Q9HRN4 - HALSA - GREMLIN Contacts

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Q9HRN4 - Uncharacterized protein

UniProt:	Q9HRN4	Sequences: MIAGGSGSFSAGELSVPGHDSPNIATQPVEEGQIEMSATTSGKVVVIDEAHGNGVGEFQLRPLINTLTENGHEVRFYGPDRGPSGEQLNKTLRGADAFVSLAPDNRFKPAEADGVSAFVDAGGRVLAAGEPESGGGGGLLGIGGFGRSGRSAAEFTPVLSQYGLTVGSGYLYDTTDNVNNHANIDAAPTGSSDLTAGVDSVVVHQAAPVTGNNVLLQTDSETELTTTRDADAYGVLARTGNIVALGDSSVLDPDWTYVADNEVLVGNLADYLVTGDRGRMPAPSE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	285 (225)
Sequences:	107 (99)
Seq/√Len:	6.6

HALSA - Q9HRN4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
158_V	268_L	3.736	0.93
243_V	268_L	3.553	0.91
171_L	235_V	3.389	0.89
98_F	115_V	3.216	0.86
166_V	244_A	2.862	0.78
48_D	51_H	2.790	0.76
173_D	221_E	2.660	0.73
89_N	115_V	2.486	0.67
45_V	70_N	2.442	0.66
99_V	110_A	2.294	0.61
163_G	207_A	2.280	0.60
188_P	198_V	2.154	0.56
207_A	246_G	2.132	0.55
201_V	264_L	2.122	0.54
119_V	125_V	2.087	0.53
51_H	103_P	2.081	0.53
95_A	118_F	2.073	0.53
235_V	273_V	1.976	0.49
100_S	212_N	1.969	0.49
97_A	271_Y	1.968	0.49
99_V	252_D	1.948	0.48
38_A	99_V	1.907	0.46
78_G	268_L	1.890	0.46
171_L	269_A	1.889	0.46
105_N	268_L	1.881	0.45
61_R	119_V	1.879	0.45
89_N	93_R	1.878	0.45
101_L	173_D	1.876	0.45
51_H	108_K	1.866	0.45
48_D	53_N	1.855	0.44
96_D	194_L	1.851	0.44
188_P	216_L	1.838	0.44
246_G	261_N	1.807	0.43
102_A	130_E	1.721	0.40
77_Y	98_F	1.670	0.38
104_D	173_D	1.665	0.38
209_V	246_G	1.636	0.37
241_N	253_P	1.624	0.36
48_D	92_L	1.619	0.36
67_L	267_N	1.583	0.35
113_D	198_V	1.547	0.34
88_L	97_A	1.536	0.33
46_V	100_S	1.524	0.33
45_V	122_G	1.502	0.32
195_T	265_V	1.499	0.32
34_I	109_P	1.495	0.32
68_T	126_L	1.492	0.32
97_A	241_N	1.487	0.32
73_E	109_P	1.485	0.32
215_L	243_V	1.466	0.31
203_V	242_I	1.439	0.30
46_V	114_G	1.435	0.30
74_V	163_G	1.423	0.30
194_L	268_L	1.422	0.30
107_F	115_V	1.415	0.29
108_K	264_L	1.411	0.29
46_V	95_A	1.394	0.29
173_D	222_T	1.392	0.29
116_S	162_Y	1.374	0.28
34_I	76_F	1.348	0.27
94_G	221_E	1.336	0.27
36_M	70_N	1.326	0.27
110_A	113_D	1.322	0.27
235_V	275_G	1.321	0.27
125_V	227_T	1.321	0.27
47_I	237_A	1.316	0.26
34_I	209_V	1.311	0.26
48_D	182_A	1.306	0.26
124_R	271_Y	1.302	0.26
224_L	269_A	1.255	0.25
65_N	115_V	1.252	0.25
126_L	173_D	1.244	0.24
236_L	264_L	1.241	0.24
169_G	206_A	1.228	0.24
60_L	85_G	1.220	0.24
61_R	107_F	1.215	0.24
107_F	191_S	1.207	0.23
188_P	194_L	1.207	0.23
118_F	123_G	1.193	0.23
172_Y	272_L	1.182	0.23
70_N	270_D	1.182	0.23
50_A	215_L	1.181	0.23
65_N	118_F	1.181	0.23
159_L	244_A	1.174	0.22
50_A	161_Q	1.171	0.22
45_V	99_V	1.166	0.22
90_K	227_T	1.143	0.22
164_L	244_A	1.141	0.22
132_E	203_V	1.125	0.21
209_V	237_A	1.125	0.21
51_H	158_V	1.123	0.21
110_A	268_L	1.117	0.21
194_L	235_V	1.115	0.21
67_L	99_V	1.110	0.21
93_R	277_R	1.104	0.21
218_T	246_G	1.095	0.20
90_K	114_G	1.094	0.20
177_N	181_H	1.094	0.20
172_Y	194_L	1.089	0.20
34_I	119_V	1.088	0.20
119_V	245_L	1.088	0.20
38_A	196_A	1.087	0.20
53_N	103_P	1.085	0.20
52_G	162_Y	1.080	0.20
49_E	107_F	1.076	0.20
114_G	277_R	1.072	0.20
201_V	216_L	1.059	0.20
90_K	98_F	1.059	0.20
51_H	100_S	1.054	0.19
264_L	274_T	1.051	0.19
261_N	272_L	1.050	0.19
203_V	236_L	1.050	0.19
51_H	122_G	1.045	0.19
50_A	109_P	1.039	0.19
89_N	107_F	1.031	0.19
89_N	114_G	1.029	0.19
35_E	256_T	1.028	0.19
71_G	272_L	1.023	0.19
62_P	271_Y	1.020	0.19
172_Y	188_P	1.018	0.19
77_Y	115_V	1.017	0.19
98_F	269_A	1.010	0.18
65_N	161_Q	0.997	0.18
214_V	217_Q	0.996	0.18
32_G	218_T	0.995	0.18
173_D	185_D	0.995	0.18
64_I	107_F	0.990	0.18
97_A	124_R	0.988	0.18
245_L	270_D	0.985	0.18
63_L	181_H	0.969	0.18
209_V	266_G	0.956	0.17
209_V	234_G	0.954	0.17
67_L	264_L	0.950	0.17
106_R	112_A	0.949	0.17
124_R	241_N	0.941	0.17
64_I	116_S	0.926	0.17
156_T	160_S	0.922	0.17
172_Y	273_V	0.915	0.16
167_G	233_Y	0.914	0.16
115_V	118_F	0.913	0.16
188_P	195_T	0.911	0.16
99_V	189_T	0.909	0.16
111_E	125_V	0.904	0.16
112_A	210_T	0.898	0.16
117_A	190_G	0.895	0.16
108_K	114_G	0.893	0.16
108_K	122_G	0.888	0.16
53_N	222_T	0.887	0.16
92_L	122_G	0.880	0.16
131_P	247_D	0.880	0.16
207_A	235_V	0.879	0.16
41_S	236_L	0.877	0.16
70_N	269_A	0.865	0.15
44_V	118_F	0.857	0.15
48_D	107_F	0.856	0.15
32_G	74_V	0.856	0.15
198_V	221_E	0.842	0.15
219_D	236_L	0.838	0.15
164_L	240_G	0.836	0.15
59_Q	98_F	0.835	0.15
50_A	86_E	0.835	0.15
160_S	212_N	0.834	0.15
162_Y	259_A	0.830	0.15
32_G	171_L	0.830	0.15
102_A	168_S	0.827	0.15
107_F	182_A	0.826	0.15
237_A	252_D	0.824	0.15
169_G	204_H	0.823	0.15
36_M	98_F	0.823	0.15
51_H	163_G	0.822	0.15
93_R	158_V	0.820	0.15
95_A	272_L	0.819	0.15
68_T	242_I	0.819	0.15
61_R	238_R	0.818	0.15
209_V	267_N	0.817	0.15
47_I	244_A	0.814	0.14
36_M	269_A	0.814	0.14
33_Q	98_F	0.814	0.14
107_F	110_A	0.804	0.14
65_N	96_D	0.802	0.14
170_Y	225_T	0.798	0.14
98_F	264_L	0.795	0.14
61_R	100_S	0.794	0.14
63_L	99_V	0.792	0.14
47_I	216_L	0.790	0.14
59_Q	73_E	0.788	0.14
195_T	261_N	0.787	0.14
33_Q	220_S	0.785	0.14
35_E	236_L	0.778	0.14
156_T	206_A	0.774	0.14
46_V	163_G	0.765	0.14
107_F	125_V	0.758	0.13
114_G	240_G	0.756	0.13
88_L	253_P	0.754	0.13
217_Q	234_G	0.754	0.13
110_A	276_D	0.749	0.13
47_I	264_L	0.749	0.13
114_G	276_D	0.749	0.13
110_A	195_T	0.746	0.13
87_Q	206_A	0.746	0.13
96_D	263_V	0.742	0.13
71_G	215_L	0.740	0.13
161_Q	217_Q	0.737	0.13
204_H	253_P	0.735	0.13
96_D	273_V	0.733	0.13
214_V	234_G	0.732	0.13
157_P	187_A	0.731	0.13
104_D	128_A	0.727	0.13
133_S	205_Q	0.724	0.13
169_G	273_V	0.722	0.13
85_G	108_K	0.722	0.13
125_V	235_V	0.720	0.13
35_E	232_A	0.720	0.13
115_V	230_A	0.719	0.13
171_L	257_Y	0.714	0.13
89_N	113_D	0.712	0.13
183_N	262_E	0.711	0.13
126_L	205_Q	0.711	0.13
123_G	242_I	0.709	0.13
151_S	243_V	0.708	0.13
241_N	271_Y	0.706	0.13
33_Q	274_T	0.703	0.13
55_V	183_N	0.702	0.13
117_A	231_D	0.700	0.12
90_K	118_F	0.700	0.12
93_R	113_D	0.699	0.12
63_L	272_L	0.697	0.12
191_S	214_V	0.696	0.12
181_H	185_D	0.696	0.12
92_L	237_A	0.691	0.12
111_E	123_G	0.691	0.12
112_A	161_Q	0.689	0.12
214_V	223_E	0.688	0.12
102_A	236_L	0.685	0.12
61_R	65_N	0.684	0.12
69_E	113_D	0.684	0.12
92_L	123_G	0.683	0.12
57_E	65_N	0.679	0.12
48_D	204_H	0.677	0.12
215_L	223_E	0.677	0.12
186_A	249_S	0.673	0.12
90_K	185_D	0.671	0.12
124_R	197_G	0.668	0.12
71_G	260_D	0.667	0.12
202_V	251_L	0.664	0.12
100_S	126_L	0.664	0.12
176_D	228_R	0.663	0.12
108_K	216_L	0.657	0.12
239_T	245_L	0.656	0.12
95_A	240_G	0.656	0.12
131_P	266_G	0.656	0.12
104_D	268_L	0.655	0.12
191_S	244_A	0.653	0.12
157_P	220_S	0.651	0.12
54_G	274_T	0.650	0.12
62_P	260_D	0.650	0.12
155_F	211_G	0.645	0.12
57_E	113_D	0.642	0.12
75_R	268_L	0.633	0.11
114_G	231_D	0.630	0.11
67_L	129_G	0.626	0.11
169_G	225_T	0.625	0.11
207_A	270_D	0.622	0.11
35_E	90_K	0.620	0.11
112_A	198_V	0.619	0.11
125_V	203_V	0.618	0.11
216_L	231_D	0.618	0.11
206_A	241_N	0.617	0.11
191_S	252_D	0.614	0.11
61_R	275_G	0.614	0.11
89_N	268_L	0.612	0.11
201_V	204_H	0.609	0.11
173_D	182_A	0.608	0.11
108_K	232_A	0.606	0.11
197_G	268_L	0.605	0.11
64_I	114_G	0.603	0.11
94_G	175_T	0.601	0.11
198_V	267_N	0.598	0.11
229_D	233_Y	0.590	0.11
208_P	222_T	0.588	0.11
31_E	229_D	0.587	0.11
160_S	165_T	0.583	0.11
99_V	269_A	0.580	0.11
101_L	116_S	0.580	0.11
93_R	114_G	0.580	0.11
45_V	164_L	0.577	0.11
103_P	122_G	0.576	0.11
51_H	159_L	0.574	0.11
185_D	222_T	0.574	0.11
108_K	242_I	0.572	0.11
35_E	115_V	0.571	0.11
129_G	179_N	0.571	0.11
169_G	246_G	0.570	0.11
237_A	268_L	0.569	0.11
48_D	98_F	0.569	0.11
45_V	94_G	0.568	0.10
73_E	206_A	0.568	0.10
47_I	177_N	0.567	0.10
48_D	111_E	0.567	0.10
72_H	131_P	0.566	0.10
236_L	272_L	0.565	0.10
88_L	93_R	0.565	0.10
78_G	110_A	0.565	0.10
102_A	106_R	0.563	0.10
128_A	203_V	0.555	0.10
44_V	135_G	0.555	0.10
125_V	241_N	0.554	0.10
127_A	196_A	0.552	0.10
242_I	249_S	0.550	0.10
214_V	218_T	0.547	0.10
94_G	215_L	0.546	0.10
127_A	177_N	0.542	0.10
243_V	262_E	0.541	0.10
38_A	41_S	0.536	0.10
109_P	119_V	0.532	0.10
66_T	271_Y	0.531	0.10
73_E	191_S	0.527	0.10
63_L	261_N	0.527	0.10
96_D	228_R	0.526	0.10
179_N	182_A	0.525	0.10
113_D	193_D	0.525	0.10
46_V	258_V	0.523	0.10
35_E	39_T	0.523	0.10
124_R	131_P	0.521	0.10
85_G	220_S	0.519	0.10
220_S	231_D	0.516	0.10
193_D	236_L	0.516	0.10
129_G	159_L	0.513	0.10
45_V	240_G	0.513	0.10
32_G	233_Y	0.513	0.10
128_A	274_T	0.511	0.10
92_L	163_G	0.508	0.10
44_V	256_T	0.507	0.10
212_N	218_T	0.505	0.10
197_G	267_N	0.503	0.10
213_N	268_L	0.503	0.10
64_I	209_V	0.502	0.10
178_V	187_A	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4e5vA	1	0.8	99.3	0.823	Contact Map
3sozA	3	0.7158	99	0.84	Contact Map
4pxyA	4	0.7754	99	0.841	Contact Map
3rhtA	3	0.7404	99	0.843	Contact Map
2gk3A	5	0.7158	98.9	0.848	Contact Map
1t0bA	4	0.7333	98.8	0.852	Contact Map
2zuvA	2	0.8667	97.1	0.903	Contact Map
3ttyA	4	0.8316	96.5	0.911	Contact Map
4oifA	3	0.8211	95.4	0.918	Contact Map
4uozA	3	0.8246	93.4	0.926	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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