GREMLIN Database
Q9HRP1 - Uncharacterized protein
UniProt: Q9HRP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (181)
Sequences: 266 (216)
Seq/√Len: 16.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_N167_F4.5541.00
148_F152_H4.4671.00
16_G129_R4.1501.00
13_V19_L3.1820.99
50_V112_L3.1550.99
33_G131_L2.9480.98
33_G168_T2.9050.98
106_T141_Y2.6490.96
28_G77_V2.6200.96
18_N155_T2.6170.96
151_L155_T2.5620.95
77_V112_L2.4170.94
110_I114_E2.2290.91
143_D169_V2.2200.90
158_V165_G2.2170.90
104_D107_G2.2000.90
112_L130_I2.1960.90
131_L166_L2.1750.89
131_L168_T2.0570.87
109_G152_H1.9410.83
152_H185_L1.9280.83
116_L183_K1.9180.82
148_F181_T1.8280.79
172_A178_T1.7720.77
183_K189_V1.7680.77
109_G148_F1.7290.75
20_L170_D1.7240.75
114_E143_D1.7010.74
110_I152_H1.6740.73
33_G166_L1.6080.70
116_L163_A1.6070.69
175_D178_T1.5890.69
36_V101_S1.5840.68
18_N158_V1.5400.66
148_F180_S1.5240.65
110_I173_A1.4940.64
149_R152_H1.4710.62
109_G113_S1.4250.60
136_S174_H1.4090.59
175_D194_E1.3630.56
109_G145_Q1.3430.55
78_D165_G1.3420.55
193_Q197_G1.3340.55
129_R165_G1.3260.54
131_L163_A1.2990.53
193_Q196_D1.2980.53
135_L161_A1.2790.51
21_V34_F1.2740.51
114_E117_Q1.2720.51
85_G192_I1.2670.51
149_R181_T1.2600.50
102_P141_Y1.2480.50
81_T98_Y1.2430.49
165_G188_G1.2090.47
130_I190_I1.1940.47
46_S119_L1.1880.46
135_L167_F1.1860.46
112_L135_L1.1810.46
129_R163_A1.1780.46
35_R193_Q1.1620.45
21_V33_G1.1600.45
13_V45_E1.1590.45
149_R185_L1.1530.44
51_S56_A1.1410.44
139_L147_V1.1370.43
105_L147_V1.1350.43
49_V165_G1.1300.43
170_D174_H1.1300.43
106_T110_I1.1220.42
130_I172_A1.1160.42
166_L190_I1.1080.42
38_A45_E1.1080.42
39_A93_A1.1010.41
132_L192_I1.0960.41
101_S106_T1.0920.41
70_E129_R1.0870.40
118_R132_L1.0750.40
21_V30_R1.0680.39
139_L152_H1.0670.39
49_V132_L1.0620.39
133_H192_I1.0520.39
12_D186_F1.0450.38
119_L128_N1.0420.38
31_D192_I1.0420.38
40_G129_R1.0410.38
105_L148_F1.0400.38
21_V182_L1.0330.37
113_S156_G1.0230.37
72_A185_L1.0210.37
92_D97_R1.0150.36
50_V157_R1.0090.36
136_S148_F1.0080.36
18_N186_F1.0030.36
169_V179_V0.9960.35
87_G139_L0.9940.35
99_A104_D0.9920.35
17_T188_G0.9860.35
30_R131_L0.9850.35
106_T177_K0.9850.35
48_L147_V0.9680.34
57_N180_S0.9660.34
114_E118_R0.9560.33
116_L194_E0.9540.33
153_V157_R0.9440.33
133_H189_V0.9410.33
56_A100_S0.9410.33
62_A133_H0.9360.32
45_E127_R0.9360.32
107_G141_Y0.9330.32
106_T149_R0.9330.32
113_S117_Q0.9320.32
131_L193_Q0.9240.32
113_S153_V0.9230.32
83_Q143_D0.9030.31
150_F181_T0.9000.31
195_H198_G0.8940.30
95_L190_I0.8910.30
14_S170_D0.8900.30
16_G45_E0.8740.29
106_T109_G0.8740.29
46_S128_N0.8640.29
152_H181_T0.8620.29
148_F153_V0.8540.28
153_V181_T0.8500.28
96_V127_R0.8300.27
147_V186_F0.8230.27
21_V36_V0.8180.27
97_R140_M0.8170.27
94_E194_E0.8170.27
17_T102_P0.8140.26
77_V137_T0.8070.26
138_L163_A0.8060.26
113_S152_H0.8060.26
114_E151_L0.8040.26
16_G164_L0.8020.26
76_V110_I0.8020.26
50_V71_T0.7940.26
49_V59_V0.7910.25
149_R160_S0.7870.25
52_T78_D0.7710.25
50_V94_E0.7650.24
113_S160_S0.7650.24
100_S141_Y0.7600.24
24_P136_S0.7580.24
44_G137_T0.7570.24
127_R164_L0.7550.24
23_G29_K0.7550.24
156_G159_Q0.7540.24
113_S150_F0.7500.24
40_G44_G0.7500.24
63_F184_Q0.7470.24
183_K190_I0.7470.24
95_L180_S0.7460.24
91_R94_E0.7450.23
52_T129_R0.7440.23
16_G19_L0.7410.23
57_N192_I0.7380.23
25_A192_I0.7380.23
152_H156_G0.7340.23
107_G184_Q0.7330.23
167_F185_L0.7270.23
26_M29_K0.7240.23
13_V108_I0.7160.22
18_N113_S0.7150.22
51_S114_E0.7100.22
161_A189_V0.7070.22
148_F186_F0.7010.22
53_K83_Q0.7000.22
50_V76_V0.6960.21
50_V109_G0.6890.21
104_D181_T0.6760.21
105_L179_V0.6720.21
151_L167_F0.6700.20
48_L196_D0.6680.20
104_D113_S0.6670.20
120_Y168_T0.6660.20
124_D169_V0.6660.20
152_H184_Q0.6660.20
106_T113_S0.6610.20
94_E103_N0.6610.20
80_V83_Q0.6600.20
112_L154_F0.6580.20
54_D131_L0.6540.20
116_L133_H0.6510.20
27_S70_E0.6500.20
139_L185_L0.6490.20
152_H155_T0.6470.20
13_V188_G0.6410.19
27_S132_L0.6400.19
169_V172_A0.6390.19
77_V138_L0.6350.19
22_E186_F0.6350.19
157_R167_F0.6340.19
49_V125_S0.6330.19
45_E164_L0.6310.19
154_F176_A0.6280.19
133_H188_G0.6230.19
146_T153_V0.6210.19
143_D187_D0.6200.19
114_E132_L0.6170.19
18_N149_R0.6170.19
56_A98_Y0.6160.19
60_I152_H0.6120.18
63_F183_K0.6020.18
36_V49_V0.5980.18
40_G54_D0.5980.18
35_R195_H0.5960.18
56_A78_D0.5950.18
28_G141_Y0.5930.18
25_A169_V0.5920.18
24_P78_D0.5910.18
158_V183_K0.5910.18
117_Q184_Q0.5890.18
18_N153_V0.5890.18
106_T150_F0.5880.18
132_L178_T0.5870.18
44_G160_S0.5830.17
57_N162_D0.5830.17
130_I151_L0.5820.17
16_G23_G0.5820.17
142_S147_V0.5780.17
19_L188_G0.5770.17
158_V163_A0.5770.17
17_T30_R0.5750.17
155_T158_V0.5740.17
94_E165_G0.5740.17
77_V187_D0.5710.17
101_S141_Y0.5700.17
127_R182_L0.5660.17
29_K62_A0.5640.17
70_E83_Q0.5630.17
36_V131_L0.5620.17
84_Q192_I0.5620.17
163_A193_Q0.5600.17
147_V187_D0.5580.17
63_F71_T0.5580.17
66_V140_M0.5570.17
55_S77_V0.5510.16
17_T113_S0.5500.16
32_L38_A0.5500.16
82_K99_A0.5490.16
30_R34_F0.5490.16
97_R104_D0.5470.16
77_V195_H0.5460.16
99_A138_L0.5460.16
95_L147_V0.5440.16
68_D147_V0.5420.16
106_T148_F0.5410.16
68_D87_G0.5400.16
49_V70_E0.5390.16
25_A48_L0.5380.16
50_V119_L0.5380.16
13_V127_R0.5370.16
71_T85_G0.5330.16
46_S77_V0.5300.16
15_E54_D0.5300.16
34_F182_L0.5290.16
190_I193_Q0.5230.15
35_R66_V0.5220.15
67_G135_L0.5170.15
61_D91_R0.5160.15
16_G192_I0.5160.15
151_L181_T0.5100.15
138_L147_V0.5070.15
83_Q190_I0.5060.15
12_D193_Q0.5050.15
27_S143_D0.5040.15
15_E121_E0.5040.15
76_V118_R0.5030.15
152_H157_R0.5010.15
156_G183_K0.5000.15
117_Q151_L0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bs4A 1 0.9349 99.5 0.742 Contact Map
4a8jA 1 0.8698 99.4 0.757 Contact Map
4bwyA 3 0.7163 98.3 0.842 Contact Map
2dr3A 3 0.9395 98 0.852 Contact Map
4blqA 3 0.7395 97.4 0.87 Contact Map
2w0mA 1 0.8605 97 0.878 Contact Map
4ppfA 1 0.814 96.6 0.884 Contact Map
2cvhA 1 0.8698 96.5 0.885 Contact Map
1tf7A 3 0.8977 96.5 0.885 Contact Map
3hr8A 1 0.8465 95.1 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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