GREMLIN Database
DGGGP - Digeranylgeranylglyceryl phosphate synthase
UniProt: Q9HRP0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (266)
Sequences: 10249 (7381)
Seq/√Len: 452.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_R82_P4.0271.00
60_Y82_P3.9141.00
6_G79_A3.4201.00
60_Y86_L3.4061.00
81_S84_G3.2071.00
53_G93_F3.2021.00
83_R87_A2.9951.00
9_E79_A2.9761.00
198_Q202_A2.9691.00
27_A40_T2.5001.00
61_F123_Q2.4971.00
241_V245_R2.4451.00
50_A96_A2.2721.00
8_V13_P2.2321.00
7_L84_G2.2121.00
252_A256_L2.1801.00
199_R202_A2.0791.00
251_A255_R2.0541.00
65_V188_L2.0231.00
42_A102_T2.0121.00
181_A184_R2.0111.00
180_L184_R2.0081.00
237_V241_V1.9861.00
87_A91_V1.9581.00
49_L95_G1.9511.00
105_V109_C1.9131.00
104_P107_A1.9101.00
7_L88_Y1.9081.00
42_A99_L1.8571.00
90_V94_V1.8551.00
56_A92_L1.8421.00
240_V244_A1.8361.00
5_R9_E1.8281.00
254_Q258_K1.8271.00
101_A108_V1.8271.00
36_R39_A1.7601.00
260_G264_A1.7471.00
252_A255_R1.7011.00
202_A206_V1.6821.00
11_A56_A1.6601.00
234_P238_V1.6501.00
10_L56_A1.6401.00
63_R75_I1.6341.00
109_C113_L1.6251.00
225_G228_Y1.6001.00
67_R76_P1.5961.00
107_A149_A1.5901.00
75_I85_A1.5881.00
63_R67_R1.5691.00
46_A99_L1.5541.00
192_P200_A1.5521.00
49_L96_A1.5291.00
117_G139_L1.5251.00
80_V85_A1.5131.00
219_Y229_L1.5051.00
49_L92_L1.4961.00
184_R193_V1.4941.00
211_A215_S1.4691.00
86_L90_V1.4651.00
56_A88_Y1.4631.00
23_T44_V1.4621.00
60_Y85_A1.4381.00
255_R258_K1.4171.00
11_A92_L1.4151.00
180_L197_H1.4061.00
60_Y89_S1.3891.00
18_A171_R1.3841.00
234_P237_V1.3811.00
195_V199_R1.3791.00
82_P86_L1.3651.00
125_L128_R1.3641.00
98_A102_T1.3541.00
253_G260_G1.3371.00
125_L135_L1.3351.00
243_A246_S1.3331.00
11_A52_A1.3321.00
242_A246_S1.3201.00
26_G30_A1.3191.00
254_Q257_L1.3181.00
56_A89_S1.2861.00
11_A88_Y1.2811.00
257_L261_Q1.2511.00
202_A205_A1.2461.00
209_V213_A1.2451.00
197_H201_L1.2411.00
138_Y161_A1.2351.00
57_I89_S1.2271.00
232_V236_V1.2251.00
126_K129_P1.2251.00
8_V11_A1.2241.00
158_G162_A1.2221.00
120_T135_L1.2171.00
54_G118_L1.2161.00
258_K262_L1.2101.00
208_V211_A1.2001.00
52_A92_L1.1881.00
231_A270_V1.1761.00
141_G165_A1.1761.00
23_T47_T1.1721.00
253_G257_L1.1681.00
93_F115_L1.1631.00
50_A111_A1.1631.00
199_R203_V1.1591.00
106_L110_I1.1521.00
204_S208_V1.1471.00
83_R86_L1.1441.00
230_V234_P1.1411.00
163_L214_A1.1371.00
10_L80_V1.1341.00
253_G256_L1.1201.00
241_V244_A1.1131.00
41_G45_G1.1131.00
37_P41_G1.1091.00
155_L158_G1.0891.00
177_V200_A1.0891.00
133_N173_V1.0871.00
205_A209_V1.0821.00
19_A48_W1.0651.00
106_L109_C1.0611.00
258_K264_A1.0541.00
243_A247_Y1.0431.00
233_C237_V1.0411.00
198_Q201_L1.0351.00
215_S218_P1.0301.00
231_A235_G1.0261.00
242_A245_R1.0241.00
244_A247_Y1.0211.00
162_A166_L1.0141.00
240_V243_A1.0141.00
239_M242_A1.0121.00
130_G194_V1.0021.00
100_A111_A1.0021.00
233_C236_V1.0011.00
56_A80_V0.9941.00
191_L195_V0.9941.00
255_R259_R0.9911.00
257_L260_G0.9881.00
132_G190_T0.9881.00
173_V203_V0.9861.00
10_L85_A0.9791.00
101_A105_V0.9761.00
251_A254_Q0.9731.00
23_T27_A0.9701.00
97_A108_V0.9691.00
136_V172_E0.9691.00
180_L193_V0.9641.00
238_V241_V0.9601.00
88_Y92_L0.9591.00
72_D79_A0.9581.00
201_L204_S0.9361.00
137_A169_F0.9361.00
13_P48_W0.9341.00
60_Y75_I0.9331.00
251_A257_L0.9311.00
236_V240_V0.9291.00
254_Q264_A0.9271.00
183_D190_T0.9251.00
189_R194_V0.9241.00
62_D127_G0.9241.00
263_L267_A0.9241.00
46_A100_A0.9231.00
45_G49_L0.9211.00
74_A78_G0.9171.00
227_W231_A0.9061.00
203_V206_V0.9051.00
100_A103_L0.9041.00
256_L264_A0.9031.00
65_V127_G0.9031.00
258_K261_Q0.9021.00
235_G238_V0.8991.00
260_G263_L0.8931.00
219_Y228_Y0.8911.00
256_L260_G0.8891.00
45_G99_L0.8891.00
201_L205_A0.8881.00
89_S93_F0.8871.00
116_A120_T0.8861.00
166_L207_F0.8841.00
181_A185_A0.8811.00
18_A22_L0.8741.00
255_R260_G0.8641.00
80_V88_Y0.8621.00
84_G87_A0.8621.00
115_L119_L0.8611.00
133_N172_E0.8581.00
259_R263_L0.8571.00
38_A42_A0.8571.00
257_L264_A0.8561.00
38_A41_G0.8521.00
104_P110_I0.8481.00
69_N182_G0.8461.00
76_P85_A0.8451.00
242_A259_R0.8441.00
86_L89_S0.8391.00
207_F210_G0.8381.00
238_V242_A0.8361.00
249_D252_A0.8321.00
239_M246_S0.8261.00
119_L123_Q0.8231.00
239_M244_A0.8221.00
262_L266_A0.8211.00
26_G29_V0.8211.00
191_L194_V0.8171.00
170_A207_F0.8031.00
179_D183_D0.8021.00
117_G135_L0.8011.00
253_G258_K0.8001.00
112_A116_A0.7981.00
16_T48_W0.7961.00
64_E68_I0.7951.00
176_D192_P0.7941.00
27_A44_V0.7941.00
87_A90_V0.7941.00
125_L129_P0.7921.00
51_T55_N0.7851.00
97_A100_A0.7851.00
9_E14_V0.7831.00
260_G268_F0.7801.00
226_W230_V0.7781.00
145_V161_A0.7761.00
131_A134_A0.7741.00
188_L194_V0.7721.00
192_P195_V0.7711.00
35_G40_T0.7711.00
52_A88_Y0.7701.00
91_V95_G0.7691.00
107_A146_F0.7671.00
141_G168_T0.7641.00
231_A234_P0.7631.00
133_N176_D0.7561.00
177_V199_R0.7551.00
216_P219_Y0.7541.00
84_G88_Y0.7541.00
225_G229_L0.7521.00
120_T125_L0.7511.00
259_R262_L0.7471.00
68_I186_A0.7461.00
56_A85_A0.7461.00
39_A103_L0.7461.00
141_G164_A0.7431.00
18_A21_A0.7431.00
105_V108_V0.7401.00
106_L149_A0.7391.00
149_A157_G0.7381.00
60_Y63_R0.7371.00
219_Y222_G0.7341.00
62_D65_V0.7331.00
261_Q265_A0.7321.00
147_G151_V0.7301.00
156_A159_V0.7281.00
203_V207_F0.7261.00
148_A152_G0.7261.00
206_V210_G0.7221.00
95_G99_L0.7161.00
180_L192_P0.7141.00
210_G214_A0.7041.00
261_Q264_A0.6991.00
237_V244_A0.6931.00
230_V233_C0.6901.00
228_Y235_G0.6901.00
260_G267_A0.6891.00
140_G168_T0.6861.00
224_F228_Y0.6861.00
149_A153_S0.6861.00
265_A268_F0.6851.00
177_V197_H0.6821.00
23_T43_A0.6821.00
13_P52_A0.6821.00
170_A208_V0.6821.00
62_D122_T0.6801.00
74_A79_A0.6781.00
254_Q261_Q0.6761.00
172_E175_K0.6761.00
181_A197_H0.6751.00
43_A150_A0.6711.00
25_I160_L0.6701.00
237_V240_V0.6671.00
25_I29_V0.6661.00
53_G92_L0.6661.00
252_A259_R0.6661.00
229_L233_C0.6641.00
207_F214_A0.6641.00
65_V68_I0.6631.00
261_Q268_F0.6601.00
162_A214_A0.6591.00
212_A215_S0.6581.00
64_E67_R0.6561.00
5_R8_V0.6521.00
31_G35_G0.6511.00
52_A56_A0.6481.00
7_L80_V0.6461.00
65_V186_A0.6461.00
164_A168_T0.6461.00
93_F96_A0.6461.00
136_V171_R0.6461.00
99_L103_L0.6431.00
235_G267_A0.6390.99
49_L99_L0.6380.99
108_V112_A0.6380.99
254_Q260_G0.6370.99
137_A168_T0.6330.99
94_V98_A0.6280.99
228_Y231_A0.6280.99
97_A101_A0.6230.99
53_G119_L0.6200.99
214_A217_V0.6200.99
75_I80_V0.6200.99
228_Y232_V0.6180.99
107_A150_A0.6180.99
39_A151_V0.6180.99
215_S219_Y0.6170.99
206_V209_V0.6160.99
176_D179_D0.6140.99
53_G96_A0.6100.99
9_E74_A0.6090.99
89_S119_L0.6080.99
96_A100_A0.6060.99
7_L11_A0.6050.99
224_F227_W0.6020.99
183_D187_G0.6020.99
241_V246_S0.6020.99
196_G200_A0.6010.99
63_R66_D0.6000.99
114_N142_S0.6000.99
20_G261_Q0.5970.99
13_P16_T0.5970.99
31_G34_V0.5970.99
170_A211_A0.5960.99
100_A108_V0.5960.99
227_W230_V0.5930.99
175_K178_E0.5920.99
43_A47_T0.5920.99
73_R76_P0.5910.99
235_G263_L0.5910.99
163_L215_S0.5910.99
42_A103_L0.5900.99
80_V84_G0.5900.99
232_V235_G0.5900.99
188_L191_L0.5890.99
251_A261_Q0.5890.99
29_V33_A0.5870.99
33_A149_A0.5850.99
57_I119_L0.5850.99
201_L211_A0.5830.99
216_P220_L0.5820.99
177_V201_L0.5790.99
22_L25_I0.5780.99
62_D188_L0.5770.99
36_R151_V0.5760.99
224_F271_G0.5740.99
27_A43_A0.5730.99
148_A157_G0.5710.99
24_F44_V0.5710.99
207_F211_A0.5700.99
256_L259_R0.5680.99
131_A135_L0.5670.99
167_S211_A0.5650.99
22_L26_G0.5630.99
189_R193_V0.5620.99
256_L261_Q0.5620.99
223_V227_W0.5560.99
19_A51_T0.5510.98
184_R189_R0.5450.98
256_L263_L0.5440.98
212_A234_P0.5430.98
27_A35_G0.5430.98
74_A77_R0.5400.98
76_P79_A0.5390.98
172_E176_D0.5370.98
19_A22_L0.5360.98
142_S161_A0.5360.98
59_D62_D0.5350.98
217_V221_V0.5340.98
212_A216_P0.5320.98
223_V226_W0.5320.98
252_A260_G0.5310.98
195_V203_V0.5300.98
137_A165_A0.5300.98
240_V246_S0.5280.98
253_G264_A0.5270.98
238_V245_R0.5250.98
259_R264_A0.5250.98
54_G122_T0.5240.98
61_F122_T0.5230.98
137_A142_S0.5220.98
97_A112_A0.5210.98
142_S146_F0.5210.98
231_A238_V0.5180.98
258_K268_F0.5160.98
213_A217_V0.5160.98
264_A268_F0.5150.98
16_T51_T0.5150.98
71_P76_P0.5100.97
239_M243_A0.5060.97
73_R78_G0.5050.97
129_P194_V0.5040.97
225_G236_V0.5040.97
242_A247_Y0.5030.97
240_V245_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.942 100 0.212 Contact Map
4tq3A 1 0.9746 100 0.277 Contact Map
2xq2A 2 0.837 63.3 0.923 Contact Map
3dh4A 3 0.7754 10.7 0.949 Contact Map
3ze3A 4 0.3659 8.8 0.951 Contact Map
1pw4A 1 0.8768 5.2 0.956 Contact Map
3m0gA 2 0.7717 3.8 0.959 Contact Map
4tkrA 2 0.5906 3.4 0.96 Contact Map
2onkC 2 0.2572 2.9 0.961 Contact Map
3wajA 1 0.808 2.9 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.