GREMLIN Database
Q9HRQ2 - Uncharacterized protein
UniProt: Q9HRQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (170)
Sequences: 1761 (1187)
Seq/√Len: 91.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_S146_D4.7321.00
158_V161_T3.7371.00
130_S144_A3.7051.00
37_A41_D3.4191.00
47_L50_R3.2881.00
155_R158_V3.0681.00
101_I143_L2.8011.00
25_V97_L2.7711.00
48_V65_D2.6081.00
111_A115_D2.5231.00
63_F76_V2.4941.00
36_I64_F2.4571.00
151_P156_G2.4051.00
47_L64_F2.2701.00
110_M114_D2.2051.00
172_D175_A2.1321.00
80_R83_N2.1191.00
14_D17_F2.0381.00
102_A105_D2.0261.00
112_A116_A2.0161.00
46_P65_D1.9361.00
133_T143_L1.8851.00
107_E122_V1.8351.00
120_Y131_L1.7691.00
80_R84_H1.7581.00
36_I40_R1.7521.00
47_L62_L1.6931.00
45_M99_F1.6501.00
128_F144_A1.6241.00
32_A79_E1.6221.00
153_D159_L1.6101.00
127_I164_R1.5851.00
134_Q140_I1.5721.00
36_I47_L1.5391.00
165_I173_F1.4651.00
175_A179_M1.4530.99
111_A114_D1.4160.99
35_T135_D1.4130.99
45_M66_T1.3860.99
127_I150_I1.3800.99
126_G167_E1.3720.99
32_A62_L1.3610.99
106_F123_F1.3580.99
109_V143_L1.3410.99
27_I139_L1.3350.99
38_F43_L1.3250.99
42_L116_A1.3050.99
173_F176_D1.3050.99
33_E37_A1.3010.99
50_R62_L1.2970.99
149_D160_A1.2930.99
101_I105_D1.2910.99
61_H78_D1.2870.99
173_F177_R1.2460.98
104_A108_D1.2420.98
98_S144_A1.2140.98
89_T93_G1.2040.98
105_D108_D1.2020.98
174_A178_H1.1710.98
129_C147_K1.1400.97
110_M122_V1.1290.97
107_E110_M1.1290.97
153_D160_A1.1270.97
31_N34_D1.1120.97
169_D172_D1.0990.96
87_L93_G1.0930.96
70_R73_T1.0830.96
126_G164_R1.0770.96
122_V129_C1.0660.96
49_M58_S1.0620.96
170_G173_F1.0550.96
25_V45_M1.0520.96
60_T63_F1.0400.95
154_R160_A1.0370.95
63_F74_V1.0360.95
9_S15_S1.0340.95
27_I35_T1.0290.95
59_Q63_F1.0220.95
110_M123_F1.0180.95
172_D176_D1.0160.95
156_G159_L1.0150.95
72_L75_F1.0140.95
92_G125_R1.0120.94
72_L76_V1.0020.94
127_I160_A1.0020.94
106_F122_V1.0010.94
11_D18_R0.9930.94
149_D153_D0.9890.94
42_L112_A0.9880.94
26_T61_H0.9860.94
148_Y160_A0.9850.94
38_F136_N0.9810.93
15_S20_T0.9550.93
92_G145_A0.9420.92
108_D111_A0.9410.92
9_S14_D0.9380.92
10_A13_P0.9370.92
114_D120_Y0.9360.92
41_D44_G0.9290.91
151_P159_L0.9140.91
73_T109_V0.9120.91
31_N37_A0.9050.90
180_E183_L0.8980.90
95_H140_I0.8960.90
110_M131_L0.8930.90
50_R60_T0.8900.90
35_T137_N0.8810.89
154_R159_L0.8760.89
78_D84_H0.8760.89
124_D168_A0.8730.89
163_Q166_R0.8720.89
39_Y141_V0.8690.89
34_D37_A0.8620.88
112_A115_D0.8500.87
123_F131_L0.8460.87
96_H142_E0.8350.86
127_I154_R0.8300.86
170_G176_D0.8280.86
34_D137_N0.8200.85
85_D88_R0.8200.85
41_D116_A0.8190.85
113_L133_T0.8120.85
33_E79_E0.8120.85
110_M120_Y0.8060.84
26_T73_T0.7980.84
24_H28_W0.7980.84
24_H137_N0.7930.84
148_Y154_R0.7870.83
145_A148_Y0.7820.83
128_F160_A0.7820.83
165_I170_G0.7810.83
36_I77_N0.7700.82
95_H121_N0.7670.81
120_Y123_F0.7640.81
132_Y142_E0.7620.81
106_F130_S0.7440.79
7_P20_T0.7420.79
8_V13_P0.7420.79
34_D136_N0.7390.79
126_G152_D0.7360.79
117_G120_Y0.7320.78
71_I74_V0.7310.78
11_D14_D0.7310.78
168_A171_A0.7190.77
106_F110_M0.7130.76
128_F146_D0.7130.76
127_I152_D0.7110.76
81_A84_H0.7060.76
127_I149_D0.7060.76
125_R128_F0.7050.76
121_N140_I0.7040.76
29_G32_A0.6980.75
106_F131_L0.6970.75
171_A176_D0.6970.75
150_I153_D0.6940.75
92_G128_F0.6890.74
73_T76_V0.6840.73
153_D166_R0.6800.73
48_V74_V0.6740.72
107_E114_D0.6650.71
35_T136_N0.6610.71
168_A172_D0.6600.71
92_G166_R0.6580.71
114_D178_H0.6560.70
149_D166_R0.6540.70
89_T99_F0.6520.70
166_R170_G0.6460.69
124_D148_Y0.6440.69
160_A166_R0.6430.69
50_R59_Q0.6390.68
121_N134_Q0.6390.68
18_R127_I0.6370.68
69_G73_T0.6360.68
135_D138_G0.6320.68
29_G34_D0.6300.67
28_W80_R0.6280.67
21_G150_I0.6230.66
15_S178_H0.6230.66
33_E36_I0.6230.66
92_G153_D0.6220.66
38_F141_V0.6180.66
30_S86_R0.6170.66
150_I154_R0.6120.65
90_Q125_R0.6110.65
74_V137_N0.6100.65
72_L78_D0.6090.65
92_G154_R0.6080.65
46_P67_G0.6070.64
92_G95_H0.6060.64
42_L109_V0.6060.64
145_A149_D0.6050.64
95_H173_F0.6030.64
113_L118_H0.6020.64
148_Y153_D0.6020.64
90_Q163_Q0.6010.64
127_I148_Y0.6000.64
128_F149_D0.6000.64
173_F180_E0.5930.63
41_D50_R0.5920.62
138_G168_A0.5900.62
92_G144_A0.5880.62
72_L77_N0.5860.62
133_T141_V0.5760.60
61_H117_G0.5750.60
149_D154_R0.5740.60
30_S79_E0.5740.60
8_V11_D0.5670.59
106_F137_N0.5670.59
31_N138_G0.5650.59
144_A166_R0.5650.59
123_F127_I0.5640.59
145_A160_A0.5630.59
58_S61_H0.5620.59
148_Y163_Q0.5600.58
87_L91_V0.5590.58
152_D180_E0.5580.58
127_I159_L0.5570.58
145_A163_Q0.5560.58
23_D139_L0.5550.58
29_G139_L0.5550.58
127_I153_D0.5540.57
89_T140_I0.5540.57
98_S130_S0.5450.56
133_T140_I0.5450.56
20_T129_C0.5440.56
150_I160_A0.5440.56
126_G168_A0.5420.56
31_N79_E0.5370.55
32_A77_N0.5370.55
75_F99_F0.5350.55
130_S147_K0.5330.55
13_P18_R0.5320.54
92_G140_I0.5310.54
40_R46_P0.5300.54
24_H71_I0.5280.54
60_T79_E0.5240.53
92_G160_A0.5240.53
94_V99_F0.5230.53
85_D179_M0.5210.53
44_G169_D0.5190.53
41_D115_D0.5180.53
160_A163_Q0.5170.52
59_Q94_V0.5160.52
95_H128_F0.5130.52
34_D104_A0.5120.52
131_L159_L0.5090.51
35_T76_V0.5090.51
175_A178_H0.5080.51
15_S44_G0.5080.51
37_A40_R0.5060.51
67_G70_R0.5050.51
43_L112_A0.5040.51
92_G148_Y0.5020.50
163_Q170_G0.5010.50
125_R144_A0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oajA 2 0.8725 100 0.374 Contact Map
4huzA 2 0.8431 100 0.465 Contact Map
1zswA 1 0.8676 100 0.483 Contact Map
3kolA 2 0.6814 99.8 0.623 Contact Map
1mpyA 3 0.848 99.8 0.641 Contact Map
3hpyA 4 0.7941 99.8 0.649 Contact Map
4ghgA 4 0.8922 99.7 0.652 Contact Map
3e0rA 1 0.7941 99.7 0.656 Contact Map
2rk0A 4 0.652 99.7 0.658 Contact Map
2zyqA 2 0.7843 99.7 0.661 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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