GREMLIN Database
Q9HRP9 - Uncharacterized protein
UniProt: Q9HRP9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (279)
Sequences: 53541 (45049)
Seq/√Len: 2697.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_G232_L4.6631.00
190_T215_R3.5891.00
111_L133_E3.2851.00
200_R204_E3.1971.00
235_F251_A2.9741.00
164_L192_V2.8291.00
186_G288_R2.8101.00
48_H325_Y2.7911.00
162_E190_T2.6091.00
192_V217_L2.6001.00
182_A206_E2.5671.00
167_Y177_L2.5581.00
120_R124_R2.1731.00
163_P295_L2.1341.00
182_A284_I2.1021.00
176_R179_D2.0701.00
297_D300_T2.0561.00
262_D267_S2.0201.00
164_L190_T1.9811.00
206_E210_R1.9701.00
290_A293_R1.9491.00
194_G228_F1.9241.00
184_A191_V1.8851.00
186_G285_P1.8721.00
270_I276_G1.8581.00
199_A202_D1.8511.00
293_R297_D1.8491.00
165_I234_V1.8461.00
192_V215_R1.8451.00
48_H73_T1.8331.00
164_L231_A1.8281.00
163_P233_D1.8191.00
271_I274_T1.8011.00
293_R300_T1.7681.00
176_R240_P1.7571.00
316_R320_R1.7501.00
138_G314_V1.7371.00
111_L324_R1.7281.00
180_L191_V1.7161.00
280_D286_G1.6921.00
277_Y290_A1.6851.00
117_E120_R1.6771.00
301_L305_C1.6751.00
185_A210_R1.6721.00
120_R134_A1.6721.00
133_E327_E1.6701.00
262_D280_D1.6401.00
220_L224_E1.6361.00
168_T225_M1.6341.00
72_A109_A1.6301.00
235_F256_T1.6011.00
117_E268_E1.5961.00
255_G309_R1.5691.00
292_R296_D1.5651.00
114_T132_V1.5621.00
120_R132_V1.5291.00
271_I275_T1.5121.00
277_Y293_R1.5021.00
184_A189_A1.5011.00
283_D286_G1.4791.00
286_G290_A1.4611.00
187_V292_R1.4571.00
180_L236_A1.4461.00
117_E134_A1.4381.00
300_T303_E1.4301.00
179_D240_P1.4111.00
224_E227_A1.4021.00
174_E241_I1.4011.00
179_D284_I1.3971.00
49_A70_L1.3851.00
196_D200_R1.3831.00
274_T307_A1.3791.00
322_A326_R1.3781.00
178_G206_E1.3721.00
192_V228_F1.3551.00
194_G217_L1.3371.00
260_G266_L1.3371.00
164_L233_D1.3331.00
279_Y290_A1.3231.00
205_A209_A1.3201.00
113_L321_L1.3131.00
220_L228_F1.3091.00
177_L193_F1.3071.00
194_G220_L1.3061.00
303_E307_A1.3041.00
114_T120_R1.2961.00
208_D213_D1.2931.00
284_I288_R1.2921.00
232_L256_T1.2901.00
186_G284_I1.2891.00
192_V232_L1.2881.00
171_H193_F1.2841.00
167_Y180_L1.2731.00
226_P254_C1.2621.00
113_L324_R1.2551.00
183_A287_F1.2311.00
320_R323_A1.2291.00
217_L220_L1.2151.00
111_L327_E1.2101.00
165_I291_I1.2071.00
221_D224_E1.2051.00
286_G289_R1.1891.00
206_E209_A1.1881.00
316_R319_D1.1871.00
144_F254_C1.1841.00
166_G194_G1.1841.00
165_I236_A1.1831.00
305_C308_R1.1811.00
302_A306_V1.1711.00
230_S254_C1.1701.00
117_E121_R1.1511.00
163_P234_V1.1341.00
124_R130_T1.1331.00
240_P282_G1.1261.00
300_T304_N1.1231.00
75_H246_L1.1171.00
244_E249_L1.1141.00
121_R124_R1.1091.00
143_R226_P1.1091.00
225_M229_Y1.1031.00
178_G182_A1.1021.00
288_R292_R1.0931.00
163_P189_A1.0891.00
50_H75_H1.0761.00
314_V317_A1.0731.00
272_D290_A1.0671.00
313_S316_R1.0671.00
264_G267_S1.0621.00
114_T123_V1.0551.00
115_P137_N1.0521.00
49_A72_A1.0451.00
35_P38_P1.0441.00
305_C309_R1.0411.00
248_A266_L1.0361.00
179_D282_G1.0351.00
237_F248_A1.0341.00
201_G204_E1.0331.00
238_P287_F1.0321.00
229_Y254_C1.0301.00
163_P188_D1.0271.00
237_F247_V1.0261.00
179_D261_V1.0251.00
165_I184_A1.0251.00
255_G306_V1.0231.00
317_A320_R1.0221.00
279_Y287_F1.0201.00
179_D182_A1.0201.00
222_R225_M1.0161.00
164_L232_L1.0111.00
261_V279_Y1.0091.00
144_F226_P1.0051.00
217_L228_F1.0011.00
204_E208_D0.9951.00
317_A321_L0.9951.00
170_R174_E0.9941.00
226_P230_S0.9861.00
239_S242_E0.9841.00
245_G266_L0.9831.00
201_G205_A0.9781.00
141_T313_S0.9741.00
252_N258_V0.9601.00
260_G278_H0.9581.00
294_A304_N0.9571.00
289_R293_R0.9561.00
304_N307_A0.9511.00
159_P162_E0.9491.00
265_A268_E0.9441.00
166_G228_F0.9431.00
114_T119_T0.9401.00
137_N246_L0.9341.00
122_E125_A0.9331.00
168_T229_Y0.9311.00
71_V113_L0.9291.00
298_R301_L0.9271.00
115_P119_T0.9251.00
277_Y304_N0.9221.00
180_L238_P0.9191.00
277_Y294_A0.9151.00
121_R125_A0.9111.00
168_T194_G0.9071.00
70_L109_A0.9071.00
39_D44_A0.9051.00
302_A305_C0.9041.00
189_A295_L0.9021.00
178_G240_P0.9021.00
115_P243_T0.9001.00
298_R302_A0.8961.00
207_A216_F0.8951.00
109_A112_V0.8951.00
185_A212_V0.8951.00
248_A260_G0.8931.00
138_G317_A0.8881.00
187_V295_L0.8881.00
235_F247_V0.8881.00
178_G202_D0.8851.00
319_D323_A0.8811.00
167_Y193_F0.8801.00
192_V231_A0.8791.00
162_E188_D0.8781.00
181_L207_A0.8751.00
179_D287_F0.8741.00
251_A256_T0.8701.00
259_A279_Y0.8701.00
175_K242_E0.8691.00
207_A212_V0.8681.00
183_A288_R0.8651.00
182_A210_R0.8551.00
270_I278_H0.8511.00
133_E324_R0.8491.00
242_E245_G0.8441.00
252_N308_R0.8431.00
133_E320_R0.8341.00
187_V288_R0.8321.00
122_E126_L0.8311.00
252_N275_T0.8301.00
277_Y300_T0.8271.00
256_T305_C0.8251.00
140_D143_R0.8251.00
187_V291_I0.8171.00
63_A70_L0.8161.00
202_D205_A0.8131.00
140_D144_F0.8101.00
237_F266_L0.8031.00
272_D275_T0.8021.00
248_A269_T0.7981.00
234_V294_A0.7961.00
202_D206_E0.7941.00
301_L304_N0.7921.00
313_S317_A0.7901.00
260_G270_I0.7881.00
104_W108_R0.7881.00
314_V318_I0.7861.00
205_A208_D0.7851.00
172_G198_P0.7831.00
259_A290_A0.7811.00
228_F231_A0.7791.00
280_D283_D0.7731.00
124_R132_V0.7721.00
263_A266_L0.7691.00
248_A258_V0.7681.00
169_G175_K0.7661.00
236_A291_I0.7651.00
227_A231_A0.7631.00
118_R121_R0.7621.00
304_N308_R0.7601.00
171_H200_R0.7591.00
160_A163_P0.7591.00
61_R65_R0.7571.00
182_A185_A0.7551.00
175_K239_S0.7541.00
113_L135_M0.7521.00
229_Y256_T0.7461.00
167_Y238_P0.7441.00
71_V111_L0.7431.00
257_P305_C0.7421.00
321_L325_Y0.7401.00
75_H115_P0.7391.00
178_G199_A0.7351.00
50_H73_T0.7331.00
262_D278_H0.7321.00
166_G229_Y0.7301.00
175_K247_V0.7301.00
182_A186_G0.7271.00
135_M324_R0.7261.00
147_T230_S0.7261.00
183_A284_I0.7251.00
227_A230_S0.7241.00
222_R226_P0.7121.00
285_P289_R0.7121.00
48_H321_L0.7111.00
136_P320_R0.7111.00
100_R104_W0.7101.00
76_T174_E0.7071.00
234_V291_I0.7071.00
275_T307_A0.7051.00
69_P110_D0.7041.00
289_R292_R0.7031.00
318_I322_A0.7001.00
118_R122_E0.6991.00
167_Y235_F0.6971.00
267_S278_H0.6961.00
275_T308_R0.6951.00
259_A294_A0.6911.00
173_Y240_P0.6911.00
323_A327_E0.6851.00
173_Y178_G0.6851.00
136_P268_E0.6831.00
249_L312_I0.6781.00
168_T235_F0.6781.00
207_A210_R0.6741.00
233_D301_L0.6721.00
115_P246_L0.6711.00
323_A326_R0.6711.00
165_I189_A0.6701.00
303_E306_V0.6691.00
261_V281_A0.6671.00
62_L66_N0.6621.00
207_A214_A0.6621.00
44_A68_A0.6611.00
299_D303_E0.6601.00
273_G293_R0.6601.00
167_Y191_V0.6591.00
285_P288_R0.6581.00
257_P294_A0.6551.00
272_D277_Y0.6551.00
49_A59_A0.6541.00
135_M321_L0.6541.00
306_V309_R0.6501.00
245_G248_A0.6481.00
261_V287_F0.6481.00
135_M320_R0.6471.00
73_T321_L0.6431.00
293_R296_D0.6391.00
71_V325_Y0.6381.00
46_V71_V0.6341.00
39_D42_A0.6341.00
36_S65_R0.6331.00
141_T253_A0.6331.00
220_L225_M0.6331.00
38_P42_A0.6331.00
63_A66_N0.6321.00
294_A301_L0.6271.00
165_I295_L0.6251.00
297_D301_L0.6231.00
173_Y199_A0.6211.00
100_R103_R0.6191.00
204_E216_F0.6161.00
279_Y286_G0.6151.00
118_R267_S0.6131.00
64_R108_R0.6131.00
319_D322_A0.6121.00
183_A291_I0.6101.00
96_R99_E0.6091.00
184_A187_V0.6091.00
169_G177_L0.6071.00
252_N305_C0.6051.00
299_D302_A0.6031.00
92_G96_R0.6001.00
236_A287_F0.5981.00
119_T122_E0.5951.00
311_D316_R0.5951.00
171_H177_L0.5941.00
128_V131_P0.5921.00
176_R282_G0.5901.00
207_A213_D0.5891.00
46_V325_Y0.5891.00
270_I275_T0.5891.00
237_F245_G0.5871.00
244_E312_I0.5861.00
166_G235_F0.5841.00
170_R175_K0.5821.00
103_R107_S0.5781.00
315_G319_D0.5761.00
235_F258_V0.5751.00
133_E136_P0.5721.00
195_G218_G0.5711.00
75_H137_N0.5701.00
181_L214_A0.5691.00
145_Q230_S0.5671.00
159_P190_T0.5661.00
229_Y247_V0.5661.00
228_F232_L0.5651.00
179_D183_A0.5611.00
163_P301_L0.5611.00
70_L110_D0.5591.00
136_P312_I0.5541.00
40_A66_N0.5521.00
163_P298_R0.5511.00
234_V259_A0.5511.00
143_R222_R0.5481.00
36_S40_A0.5441.00
142_D145_Q0.5431.00
263_A281_A0.5381.00
47_V68_A0.5371.00
92_G95_R0.5371.00
117_E136_P0.5351.00
73_T113_L0.5331.00
183_A187_V0.5331.00
78_T81_Y0.5331.00
124_R129_D0.5311.00
166_G256_T0.5281.00
251_A258_V0.5271.00
111_L131_P0.5251.00
176_R261_V0.5251.00
233_D298_R0.5251.00
199_A203_L0.5241.00
49_A56_G0.5221.00
324_R327_E0.5221.00
73_T325_Y0.5211.00
47_V63_A0.5201.00
39_D43_G0.5191.00
124_R127_G0.5191.00
166_G192_V0.5181.00
197_G200_R0.5181.00
136_P244_E0.5181.00
74_Y119_T0.5181.00
183_A236_A0.5151.00
259_A291_I0.5151.00
257_P308_R0.5141.00
238_P261_V0.5141.00
177_L199_A0.5131.00
263_A267_S0.5131.00
245_G249_L0.5121.00
124_R131_P0.5111.00
66_N69_P0.5111.00
194_G225_M0.5111.00
181_L203_L0.5091.00
73_T115_P0.5081.00
63_A110_D0.5081.00
56_G59_A0.5081.00
173_Y202_D0.5071.00
229_Y235_F0.5051.00
257_P301_L0.5051.00
116_S119_T0.5041.00
204_E207_A0.5021.00
136_P317_A0.5021.00
139_V253_A0.5011.00
191_V214_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r60A 1 0.997 100 0.245 Contact Map
1rzuA 1 0.9909 100 0.251 Contact Map
2qzsA 1 0.9848 100 0.256 Contact Map
3c48A 2 0.9667 100 0.258 Contact Map
3froA 3 0.9879 100 0.261 Contact Map
4n9wA 1 0.897 100 0.268 Contact Map
2jjmA 4 0.9394 100 0.27 Contact Map
3okpA 1 0.9606 100 0.281 Contact Map
3vueA 1 0.9909 100 0.291 Contact Map
3oy2A 2 0.9303 100 0.293 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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