GREMLIN Database
Q9HRN4 - Uncharacterized protein
UniProt: Q9HRN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (225)
Sequences: 107 (99)
Seq/√Len: 6.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_V268_L3.7360.93
243_V268_L3.5530.91
171_L235_V3.3890.89
98_F115_V3.2160.86
166_V244_A2.8620.78
48_D51_H2.7900.76
173_D221_E2.6600.73
89_N115_V2.4860.67
45_V70_N2.4420.66
99_V110_A2.2940.61
163_G207_A2.2800.60
188_P198_V2.1540.56
207_A246_G2.1320.55
201_V264_L2.1220.54
119_V125_V2.0870.53
51_H103_P2.0810.53
95_A118_F2.0730.53
235_V273_V1.9760.49
100_S212_N1.9690.49
97_A271_Y1.9680.49
99_V252_D1.9480.48
38_A99_V1.9070.46
78_G268_L1.8900.46
171_L269_A1.8890.46
105_N268_L1.8810.45
61_R119_V1.8790.45
89_N93_R1.8780.45
101_L173_D1.8760.45
51_H108_K1.8660.45
48_D53_N1.8550.44
96_D194_L1.8510.44
188_P216_L1.8380.44
246_G261_N1.8070.43
102_A130_E1.7210.40
77_Y98_F1.6700.38
104_D173_D1.6650.38
209_V246_G1.6360.37
241_N253_P1.6240.36
48_D92_L1.6190.36
67_L267_N1.5830.35
113_D198_V1.5470.34
88_L97_A1.5360.33
46_V100_S1.5240.33
45_V122_G1.5020.32
195_T265_V1.4990.32
34_I109_P1.4950.32
68_T126_L1.4920.32
97_A241_N1.4870.32
73_E109_P1.4850.32
215_L243_V1.4660.31
203_V242_I1.4390.30
46_V114_G1.4350.30
74_V163_G1.4230.30
194_L268_L1.4220.30
107_F115_V1.4150.29
108_K264_L1.4110.29
46_V95_A1.3940.29
173_D222_T1.3920.29
116_S162_Y1.3740.28
34_I76_F1.3480.27
94_G221_E1.3360.27
36_M70_N1.3260.27
110_A113_D1.3220.27
235_V275_G1.3210.27
125_V227_T1.3210.27
47_I237_A1.3160.26
34_I209_V1.3110.26
48_D182_A1.3060.26
124_R271_Y1.3020.26
224_L269_A1.2550.25
65_N115_V1.2520.25
126_L173_D1.2440.24
236_L264_L1.2410.24
169_G206_A1.2280.24
60_L85_G1.2200.24
61_R107_F1.2150.24
107_F191_S1.2070.23
188_P194_L1.2070.23
118_F123_G1.1930.23
172_Y272_L1.1820.23
70_N270_D1.1820.23
50_A215_L1.1810.23
65_N118_F1.1810.23
159_L244_A1.1740.22
50_A161_Q1.1710.22
45_V99_V1.1660.22
90_K227_T1.1430.22
164_L244_A1.1410.22
132_E203_V1.1250.21
209_V237_A1.1250.21
51_H158_V1.1230.21
110_A268_L1.1170.21
194_L235_V1.1150.21
67_L99_V1.1100.21
93_R277_R1.1040.21
218_T246_G1.0950.20
90_K114_G1.0940.20
177_N181_H1.0940.20
172_Y194_L1.0890.20
34_I119_V1.0880.20
119_V245_L1.0880.20
38_A196_A1.0870.20
53_N103_P1.0850.20
52_G162_Y1.0800.20
49_E107_F1.0760.20
114_G277_R1.0720.20
201_V216_L1.0590.20
90_K98_F1.0590.20
51_H100_S1.0540.19
264_L274_T1.0510.19
261_N272_L1.0500.19
203_V236_L1.0500.19
51_H122_G1.0450.19
50_A109_P1.0390.19
89_N107_F1.0310.19
89_N114_G1.0290.19
35_E256_T1.0280.19
71_G272_L1.0230.19
62_P271_Y1.0200.19
172_Y188_P1.0180.19
77_Y115_V1.0170.19
98_F269_A1.0100.18
65_N161_Q0.9970.18
214_V217_Q0.9960.18
32_G218_T0.9950.18
173_D185_D0.9950.18
64_I107_F0.9900.18
97_A124_R0.9880.18
245_L270_D0.9850.18
63_L181_H0.9690.18
209_V266_G0.9560.17
209_V234_G0.9540.17
67_L264_L0.9500.17
106_R112_A0.9490.17
124_R241_N0.9410.17
64_I116_S0.9260.17
156_T160_S0.9220.17
172_Y273_V0.9150.16
167_G233_Y0.9140.16
115_V118_F0.9130.16
188_P195_T0.9110.16
99_V189_T0.9090.16
111_E125_V0.9040.16
112_A210_T0.8980.16
117_A190_G0.8950.16
108_K114_G0.8930.16
108_K122_G0.8880.16
53_N222_T0.8870.16
92_L122_G0.8800.16
131_P247_D0.8800.16
207_A235_V0.8790.16
41_S236_L0.8770.16
70_N269_A0.8650.15
44_V118_F0.8570.15
48_D107_F0.8560.15
32_G74_V0.8560.15
198_V221_E0.8420.15
219_D236_L0.8380.15
164_L240_G0.8360.15
59_Q98_F0.8350.15
50_A86_E0.8350.15
160_S212_N0.8340.15
162_Y259_A0.8300.15
32_G171_L0.8300.15
102_A168_S0.8270.15
107_F182_A0.8260.15
237_A252_D0.8240.15
169_G204_H0.8230.15
36_M98_F0.8230.15
51_H163_G0.8220.15
93_R158_V0.8200.15
95_A272_L0.8190.15
68_T242_I0.8190.15
61_R238_R0.8180.15
209_V267_N0.8170.15
47_I244_A0.8140.14
36_M269_A0.8140.14
33_Q98_F0.8140.14
107_F110_A0.8040.14
65_N96_D0.8020.14
170_Y225_T0.7980.14
98_F264_L0.7950.14
61_R100_S0.7940.14
63_L99_V0.7920.14
47_I216_L0.7900.14
59_Q73_E0.7880.14
195_T261_N0.7870.14
33_Q220_S0.7850.14
35_E236_L0.7780.14
156_T206_A0.7740.14
46_V163_G0.7650.14
107_F125_V0.7580.13
114_G240_G0.7560.13
88_L253_P0.7540.13
217_Q234_G0.7540.13
110_A276_D0.7490.13
47_I264_L0.7490.13
114_G276_D0.7490.13
110_A195_T0.7460.13
87_Q206_A0.7460.13
96_D263_V0.7420.13
71_G215_L0.7400.13
161_Q217_Q0.7370.13
204_H253_P0.7350.13
96_D273_V0.7330.13
214_V234_G0.7320.13
157_P187_A0.7310.13
104_D128_A0.7270.13
133_S205_Q0.7240.13
169_G273_V0.7220.13
85_G108_K0.7220.13
125_V235_V0.7200.13
35_E232_A0.7200.13
115_V230_A0.7190.13
171_L257_Y0.7140.13
89_N113_D0.7120.13
183_N262_E0.7110.13
126_L205_Q0.7110.13
123_G242_I0.7090.13
151_S243_V0.7080.13
241_N271_Y0.7060.13
33_Q274_T0.7030.13
55_V183_N0.7020.13
117_A231_D0.7000.12
90_K118_F0.7000.12
93_R113_D0.6990.12
63_L272_L0.6970.12
191_S214_V0.6960.12
181_H185_D0.6960.12
92_L237_A0.6910.12
111_E123_G0.6910.12
112_A161_Q0.6890.12
214_V223_E0.6880.12
102_A236_L0.6850.12
61_R65_N0.6840.12
69_E113_D0.6840.12
92_L123_G0.6830.12
57_E65_N0.6790.12
48_D204_H0.6770.12
215_L223_E0.6770.12
186_A249_S0.6730.12
90_K185_D0.6710.12
124_R197_G0.6680.12
71_G260_D0.6670.12
202_V251_L0.6640.12
100_S126_L0.6640.12
176_D228_R0.6630.12
108_K216_L0.6570.12
239_T245_L0.6560.12
95_A240_G0.6560.12
131_P266_G0.6560.12
104_D268_L0.6550.12
191_S244_A0.6530.12
157_P220_S0.6510.12
54_G274_T0.6500.12
62_P260_D0.6500.12
155_F211_G0.6450.12
57_E113_D0.6420.12
75_R268_L0.6330.11
114_G231_D0.6300.11
67_L129_G0.6260.11
169_G225_T0.6250.11
207_A270_D0.6220.11
35_E90_K0.6200.11
112_A198_V0.6190.11
125_V203_V0.6180.11
216_L231_D0.6180.11
206_A241_N0.6170.11
191_S252_D0.6140.11
61_R275_G0.6140.11
89_N268_L0.6120.11
201_V204_H0.6090.11
173_D182_A0.6080.11
108_K232_A0.6060.11
197_G268_L0.6050.11
64_I114_G0.6030.11
94_G175_T0.6010.11
198_V267_N0.5980.11
229_D233_Y0.5900.11
208_P222_T0.5880.11
31_E229_D0.5870.11
160_S165_T0.5830.11
99_V269_A0.5800.11
101_L116_S0.5800.11
93_R114_G0.5800.11
45_V164_L0.5770.11
103_P122_G0.5760.11
51_H159_L0.5740.11
185_D222_T0.5740.11
108_K242_I0.5720.11
35_E115_V0.5710.11
129_G179_N0.5710.11
169_G246_G0.5700.11
237_A268_L0.5690.11
48_D98_F0.5690.11
45_V94_G0.5680.10
73_E206_A0.5680.10
47_I177_N0.5670.10
48_D111_E0.5670.10
72_H131_P0.5660.10
236_L272_L0.5650.10
88_L93_R0.5650.10
78_G110_A0.5650.10
102_A106_R0.5630.10
128_A203_V0.5550.10
44_V135_G0.5550.10
125_V241_N0.5540.10
127_A196_A0.5520.10
242_I249_S0.5500.10
214_V218_T0.5470.10
94_G215_L0.5460.10
127_A177_N0.5420.10
243_V262_E0.5410.10
38_A41_S0.5360.10
109_P119_V0.5320.10
66_T271_Y0.5310.10
73_E191_S0.5270.10
63_L261_N0.5270.10
96_D228_R0.5260.10
179_N182_A0.5250.10
113_D193_D0.5250.10
46_V258_V0.5230.10
35_E39_T0.5230.10
124_R131_P0.5210.10
85_G220_S0.5190.10
220_S231_D0.5160.10
193_D236_L0.5160.10
129_G159_L0.5130.10
45_V240_G0.5130.10
32_G233_Y0.5130.10
128_A274_T0.5110.10
92_L163_G0.5080.10
44_V256_T0.5070.10
212_N218_T0.5050.10
197_G267_N0.5030.10
213_N268_L0.5030.10
64_I209_V0.5020.10
178_V187_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e5vA 1 0.8 99.3 0.823 Contact Map
3sozA 3 0.7158 99 0.84 Contact Map
4pxyA 4 0.7754 99 0.841 Contact Map
3rhtA 3 0.7404 99 0.843 Contact Map
2gk3A 5 0.7158 98.9 0.848 Contact Map
1t0bA 4 0.7333 98.8 0.852 Contact Map
2zuvA 2 0.8667 97.1 0.903 Contact Map
3ttyA 4 0.8316 96.5 0.911 Contact Map
4oifA 3 0.8211 95.4 0.918 Contact Map
4uozA 3 0.8246 93.4 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.009 seconds.