Q9HRP5 - HALSA - GREMLIN Contacts

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Q9HRP5 - Uncharacterized protein

UniProt:	Q9HRP5	Sequences: MYDRVCLATNGGVASENAETHALNLAAAMDATLHAVYVVDEAVTTAYSGDEYVDTAEGPAHGLTEYGNSVLGALAERADAAGVTIETAVLYGSPADEIVTVADEVDADIVILGTKRRSDEYRSLLGSVTDRVLRVTDWSTTVVKTNVSDEDAP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	153 (138)
Sequences:	21156 (16938)
Seq/√Len:	1441.8

ECOLI - USPF USPE USPG USPC USPD USPA
BACSU - YXIE NHAX
HALSA - Q9HRP5 Q9HPQ8 Q9HPP5 Q9HPF7 Q9HMJ0 Q9HP90 Q9HNX9 Q9HRD8 Q9HMI9 Q9HHV8 Q9HHX5 Q9HHY0 Q9HMU1
SULSO - Q97X90 Q97V57 Q7LXW4 Q97U40

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
34_H	88_A	3.062	1.00
4_R	34_H	2.726	1.00
6_C	107_A	2.704	1.00
95_A	131_R	2.656	1.00
32_T	86_E	2.625	1.00
4_R	32_T	2.487	1.00
21_H	141_T	2.468	1.00
109_I	141_T	2.335	1.00
88_A	101_V	2.302	1.00
101_V	105_V	2.237	1.00
34_H	86_E	1.966	1.00
112_L	132_V	1.965	1.00
110_V	138_W	1.950	1.00
92_G	97_E	1.844	1.00
102_A	110_V	1.836	1.00
34_H	105_V	1.835	1.00
75_A	87_T	1.833	1.00
90_L	97_E	1.821	1.00
34_H	107_A	1.800	1.00
130_D	134_R	1.790	1.00
32_T	84_T	1.760	1.00
114_T	144_K	1.706	1.00
75_A	79_D	1.696	1.00
36_V	101_V	1.665	1.00
7_L	22_A	1.648	1.00
8_A	112_L	1.647	1.00
8_A	98_I	1.638	1.00
38_V	97_E	1.626	1.00
34_H	101_V	1.611	1.00
20_T	77_R	1.582	1.00
97_E	100_T	1.489	1.00
25_L	29_M	1.439	1.00
37_Y	67_G	1.421	1.00
64_T	68_N	1.392	1.00
103_D	137_D	1.390	1.00
131_R	135_V	1.377	1.00
99_V	135_V	1.373	1.00
68_N	72_G	1.362	1.00
110_V	136_T	1.352	1.00
31_A	108_D	1.319	1.00
22_A	26_A	1.306	1.00
16_E	77_R	1.290	1.00
88_A	105_V	1.275	1.00
90_L	101_V	1.273	1.00
102_A	137_D	1.259	1.00
7_L	19_E	1.254	1.00
4_R	108_D	1.183	1.00
72_G	75_A	1.180	1.00
94_P	128_V	1.178	1.00
110_V	132_V	1.170	1.00
60_A	64_T	1.165	1.00
36_V	90_L	1.114	1.00
70_V	74_L	1.109	1.00
38_V	94_P	1.101	1.00
102_A	138_W	1.098	1.00
74_L	78_A	1.067	1.00
101_V	104_E	1.061	1.00
136_T	140_T	1.042	1.00
21_H	143_V	1.041	1.00
63_L	66_Y	1.036	1.00
70_V	73_A	1.025	1.00
19_E	35_A	1.012	1.00
55_T	58_G	1.005	1.00
4_R	105_V	1.004	1.00
120_E	124_L	1.000	1.00
72_G	76_E	0.993	1.00
67_G	71_L	0.981	1.00
11_G	37_Y	0.978	1.00
15_S	18_A	0.964	1.00
5_V	109_I	0.964	1.00
4_R	107_A	0.963	1.00
114_T	142_V	0.950	1.00
27_A	81_A	0.948	1.00
22_A	111_I	0.946	1.00
90_L	104_E	0.942	1.00
133_L	142_V	0.938	1.00
36_V	98_I	0.937	1.00
39_V	91_Y	0.933	1.00
99_V	102_A	0.933	1.00
16_E	73_A	0.930	1.00
112_L	129_T	0.929	1.00
102_A	107_A	0.929	1.00
122_R	130_D	0.921	1.00
65_E	69_S	0.921	1.00
19_E	74_L	0.919	1.00
100_T	104_E	0.918	1.00
61_H	65_E	0.917	1.00
21_H	25_L	0.915	1.00
29_M	108_D	0.900	1.00
71_L	87_T	0.896	1.00
21_H	24_N	0.895	1.00
9_T	74_L	0.889	1.00
67_G	70_V	0.878	1.00
66_Y	70_V	0.877	1.00
26_A	33_L	0.875	1.00
6_C	36_V	0.860	1.00
35_A	85_I	0.853	1.00
24_N	28_A	0.852	1.00
17_N	20_T	0.839	1.00
101_V	107_A	0.839	1.00
6_C	101_V	0.834	1.00
99_V	132_V	0.830	1.00
16_E	20_T	0.829	1.00
117_R	121_Y	0.824	1.00
129_T	142_V	0.820	1.00
23_L	83_V	0.819	1.00
77_R	80_A	0.815	1.00
74_L	77_R	0.812	1.00
12_G	15_S	0.812	1.00
9_T	35_A	0.804	1.00
93_S	96_D	0.800	1.00
73_A	77_R	0.800	1.00
119_D	122_R	0.798	1.00
22_A	33_L	0.797	1.00
39_V	89_V	0.797	1.00
63_L	67_G	0.792	1.00
26_A	31_A	0.789	1.00
8_A	113_G	0.789	1.00
9_T	16_E	0.786	1.00
6_C	110_V	0.785	1.00
67_G	89_V	0.783	1.00
114_T	129_T	0.780	1.00
78_A	85_I	0.778	1.00
23_L	78_A	0.774	1.00
66_Y	69_S	0.774	1.00
72_G	87_T	0.772	1.00
73_A	76_E	0.767	1.00
86_E	105_V	0.766	1.00
23_L	81_A	0.765	1.00
99_V	136_T	0.761	1.00
21_H	139_S	0.758	1.00
9_T	18_A	0.758	1.00
9_T	19_E	0.758	1.00
7_L	33_L	0.751	1.00
27_A	82_G	0.751	1.00
26_A	29_M	0.739	1.00
111_I	141_T	0.735	1.00
58_G	61_H	0.727	1.00
57_E	61_H	0.725	1.00
69_S	73_A	0.719	1.00
68_N	87_T	0.710	1.00
35_A	74_L	0.706	1.00
19_E	23_L	0.705	1.00
76_E	79_D	0.700	1.00
97_E	101_V	0.695	1.00
14_A	145_T	0.695	1.00
62_G	65_E	0.691	1.00
24_N	27_A	0.688	1.00
76_E	80_A	0.685	1.00
95_A	128_V	0.681	1.00
23_L	27_A	0.680	1.00
98_I	132_V	0.679	1.00
119_D	123_S	0.679	1.00
71_L	75_A	0.678	1.00
35_A	78_A	0.676	1.00
62_G	66_Y	0.669	1.00
65_E	68_N	0.665	1.00
9_T	15_S	0.663	1.00
112_L	142_V	0.662	1.00
37_Y	70_V	0.661	1.00
11_G	70_V	0.657	1.00
57_E	60_A	0.652	1.00
22_A	31_A	0.649	1.00
7_L	18_A	0.635	1.00
116_R	125_L	0.630	1.00
120_E	123_S	0.624	1.00
25_L	28_A	0.619	1.00
36_V	97_E	0.618	1.00
95_A	99_V	0.614	1.00
5_V	26_A	0.614	1.00
125_L	129_T	0.611	1.00
12_G	116_R	0.610	1.00
106_D	138_W	0.603	1.00
95_A	135_V	0.602	1.00
88_A	91_Y	0.601	1.00
14_A	17_N	0.598	1.00
69_S	72_G	0.597	1.00
56_A	60_A	0.594	1.00
78_A	81_A	0.594	1.00
56_A	59_P	0.588	1.00
103_D	138_W	0.584	1.00
111_I	143_V	0.575	1.00
75_A	78_A	0.575	1.00
39_V	67_G	0.575	1.00
61_H	64_T	0.572	1.00
77_R	81_A	0.572	1.00
23_L	77_R	0.571	1.00
113_G	143_V	0.557	1.00
5_V	111_I	0.557	1.00
96_D	100_T	0.553	1.00
75_A	85_I	0.550	1.00
58_G	62_G	0.547	1.00
132_V	140_T	0.543	1.00
60_A	91_Y	0.543	1.00
45_T	49_G	0.537	1.00
17_N	145_T	0.537	1.00
42_A	45_T	0.531	1.00
95_A	132_V	0.529	1.00
115_K	129_T	0.528	1.00
99_V	131_R	0.527	1.00
10_N	15_S	0.522	1.00
114_T	124_L	0.521	1.00
25_L	111_I	0.514	1.00
11_G	74_L	0.511	1.00
133_L	140_T	0.507	1.00
67_G	78_A	0.505	1.00
18_A	111_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wnyA	2	0.8301	99.9	0.175	Contact Map
5ahwA	4	0.9412	99.9	0.178	Contact Map
1mjhA	2	0.9281	99.9	0.179	Contact Map
3hgmA	2	0.9346	99.9	0.18	Contact Map
3s3tA	4	0.9216	99.9	0.18	Contact Map
2dumA	2	0.9412	99.9	0.182	Contact Map
2gm3A	2	0.8758	99.9	0.188	Contact Map
4r2kA	2	0.9935	99.9	0.212	Contact Map
1tq8A	4	0.8039	99.9	0.212	Contact Map
3tnjA	2	0.8366	99.9	0.213	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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