_W	92_Q	3.228	0.94
55_A	77_V	3.155	0.93
84_V	97_S	2.870	0.89
76_L	123_L	2.480	0.80
59_A	63_D	2.354	0.77
22_V	59_A	2.277	0.74
90_S	93_G	2.250	0.73
12_S	62_V	2.181	0.71
189_L	197_A	2.168	0.70
35_A	71_Y	2.145	0.69
80_D	108_L	2.142	0.69
24_I	126_L	2.091	0.67
24_I	105_T	2.077	0.67
28_A	112_D	2.077	0.67
19_S	110_A	2.070	0.67
101_P	107_V	1.940	0.61
104_D	110_A	1.934	0.61
65_S	68_N	1.933	0.61
44_I	47_A	1.885	0.59
45_L	66_L	1.817	0.56
49_Y	70_S	1.792	0.55
82_L	208_A	1.783	0.54
22_V	88_W	1.711	0.51
79_A	87_T	1.687	0.50
73_I	82_L	1.665	0.49
19_S	34_D	1.635	0.48
82_L	163_T	1.621	0.47
66_L	92_Q	1.601	0.46
29_A	72_H	1.600	0.46
42_R	65_S	1.582	0.46
194_V	199_G	1.576	0.45
50_E	208_A	1.539	0.44
75_N	202_V	1.534	0.44
17_D	75_N	1.530	0.43
169_T	176_D	1.528	0.43
65_S	96_M	1.517	0.43
33_F	92_Q	1.507	0.42
56_S	63_D	1.506	0.42
63_D	192_G	1.500	0.42
101_P	111_A	1.496	0.42
53_D	58_V	1.495	0.42
28_A	36_L	1.487	0.42
17_D	102_A	1.444	0.40
49_Y	103_S	1.444	0.40
84_V	103_S	1.439	0.40
172_P	178_I	1.432	0.39
36_L	141_Q	1.425	0.39
16_G	209_Y	1.418	0.39
141_Q	190_P	1.402	0.38
55_A	122_R	1.388	0.37
174_V	179_G	1.383	0.37
20_E	68_N	1.366	0.36
21_V	92_Q	1.361	0.36
14_D	121_S	1.331	0.35
74_E	116_S	1.321	0.35
59_A	82_L	1.321	0.35
87_T	129_V	1.298	0.34
47_A	64_T	1.294	0.34
67_Q	96_M	1.289	0.33
21_V	126_L	1.250	0.32
20_E	89_Y	1.238	0.31
29_A	83_E	1.231	0.31
42_R	67_Q	1.217	0.31
22_V	109_F	1.199	0.30
54_T	81_L	1.198	0.30
24_I	205_M	1.187	0.30
116_S	122_R	1.185	0.29
33_F	94_R	1.181	0.29
66_L	107_V	1.154	0.28
165_A	179_G	1.154	0.28
15_G	27_D	1.153	0.28
35_A	120_R	1.139	0.28
144_L	185_T	1.134	0.28
75_N	189_L	1.131	0.28
69_A	108_L	1.128	0.27
168_N	175_I	1.123	0.27
170_T	173_G	1.121	0.27
176_D	180_H	1.118	0.27
47_A	61_R	1.115	0.27
35_A	91_A	1.115	0.27
15_G	117_P	1.108	0.27
27_D	86_D	1.091	0.26
70_S	103_S	1.089	0.26
42_R	96_M	1.089	0.26
35_A	87_T	1.089	0.26
71_Y	122_R	1.079	0.26
68_N	89_Y	1.075	0.26
87_T	93_G	1.072	0.25
135_V	187_Q	1.071	0.25
48_L	106_L	1.067	0.25
67_Q	89_Y	1.066	0.25
52_P	95_E	1.055	0.25
76_L	93_G	1.049	0.25
78_E	150_R	1.042	0.24
26_E	72_H	1.035	0.24
56_S	81_L	1.032	0.24
170_T	174_V	1.031	0.24
192_G	200_V	1.023	0.24
164_Q	176_D	1.019	0.24
123_L	209_Y	1.014	0.24
64_T	110_A	1.005	0.23
41_A	203_L	1.000	0.23
82_L	201_F	0.998	0.23
68_N	86_D	0.998	0.23
54_T	120_R	0.997	0.23
122_R	127_L	0.997	0.23
169_T	183_T	0.993	0.23
47_A	145_T	0.989	0.23
75_N	108_L	0.980	0.23
72_H	96_M	0.979	0.22
167_E	171_E	0.978	0.22
44_I	58_V	0.975	0.22
68_N	106_L	0.966	0.22
87_T	90_S	0.965	0.22
41_A	46_S	0.964	0.22
174_V	178_I	0.964	0.22
49_Y	101_P	0.956	0.22
26_E	116_S	0.943	0.21
81_L	108_L	0.937	0.21
30_D	38_S	0.933	0.21
54_T	65_S	0.932	0.21
91_A	118_S	0.927	0.21
13_V	16_G	0.925	0.21
104_D	109_F	0.923	0.21
103_S	126_L	0.922	0.21
136_V	190_P	0.922	0.21
171_E	174_V	0.907	0.20
26_E	80_D	0.904	0.20
105_T	141_Q	0.902	0.20
173_G	176_D	0.900	0.20
73_I	128_G	0.898	0.20
139_A	143_L	0.893	0.20
35_A	79_A	0.886	0.20
58_V	73_I	0.885	0.20
116_S	134_G	0.883	0.20
66_L	203_L	0.877	0.20
41_A	125_G	0.874	0.19
27_D	78_E	0.873	0.19
117_P	149_P	0.865	0.19
32_V	53_D	0.864	0.19
24_I	85_A	0.855	0.19
56_S	89_Y	0.847	0.19
48_L	191_P	0.842	0.19
26_E	94_R	0.839	0.18
37_G	113_S	0.835	0.18
75_N	185_T	0.827	0.18
26_E	70_S	0.827	0.18
82_L	196_F	0.826	0.18
21_V	131_G	0.823	0.18
196_F	202_V	0.822	0.18
118_S	129_V	0.821	0.18
20_E	67_Q	0.817	0.18
34_D	190_P	0.812	0.18
56_S	70_S	0.806	0.18
90_S	95_E	0.801	0.17
170_T	175_I	0.798	0.17
25_R	72_H	0.788	0.17
70_S	126_L	0.787	0.17
32_V	60_D	0.786	0.17
56_S	171_E	0.785	0.17
66_L	70_S	0.785	0.17
58_V	87_T	0.784	0.17
93_G	123_L	0.781	0.17
52_P	79_A	0.773	0.17
131_G	146_G	0.771	0.17
172_P	176_D	0.771	0.17
70_S	92_Q	0.767	0.17
132_A	136_V	0.766	0.17
172_P	175_I	0.763	0.17
80_D	92_Q	0.751	0.16
117_P	130_L	0.740	0.16
115_Q	202_V	0.736	0.16
47_A	151_P	0.732	0.16
80_D	124_A	0.730	0.16
20_E	70_S	0.729	0.16
26_E	33_F	0.726	0.16
193_V	196_F	0.723	0.16
73_I	80_D	0.720	0.16
55_A	105_T	0.718	0.15
167_E	170_T	0.718	0.15
44_I	109_F	0.716	0.15
105_T	110_A	0.715	0.15
68_N	100_A	0.714	0.15
133_L	199_G	0.710	0.15
72_H	199_G	0.709	0.15
89_Y	95_E	0.709	0.15
74_E	196_F	0.705	0.15
23_H	118_S	0.704	0.15
74_E	137_S	0.702	0.15
175_I	178_I	0.699	0.15
165_A	168_N	0.699	0.15
55_A	199_G	0.697	0.15
195_F	202_V	0.697	0.15
175_I	181_A	0.696	0.15
16_G	22_V	0.696	0.15
18_G	62_V	0.696	0.15
39_R	119_L	0.692	0.15
122_R	125_G	0.691	0.15
52_P	87_T	0.688	0.15
108_L	196_F	0.686	0.15
92_Q	107_V	0.685	0.15
19_S	72_H	0.680	0.15
179_G	197_A	0.679	0.15
81_L	200_V	0.678	0.15
122_R	134_G	0.674	0.14
190_P	193_V	0.672	0.14
73_I	96_M	0.667	0.14
40_T	93_G	0.667	0.14
50_E	135_V	0.665	0.14
57_S	194_V	0.663	0.14
38_S	87_T	0.658	0.14
21_V	115_Q	0.657	0.14
120_R	148_T	0.653	0.14
79_A	95_E	0.648	0.14
21_V	55_A	0.646	0.14
179_G	196_F	0.645	0.14
125_G	197_A	0.635	0.14
70_S	73_I	0.635	0.14
30_D	129_V	0.633	0.14
172_P	177_R	0.632	0.14
71_Y	110_A	0.630	0.14
34_D	37_G	0.629	0.14
46_S	185_T	0.627	0.14
169_T	174_V	0.626	0.13
43_E	75_N	0.626	0.13
34_D	110_A	0.625	0.13
56_S	98_V	0.624	0.13
152_G	201_F	0.624	0.13
33_F	88_W	0.619	0.13
69_A	94_R	0.611	0.13
32_V	126_L	0.611	0.13
148_T	204_A	0.611	0.13
69_A	144_L	0.610	0.13
190_P	197_A	0.608	0.13
173_G	179_G	0.603	0.13
68_N	128_G	0.601	0.13
79_A	93_G	0.601	0.13
16_G	58_V	0.598	0.13
38_S	72_H	0.591	0.13
44_I	145_T	0.590	0.13
66_L	143_L	0.590	0.13
164_Q	167_E	0.588	0.13
54_T	88_W	0.585	0.13
63_D	73_I	0.577	0.13
34_D	104_D	0.576	0.12
37_G	80_D	0.574	0.12
138_V	205_M	0.571	0.12
24_I	68_N	0.570	0.12
22_V	97_S	0.570	0.12
82_L	86_D	0.570	0.12
184_A	203_L	0.569	0.12
34_D	122_R	0.566	0.12
108_L	194_V	0.565	0.12
56_S	60_D	0.563	0.12
23_H	125_G	0.561	0.12
33_F	68_N	0.556	0.12
62_V	106_L	0.554	0.12
185_T	207_G	0.554	0.12
93_G	128_G	0.551	0.12
52_P	63_D	0.545	0.12
80_D	174_V	0.543	0.12
190_P	203_L	0.542	0.12
45_L	61_R	0.540	0.12
136_V	197_A	0.537	0.12
131_G	185_T	0.535	0.12
37_G	191_P	0.534	0.12
198_G	202_V	0.532	0.12
88_W	110_A	0.530	0.12
66_L	117_P	0.528	0.12
58_V	201_F	0.528	0.12
130_L	180_H	0.526	0.12
42_R	63_D	0.525	0.12
73_I	103_S	0.525	0.12
54_T	96_M	0.525	0.12
179_G	204_A	0.519	0.11
165_A	181_A	0.518	0.11
48_L	70_S	0.516	0.11
42_R	54_T	0.513	0.11
90_S	124_A	0.504	0.11
116_S	137_S	0.503	0.11
52_P	90_S	0.502	0.11
86_D	98_V	0.502	0.11
29_A	98_V	0.501	0.11
50_E	148_T	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3f6vA	2	0.4439	98.9	0.841	Contact Map
4g6qA	4	0.6822	98.9	0.843	Contact Map
1q1hA	1	0.3879	98.9	0.843	Contact Map
1r1tA	2	0.4579	98.7	0.855	Contact Map
4k2eA	2	0.4439	98.7	0.855	Contact Map
2oqgA	4	0.4953	98.7	0.855	Contact Map
2qlzA	2	0.6495	98.7	0.856	Contact Map
1u2wA	2	0.5047	98.6	0.857	Contact Map
1y0uA	2	0.3925	98.6	0.857	Contact Map
1r1uA	2	0.4579	98.6	0.858	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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