GREMLIN Database
Q9HRQ6 - Uncharacterized protein
UniProt: Q9HRQ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 214 (190)
Sequences: 146 (127)
Seq/√Len: 9.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_F198_G3.8650.98
88_W92_Q3.2280.94
55_A77_V3.1550.93
84_V97_S2.8700.89
76_L123_L2.4800.80
59_A63_D2.3540.77
22_V59_A2.2770.74
90_S93_G2.2500.73
12_S62_V2.1810.71
189_L197_A2.1680.70
35_A71_Y2.1450.69
80_D108_L2.1420.69
24_I126_L2.0910.67
24_I105_T2.0770.67
28_A112_D2.0770.67
19_S110_A2.0700.67
101_P107_V1.9400.61
104_D110_A1.9340.61
65_S68_N1.9330.61
44_I47_A1.8850.59
45_L66_L1.8170.56
49_Y70_S1.7920.55
82_L208_A1.7830.54
22_V88_W1.7110.51
79_A87_T1.6870.50
73_I82_L1.6650.49
19_S34_D1.6350.48
82_L163_T1.6210.47
66_L92_Q1.6010.46
29_A72_H1.6000.46
42_R65_S1.5820.46
194_V199_G1.5760.45
50_E208_A1.5390.44
75_N202_V1.5340.44
17_D75_N1.5300.43
169_T176_D1.5280.43
65_S96_M1.5170.43
33_F92_Q1.5070.42
56_S63_D1.5060.42
63_D192_G1.5000.42
101_P111_A1.4960.42
53_D58_V1.4950.42
28_A36_L1.4870.42
17_D102_A1.4440.40
49_Y103_S1.4440.40
84_V103_S1.4390.40
172_P178_I1.4320.39
36_L141_Q1.4250.39
16_G209_Y1.4180.39
141_Q190_P1.4020.38
55_A122_R1.3880.37
174_V179_G1.3830.37
20_E68_N1.3660.36
21_V92_Q1.3610.36
14_D121_S1.3310.35
74_E116_S1.3210.35
59_A82_L1.3210.35
87_T129_V1.2980.34
47_A64_T1.2940.34
67_Q96_M1.2890.33
21_V126_L1.2500.32
20_E89_Y1.2380.31
29_A83_E1.2310.31
42_R67_Q1.2170.31
22_V109_F1.1990.30
54_T81_L1.1980.30
24_I205_M1.1870.30
116_S122_R1.1850.29
33_F94_R1.1810.29
66_L107_V1.1540.28
165_A179_G1.1540.28
15_G27_D1.1530.28
35_A120_R1.1390.28
144_L185_T1.1340.28
75_N189_L1.1310.28
69_A108_L1.1280.27
168_N175_I1.1230.27
170_T173_G1.1210.27
176_D180_H1.1180.27
47_A61_R1.1150.27
35_A91_A1.1150.27
15_G117_P1.1080.27
27_D86_D1.0910.26
70_S103_S1.0890.26
42_R96_M1.0890.26
35_A87_T1.0890.26
71_Y122_R1.0790.26
68_N89_Y1.0750.26
87_T93_G1.0720.25
135_V187_Q1.0710.25
48_L106_L1.0670.25
67_Q89_Y1.0660.25
52_P95_E1.0550.25
76_L93_G1.0490.25
78_E150_R1.0420.24
26_E72_H1.0350.24
56_S81_L1.0320.24
170_T174_V1.0310.24
192_G200_V1.0230.24
164_Q176_D1.0190.24
123_L209_Y1.0140.24
64_T110_A1.0050.23
41_A203_L1.0000.23
82_L201_F0.9980.23
68_N86_D0.9980.23
54_T120_R0.9970.23
122_R127_L0.9970.23
169_T183_T0.9930.23
47_A145_T0.9890.23
75_N108_L0.9800.23
72_H96_M0.9790.22
167_E171_E0.9780.22
44_I58_V0.9750.22
68_N106_L0.9660.22
87_T90_S0.9650.22
41_A46_S0.9640.22
174_V178_I0.9640.22
49_Y101_P0.9560.22
26_E116_S0.9430.21
81_L108_L0.9370.21
30_D38_S0.9330.21
54_T65_S0.9320.21
91_A118_S0.9270.21
13_V16_G0.9250.21
104_D109_F0.9230.21
103_S126_L0.9220.21
136_V190_P0.9220.21
171_E174_V0.9070.20
26_E80_D0.9040.20
105_T141_Q0.9020.20
173_G176_D0.9000.20
73_I128_G0.8980.20
139_A143_L0.8930.20
35_A79_A0.8860.20
58_V73_I0.8850.20
116_S134_G0.8830.20
66_L203_L0.8770.20
41_A125_G0.8740.19
27_D78_E0.8730.19
117_P149_P0.8650.19
32_V53_D0.8640.19
24_I85_A0.8550.19
56_S89_Y0.8470.19
48_L191_P0.8420.19
26_E94_R0.8390.18
37_G113_S0.8350.18
75_N185_T0.8270.18
26_E70_S0.8270.18
82_L196_F0.8260.18
21_V131_G0.8230.18
196_F202_V0.8220.18
118_S129_V0.8210.18
20_E67_Q0.8170.18
34_D190_P0.8120.18
56_S70_S0.8060.18
90_S95_E0.8010.17
170_T175_I0.7980.17
25_R72_H0.7880.17
70_S126_L0.7870.17
32_V60_D0.7860.17
56_S171_E0.7850.17
66_L70_S0.7850.17
58_V87_T0.7840.17
93_G123_L0.7810.17
52_P79_A0.7730.17
131_G146_G0.7710.17
172_P176_D0.7710.17
70_S92_Q0.7670.17
132_A136_V0.7660.17
172_P175_I0.7630.17
80_D92_Q0.7510.16
117_P130_L0.7400.16
115_Q202_V0.7360.16
47_A151_P0.7320.16
80_D124_A0.7300.16
20_E70_S0.7290.16
26_E33_F0.7260.16
193_V196_F0.7230.16
73_I80_D0.7200.16
55_A105_T0.7180.15
167_E170_T0.7180.15
44_I109_F0.7160.15
105_T110_A0.7150.15
68_N100_A0.7140.15
133_L199_G0.7100.15
72_H199_G0.7090.15
89_Y95_E0.7090.15
74_E196_F0.7050.15
23_H118_S0.7040.15
74_E137_S0.7020.15
175_I178_I0.6990.15
165_A168_N0.6990.15
55_A199_G0.6970.15
195_F202_V0.6970.15
175_I181_A0.6960.15
16_G22_V0.6960.15
18_G62_V0.6960.15
39_R119_L0.6920.15
122_R125_G0.6910.15
52_P87_T0.6880.15
108_L196_F0.6860.15
92_Q107_V0.6850.15
19_S72_H0.6800.15
179_G197_A0.6790.15
81_L200_V0.6780.15
122_R134_G0.6740.14
190_P193_V0.6720.14
73_I96_M0.6670.14
40_T93_G0.6670.14
50_E135_V0.6650.14
57_S194_V0.6630.14
38_S87_T0.6580.14
21_V115_Q0.6570.14
120_R148_T0.6530.14
79_A95_E0.6480.14
21_V55_A0.6460.14
179_G196_F0.6450.14
125_G197_A0.6350.14
70_S73_I0.6350.14
30_D129_V0.6330.14
172_P177_R0.6320.14
71_Y110_A0.6300.14
34_D37_G0.6290.14
46_S185_T0.6270.14
169_T174_V0.6260.13
43_E75_N0.6260.13
34_D110_A0.6250.13
56_S98_V0.6240.13
152_G201_F0.6240.13
33_F88_W0.6190.13
69_A94_R0.6110.13
32_V126_L0.6110.13
148_T204_A0.6110.13
69_A144_L0.6100.13
190_P197_A0.6080.13
173_G179_G0.6030.13
68_N128_G0.6010.13
79_A93_G0.6010.13
16_G58_V0.5980.13
38_S72_H0.5910.13
44_I145_T0.5900.13
66_L143_L0.5900.13
164_Q167_E0.5880.13
54_T88_W0.5850.13
63_D73_I0.5770.13
34_D104_D0.5760.12
37_G80_D0.5740.12
138_V205_M0.5710.12
24_I68_N0.5700.12
22_V97_S0.5700.12
82_L86_D0.5700.12
184_A203_L0.5690.12
34_D122_R0.5660.12
108_L194_V0.5650.12
56_S60_D0.5630.12
23_H125_G0.5610.12
33_F68_N0.5560.12
62_V106_L0.5540.12
185_T207_G0.5540.12
93_G128_G0.5510.12
52_P63_D0.5450.12
80_D174_V0.5430.12
190_P203_L0.5420.12
45_L61_R0.5400.12
136_V197_A0.5370.12
131_G185_T0.5350.12
37_G191_P0.5340.12
198_G202_V0.5320.12
88_W110_A0.5300.12
66_L117_P0.5280.12
58_V201_F0.5280.12
130_L180_H0.5260.12
42_R63_D0.5250.12
73_I103_S0.5250.12
54_T96_M0.5250.12
179_G204_A0.5190.11
165_A181_A0.5180.11
48_L70_S0.5160.11
42_R54_T0.5130.11
90_S124_A0.5040.11
116_S137_S0.5030.11
52_P90_S0.5020.11
86_D98_V0.5020.11
29_A98_V0.5010.11
50_E148_T0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f6vA 2 0.4439 98.9 0.841 Contact Map
4g6qA 4 0.6822 98.9 0.843 Contact Map
1q1hA 1 0.3879 98.9 0.843 Contact Map
1r1tA 2 0.4579 98.7 0.855 Contact Map
4k2eA 2 0.4439 98.7 0.855 Contact Map
2oqgA 4 0.4953 98.7 0.855 Contact Map
2qlzA 2 0.6495 98.7 0.856 Contact Map
1u2wA 2 0.5047 98.6 0.857 Contact Map
1y0uA 2 0.3925 98.6 0.857 Contact Map
1r1uA 2 0.4579 98.6 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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