GREMLIN Database
Q9HRQ4 - Diphosphomevalonate decarboxylase
UniProt: Q9HRQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (303)
Sequences: 1012 (679)
Seq/√Len: 39.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_T53_T4.3561.00
224_M239_T4.1501.00
161_H172_E3.7571.00
29_R35_M3.6081.00
16_A119_A3.5691.00
63_D88_R3.5361.00
234_Q281_P3.4801.00
282_T294_V3.3541.00
64_Q71_T3.0571.00
15_R51_T3.0441.00
50_T116_S2.9511.00
188_V268_I2.8211.00
159_D225_R2.8111.00
57_D60_R2.7931.00
134_D137_T2.6841.00
11_K55_E2.6491.00
224_M236_V2.5761.00
265_T286_T2.5261.00
281_P300_H2.5161.00
297_T300_H2.4611.00
65_Y101_S2.4611.00
211_D215_A2.4351.00
13_T51_T2.4191.00
103_N116_S2.3741.00
226_D230_A2.3731.00
66_V71_T2.3651.00
64_Q98_R2.3151.00
186_I268_I2.2661.00
15_R49_N2.2240.99
101_S117_G2.1930.99
223_E235_R2.1840.99
261_W269_F2.1430.99
97_V128_A2.1250.99
227_A239_T2.0870.99
278_D307_A2.0410.99
31_E201_H2.0340.99
165_N168_D2.0220.99
245_L284_F1.9480.99
41_I221_L1.9410.99
232_D235_R1.8980.98
269_F284_F1.8880.98
55_E100_E1.8540.98
234_Q238_E1.8360.98
261_W265_T1.8060.98
220_Q243_D1.8060.98
144_R166_D1.7930.97
103_N107_T1.7570.97
140_T166_D1.7370.97
87_V125_C1.7230.97
147_A160_L1.7180.97
236_V239_T1.6980.96
243_D247_L1.6840.96
241_E276_R1.6690.96
203_E251_T1.6360.96
29_R166_D1.6290.96
219_G223_E1.6070.95
209_M253_T1.5910.95
263_P266_L1.5740.95
261_W266_L1.5540.94
54_V124_A1.5450.94
136_P154_T1.5430.94
238_E255_P1.5250.94
274_E278_D1.5130.93
67_V107_T1.5030.93
250_T253_T1.4970.93
175_D179_E1.4910.93
182_S298_A1.4870.93
209_M246_S1.4790.93
233_F297_T1.4720.92
237_F283_Y1.4640.92
14_A127_R1.4580.92
38_H217_V1.4550.92
39_D218_Q1.4420.92
213_R243_D1.4420.92
53_T100_E1.4110.91
273_R284_F1.4010.90
272_V282_T1.3870.90
55_E98_R1.3850.90
84_V97_V1.3820.90
31_E34_R1.3790.90
160_L291_T1.3780.90
286_T292_V1.3780.90
224_M240_A1.3770.90
84_V99_L1.3710.89
81_R85_D1.3680.89
182_S301_A1.3160.87
56_F129_A1.3090.87
84_V125_C1.2950.86
198_E202_A1.2910.86
176_A179_E1.2900.86
39_D159_D1.2890.86
97_V125_C1.2830.86
272_V294_V1.2640.85
235_R239_T1.2600.85
34_R197_T1.2530.85
251_T258_W1.2510.84
203_E253_T1.2370.84
223_E239_T1.2350.84
274_E277_A1.2340.84
150_A160_L1.2240.83
164_L168_D1.2200.83
213_R293_Y1.1990.82
65_Y72_V1.1900.81
39_D161_H1.1790.81
29_R168_D1.1710.80
198_E201_H1.1660.80
19_I26_H1.1620.80
111_L185_R1.1600.80
197_T286_T1.1540.79
112_G288_T1.1380.78
238_E242_H1.1380.78
296_T304_V1.1360.78
176_A180_F1.1290.78
78_D82_S1.1080.76
245_L253_T1.1020.76
227_A235_R1.0880.75
235_R238_E1.0840.75
203_E250_T1.0840.75
33_L163_G1.0790.74
209_M250_T1.0740.74
50_T103_N1.0720.74
160_L169_C1.0720.74
51_T268_I1.0680.74
51_T102_Q1.0620.73
196_E288_T1.0590.73
37_Y210_F1.0550.73
43_V157_F1.0480.72
21_G26_H1.0410.72
61_D96_R1.0400.72
87_V97_V1.0390.72
89_D277_A1.0320.71
199_S258_W1.0250.71
243_D293_Y1.0130.70
181_A295_N1.0110.70
60_R96_R1.0030.69
187_V190_E0.9990.69
181_A236_V0.9940.68
56_F128_A0.9880.68
264_E267_S0.9810.67
37_Y214_L0.9780.67
275_L307_A0.9700.66
216_H246_S0.9680.66
90_R131_L0.9610.66
184_L296_T0.9560.65
180_F231_G0.9540.65
197_T247_L0.9520.65
251_T259_V0.9490.65
249_A252_M0.9440.64
268_I308_V0.9420.64
139_S142_A0.9380.64
41_I174_L0.9370.64
228_V236_V0.9340.63
268_I272_V0.9340.63
125_C128_A0.9280.63
285_S295_N0.9240.62
67_V103_N0.9120.61
19_I28_M0.9110.61
126_V129_A0.9100.61
65_Y116_S0.9020.61
225_R229_R0.8990.60
288_T291_T0.8980.60
18_P48_S0.8980.60
28_M196_E0.8970.60
213_R220_Q0.8960.60
87_V126_V0.8950.60
241_E283_Y0.8930.60
157_F180_F0.8930.60
230_A278_D0.8920.60
105_F213_R0.8910.60
60_R98_R0.8910.60
139_S143_R0.8890.59
49_N104_S0.8870.59
241_E244_S0.8870.59
69_G100_E0.8870.59
29_R164_L0.8850.59
247_L293_Y0.8830.59
85_D89_D0.8800.59
296_T300_H0.8780.58
203_E210_F0.8780.58
86_A90_R0.8720.58
233_F236_V0.8720.58
226_D235_R0.8700.58
254_G257_G0.8690.58
176_A228_V0.8600.57
21_G28_M0.8600.57
54_V97_V0.8600.57
19_I25_Y0.8580.57
21_G112_G0.8510.56
20_Q45_T0.8510.56
79_R118_F0.8500.56
82_S85_D0.8490.56
93_F129_A0.8430.55
275_L303_E0.8430.55
112_G196_E0.8380.55
86_A144_R0.8350.55
244_S276_R0.8340.55
54_V128_A0.8300.54
57_D61_D0.8260.54
18_P104_S0.8260.54
18_P251_T0.8260.54
48_S185_R0.8190.53
136_P170_R0.8180.53
97_V129_A0.8160.53
159_D221_L0.8150.53
22_L236_V0.8140.53
28_M288_T0.8130.53
28_M44_C0.8100.52
19_I248_A0.8020.52
162_A218_Q0.8010.52
28_M112_G0.8000.52
109_I200_A0.7980.51
21_G24_K0.7950.51
62_A230_A0.7920.51
19_I42_S0.7910.51
113_S146_S0.7880.50
280_V300_H0.7870.50
221_L239_T0.7860.50
20_Q26_H0.7850.50
45_T121_A0.7840.50
19_I24_K0.7830.50
261_W284_F0.7830.50
11_K53_T0.7830.50
19_I45_T0.7820.50
18_P105_F0.7820.50
19_I291_T0.7800.50
79_R197_T0.7800.50
56_F97_V0.7740.49
216_H219_G0.7740.49
224_M228_V0.7730.49
65_Y99_L0.7710.49
185_R188_V0.7680.49
122_A142_A0.7670.49
106_P288_T0.7650.48
107_T116_S0.7640.48
175_D178_A0.7640.48
233_F281_P0.7630.48
89_D306_A0.7620.48
271_T274_E0.7620.48
294_V308_V0.7620.48
242_H246_S0.7570.48
237_F280_V0.7520.47
196_E200_A0.7480.47
182_S296_T0.7480.47
81_R99_L0.7450.47
41_I228_V0.7430.46
192_P200_A0.7410.46
163_G169_C0.7380.46
14_A124_A0.7380.46
137_T140_T0.7370.46
183_D293_Y0.7360.46
247_L285_S0.7350.46
54_V121_A0.7350.46
68_D74_G0.7330.45
25_Y28_M0.7330.45
73_T76_G0.7320.45
296_T301_A0.7320.45
117_G202_A0.7280.45
306_A310_D0.7240.45
18_P259_V0.7240.45
194_Y199_S0.7240.45
298_A301_A0.7200.44
26_H200_A0.7170.44
241_E284_F0.7150.44
80_I117_G0.7130.44
58_P95_H0.7090.43
157_F228_V0.7060.43
19_I288_T0.7040.43
277_A306_A0.7020.43
212_A216_H0.7010.43
286_T293_Y0.6990.42
20_Q285_S0.6970.42
59_D274_E0.6960.42
67_V101_S0.6960.42
43_V183_D0.6940.42
28_M45_T0.6920.42
241_E245_L0.6920.42
249_A253_T0.6920.42
16_A121_A0.6910.42
43_V181_A0.6910.42
197_T250_T0.6900.42
236_V240_A0.6890.42
29_R163_G0.6880.41
213_R253_T0.6860.41
181_A297_T0.6850.41
90_R137_T0.6850.41
201_H205_A0.6830.41
123_L127_R0.6830.41
200_A203_E0.6820.41
44_C155_G0.6810.41
106_P196_E0.6800.41
192_P195_K0.6750.40
232_D238_E0.6720.40
226_D229_R0.6710.40
18_P258_W0.6700.40
19_I152_A0.6690.40
38_H265_T0.6660.40
276_R283_Y0.6650.39
108_N252_M0.6620.39
186_I312_G0.6620.39
87_V91_A0.6590.39
54_V63_D0.6580.39
83_V197_T0.6570.39
276_R292_V0.6570.39
202_A205_A0.6560.39
268_I312_G0.6540.38
250_T257_G0.6540.38
105_F243_D0.6530.38
65_Y80_I0.6490.38
147_A248_A0.6460.38
165_N309_A0.6450.38
122_A153_V0.6450.38
240_A257_G0.6390.37
268_I313_V0.6390.37
302_D306_A0.6380.37
234_Q279_G0.6370.37
188_V191_V0.6350.37
109_I288_T0.6350.37
55_E116_S0.6340.37
112_G291_T0.6330.37
89_D302_D0.6320.37
41_I224_M0.6320.37
244_S286_T0.6310.37
67_V72_V0.6300.36
92_G95_H0.6290.36
17_H105_F0.6290.36
138_V153_V0.6290.36
19_I112_G0.6240.36
285_S288_T0.6240.36
15_R104_S0.6240.36
116_S234_Q0.6230.36
207_S254_G0.6210.36
186_I294_V0.6190.36
135_L303_E0.6190.36
26_H288_T0.6190.36
197_T254_G0.6170.35
20_Q152_A0.6160.35
22_L295_N0.6150.35
282_T304_V0.6130.35
215_A304_V0.6120.35
150_A158_S0.6120.35
215_A222_A0.6100.35
38_H160_L0.6060.34
130_G133_L0.6060.34
139_S171_S0.6060.34
163_G168_D0.6060.34
21_G25_Y0.6060.34
68_D102_Q0.6050.34
251_T276_R0.6030.34
220_Q246_S0.5990.34
22_L221_L0.5980.34
268_I303_E0.5970.34
56_F60_R0.5950.34
246_S253_T0.5920.33
248_A291_T0.5890.33
99_L121_A0.5890.33
50_T239_T0.5880.33
202_A294_V0.5860.33
301_A305_E0.5840.33
78_D303_E0.5840.33
19_I196_E0.5820.33
173_R177_P0.5810.32
183_D213_R0.5800.32
26_H196_E0.5790.32
58_P310_D0.5790.32
74_G77_A0.5760.32
213_R247_L0.5760.32
118_F145_G0.5750.32
81_R274_E0.5750.32
83_V251_T0.5730.32
245_L257_G0.5730.32
24_K27_G0.5710.32
162_A172_E0.5710.32
199_S260_Y0.5700.32
268_I292_V0.5700.32
126_V138_V0.5690.32
214_L217_V0.5680.31
192_P199_S0.5680.31
194_Y198_E0.5670.31
304_V310_D0.5660.31
269_F293_Y0.5650.31
106_P112_G0.5640.31
25_Y36_P0.5630.31
160_L265_T0.5630.31
19_I147_A0.5620.31
99_L274_E0.5620.31
50_T54_V0.5610.31
26_H45_T0.5600.31
134_D299_S0.5600.31
79_R258_W0.5590.31
59_D230_A0.5590.31
29_R162_A0.5550.30
181_A239_T0.5550.30
200_A293_Y0.5550.30
275_L279_G0.5540.30
49_N101_S0.5520.30
57_D98_R0.5510.30
125_C282_T0.5480.30
149_A153_V0.5470.30
66_V100_E0.5470.30
177_P299_S0.5460.30
109_I290_A0.5450.30
257_G273_R0.5450.30
222_A225_R0.5440.30
180_F236_V0.5420.29
111_L265_T0.5400.29
17_H104_S0.5400.29
38_H168_D0.5380.29
152_A248_A0.5360.29
38_H213_R0.5350.29
192_P260_Y0.5350.29
239_T243_D0.5330.29
275_L304_V0.5330.29
61_D78_D0.5310.29
35_M166_D0.5300.29
196_E199_S0.5280.28
245_L276_R0.5270.28
73_T77_A0.5270.28
220_Q293_Y0.5260.28
182_S297_T0.5260.28
23_V239_T0.5240.28
264_E268_I0.5240.28
303_E307_A0.5230.28
61_D64_Q0.5220.28
80_I87_V0.5220.28
187_V245_L0.5220.28
127_R130_G0.5200.28
65_Y81_R0.5190.28
158_S173_R0.5170.28
26_H112_G0.5150.27
120_A131_L0.5140.27
244_S291_T0.5130.27
45_T285_S0.5120.27
53_T132_D0.5110.27
215_A300_H0.5110.27
91_A131_L0.5110.27
173_R176_A0.5100.27
17_H236_V0.5090.27
189_G262_K0.5090.27
204_A217_V0.5080.27
87_V129_A0.5080.27
200_A288_T0.5080.27
76_G272_V0.5070.27
32_S229_R0.5060.27
51_T104_S0.5060.27
267_S270_E0.5050.27
253_T257_G0.5040.27
211_D214_L0.5020.27
23_V41_I0.5020.27
212_A253_T0.5020.27
282_T296_T0.5010.26
73_T277_A0.5010.26
72_V286_T0.5010.26
229_R310_D0.5010.26
123_L174_L0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fi4A 2 0.9731 100 0.564 Contact Map
3f0nA 2 0.9701 100 0.581 Contact Map
3qt5A 2 0.9701 100 0.598 Contact Map
2hkeA 1 0.9641 100 0.599 Contact Map
4rksA 1 0.9281 100 0.612 Contact Map
2gs8A 1 0.9401 100 0.629 Contact Map
3ltoA 2 0.9042 100 0.631 Contact Map
1h72C 2 0.8503 99.9 0.789 Contact Map
3hulA 4 0.8144 99.9 0.797 Contact Map
4p52A 2 0.8713 99.9 0.803 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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