GREMLIN Database
Q9HRP3 - Cysteine synthase
UniProt: Q9HRP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (238)
Sequences: 20293 (10460)
Seq/√Len: 678.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_A40_A3.8971.00
78_R81_D3.2771.00
112_I250_V2.7011.00
203_D232_D2.6791.00
50_L54_Q2.6671.00
43_V82_L2.6191.00
122_A150_T2.5611.00
155_E200_P2.5151.00
210_R214_E2.4791.00
16_T41_V2.4031.00
46_E67_P2.3811.00
39_D62_D2.3651.00
148_H195_D2.3331.00
41_V62_D2.2901.00
156_G201_D2.2091.00
102_E106_E2.1351.00
137_S192_F2.1321.00
137_S149_V2.0941.00
200_P203_D2.0491.00
96_S186_E2.0461.00
226_N251_T2.0401.00
144_I147_L2.0301.00
161_S165_A2.0271.00
110_P139_F2.0011.00
41_V64_V1.9761.00
105_Y142_D1.8821.00
123_F140_L1.8591.00
150_T195_D1.8551.00
127_C151_A1.8531.00
152_V229_A1.8351.00
105_Y138_R1.7851.00
93_Q96_S1.7711.00
53_Q65_N1.7271.00
80_H84_A1.7241.00
158_M162_A1.7091.00
211_L219_V1.6951.00
120_V250_V1.6911.00
207_E228_L1.6661.00
210_R231_I1.6591.00
123_F136_T1.6491.00
195_D236_R1.6301.00
177_I225_A1.6201.00
113_Y143_Q1.5931.00
211_L227_S1.5731.00
21_T26_G1.5731.00
141_R194_D1.5571.00
81_D86_R1.5491.00
109_G136_T1.5251.00
121_G248_C1.5151.00
54_Q57_R1.5101.00
53_Q57_R1.4581.00
50_L53_Q1.4371.00
82_L86_R1.4271.00
133_L193_V1.4131.00
16_T39_D1.4111.00
121_G247_D1.4101.00
64_V78_R1.4051.00
124_V152_V1.3931.00
207_E231_I1.3921.00
83_A91_V1.3861.00
155_E198_Q1.3731.00
228_L232_D1.3551.00
122_A148_H1.3481.00
161_S198_Q1.3401.00
203_D228_L1.3391.00
233_V236_R1.3351.00
76_I80_H1.3291.00
238_A247_D1.3151.00
56_M61_A1.3081.00
139_F143_Q1.3061.00
207_E227_S1.2961.00
71_G74_G1.2801.00
223_A253_F1.2791.00
124_V233_V1.2781.00
133_L149_V1.2761.00
219_V253_F1.2651.00
44_V56_M1.2631.00
43_V78_R1.2571.00
109_G140_L1.2571.00
116_L120_V1.2501.00
140_L147_L1.2491.00
113_Y139_F1.2481.00
53_Q63_V1.2481.00
162_A165_A1.2341.00
197_T229_A1.2341.00
116_L250_V1.2091.00
173_K205_H1.2081.00
109_G139_F1.2071.00
110_P114_H1.1961.00
162_A166_D1.1881.00
199_I228_L1.1871.00
158_M198_Q1.1811.00
86_R89_A1.1801.00
73_G77_Q1.1711.00
150_T197_T1.1701.00
206_A210_R1.1591.00
151_A196_V1.1531.00
138_R189_D1.1531.00
122_A239_A1.1451.00
174_T204_T1.1441.00
46_E68_T1.1431.00
26_G56_M1.1281.00
157_S163_A1.1241.00
232_D235_E1.1171.00
116_L248_C1.1111.00
12_P15_G1.1071.00
133_L151_A1.1021.00
203_D206_A1.1011.00
119_A248_C1.1011.00
80_H83_A1.0941.00
78_R82_L1.0911.00
219_V223_A1.0901.00
212_A218_L1.0821.00
122_A249_V1.0821.00
112_I120_V1.0791.00
136_T252_V1.0651.00
122_A247_D1.0541.00
106_E110_P1.0491.00
31_V59_L1.0421.00
79_A83_A1.0411.00
233_V237_A1.0411.00
44_V65_N1.0341.00
29_F40_A1.0331.00
208_M224_A1.0331.00
230_A251_T1.0291.00
113_Y144_I1.0281.00
104_H108_T1.0261.00
158_M163_A1.0221.00
184_T187_L1.0191.00
74_G77_Q1.0191.00
148_H194_D1.0151.00
17_I33_A1.0091.00
197_T232_D0.9991.00
77_Q80_H0.9981.00
16_T89_A0.9971.00
172_Y178_G0.9951.00
18_I79_A0.9901.00
237_A247_D0.9901.00
47_R68_T0.9881.00
223_A254_P0.9871.00
28_G32_A0.9801.00
202_E206_A0.9791.00
158_M161_S0.9651.00
124_V230_A0.9581.00
30_A61_A0.9571.00
19_E42_F0.9551.00
57_R62_D0.9531.00
82_L87_E0.9521.00
177_I222_S0.9511.00
139_F142_D0.9491.00
77_Q81_D0.9461.00
209_Q213_A0.9391.00
31_V35_Q0.9351.00
18_I89_A0.9341.00
173_K201_D0.9341.00
218_L257_S0.9301.00
105_Y139_F0.9261.00
54_Q58_A0.9201.00
72_M75_A0.9171.00
34_S40_A0.9091.00
187_L191_E0.9081.00
125_A136_T0.9011.00
113_Y140_L0.8941.00
41_V82_L0.8941.00
207_E210_R0.8851.00
227_S253_F0.8821.00
57_R65_N0.8811.00
197_T236_R0.8731.00
122_A233_V0.8701.00
108_T136_T0.8691.00
110_P143_Q0.8661.00
18_I82_L0.8641.00
134_M187_L0.8571.00
226_N254_P0.8551.00
108_T132_T0.8551.00
133_L189_D0.8451.00
124_V229_A0.8431.00
161_S196_V0.8411.00
15_G88_D0.8381.00
234_A237_A0.8351.00
27_V56_M0.8311.00
15_G39_D0.8311.00
83_A89_A0.8281.00
66_T78_R0.8261.00
122_A237_A0.8251.00
18_I83_A0.8221.00
240_G247_D0.8201.00
103_A106_E0.8161.00
124_V150_T0.8151.00
237_A240_G0.8141.00
219_V224_A0.8141.00
127_C133_L0.8121.00
41_V89_A0.8061.00
126_G254_P0.8051.00
102_E105_Y0.7921.00
27_V55_L0.7891.00
227_S251_T0.7851.00
98_P184_T0.7851.00
204_T225_A0.7821.00
167_V190_P0.7761.00
102_E138_R0.7701.00
138_R142_D0.7691.00
79_A91_V0.7691.00
17_I38_I0.7591.00
43_V64_V0.7481.00
123_F252_V0.7461.00
34_S59_L0.7451.00
39_D89_A0.7411.00
136_T140_L0.7391.00
93_Q97_N0.7381.00
50_L57_R0.7351.00
205_H221_S0.7341.00
190_P193_V0.7331.00
48_F53_Q0.7331.00
165_A195_D0.7311.00
68_T74_G0.7311.00
159_Y180_H0.7291.00
13_E38_I0.7261.00
20_P91_V0.7231.00
40_A61_A0.7221.00
42_F56_M0.7201.00
150_T233_V0.7191.00
231_I235_E0.7171.00
201_D205_H0.7151.00
160_A196_V0.7141.00
20_P72_M0.7101.00
229_A233_V0.7071.00
126_G226_N0.7061.00
81_D84_A0.7041.00
120_V147_L0.7021.00
185_S188_F0.7001.00
160_A189_D0.6961.00
154_P177_I0.6911.00
187_L190_P0.6891.00
119_A144_I0.6881.00
62_D87_E0.6861.00
17_I92_P0.6831.00
239_A247_D0.6821.00
211_L215_E0.6821.00
51_E262_S0.6811.00
43_V66_T0.6791.00
99_L103_A0.6751.00
52_K175_E0.6741.00
211_L253_F0.6721.00
176_G222_S0.6711.00
113_Y117_D0.6641.00
44_V48_F0.6641.00
127_C196_V0.6631.00
114_H143_Q0.6631.00
120_V248_C0.6611.00
189_D192_F0.6611.00
48_F175_E0.6601.00
46_E65_N0.6561.00
127_C160_A0.6551.00
72_M76_I0.6531.00
141_R192_F0.6511.00
91_V134_M0.6501.00
151_A193_V0.6491.00
195_D233_V0.6491.00
141_R191_E0.6461.00
125_A133_L0.6451.00
152_V197_T0.6421.00
44_V53_Q0.6391.00
113_Y116_L0.6381.00
123_F147_L0.6371.00
208_M221_S0.6371.00
113_Y118_G0.6331.00
123_F149_V0.6331.00
18_I43_V0.6321.00
74_G78_R0.6281.00
108_T112_I0.6251.00
112_I136_T0.6231.00
103_A138_R0.6181.00
163_A167_V0.6151.00
152_V225_A0.6111.00
124_V249_V0.6081.00
19_E29_F0.6081.00
29_F42_F0.6021.00
98_P101_A0.6001.00
16_T62_D0.6001.00
204_T224_A0.5991.00
156_G170_G0.5981.00
30_A56_M0.5971.00
82_L89_A0.5951.00
12_P88_D0.5951.00
72_M179_T0.5951.00
189_D193_V0.5931.00
186_E190_P0.5921.00
41_V87_E0.5901.00
55_L58_A0.5891.00
108_T252_V0.5871.00
101_A187_L0.5801.00
102_E184_T0.5801.00
200_P232_D0.5791.00
163_A186_E0.5781.00
15_G90_I0.5781.00
232_D236_R0.5761.00
80_H91_V0.5721.00
65_N68_T0.5671.00
162_A168_S0.5661.00
101_A105_Y0.5631.00
240_G248_C0.5621.00
208_M259_R0.5611.00
127_C130_A0.5581.00
26_G42_F0.5571.00
21_T42_F0.5561.00
103_A107_T0.5531.00
20_P79_A0.5521.00
223_A226_N0.5521.00
248_C251_T0.5521.00
20_P92_P0.5521.00
110_P142_D0.5511.00
55_L218_L0.5511.00
67_P74_G0.5491.00
17_I40_A0.5491.00
168_S171_E0.5491.00
184_T188_F0.5471.00
136_T149_V0.5441.00
64_V82_L0.5441.00
134_M138_R0.5421.00
20_P76_I0.5421.00
153_E159_Y0.5411.00
199_I229_A0.5411.00
174_T177_I0.5401.00
76_I79_A0.5391.00
116_L119_A0.5391.00
72_M94_Q0.5361.00
199_I225_A0.5351.00
76_I91_V0.5301.00
174_T222_S0.5291.00
134_M185_S0.5281.00
148_H247_D0.5271.00
211_L217_Q0.5261.00
14_G39_D0.5261.00
63_V67_P0.5251.00
71_G180_H0.5241.00
157_S170_G0.5231.00
80_H93_Q0.5220.99
15_G38_I0.5210.99
155_E158_M0.5180.99
83_A87_E0.5180.99
141_R149_V0.5180.99
75_A79_A0.5170.99
136_T139_F0.5170.99
102_E188_F0.5160.99
188_F193_V0.5160.99
16_T86_R0.5160.99
229_A232_D0.5150.99
153_E161_S0.5140.99
120_V144_I0.5140.99
156_G171_E0.5120.99
210_R227_S0.5120.99
206_A209_Q0.5070.99
32_A36_L0.5050.99
15_G82_L0.5030.99
43_V75_A0.5020.99
43_V79_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pqmA 2 0.9562 100 0.219 Contact Map
1y7lA 2 0.9416 100 0.222 Contact Map
4ofxA 2 0.8577 100 0.222 Contact Map
3pc3A 2 0.9672 100 0.227 Contact Map
4aecA 2 0.9599 100 0.232 Contact Map
2v03A 2 0.8942 100 0.232 Contact Map
3tbhA 2 0.9526 100 0.235 Contact Map
3x44A 3 0.9489 100 0.237 Contact Map
4cooA 2 0.9672 100 0.24 Contact Map
4ql4A 2 0.8139 100 0.24 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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