GREMLIN Database
Q9HRQ5 - Endonuclease III
UniProt: Q9HRQ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (202)
Sequences: 8405 (5264)
Seq/√Len: 370.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_T116_D3.9181.00
66_T69_D3.5111.00
200_D203_A3.2611.00
101_S105_D3.1581.00
112_D138_L2.8001.00
195_T200_D2.7011.00
63_T77_A2.6861.00
101_S121_S2.5901.00
78_L96_K2.4751.00
96_K100_Q2.3431.00
63_T81_E2.3141.00
20_R178_H2.2981.00
114_M118_T2.2621.00
106_H119_D2.2331.00
80_A83_N2.1741.00
164_E168_T2.0901.00
68_A103_L2.0431.00
207_A213_S2.0101.00
43_I98_A2.0061.00
34_S37_E1.9811.00
65_E69_D1.9721.00
100_Q104_E1.9551.00
94_Y97_S1.9081.00
75_E79_A1.8741.00
74_D77_A1.8601.00
97_S121_S1.8331.00
90_S94_Y1.8291.00
20_R181_N1.8141.00
75_E96_K1.7961.00
105_D119_D1.7591.00
64_Y73_A1.7191.00
40_V95_I1.7131.00
68_A72_N1.6941.00
36_M67_V1.6811.00
58_E62_D1.6241.00
149_Q166_I1.6021.00
18_R208_D1.5891.00
116_D119_D1.5881.00
103_L108_G1.5251.00
114_M141_G1.5061.00
33_S37_E1.5041.00
158_T169_D1.5011.00
48_C52_R1.5001.00
36_M99_A1.4981.00
14_T209_I1.4781.00
59_H62_D1.4771.00
97_S100_Q1.4701.00
90_S93_G1.4291.00
64_Y81_E1.4241.00
37_E61_F1.4221.00
167_E171_M1.3981.00
211_P215_T1.3801.00
114_M132_L1.3771.00
59_H81_E1.3481.00
178_H181_N1.3361.00
109_A112_D1.3331.00
79_A88_Y1.3251.00
132_L138_L1.3001.00
73_A78_L1.2951.00
174_V182_Y1.2861.00
48_C85_I1.2771.00
112_D136_H1.2741.00
118_T125_R1.2711.00
155_L206_L1.2461.00
52_R55_A1.2461.00
125_R167_E1.2441.00
101_S119_D1.2311.00
14_T17_D1.2271.00
188_A192_E1.2211.00
76_E79_A1.2041.00
45_S50_D1.1981.00
138_L141_G1.1741.00
75_E93_G1.1681.00
152_S170_L1.1671.00
101_S106_H1.1581.00
166_I170_L1.1451.00
157_I211_P1.1401.00
98_A120_L1.1351.00
39_L43_I1.1301.00
171_M174_V1.1241.00
74_D96_K1.1191.00
97_S101_S1.1171.00
55_A58_E1.1161.00
35_R135_G1.1161.00
181_N185_W1.1071.00
102_I110_V1.1011.00
137_D180_K1.0991.00
193_T205_V1.0951.00
19_L23_H1.0901.00
167_E170_L1.0891.00
106_H116_D1.0841.00
18_R22_Q1.0731.00
105_D116_D1.0671.00
117_L132_L1.0651.00
16_I20_R1.0631.00
164_E167_E1.0601.00
70_Y78_L1.0571.00
155_L209_I1.0491.00
201_C210_C1.0461.00
40_V61_F1.0461.00
39_L131_V1.0421.00
49_T52_R1.0301.00
75_E92_A1.0291.00
162_R165_A1.0251.00
57_T61_F1.0211.00
17_D21_E1.0141.00
29_S192_E1.0101.00
15_V206_L0.9881.00
160_K165_A0.9851.00
37_E57_T0.9771.00
36_M70_Y0.9741.00
176_E179_W0.9711.00
132_L141_G0.9701.00
22_Q205_V0.9571.00
70_Y99_A0.9561.00
75_E100_Q0.9531.00
54_N58_E0.9391.00
14_T18_R0.9371.00
189_H193_T0.9361.00
206_L209_I0.9341.00
165_A169_D0.9171.00
194_C204_C0.9171.00
93_G97_S0.9151.00
194_C201_C0.9121.00
51_E55_A0.9081.00
142_I171_M0.8951.00
189_H205_V0.8931.00
98_A102_I0.8911.00
39_L98_A0.8911.00
67_V103_L0.8901.00
140_Q176_E0.8751.00
169_D172_P0.8741.00
98_A101_S0.8711.00
168_T171_M0.8671.00
31_R58_E0.8661.00
42_V131_V0.8641.00
152_S186_L0.8631.00
157_I215_T0.8631.00
18_R205_V0.8611.00
133_Q143_V0.8601.00
23_H188_A0.8591.00
46_A127_T0.8581.00
115_S118_T0.8561.00
32_F37_E0.8561.00
25_D31_R0.8511.00
71_A99_A0.8501.00
77_A81_E0.8491.00
133_Q183_T0.8441.00
182_Y186_L0.8311.00
73_A77_A0.8281.00
114_M138_L0.8261.00
114_M129_N0.8211.00
163_P167_E0.8201.00
211_P214_K0.8201.00
18_R21_E0.8171.00
153_R166_I0.8131.00
59_H84_S0.8101.00
71_A103_L0.8091.00
168_T172_P0.8071.00
37_E65_E0.8031.00
132_L136_H0.8031.00
13_G17_D0.7981.00
133_Q180_K0.7961.00
56_E59_H0.7931.00
40_V98_A0.7921.00
153_R158_T0.7851.00
52_R84_S0.7841.00
143_V183_T0.7751.00
193_T203_A0.7731.00
161_K165_A0.7721.00
16_I181_N0.7711.00
123_V127_T0.7621.00
160_K166_I0.7611.00
32_F38_L0.7591.00
110_V117_L0.7581.00
64_Y77_A0.7541.00
171_M179_W0.7511.00
26_P188_A0.7461.00
67_V110_V0.7451.00
163_P166_I0.7431.00
114_M128_A0.7421.00
59_H63_T0.7421.00
77_A80_A0.7411.00
142_I179_W0.7381.00
38_L135_G0.7321.00
19_L184_H0.7281.00
102_I108_G0.7201.00
149_Q153_R0.7191.00
95_I99_A0.7151.00
129_N142_I0.7141.00
55_A59_H0.7110.99
175_P179_W0.7080.99
42_V134_H0.7030.99
134_H180_K0.7020.99
52_R85_I0.6990.99
17_D20_R0.6980.99
71_A100_Q0.6910.99
68_A108_G0.6910.99
170_L174_V0.6900.99
71_A74_D0.6870.99
201_C204_C0.6860.99
44_L53_V0.6850.99
144_V166_I0.6790.99
151_L189_H0.6770.99
189_H192_E0.6760.99
42_V127_T0.6730.99
165_A168_T0.6690.99
125_R129_N0.6660.99
81_E84_S0.6600.99
133_Q141_G0.6600.99
103_L106_H0.6530.99
199_P210_C0.6520.99
129_N167_E0.6520.99
71_A96_K0.6440.99
141_G171_M0.6400.99
20_R185_W0.6400.99
194_C210_C0.6290.99
92_A95_I0.6260.99
15_V185_W0.6260.99
123_V128_A0.6250.99
64_Y78_L0.6210.99
12_V173_V0.6200.99
141_G179_W0.6160.99
142_I174_V0.6150.99
178_H185_W0.6130.99
92_A96_K0.6120.98
53_V85_I0.6110.98
207_A212_S0.6100.98
44_L85_I0.6100.98
51_E54_N0.6080.98
131_V135_G0.6080.98
65_E70_Y0.6060.98
148_V186_L0.6060.98
154_R199_P0.6050.98
117_L131_V0.6040.98
67_V99_A0.6040.98
119_D132_L0.6020.98
127_T131_V0.6010.98
153_R160_K0.6000.98
162_R166_I0.5970.98
73_A96_K0.5970.98
118_T128_A0.5940.98
37_E70_Y0.5940.98
209_I213_S0.5940.98
23_H189_H0.5920.98
18_R209_I0.5860.98
69_D72_N0.5860.98
78_L82_L0.5860.98
112_D116_D0.5840.98
125_R164_E0.5820.98
43_I95_I0.5810.98
114_M125_R0.5800.98
13_G178_H0.5800.98
153_R161_K0.5780.98
137_D140_Q0.5780.98
123_V131_V0.5780.98
101_S120_L0.5760.98
14_T208_D0.5750.98
34_S65_E0.5730.98
142_I182_Y0.5730.98
16_I178_H0.5690.98
134_H184_H0.5680.98
28_I134_H0.5670.98
109_A136_H0.5670.98
146_T196_A0.5650.97
39_L102_I0.5630.97
113_T132_L0.5580.97
79_A92_A0.5560.97
100_Q103_L0.5520.97
40_V43_I0.5520.97
12_V175_P0.5510.97
154_R201_C0.5500.97
24_P27_E0.5490.97
162_R167_E0.5480.97
129_N143_V0.5460.97
56_E85_I0.5440.97
117_L123_V0.5430.97
149_Q162_R0.5430.97
166_I174_V0.5420.97
195_T198_N0.5400.97
204_C210_C0.5390.97
40_V99_A0.5370.97
167_E174_V0.5320.96
34_S38_L0.5300.96
161_K166_I0.5290.96
207_A214_K0.5270.96
113_T138_L0.5240.96
144_V148_V0.5220.96
41_A57_T0.5210.96
76_E96_K0.5190.96
169_D173_V0.5190.96
13_G177_D0.5180.96
149_Q163_P0.5130.96
144_V149_Q0.5120.96
161_K171_M0.5110.95
129_N141_G0.5100.95
140_Q180_K0.5100.95
19_L185_W0.5080.95
126_K144_V0.5060.95
15_V155_L0.5040.95
126_K147_H0.5040.95
45_S187_I0.5000.95
55_A84_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fspA 1 0.9559 100 0.224 Contact Map
1kg2A 1 0.9604 100 0.234 Contact Map
3n5nX 1 0.9868 100 0.236 Contact Map
2abkA 1 0.9295 100 0.239 Contact Map
4unfA 1 0.9383 100 0.239 Contact Map
1ornA 1 0.9339 100 0.241 Contact Map
1keaA 2 0.9339 100 0.247 Contact Map
4uobA 1 0.9648 100 0.251 Contact Map
1pu6A 1 0.837 100 0.363 Contact Map
3n0uA 1 0.8722 100 0.466 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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