GREMLIN Database
Q9HRP2 - Uncharacterized protein
UniProt: Q9HRP2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (127)
Sequences: 1893 (1293)
Seq/√Len: 114.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_S66_E3.5381.00
88_D113_R2.9011.00
37_Y131_H2.3951.00
44_T58_H2.3611.00
17_T44_T2.3401.00
39_D58_H2.2881.00
112_E116_A2.2291.00
93_R96_V2.2261.00
15_A73_V2.2061.00
61_A68_D2.1491.00
84_P107_H2.0791.00
67_I71_V2.0661.00
65_A89_A2.0441.00
103_V129_V2.0031.00
87_V99_V1.9981.00
62_D66_E1.9881.00
65_A92_A1.8431.00
23_C35_P1.8291.00
36_A40_A1.7961.00
9_R13_L1.7421.00
44_T69_Q1.7171.00
10_R14_D1.6971.00
111_E123_S1.6971.00
83_V101_L1.6181.00
46_V69_Q1.5841.00
11_A98_A1.5651.00
130_D133_R1.5611.00
70_R97_G1.5601.00
17_T69_Q1.5161.00
48_V67_I1.4661.00
87_V110_A1.4651.00
64_L93_R1.4011.00
26_T29_K1.3791.00
54_R59_A1.3661.00
106_Q124_N1.3441.00
84_P113_R1.3371.00
125_S130_D1.3321.00
55_V60_A1.2830.99
82_E85_G1.2660.99
111_E121_V1.2440.99
71_V93_R1.2440.99
85_G88_D1.2430.99
91_I117_A1.2340.99
91_I113_R1.2270.99
15_A98_A1.2190.99
41_H131_H1.1930.99
73_V127_I1.1820.99
108_A123_S1.1800.99
52_A55_V1.1700.99
98_A120_R1.1660.99
76_V101_L1.1590.99
113_R117_A1.1540.99
112_E115_A1.1360.99
33_E128_K1.1240.99
76_V99_V1.1100.98
111_E115_A1.1080.98
20_V45_V1.0990.98
73_V98_A1.0920.98
17_T46_V1.0820.98
79_P82_E1.0810.98
114_A119_L1.0800.98
39_D56_L1.0530.98
15_A72_D1.0400.98
18_I73_V1.0370.98
87_V114_A1.0350.98
30_P33_E1.0350.98
91_I119_L1.0350.98
108_A112_E1.0280.97
18_I127_I1.0090.97
52_A60_A1.0060.97
32_H36_A0.9970.97
24_S31_A0.9720.96
128_K132_Q0.9710.96
103_V130_D0.9640.96
20_V35_P0.9610.96
21_V74_V0.9610.96
99_V114_A0.9580.96
78_R82_E0.9490.96
63_S89_A0.9490.96
30_P34_V0.9450.96
29_K79_P0.9390.96
106_Q123_S0.9350.96
96_V119_L0.9350.96
94_D119_L0.9280.95
39_D45_V0.9240.95
83_V105_I0.9180.95
91_I96_V0.9020.95
75_D127_I0.8990.94
84_P88_D0.8910.94
26_T51_Y0.8820.94
37_Y128_K0.8710.93
10_R120_R0.8600.93
23_C55_V0.8500.93
39_D44_T0.8420.92
77_F102_Q0.8370.92
49_N52_A0.8360.92
7_S120_R0.8310.92
33_E36_A0.8310.92
107_H113_R0.8220.91
107_H110_A0.8050.91
101_L121_V0.7990.90
84_P109_D0.7950.90
53_E62_D0.7890.90
25_A52_A0.7870.89
25_A55_V0.7860.89
7_S10_R0.7810.89
54_R60_A0.7790.89
32_H56_L0.7680.88
18_I43_Y0.7620.88
6_D9_R0.7590.88
90_A119_L0.7580.88
34_V77_F0.7560.88
53_E59_A0.7550.87
25_A51_Y0.7360.86
46_V67_I0.7290.86
88_D92_A0.7250.85
21_V90_A0.7210.85
38_L127_I0.7070.84
54_R57_G0.7020.83
61_A67_I0.7010.83
23_C45_V0.6890.82
21_V86_I0.6680.80
37_Y41_H0.6680.80
10_R13_L0.6680.80
38_L45_V0.6630.80
31_A35_P0.6620.80
90_A99_V0.6620.80
27_P36_A0.6580.79
85_G89_A0.6570.79
24_S86_I0.6560.79
35_P38_L0.6560.79
47_P60_A0.6520.79
28_G33_E0.6490.78
27_P32_H0.6470.78
83_V107_H0.6470.78
7_S14_D0.6460.78
91_I94_D0.6430.78
108_A111_E0.6410.77
14_D97_G0.6390.77
29_K105_I0.6350.77
97_G120_R0.6270.76
35_P45_V0.6220.75
49_N60_A0.6180.75
25_A32_H0.6160.75
34_V102_Q0.6130.74
76_V83_V0.6130.74
45_V58_H0.6130.74
80_R107_H0.6060.73
103_V128_K0.6060.73
87_V113_R0.6050.73
52_A62_D0.6050.73
67_I93_R0.6000.73
47_P59_A0.5930.72
35_P56_L0.5860.71
8_E125_S0.5760.70
23_C34_V0.5750.70
25_A31_A0.5700.69
87_V91_I0.5680.69
101_L114_A0.5650.68
37_Y132_Q0.5650.68
58_H61_A0.5600.68
33_E132_Q0.5560.67
20_V23_C0.5540.67
6_D10_R0.5520.66
103_V106_Q0.5470.66
88_D91_I0.5420.65
75_D102_Q0.5380.64
90_A96_V0.5380.64
76_V86_I0.5370.64
23_C39_D0.5370.64
85_G107_H0.5350.64
87_V107_H0.5310.63
49_N79_P0.5300.63
80_R105_I0.5230.62
109_D112_E0.5210.62
27_P34_V0.5180.62
24_S29_K0.5170.61
33_E37_Y0.5160.61
72_D97_G0.5140.61
11_A122_V0.5080.60
86_I105_I0.5080.60
23_C60_A0.5070.60
11_A15_A0.5070.60
25_A49_N0.5070.60
15_A127_I0.5040.59
24_S49_N0.5030.59
59_A66_E0.5020.59
70_R93_R0.5010.59
83_V90_A0.5000.59
46_V71_V0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ff4A 1 0.8832 99.9 0.479 Contact Map
2csuA 2 0.9343 99.9 0.527 Contact Map
1iukA 1 0.9781 99.9 0.574 Contact Map
2duwA 1 0.9781 99.8 0.578 Contact Map
1y81A 1 0.8467 99.8 0.597 Contact Map
2d59A 1 0.9927 99.8 0.604 Contact Map
3pffA 2 0.8978 99.7 0.636 Contact Map
2fp4A 1 0.9635 99.6 0.673 Contact Map
2yv1A 1 0.9124 99.5 0.682 Contact Map
3mwdB 1 0.9051 99.5 0.682 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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