GREMLIN Database
Q9HRP5 - Uncharacterized protein
UniProt: Q9HRP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 153 (138)
Sequences: 21156 (16938)
Seq/√Len: 1441.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_H88_A3.0621.00
4_R34_H2.7261.00
6_C107_A2.7041.00
95_A131_R2.6561.00
32_T86_E2.6251.00
4_R32_T2.4871.00
21_H141_T2.4681.00
109_I141_T2.3351.00
88_A101_V2.3021.00
101_V105_V2.2371.00
34_H86_E1.9661.00
112_L132_V1.9651.00
110_V138_W1.9501.00
92_G97_E1.8441.00
102_A110_V1.8361.00
34_H105_V1.8351.00
75_A87_T1.8331.00
90_L97_E1.8211.00
34_H107_A1.8001.00
130_D134_R1.7901.00
32_T84_T1.7601.00
114_T144_K1.7061.00
75_A79_D1.6961.00
36_V101_V1.6651.00
7_L22_A1.6481.00
8_A112_L1.6471.00
8_A98_I1.6381.00
38_V97_E1.6261.00
34_H101_V1.6111.00
20_T77_R1.5821.00
97_E100_T1.4891.00
25_L29_M1.4391.00
37_Y67_G1.4211.00
64_T68_N1.3921.00
103_D137_D1.3901.00
131_R135_V1.3771.00
99_V135_V1.3731.00
68_N72_G1.3621.00
110_V136_T1.3521.00
31_A108_D1.3191.00
22_A26_A1.3061.00
16_E77_R1.2901.00
88_A105_V1.2751.00
90_L101_V1.2731.00
102_A137_D1.2591.00
7_L19_E1.2541.00
4_R108_D1.1831.00
72_G75_A1.1801.00
94_P128_V1.1781.00
110_V132_V1.1701.00
60_A64_T1.1651.00
36_V90_L1.1141.00
70_V74_L1.1091.00
38_V94_P1.1011.00
102_A138_W1.0981.00
74_L78_A1.0671.00
101_V104_E1.0611.00
136_T140_T1.0421.00
21_H143_V1.0411.00
63_L66_Y1.0361.00
70_V73_A1.0251.00
19_E35_A1.0121.00
55_T58_G1.0051.00
4_R105_V1.0041.00
120_E124_L1.0001.00
72_G76_E0.9931.00
67_G71_L0.9811.00
11_G37_Y0.9781.00
15_S18_A0.9641.00
5_V109_I0.9641.00
4_R107_A0.9631.00
114_T142_V0.9501.00
27_A81_A0.9481.00
22_A111_I0.9461.00
90_L104_E0.9421.00
133_L142_V0.9381.00
36_V98_I0.9371.00
39_V91_Y0.9331.00
99_V102_A0.9331.00
16_E73_A0.9301.00
112_L129_T0.9291.00
102_A107_A0.9291.00
122_R130_D0.9211.00
65_E69_S0.9211.00
19_E74_L0.9191.00
100_T104_E0.9181.00
61_H65_E0.9171.00
21_H25_L0.9151.00
29_M108_D0.9001.00
71_L87_T0.8961.00
21_H24_N0.8951.00
9_T74_L0.8891.00
67_G70_V0.8781.00
66_Y70_V0.8771.00
26_A33_L0.8751.00
6_C36_V0.8601.00
35_A85_I0.8531.00
24_N28_A0.8521.00
17_N20_T0.8391.00
101_V107_A0.8391.00
6_C101_V0.8341.00
99_V132_V0.8301.00
16_E20_T0.8291.00
117_R121_Y0.8241.00
129_T142_V0.8201.00
23_L83_V0.8191.00
77_R80_A0.8151.00
74_L77_R0.8121.00
12_G15_S0.8121.00
9_T35_A0.8041.00
93_S96_D0.8001.00
73_A77_R0.8001.00
119_D122_R0.7981.00
22_A33_L0.7971.00
39_V89_V0.7971.00
63_L67_G0.7921.00
26_A31_A0.7891.00
8_A113_G0.7891.00
9_T16_E0.7861.00
6_C110_V0.7851.00
67_G89_V0.7831.00
114_T129_T0.7801.00
78_A85_I0.7781.00
23_L78_A0.7741.00
66_Y69_S0.7741.00
72_G87_T0.7721.00
73_A76_E0.7671.00
86_E105_V0.7661.00
23_L81_A0.7651.00
99_V136_T0.7611.00
21_H139_S0.7581.00
9_T18_A0.7581.00
9_T19_E0.7581.00
7_L33_L0.7511.00
27_A82_G0.7511.00
26_A29_M0.7391.00
111_I141_T0.7351.00
58_G61_H0.7271.00
57_E61_H0.7251.00
69_S73_A0.7191.00
68_N87_T0.7101.00
35_A74_L0.7061.00
19_E23_L0.7051.00
76_E79_D0.7001.00
97_E101_V0.6951.00
14_A145_T0.6951.00
62_G65_E0.6911.00
24_N27_A0.6881.00
76_E80_A0.6851.00
95_A128_V0.6811.00
23_L27_A0.6801.00
98_I132_V0.6791.00
119_D123_S0.6791.00
71_L75_A0.6781.00
35_A78_A0.6761.00
62_G66_Y0.6691.00
65_E68_N0.6651.00
9_T15_S0.6631.00
112_L142_V0.6621.00
37_Y70_V0.6611.00
11_G70_V0.6571.00
57_E60_A0.6521.00
22_A31_A0.6491.00
7_L18_A0.6351.00
116_R125_L0.6301.00
120_E123_S0.6241.00
25_L28_A0.6191.00
36_V97_E0.6181.00
95_A99_V0.6141.00
5_V26_A0.6141.00
125_L129_T0.6111.00
12_G116_R0.6101.00
106_D138_W0.6031.00
95_A135_V0.6021.00
88_A91_Y0.6011.00
14_A17_N0.5981.00
69_S72_G0.5971.00
56_A60_A0.5941.00
78_A81_A0.5941.00
56_A59_P0.5881.00
103_D138_W0.5841.00
111_I143_V0.5751.00
75_A78_A0.5751.00
39_V67_G0.5751.00
61_H64_T0.5721.00
77_R81_A0.5721.00
23_L77_R0.5711.00
113_G143_V0.5571.00
5_V111_I0.5571.00
96_D100_T0.5531.00
75_A85_I0.5501.00
58_G62_G0.5471.00
132_V140_T0.5431.00
60_A91_Y0.5431.00
45_T49_G0.5371.00
17_N145_T0.5371.00
42_A45_T0.5311.00
95_A132_V0.5291.00
115_K129_T0.5281.00
99_V131_R0.5271.00
10_N15_S0.5221.00
114_T124_L0.5211.00
25_L111_I0.5141.00
11_G74_L0.5111.00
133_L140_T0.5071.00
67_G78_A0.5051.00
18_A111_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wnyA 2 0.8301 99.9 0.175 Contact Map
5ahwA 4 0.9412 99.9 0.178 Contact Map
1mjhA 2 0.9281 99.9 0.179 Contact Map
3hgmA 2 0.9346 99.9 0.18 Contact Map
3s3tA 4 0.9216 99.9 0.18 Contact Map
2dumA 2 0.9412 99.9 0.182 Contact Map
2gm3A 2 0.8758 99.9 0.188 Contact Map
4r2kA 2 0.9935 99.9 0.212 Contact Map
1tq8A 4 0.8039 99.9 0.212 Contact Map
3tnjA 2 0.8366 99.9 0.213 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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