Q9HRP9 - HALSA - GREMLIN Contacts

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Q9HRP9 - Uncharacterized protein

UniProt:	Q9HRP9	Sequences: MPVVYPASDHEPAETEHPVASLAFPFYDGYRMAFPSPPDAVAGADVVHAHTPFGLGLAAVRLARRNDAPLVATYHTPTAEYAEYVGPDAVTGAVRRASERYERWFLSRADLVLTPSERTRREVRALGVDTPVEAMPNGVDTDRFQPTDPTAFLAAHDLPADEPLIGYTGRHGYEKRLGDLLAAAAGVDATVVFGGDGPARGDLEAEADARGVDARFLGFLDREEMPAFYSALDVFAFPSPIETEGLVALEANACGTPVAGVDAGALSETIIDGTTGYHYDAGDIPGFRRAIRRALDDRDTLAENCVARRPDISVGRAIDRLAARYRELLG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	330 (279)
Sequences:	53541 (45049)
Seq/√Len:	2697.0

ECOLI - WCAL GLGA RFAG WCAI WBBK RFAB WCAC
BACSU - EPSD YPJH EPSF YTCC GLGA YQGM TUAC COTSA TUAH YKVP CGEB TAGE
HALSA - Q9HRP9 Q9HQQ0 Q9HRP8 Q9HSV2 Q9HS45 Q9HSW1 Q9HSV4 Q9HQT2
SULSO - Q97V80 Q97XT7 Q980C8 Q97V61 Q97UM0 Q97ZD3 Q97UU3 Q7LXI2 Q97VL4 Q97XT1 Q97XF6 Q97XU2 Q7LXM9 Q97XT8 Q97XT9 Q97XT6 Q97XT5 Q7LXF8 Q7LXF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
166_G	232_L	4.663	1.00
190_T	215_R	3.589	1.00
111_L	133_E	3.285	1.00
200_R	204_E	3.197	1.00
235_F	251_A	2.974	1.00
164_L	192_V	2.829	1.00
186_G	288_R	2.810	1.00
48_H	325_Y	2.791	1.00
162_E	190_T	2.609	1.00
192_V	217_L	2.600	1.00
182_A	206_E	2.567	1.00
167_Y	177_L	2.558	1.00
120_R	124_R	2.173	1.00
163_P	295_L	2.134	1.00
182_A	284_I	2.102	1.00
176_R	179_D	2.070	1.00
297_D	300_T	2.056	1.00
262_D	267_S	2.020	1.00
164_L	190_T	1.981	1.00
206_E	210_R	1.970	1.00
290_A	293_R	1.949	1.00
194_G	228_F	1.924	1.00
184_A	191_V	1.885	1.00
186_G	285_P	1.872	1.00
270_I	276_G	1.858	1.00
199_A	202_D	1.851	1.00
293_R	297_D	1.849	1.00
165_I	234_V	1.846	1.00
192_V	215_R	1.845	1.00
48_H	73_T	1.833	1.00
164_L	231_A	1.828	1.00
163_P	233_D	1.819	1.00
271_I	274_T	1.801	1.00
293_R	300_T	1.768	1.00
176_R	240_P	1.757	1.00
316_R	320_R	1.750	1.00
138_G	314_V	1.737	1.00
111_L	324_R	1.728	1.00
180_L	191_V	1.716	1.00
280_D	286_G	1.692	1.00
277_Y	290_A	1.685	1.00
117_E	120_R	1.677	1.00
301_L	305_C	1.675	1.00
185_A	210_R	1.672	1.00
120_R	134_A	1.672	1.00
133_E	327_E	1.670	1.00
262_D	280_D	1.640	1.00
220_L	224_E	1.636	1.00
168_T	225_M	1.634	1.00
72_A	109_A	1.630	1.00
235_F	256_T	1.601	1.00
117_E	268_E	1.596	1.00
255_G	309_R	1.569	1.00
292_R	296_D	1.565	1.00
114_T	132_V	1.562	1.00
120_R	132_V	1.529	1.00
271_I	275_T	1.512	1.00
277_Y	293_R	1.502	1.00
184_A	189_A	1.501	1.00
283_D	286_G	1.479	1.00
286_G	290_A	1.461	1.00
187_V	292_R	1.457	1.00
180_L	236_A	1.446	1.00
117_E	134_A	1.438	1.00
300_T	303_E	1.430	1.00
179_D	240_P	1.411	1.00
224_E	227_A	1.402	1.00
174_E	241_I	1.401	1.00
179_D	284_I	1.397	1.00
49_A	70_L	1.385	1.00
196_D	200_R	1.383	1.00
274_T	307_A	1.379	1.00
322_A	326_R	1.378	1.00
178_G	206_E	1.372	1.00
192_V	228_F	1.355	1.00
194_G	217_L	1.337	1.00
260_G	266_L	1.337	1.00
164_L	233_D	1.333	1.00
279_Y	290_A	1.323	1.00
205_A	209_A	1.320	1.00
113_L	321_L	1.313	1.00
220_L	228_F	1.309	1.00
177_L	193_F	1.307	1.00
194_G	220_L	1.306	1.00
303_E	307_A	1.304	1.00
114_T	120_R	1.296	1.00
208_D	213_D	1.293	1.00
284_I	288_R	1.292	1.00
232_L	256_T	1.290	1.00
186_G	284_I	1.289	1.00
192_V	232_L	1.288	1.00
171_H	193_F	1.284	1.00
167_Y	180_L	1.273	1.00
226_P	254_C	1.262	1.00
113_L	324_R	1.255	1.00
183_A	287_F	1.231	1.00
320_R	323_A	1.229	1.00
217_L	220_L	1.215	1.00
111_L	327_E	1.210	1.00
165_I	291_I	1.207	1.00
221_D	224_E	1.205	1.00
286_G	289_R	1.189	1.00
206_E	209_A	1.188	1.00
316_R	319_D	1.187	1.00
144_F	254_C	1.184	1.00
166_G	194_G	1.184	1.00
165_I	236_A	1.183	1.00
305_C	308_R	1.181	1.00
302_A	306_V	1.171	1.00
230_S	254_C	1.170	1.00
117_E	121_R	1.151	1.00
163_P	234_V	1.134	1.00
124_R	130_T	1.133	1.00
240_P	282_G	1.126	1.00
300_T	304_N	1.123	1.00
75_H	246_L	1.117	1.00
244_E	249_L	1.114	1.00
121_R	124_R	1.109	1.00
143_R	226_P	1.109	1.00
225_M	229_Y	1.103	1.00
178_G	182_A	1.102	1.00
288_R	292_R	1.093	1.00
163_P	189_A	1.089	1.00
50_H	75_H	1.076	1.00
314_V	317_A	1.073	1.00
272_D	290_A	1.067	1.00
313_S	316_R	1.067	1.00
264_G	267_S	1.062	1.00
114_T	123_V	1.055	1.00
115_P	137_N	1.052	1.00
49_A	72_A	1.045	1.00
35_P	38_P	1.044	1.00
305_C	309_R	1.041	1.00
248_A	266_L	1.036	1.00
179_D	282_G	1.035	1.00
237_F	248_A	1.034	1.00
201_G	204_E	1.033	1.00
238_P	287_F	1.032	1.00
229_Y	254_C	1.030	1.00
163_P	188_D	1.027	1.00
237_F	247_V	1.026	1.00
179_D	261_V	1.025	1.00
165_I	184_A	1.025	1.00
255_G	306_V	1.023	1.00
317_A	320_R	1.022	1.00
279_Y	287_F	1.020	1.00
179_D	182_A	1.020	1.00
222_R	225_M	1.016	1.00
164_L	232_L	1.011	1.00
261_V	279_Y	1.009	1.00
144_F	226_P	1.005	1.00
217_L	228_F	1.001	1.00
204_E	208_D	0.995	1.00
317_A	321_L	0.995	1.00
170_R	174_E	0.994	1.00
226_P	230_S	0.986	1.00
239_S	242_E	0.984	1.00
245_G	266_L	0.983	1.00
201_G	205_A	0.978	1.00
141_T	313_S	0.974	1.00
252_N	258_V	0.960	1.00
260_G	278_H	0.958	1.00
294_A	304_N	0.957	1.00
289_R	293_R	0.956	1.00
304_N	307_A	0.951	1.00
159_P	162_E	0.949	1.00
265_A	268_E	0.944	1.00
166_G	228_F	0.943	1.00
114_T	119_T	0.940	1.00
137_N	246_L	0.934	1.00
122_E	125_A	0.933	1.00
168_T	229_Y	0.931	1.00
71_V	113_L	0.929	1.00
298_R	301_L	0.927	1.00
115_P	119_T	0.925	1.00
277_Y	304_N	0.922	1.00
180_L	238_P	0.919	1.00
277_Y	294_A	0.915	1.00
121_R	125_A	0.911	1.00
168_T	194_G	0.907	1.00
70_L	109_A	0.907	1.00
39_D	44_A	0.905	1.00
302_A	305_C	0.904	1.00
189_A	295_L	0.902	1.00
178_G	240_P	0.902	1.00
115_P	243_T	0.900	1.00
298_R	302_A	0.896	1.00
207_A	216_F	0.895	1.00
109_A	112_V	0.895	1.00
185_A	212_V	0.895	1.00
248_A	260_G	0.893	1.00
138_G	317_A	0.888	1.00
187_V	295_L	0.888	1.00
235_F	247_V	0.888	1.00
178_G	202_D	0.885	1.00
319_D	323_A	0.881	1.00
167_Y	193_F	0.880	1.00
192_V	231_A	0.879	1.00
162_E	188_D	0.878	1.00
181_L	207_A	0.875	1.00
179_D	287_F	0.874	1.00
251_A	256_T	0.870	1.00
259_A	279_Y	0.870	1.00
175_K	242_E	0.869	1.00
207_A	212_V	0.868	1.00
183_A	288_R	0.865	1.00
182_A	210_R	0.855	1.00
270_I	278_H	0.851	1.00
133_E	324_R	0.849	1.00
242_E	245_G	0.844	1.00
252_N	308_R	0.843	1.00
133_E	320_R	0.834	1.00
187_V	288_R	0.832	1.00
122_E	126_L	0.831	1.00
252_N	275_T	0.830	1.00
277_Y	300_T	0.827	1.00
256_T	305_C	0.825	1.00
140_D	143_R	0.825	1.00
187_V	291_I	0.817	1.00
63_A	70_L	0.816	1.00
202_D	205_A	0.813	1.00
140_D	144_F	0.810	1.00
237_F	266_L	0.803	1.00
272_D	275_T	0.802	1.00
248_A	269_T	0.798	1.00
234_V	294_A	0.796	1.00
202_D	206_E	0.794	1.00
301_L	304_N	0.792	1.00
313_S	317_A	0.790	1.00
260_G	270_I	0.788	1.00
104_W	108_R	0.788	1.00
314_V	318_I	0.786	1.00
205_A	208_D	0.785	1.00
172_G	198_P	0.783	1.00
259_A	290_A	0.781	1.00
228_F	231_A	0.779	1.00
280_D	283_D	0.773	1.00
124_R	132_V	0.772	1.00
263_A	266_L	0.769	1.00
248_A	258_V	0.768	1.00
169_G	175_K	0.766	1.00
236_A	291_I	0.765	1.00
227_A	231_A	0.763	1.00
118_R	121_R	0.762	1.00
304_N	308_R	0.760	1.00
171_H	200_R	0.759	1.00
160_A	163_P	0.759	1.00
61_R	65_R	0.757	1.00
182_A	185_A	0.755	1.00
175_K	239_S	0.754	1.00
113_L	135_M	0.752	1.00
229_Y	256_T	0.746	1.00
167_Y	238_P	0.744	1.00
71_V	111_L	0.743	1.00
257_P	305_C	0.742	1.00
321_L	325_Y	0.740	1.00
75_H	115_P	0.739	1.00
178_G	199_A	0.735	1.00
50_H	73_T	0.733	1.00
262_D	278_H	0.732	1.00
166_G	229_Y	0.730	1.00
175_K	247_V	0.730	1.00
182_A	186_G	0.727	1.00
135_M	324_R	0.726	1.00
147_T	230_S	0.726	1.00
183_A	284_I	0.725	1.00
227_A	230_S	0.724	1.00
222_R	226_P	0.712	1.00
285_P	289_R	0.712	1.00
48_H	321_L	0.711	1.00
136_P	320_R	0.711	1.00
100_R	104_W	0.710	1.00
76_T	174_E	0.707	1.00
234_V	291_I	0.707	1.00
275_T	307_A	0.705	1.00
69_P	110_D	0.704	1.00
289_R	292_R	0.703	1.00
318_I	322_A	0.700	1.00
118_R	122_E	0.699	1.00
167_Y	235_F	0.697	1.00
267_S	278_H	0.696	1.00
275_T	308_R	0.695	1.00
259_A	294_A	0.691	1.00
173_Y	240_P	0.691	1.00
323_A	327_E	0.685	1.00
173_Y	178_G	0.685	1.00
136_P	268_E	0.683	1.00
249_L	312_I	0.678	1.00
168_T	235_F	0.678	1.00
207_A	210_R	0.674	1.00
233_D	301_L	0.672	1.00
115_P	246_L	0.671	1.00
323_A	326_R	0.671	1.00
165_I	189_A	0.670	1.00
303_E	306_V	0.669	1.00
261_V	281_A	0.667	1.00
62_L	66_N	0.662	1.00
207_A	214_A	0.662	1.00
44_A	68_A	0.661	1.00
299_D	303_E	0.660	1.00
273_G	293_R	0.660	1.00
167_Y	191_V	0.659	1.00
285_P	288_R	0.658	1.00
257_P	294_A	0.655	1.00
272_D	277_Y	0.655	1.00
49_A	59_A	0.654	1.00
135_M	321_L	0.654	1.00
306_V	309_R	0.650	1.00
245_G	248_A	0.648	1.00
261_V	287_F	0.648	1.00
135_M	320_R	0.647	1.00
73_T	321_L	0.643	1.00
293_R	296_D	0.639	1.00
71_V	325_Y	0.638	1.00
46_V	71_V	0.634	1.00
39_D	42_A	0.634	1.00
36_S	65_R	0.633	1.00
141_T	253_A	0.633	1.00
220_L	225_M	0.633	1.00
38_P	42_A	0.633	1.00
63_A	66_N	0.632	1.00
294_A	301_L	0.627	1.00
165_I	295_L	0.625	1.00
297_D	301_L	0.623	1.00
173_Y	199_A	0.621	1.00
100_R	103_R	0.619	1.00
204_E	216_F	0.616	1.00
279_Y	286_G	0.615	1.00
118_R	267_S	0.613	1.00
64_R	108_R	0.613	1.00
319_D	322_A	0.612	1.00
183_A	291_I	0.610	1.00
96_R	99_E	0.609	1.00
184_A	187_V	0.609	1.00
169_G	177_L	0.607	1.00
252_N	305_C	0.605	1.00
299_D	302_A	0.603	1.00
92_G	96_R	0.600	1.00
236_A	287_F	0.598	1.00
119_T	122_E	0.595	1.00
311_D	316_R	0.595	1.00
171_H	177_L	0.594	1.00
128_V	131_P	0.592	1.00
176_R	282_G	0.590	1.00
207_A	213_D	0.589	1.00
46_V	325_Y	0.589	1.00
270_I	275_T	0.589	1.00
237_F	245_G	0.587	1.00
244_E	312_I	0.586	1.00
166_G	235_F	0.584	1.00
170_R	175_K	0.582	1.00
103_R	107_S	0.578	1.00
315_G	319_D	0.576	1.00
235_F	258_V	0.575	1.00
133_E	136_P	0.572	1.00
195_G	218_G	0.571	1.00
75_H	137_N	0.570	1.00
181_L	214_A	0.569	1.00
145_Q	230_S	0.567	1.00
159_P	190_T	0.566	1.00
229_Y	247_V	0.566	1.00
228_F	232_L	0.565	1.00
179_D	183_A	0.561	1.00
163_P	301_L	0.561	1.00
70_L	110_D	0.559	1.00
136_P	312_I	0.554	1.00
40_A	66_N	0.552	1.00
163_P	298_R	0.551	1.00
234_V	259_A	0.551	1.00
143_R	222_R	0.548	1.00
36_S	40_A	0.544	1.00
142_D	145_Q	0.543	1.00
263_A	281_A	0.538	1.00
47_V	68_A	0.537	1.00
92_G	95_R	0.537	1.00
117_E	136_P	0.535	1.00
73_T	113_L	0.533	1.00
183_A	187_V	0.533	1.00
78_T	81_Y	0.533	1.00
124_R	129_D	0.531	1.00
166_G	256_T	0.528	1.00
251_A	258_V	0.527	1.00
111_L	131_P	0.525	1.00
176_R	261_V	0.525	1.00
233_D	298_R	0.525	1.00
199_A	203_L	0.524	1.00
49_A	56_G	0.522	1.00
324_R	327_E	0.522	1.00
73_T	325_Y	0.521	1.00
47_V	63_A	0.520	1.00
39_D	43_G	0.519	1.00
124_R	127_G	0.519	1.00
166_G	192_V	0.518	1.00
197_G	200_R	0.518	1.00
136_P	244_E	0.518	1.00
74_Y	119_T	0.518	1.00
183_A	236_A	0.515	1.00
259_A	291_I	0.515	1.00
257_P	308_R	0.514	1.00
238_P	261_V	0.514	1.00
177_L	199_A	0.513	1.00
263_A	267_S	0.513	1.00
245_G	249_L	0.512	1.00
124_R	131_P	0.511	1.00
66_N	69_P	0.511	1.00
194_G	225_M	0.511	1.00
181_L	203_L	0.509	1.00
73_T	115_P	0.508	1.00
63_A	110_D	0.508	1.00
56_G	59_A	0.508	1.00
173_Y	202_D	0.507	1.00
229_Y	235_F	0.505	1.00
257_P	301_L	0.505	1.00
116_S	119_T	0.504	1.00
204_E	207_A	0.502	1.00
136_P	317_A	0.502	1.00
139_V	253_A	0.501	1.00
191_V	214_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2r60A	1	0.997	100	0.245	Contact Map
1rzuA	1	0.9909	100	0.251	Contact Map
2qzsA	1	0.9848	100	0.256	Contact Map
3c48A	2	0.9667	100	0.258	Contact Map
3froA	3	0.9879	100	0.261	Contact Map
4n9wA	1	0.897	100	0.268	Contact Map
2jjmA	4	0.9394	100	0.27	Contact Map
3okpA	1	0.9606	100	0.281	Contact Map
3vueA	1	0.9909	100	0.291	Contact Map
3oy2A	2	0.9303	100	0.293	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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