Q9HRP1 - HALSA - GREMLIN Contacts

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Q9HRP1 - Uncharacterized protein

UniProt:	Q9HRP1	Sequences: MYELGAAFSGVDVSEGTNLLVEGPAMSGKRDLGFRVLAAGTDAGESALVVSTKDSANRVIDAFDGVGDAETATLGVVDCVTKQQGMGGERRDAELVRYASSPNDLTGIGIELSELLQRLYEQRDSTRNRILLHSLSTLLMYSDLQTVFRFLHVFTGRVQSADALGLFTVDGAAHDAKTVSTLKQLFDGVITIQEHDGGFRARVLGVGDDTSWREL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	215 (181)
Sequences:	266 (216)
Seq/√Len:	16.1

HALSA - Q9HRP1 Q9HRH3 Q9HMT0 Q9HS97

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
18_N	167_F	4.554	1.00
148_F	152_H	4.467	1.00
16_G	129_R	4.150	1.00
13_V	19_L	3.182	0.99
50_V	112_L	3.155	0.99
33_G	131_L	2.948	0.98
33_G	168_T	2.905	0.98
106_T	141_Y	2.649	0.96
28_G	77_V	2.620	0.96
18_N	155_T	2.617	0.96
151_L	155_T	2.562	0.95
77_V	112_L	2.417	0.94
110_I	114_E	2.229	0.91
143_D	169_V	2.220	0.90
158_V	165_G	2.217	0.90
104_D	107_G	2.200	0.90
112_L	130_I	2.196	0.90
131_L	166_L	2.175	0.89
131_L	168_T	2.057	0.87
109_G	152_H	1.941	0.83
152_H	185_L	1.928	0.83
116_L	183_K	1.918	0.82
148_F	181_T	1.828	0.79
172_A	178_T	1.772	0.77
183_K	189_V	1.768	0.77
109_G	148_F	1.729	0.75
20_L	170_D	1.724	0.75
114_E	143_D	1.701	0.74
110_I	152_H	1.674	0.73
33_G	166_L	1.608	0.70
116_L	163_A	1.607	0.69
175_D	178_T	1.589	0.69
36_V	101_S	1.584	0.68
18_N	158_V	1.540	0.66
148_F	180_S	1.524	0.65
110_I	173_A	1.494	0.64
149_R	152_H	1.471	0.62
109_G	113_S	1.425	0.60
136_S	174_H	1.409	0.59
175_D	194_E	1.363	0.56
109_G	145_Q	1.343	0.55
78_D	165_G	1.342	0.55
193_Q	197_G	1.334	0.55
129_R	165_G	1.326	0.54
131_L	163_A	1.299	0.53
193_Q	196_D	1.298	0.53
135_L	161_A	1.279	0.51
21_V	34_F	1.274	0.51
114_E	117_Q	1.272	0.51
85_G	192_I	1.267	0.51
149_R	181_T	1.260	0.50
102_P	141_Y	1.248	0.50
81_T	98_Y	1.243	0.49
165_G	188_G	1.209	0.47
130_I	190_I	1.194	0.47
46_S	119_L	1.188	0.46
135_L	167_F	1.186	0.46
112_L	135_L	1.181	0.46
129_R	163_A	1.178	0.46
35_R	193_Q	1.162	0.45
21_V	33_G	1.160	0.45
13_V	45_E	1.159	0.45
149_R	185_L	1.153	0.44
51_S	56_A	1.141	0.44
139_L	147_V	1.137	0.43
105_L	147_V	1.135	0.43
49_V	165_G	1.130	0.43
170_D	174_H	1.130	0.43
106_T	110_I	1.122	0.42
130_I	172_A	1.116	0.42
166_L	190_I	1.108	0.42
38_A	45_E	1.108	0.42
39_A	93_A	1.101	0.41
132_L	192_I	1.096	0.41
101_S	106_T	1.092	0.41
70_E	129_R	1.087	0.40
118_R	132_L	1.075	0.40
21_V	30_R	1.068	0.39
139_L	152_H	1.067	0.39
49_V	132_L	1.062	0.39
133_H	192_I	1.052	0.39
12_D	186_F	1.045	0.38
119_L	128_N	1.042	0.38
31_D	192_I	1.042	0.38
40_G	129_R	1.041	0.38
105_L	148_F	1.040	0.38
21_V	182_L	1.033	0.37
113_S	156_G	1.023	0.37
72_A	185_L	1.021	0.37
92_D	97_R	1.015	0.36
50_V	157_R	1.009	0.36
136_S	148_F	1.008	0.36
18_N	186_F	1.003	0.36
169_V	179_V	0.996	0.35
87_G	139_L	0.994	0.35
99_A	104_D	0.992	0.35
17_T	188_G	0.986	0.35
30_R	131_L	0.985	0.35
106_T	177_K	0.985	0.35
48_L	147_V	0.968	0.34
57_N	180_S	0.966	0.34
114_E	118_R	0.956	0.33
116_L	194_E	0.954	0.33
153_V	157_R	0.944	0.33
133_H	189_V	0.941	0.33
56_A	100_S	0.941	0.33
62_A	133_H	0.936	0.32
45_E	127_R	0.936	0.32
107_G	141_Y	0.933	0.32
106_T	149_R	0.933	0.32
113_S	117_Q	0.932	0.32
131_L	193_Q	0.924	0.32
113_S	153_V	0.923	0.32
83_Q	143_D	0.903	0.31
150_F	181_T	0.900	0.31
195_H	198_G	0.894	0.30
95_L	190_I	0.891	0.30
14_S	170_D	0.890	0.30
16_G	45_E	0.874	0.29
106_T	109_G	0.874	0.29
46_S	128_N	0.864	0.29
152_H	181_T	0.862	0.29
148_F	153_V	0.854	0.28
153_V	181_T	0.850	0.28
96_V	127_R	0.830	0.27
147_V	186_F	0.823	0.27
21_V	36_V	0.818	0.27
97_R	140_M	0.817	0.27
94_E	194_E	0.817	0.27
17_T	102_P	0.814	0.26
77_V	137_T	0.807	0.26
138_L	163_A	0.806	0.26
113_S	152_H	0.806	0.26
114_E	151_L	0.804	0.26
16_G	164_L	0.802	0.26
76_V	110_I	0.802	0.26
50_V	71_T	0.794	0.26
49_V	59_V	0.791	0.25
149_R	160_S	0.787	0.25
52_T	78_D	0.771	0.25
50_V	94_E	0.765	0.24
113_S	160_S	0.765	0.24
100_S	141_Y	0.760	0.24
24_P	136_S	0.758	0.24
44_G	137_T	0.757	0.24
127_R	164_L	0.755	0.24
23_G	29_K	0.755	0.24
156_G	159_Q	0.754	0.24
113_S	150_F	0.750	0.24
40_G	44_G	0.750	0.24
63_F	184_Q	0.747	0.24
183_K	190_I	0.747	0.24
95_L	180_S	0.746	0.24
91_R	94_E	0.745	0.23
52_T	129_R	0.744	0.23
16_G	19_L	0.741	0.23
57_N	192_I	0.738	0.23
25_A	192_I	0.738	0.23
152_H	156_G	0.734	0.23
107_G	184_Q	0.733	0.23
167_F	185_L	0.727	0.23
26_M	29_K	0.724	0.23
13_V	108_I	0.716	0.22
18_N	113_S	0.715	0.22
51_S	114_E	0.710	0.22
161_A	189_V	0.707	0.22
148_F	186_F	0.701	0.22
53_K	83_Q	0.700	0.22
50_V	76_V	0.696	0.21
50_V	109_G	0.689	0.21
104_D	181_T	0.676	0.21
105_L	179_V	0.672	0.21
151_L	167_F	0.670	0.20
48_L	196_D	0.668	0.20
104_D	113_S	0.667	0.20
120_Y	168_T	0.666	0.20
124_D	169_V	0.666	0.20
152_H	184_Q	0.666	0.20
106_T	113_S	0.661	0.20
94_E	103_N	0.661	0.20
80_V	83_Q	0.660	0.20
112_L	154_F	0.658	0.20
54_D	131_L	0.654	0.20
116_L	133_H	0.651	0.20
27_S	70_E	0.650	0.20
139_L	185_L	0.649	0.20
152_H	155_T	0.647	0.20
13_V	188_G	0.641	0.19
27_S	132_L	0.640	0.19
169_V	172_A	0.639	0.19
77_V	138_L	0.635	0.19
22_E	186_F	0.635	0.19
157_R	167_F	0.634	0.19
49_V	125_S	0.633	0.19
45_E	164_L	0.631	0.19
154_F	176_A	0.628	0.19
133_H	188_G	0.623	0.19
146_T	153_V	0.621	0.19
143_D	187_D	0.620	0.19
114_E	132_L	0.617	0.19
18_N	149_R	0.617	0.19
56_A	98_Y	0.616	0.19
60_I	152_H	0.612	0.18
63_F	183_K	0.602	0.18
36_V	49_V	0.598	0.18
40_G	54_D	0.598	0.18
35_R	195_H	0.596	0.18
56_A	78_D	0.595	0.18
28_G	141_Y	0.593	0.18
25_A	169_V	0.592	0.18
24_P	78_D	0.591	0.18
158_V	183_K	0.591	0.18
117_Q	184_Q	0.589	0.18
18_N	153_V	0.589	0.18
106_T	150_F	0.588	0.18
132_L	178_T	0.587	0.18
44_G	160_S	0.583	0.17
57_N	162_D	0.583	0.17
130_I	151_L	0.582	0.17
16_G	23_G	0.582	0.17
142_S	147_V	0.578	0.17
19_L	188_G	0.577	0.17
158_V	163_A	0.577	0.17
17_T	30_R	0.575	0.17
155_T	158_V	0.574	0.17
94_E	165_G	0.574	0.17
77_V	187_D	0.571	0.17
101_S	141_Y	0.570	0.17
127_R	182_L	0.566	0.17
29_K	62_A	0.564	0.17
70_E	83_Q	0.563	0.17
36_V	131_L	0.562	0.17
84_Q	192_I	0.562	0.17
163_A	193_Q	0.560	0.17
147_V	187_D	0.558	0.17
63_F	71_T	0.558	0.17
66_V	140_M	0.557	0.17
55_S	77_V	0.551	0.16
17_T	113_S	0.550	0.16
32_L	38_A	0.550	0.16
82_K	99_A	0.549	0.16
30_R	34_F	0.549	0.16
97_R	104_D	0.547	0.16
77_V	195_H	0.546	0.16
99_A	138_L	0.546	0.16
95_L	147_V	0.544	0.16
68_D	147_V	0.542	0.16
106_T	148_F	0.541	0.16
68_D	87_G	0.540	0.16
49_V	70_E	0.539	0.16
25_A	48_L	0.538	0.16
50_V	119_L	0.538	0.16
13_V	127_R	0.537	0.16
71_T	85_G	0.533	0.16
46_S	77_V	0.530	0.16
15_E	54_D	0.530	0.16
34_F	182_L	0.529	0.16
190_I	193_Q	0.523	0.15
35_R	66_V	0.522	0.15
67_G	135_L	0.517	0.15
61_D	91_R	0.516	0.15
16_G	192_I	0.516	0.15
151_L	181_T	0.510	0.15
138_L	147_V	0.507	0.15
83_Q	190_I	0.506	0.15
12_D	193_Q	0.505	0.15
27_S	143_D	0.504	0.15
15_E	121_E	0.504	0.15
76_V	118_R	0.503	0.15
152_H	157_R	0.501	0.15
156_G	183_K	0.500	0.15
117_Q	151_L	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bs4A	1	0.9349	99.5	0.742	Contact Map
4a8jA	1	0.8698	99.4	0.757	Contact Map
4bwyA	3	0.7163	98.3	0.842	Contact Map
2dr3A	3	0.9395	98	0.852	Contact Map
4blqA	3	0.7395	97.4	0.87	Contact Map
2w0mA	1	0.8605	97	0.878	Contact Map
4ppfA	1	0.814	96.6	0.884	Contact Map
2cvhA	1	0.8698	96.5	0.885	Contact Map
1tf7A	3	0.8977	96.5	0.885	Contact Map
3hr8A	1	0.8465	95.1	0.897	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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