Q9HRQ2 - HALSA - GREMLIN Contacts

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Q9HRQ2 - Uncharacterized protein

UniProt:	Q9HRQ2	Sequences: MADTNSPVSADAPDSPFRTTGTDHVTIWGSNAEDTIAFYRDLLGMPLVMRQPNLDDPSQTHLFFDTGDGRILTVFVNDERASNHDRLRTQVGGVHHLSFSIAAADFEDVMAALDDAGHGYNVFDRGIFCSLYTQDNNGLIVELAADKYDIPDDRRGEVLATAQRIREADGADFAADRHMEAALDELGIDAEPADLPDAATGAGV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	204 (170)
Sequences:	1761 (1187)
Seq/√Len:	91.1

BACSU - MHQA MHQO MHQE
HALSA - Q9HRQ2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
100_S	146_D	4.732	1.00
158_V	161_T	3.737	1.00
130_S	144_A	3.705	1.00
37_A	41_D	3.419	1.00
47_L	50_R	3.288	1.00
155_R	158_V	3.068	1.00
101_I	143_L	2.801	1.00
25_V	97_L	2.771	1.00
48_V	65_D	2.608	1.00
111_A	115_D	2.523	1.00
63_F	76_V	2.494	1.00
36_I	64_F	2.457	1.00
151_P	156_G	2.405	1.00
47_L	64_F	2.270	1.00
110_M	114_D	2.205	1.00
172_D	175_A	2.132	1.00
80_R	83_N	2.119	1.00
14_D	17_F	2.038	1.00
102_A	105_D	2.026	1.00
112_A	116_A	2.016	1.00
46_P	65_D	1.936	1.00
133_T	143_L	1.885	1.00
107_E	122_V	1.835	1.00
120_Y	131_L	1.769	1.00
80_R	84_H	1.758	1.00
36_I	40_R	1.752	1.00
47_L	62_L	1.693	1.00
45_M	99_F	1.650	1.00
128_F	144_A	1.624	1.00
32_A	79_E	1.622	1.00
153_D	159_L	1.610	1.00
127_I	164_R	1.585	1.00
134_Q	140_I	1.572	1.00
36_I	47_L	1.539	1.00
165_I	173_F	1.465	1.00
175_A	179_M	1.453	0.99
111_A	114_D	1.416	0.99
35_T	135_D	1.413	0.99
45_M	66_T	1.386	0.99
127_I	150_I	1.380	0.99
126_G	167_E	1.372	0.99
32_A	62_L	1.361	0.99
106_F	123_F	1.358	0.99
109_V	143_L	1.341	0.99
27_I	139_L	1.335	0.99
38_F	43_L	1.325	0.99
42_L	116_A	1.305	0.99
173_F	176_D	1.305	0.99
33_E	37_A	1.301	0.99
50_R	62_L	1.297	0.99
149_D	160_A	1.293	0.99
101_I	105_D	1.291	0.99
61_H	78_D	1.287	0.99
173_F	177_R	1.246	0.98
104_A	108_D	1.242	0.98
98_S	144_A	1.214	0.98
89_T	93_G	1.204	0.98
105_D	108_D	1.202	0.98
174_A	178_H	1.171	0.98
129_C	147_K	1.140	0.97
110_M	122_V	1.129	0.97
107_E	110_M	1.129	0.97
153_D	160_A	1.127	0.97
31_N	34_D	1.112	0.97
169_D	172_D	1.099	0.96
87_L	93_G	1.093	0.96
70_R	73_T	1.083	0.96
126_G	164_R	1.077	0.96
122_V	129_C	1.066	0.96
49_M	58_S	1.062	0.96
170_G	173_F	1.055	0.96
25_V	45_M	1.052	0.96
60_T	63_F	1.040	0.95
154_R	160_A	1.037	0.95
63_F	74_V	1.036	0.95
9_S	15_S	1.034	0.95
27_I	35_T	1.029	0.95
59_Q	63_F	1.022	0.95
110_M	123_F	1.018	0.95
172_D	176_D	1.016	0.95
156_G	159_L	1.015	0.95
72_L	75_F	1.014	0.95
92_G	125_R	1.012	0.94
72_L	76_V	1.002	0.94
127_I	160_A	1.002	0.94
106_F	122_V	1.001	0.94
11_D	18_R	0.993	0.94
149_D	153_D	0.989	0.94
42_L	112_A	0.988	0.94
26_T	61_H	0.986	0.94
148_Y	160_A	0.985	0.94
38_F	136_N	0.981	0.93
15_S	20_T	0.955	0.93
92_G	145_A	0.942	0.92
108_D	111_A	0.941	0.92
9_S	14_D	0.938	0.92
10_A	13_P	0.937	0.92
114_D	120_Y	0.936	0.92
41_D	44_G	0.929	0.91
151_P	159_L	0.914	0.91
73_T	109_V	0.912	0.91
31_N	37_A	0.905	0.90
180_E	183_L	0.898	0.90
95_H	140_I	0.896	0.90
110_M	131_L	0.893	0.90
50_R	60_T	0.890	0.90
35_T	137_N	0.881	0.89
154_R	159_L	0.876	0.89
78_D	84_H	0.876	0.89
124_D	168_A	0.873	0.89
163_Q	166_R	0.872	0.89
39_Y	141_V	0.869	0.89
34_D	37_A	0.862	0.88
112_A	115_D	0.850	0.87
123_F	131_L	0.846	0.87
96_H	142_E	0.835	0.86
127_I	154_R	0.830	0.86
170_G	176_D	0.828	0.86
34_D	137_N	0.820	0.85
85_D	88_R	0.820	0.85
41_D	116_A	0.819	0.85
113_L	133_T	0.812	0.85
33_E	79_E	0.812	0.85
110_M	120_Y	0.806	0.84
26_T	73_T	0.798	0.84
24_H	28_W	0.798	0.84
24_H	137_N	0.793	0.84
148_Y	154_R	0.787	0.83
145_A	148_Y	0.782	0.83
128_F	160_A	0.782	0.83
165_I	170_G	0.781	0.83
36_I	77_N	0.770	0.82
95_H	121_N	0.767	0.81
120_Y	123_F	0.764	0.81
132_Y	142_E	0.762	0.81
106_F	130_S	0.744	0.79
7_P	20_T	0.742	0.79
8_V	13_P	0.742	0.79
34_D	136_N	0.739	0.79
126_G	152_D	0.736	0.79
117_G	120_Y	0.732	0.78
71_I	74_V	0.731	0.78
11_D	14_D	0.731	0.78
168_A	171_A	0.719	0.77
106_F	110_M	0.713	0.76
128_F	146_D	0.713	0.76
127_I	152_D	0.711	0.76
81_A	84_H	0.706	0.76
127_I	149_D	0.706	0.76
125_R	128_F	0.705	0.76
121_N	140_I	0.704	0.76
29_G	32_A	0.698	0.75
106_F	131_L	0.697	0.75
171_A	176_D	0.697	0.75
150_I	153_D	0.694	0.75
92_G	128_F	0.689	0.74
73_T	76_V	0.684	0.73
153_D	166_R	0.680	0.73
48_V	74_V	0.674	0.72
107_E	114_D	0.665	0.71
35_T	136_N	0.661	0.71
168_A	172_D	0.660	0.71
92_G	166_R	0.658	0.71
114_D	178_H	0.656	0.70
149_D	166_R	0.654	0.70
89_T	99_F	0.652	0.70
166_R	170_G	0.646	0.69
124_D	148_Y	0.644	0.69
160_A	166_R	0.643	0.69
50_R	59_Q	0.639	0.68
121_N	134_Q	0.639	0.68
18_R	127_I	0.637	0.68
69_G	73_T	0.636	0.68
135_D	138_G	0.632	0.68
29_G	34_D	0.630	0.67
28_W	80_R	0.628	0.67
21_G	150_I	0.623	0.66
15_S	178_H	0.623	0.66
33_E	36_I	0.623	0.66
92_G	153_D	0.622	0.66
38_F	141_V	0.618	0.66
30_S	86_R	0.617	0.66
150_I	154_R	0.612	0.65
90_Q	125_R	0.611	0.65
74_V	137_N	0.610	0.65
72_L	78_D	0.609	0.65
92_G	154_R	0.608	0.65
46_P	67_G	0.607	0.64
92_G	95_H	0.606	0.64
42_L	109_V	0.606	0.64
145_A	149_D	0.605	0.64
95_H	173_F	0.603	0.64
113_L	118_H	0.602	0.64
148_Y	153_D	0.602	0.64
90_Q	163_Q	0.601	0.64
127_I	148_Y	0.600	0.64
128_F	149_D	0.600	0.64
173_F	180_E	0.593	0.63
41_D	50_R	0.592	0.62
138_G	168_A	0.590	0.62
92_G	144_A	0.588	0.62
72_L	77_N	0.586	0.62
133_T	141_V	0.576	0.60
61_H	117_G	0.575	0.60
149_D	154_R	0.574	0.60
30_S	79_E	0.574	0.60
8_V	11_D	0.567	0.59
106_F	137_N	0.567	0.59
31_N	138_G	0.565	0.59
144_A	166_R	0.565	0.59
123_F	127_I	0.564	0.59
145_A	160_A	0.563	0.59
58_S	61_H	0.562	0.59
148_Y	163_Q	0.560	0.58
87_L	91_V	0.559	0.58
152_D	180_E	0.558	0.58
127_I	159_L	0.557	0.58
145_A	163_Q	0.556	0.58
23_D	139_L	0.555	0.58
29_G	139_L	0.555	0.58
127_I	153_D	0.554	0.57
89_T	140_I	0.554	0.57
98_S	130_S	0.545	0.56
133_T	140_I	0.545	0.56
20_T	129_C	0.544	0.56
150_I	160_A	0.544	0.56
126_G	168_A	0.542	0.56
31_N	79_E	0.537	0.55
32_A	77_N	0.537	0.55
75_F	99_F	0.535	0.55
130_S	147_K	0.533	0.55
13_P	18_R	0.532	0.54
92_G	140_I	0.531	0.54
40_R	46_P	0.530	0.54
24_H	71_I	0.528	0.54
60_T	79_E	0.524	0.53
92_G	160_A	0.524	0.53
94_V	99_F	0.523	0.53
85_D	179_M	0.521	0.53
44_G	169_D	0.519	0.53
41_D	115_D	0.518	0.53
160_A	163_Q	0.517	0.52
59_Q	94_V	0.516	0.52
95_H	128_F	0.513	0.52
34_D	104_A	0.512	0.52
131_L	159_L	0.509	0.51
35_T	76_V	0.509	0.51
175_A	178_H	0.508	0.51
15_S	44_G	0.508	0.51
37_A	40_R	0.506	0.51
67_G	70_R	0.505	0.51
43_L	112_A	0.504	0.51
92_G	148_Y	0.502	0.50
163_Q	170_G	0.501	0.50
125_R	144_A	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3oajA	2	0.8725	100	0.374	Contact Map
4huzA	2	0.8431	100	0.465	Contact Map
1zswA	1	0.8676	100	0.483	Contact Map
3kolA	2	0.6814	99.8	0.623	Contact Map
1mpyA	3	0.848	99.8	0.641	Contact Map
3hpyA	4	0.7941	99.8	0.649	Contact Map
4ghgA	4	0.8922	99.7	0.652	Contact Map
3e0rA	1	0.7941	99.7	0.656	Contact Map
2rk0A	4	0.652	99.7	0.658	Contact Map
2zyqA	2	0.7843	99.7	0.661	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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