Q9HRN3 - HALSA - GREMLIN Contacts

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Q9HRN3 - Proteinase IV homolog

UniProt:	Q9HRN3	Sequences: MTNPIDKHAKTLATSWTFIIVVAAIVGGVGGVALQSGSDSGPENSVAVVNIESAITGGTGDAVAKELRSIRGNDSIDAVVLRVSSPGGAVSGSEVQYRAVKRLAQEKPVVTSVRGPAASGGYYTIAPTDKIYVTPSSLVGSVGVISSVSENNGVPSRWKSAPDKGTTGPADKARARAATFRQSFLDVVMNERGDDLTVDRETIGRAQIYAGNKAVEIGLADEIGGLDAAIADAADRASVQNYGVVYRSPGGLGGLLSIIGGNSDTGAANAVSASEFCTNEYLAYAPQAGPDLEVIQNASC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	300 (245)
Sequences:	3807 (2860)
Seq/√Len:	182.7

ECOLI - SPPA SOHB
BACSU - SPPA
HALSA - Q9HRN3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
79_V	103_L	4.603	1.00
130_K	222_E	3.656	1.00
133_V	220_A	3.389	1.00
111_T	128_T	3.299	1.00
68_R	99_A	2.865	1.00
83_V	125_I	2.851	1.00
199_D	202_T	2.831	1.00
130_K	232_D	2.722	1.00
215_V	220_A	2.619	1.00
144_V	180_F	2.619	1.00
174_R	178_A	2.438	1.00
194_D	200_R	2.424	1.00
104_A	129_D	2.413	1.00
113_V	117_A	2.298	1.00
153_G	156_S	2.294	1.00
186_D	190_N	2.188	1.00
44_N	77_D	2.186	1.00
232_D	236_R	2.180	1.00
71_R	102_R	2.118	1.00
132_Y	232_D	2.061	1.00
99_A	102_R	2.039	1.00
213_K	216_E	2.034	1.00
110_V	236_R	1.990	1.00
67_L	103_L	1.983	1.00
132_Y	222_E	1.970	1.00
170_A	173_A	1.970	1.00
225_G	228_A	1.966	1.00
195_D	199_D	1.932	1.00
76_I	107_K	1.929	1.00
220_A	223_I	1.901	1.00
233_A	237_A	1.885	1.00
212_N	216_E	1.882	1.00
196_L	201_E	1.855	1.00
78_A	233_A	1.847	1.00
67_L	100_V	1.847	1.00
50_N	82_R	1.833	1.00
93_S	120_G	1.808	1.00
100_V	109_V	1.768	1.00
101_K	105_Q	1.762	1.00
113_V	137_S	1.743	1.00
165_G	171_D	1.713	1.00
49_V	70_I	1.710	1.00
186_D	196_L	1.693	1.00
135_P	223_I	1.685	1.00
159_K	165_G	1.669	1.00
52_E	84_S	1.653	1.00
222_E	232_D	1.652	1.00
101_K	190_N	1.615	1.00
113_V	139_V	1.607	1.00
51_I	124_T	1.604	1.00
63_V	96_Q	1.602	1.00
212_N	215_V	1.581	1.00
123_Y	187_V	1.564	1.00
81_L	100_V	1.554	1.00
96_Q	124_T	1.546	1.00
126_A	191_E	1.525	1.00
47_A	76_I	1.505	1.00
67_L	79_V	1.505	1.00
152_N	156_S	1.494	1.00
185_L	196_L	1.490	1.00
232_D	235_D	1.474	1.00
80_V	226_L	1.472	1.00
97_Y	123_Y	1.469	1.00
15_S	19_I	1.452	1.00
64_A	99_A	1.443	1.00
71_R	106_E	1.419	1.00
46_V	78_A	1.407	1.00
153_G	157_R	1.401	1.00
203_I	217_I	1.382	1.00
71_R	103_L	1.379	1.00
60_G	64_A	1.360	1.00
226_L	230_I	1.357	1.00
94_E	187_V	1.353	1.00
97_Y	127_P	1.344	1.00
215_V	222_E	1.327	1.00
252_L	256_L	1.312	1.00
94_E	183_S	1.305	1.00
189_M	194_D	1.303	1.00
188_V	200_R	1.291	1.00
101_K	104_A	1.280	1.00
160_S	164_K	1.271	1.00
84_S	115_G	1.262	1.00
224_G	229_A	1.262	1.00
253_G	256_L	1.260	1.00
54_A	86_P	1.235	1.00
119_S	142_V	1.231	1.00
51_I	63_V	1.222	1.00
14_T	17_T	1.203	1.00
151_N	155_P	1.184	1.00
178_A	182_Q	1.180	1.00
161_A	164_K	1.178	1.00
224_G	228_A	1.172	1.00
89_A	92_G	1.172	1.00
45_S	76_I	1.170	1.00
57_G	60_G	1.164	1.00
185_L	201_E	1.164	1.00
101_K	127_P	1.161	1.00
20_I	24_A	1.156	1.00
83_V	121_G	1.155	1.00
94_E	98_R	1.147	1.00
97_Y	191_E	1.144	1.00
151_N	169_P	1.142	1.00
144_V	177_A	1.139	1.00
229_A	233_A	1.134	1.00
228_A	232_D	1.112	1.00
203_I	209_Y	1.104	1.00
97_Y	126_A	1.098	1.00
183_S	187_V	1.094	1.00
15_S	18_F	1.094	1.00
117_A	121_G	1.093	1.00
133_V	223_I	1.082	1.00
97_Y	101_K	1.066	1.00
132_Y	224_G	1.065	1.00
24_A	27_G	1.064	1.00
182_Q	196_L	1.059	1.00
23_A	27_G	1.043	1.00
68_R	72_G	1.042	1.00
17_T	20_I	1.038	1.00
46_V	80_V	1.035	1.00
68_R	102_R	1.035	1.00
254_G	257_S	1.034	1.00
151_N	154_V	1.033	1.00
199_D	218_G	1.032	1.00
215_V	223_I	1.022	1.00
85_S	121_G	1.006	0.99
210_A	213_K	1.003	0.99
153_G	173_A	0.994	0.99
187_V	191_E	0.991	0.99
116_P	138_L	0.979	0.99
179_T	213_K	0.975	0.99
222_E	228_A	0.975	0.99
44_N	75_S	0.972	0.99
213_K	217_I	0.957	0.99
98_R	102_R	0.954	0.99
103_L	106_E	0.951	0.99
254_G	258_I	0.945	0.99
48_V	226_L	0.942	0.99
70_I	103_L	0.940	0.99
185_L	189_M	0.939	0.99
176_R	180_F	0.937	0.99
110_V	229_A	0.936	0.99
47_A	70_I	0.930	0.99
27_G	31_G	0.929	0.99
14_T	18_F	0.925	0.99
21_V	25_I	0.917	0.99
234_A	242_Y	0.916	0.99
86_P	121_G	0.908	0.99
110_V	233_A	0.907	0.99
70_I	79_V	0.905	0.99
192_R	221_D	0.904	0.99
55_I	88_G	0.897	0.99
252_L	257_S	0.895	0.99
256_L	259_I	0.893	0.99
252_L	258_I	0.887	0.99
78_A	234_A	0.885	0.99
182_Q	201_E	0.878	0.98
45_S	73_N	0.876	0.98
80_V	112_S	0.874	0.98
201_E	205_R	0.872	0.98
163_D	166_T	0.867	0.98
133_V	215_V	0.865	0.98
164_K	167_T	0.860	0.98
194_D	218_G	0.860	0.98
127_P	191_E	0.859	0.98
250_G	256_L	0.855	0.98
154_V	158_W	0.854	0.98
151_N	170_A	0.847	0.98
130_K	236_R	0.847	0.98
108_P	112_S	0.840	0.98
94_E	134_T	0.833	0.98
102_R	105_Q	0.830	0.98
97_Y	187_V	0.824	0.98
24_A	28_G	0.823	0.98
224_G	232_D	0.820	0.98
159_K	163_D	0.814	0.98
179_T	212_N	0.808	0.97
45_S	245_V	0.804	0.97
91_S	95_V	0.803	0.97
70_I	107_K	0.801	0.97
201_E	204_G	0.800	0.97
100_V	127_P	0.796	0.97
255_L	259_I	0.786	0.97
43_E	75_S	0.785	0.97
113_V	133_V	0.785	0.97
98_R	135_P	0.782	0.97
80_V	233_A	0.779	0.97
18_F	22_V	0.773	0.97
119_S	140_G	0.772	0.97
249_P	252_L	0.771	0.97
181_R	185_L	0.766	0.96
64_A	95_V	0.758	0.96
101_K	191_E	0.754	0.96
144_V	184_F	0.753	0.96
228_A	231_A	0.749	0.96
242_Y	246_Y	0.749	0.96
253_G	257_S	0.748	0.96
119_S	141_S	0.745	0.96
46_V	237_A	0.743	0.96
22_V	25_I	0.743	0.96
141_S	184_F	0.736	0.96
49_V	66_E	0.734	0.95
251_G	254_G	0.734	0.95
80_V	229_A	0.733	0.95
93_S	124_T	0.733	0.95
203_I	219_L	0.726	0.95
248_S	251_G	0.725	0.95
78_A	237_A	0.724	0.95
189_M	200_R	0.721	0.95
256_L	260_G	0.711	0.95
138_L	208_I	0.710	0.95
16_W	29_V	0.710	0.95
21_V	28_G	0.708	0.94
164_K	169_P	0.707	0.94
142_V	188_V	0.702	0.94
251_G	256_L	0.702	0.94
104_A	127_P	0.701	0.94
90_V	180_F	0.701	0.94
18_F	21_V	0.696	0.94
150_E	172_K	0.694	0.94
257_S	260_G	0.693	0.94
71_R	99_A	0.691	0.94
182_Q	186_D	0.691	0.94
165_G	168_G	0.689	0.94
111_T	125_I	0.688	0.94
250_G	254_G	0.686	0.94
161_A	167_T	0.683	0.93
82_R	112_S	0.681	0.93
249_P	253_G	0.679	0.93
73_N	76_I	0.676	0.93
23_A	26_V	0.676	0.93
51_I	81_L	0.673	0.93
194_D	199_D	0.672	0.93
81_L	111_T	0.672	0.93
29_V	33_A	0.669	0.93
252_L	260_G	0.665	0.92
91_S	94_E	0.664	0.92
182_Q	185_L	0.662	0.92
55_I	96_Q	0.659	0.92
163_D	167_T	0.659	0.92
20_I	27_G	0.659	0.92
63_V	81_L	0.652	0.92
253_G	258_I	0.651	0.92
55_I	60_G	0.650	0.92
14_T	20_I	0.649	0.92
45_S	75_S	0.649	0.92
28_G	32_V	0.647	0.91
251_G	258_I	0.639	0.91
119_S	184_F	0.639	0.91
85_S	184_F	0.637	0.91
49_V	67_L	0.635	0.91
26_V	30_G	0.633	0.91
155_P	170_A	0.632	0.90
19_I	22_V	0.632	0.90
243_G	246_Y	0.631	0.90
179_T	210_A	0.630	0.90
16_W	20_I	0.626	0.90
168_G	171_D	0.626	0.90
250_G	257_S	0.626	0.90
160_S	165_G	0.624	0.90
154_V	157_R	0.624	0.90
239_V	243_G	0.622	0.90
53_S	211_G	0.621	0.90
190_N	235_D	0.618	0.89
132_Y	229_A	0.618	0.89
70_I	76_I	0.617	0.89
108_P	113_V	0.614	0.89
132_Y	228_A	0.614	0.89
63_V	66_E	0.613	0.89
113_V	125_I	0.613	0.89
27_G	30_G	0.611	0.89
249_P	256_L	0.611	0.89
250_G	253_G	0.608	0.89
230_I	234_A	0.607	0.89
85_S	206_A	0.606	0.89
202_T	217_I	0.604	0.88
160_S	167_T	0.603	0.88
185_L	200_R	0.601	0.88
49_V	79_V	0.600	0.88
88_G	140_G	0.598	0.88
49_V	100_V	0.595	0.88
129_D	236_R	0.594	0.88
94_E	123_Y	0.594	0.88
160_S	163_D	0.592	0.87
61_D	65_K	0.592	0.87
100_V	128_T	0.592	0.87
184_F	214_A	0.591	0.87
148_V	167_T	0.591	0.87
78_A	110_V	0.591	0.87
88_G	141_S	0.591	0.87
189_M	204_G	0.591	0.87
251_G	260_G	0.589	0.87
230_I	233_A	0.588	0.87
33_A	36_S	0.588	0.87
159_K	164_K	0.588	0.87
250_G	258_I	0.587	0.87
99_A	103_L	0.587	0.87
199_D	203_I	0.587	0.87
136_S	183_S	0.586	0.87
200_R	203_I	0.586	0.87
88_G	92_G	0.586	0.87
98_R	101_K	0.584	0.87
215_V	218_G	0.581	0.86
161_A	165_G	0.580	0.86
110_V	237_A	0.579	0.86
100_V	126_A	0.578	0.86
106_E	129_D	0.578	0.86
78_A	109_V	0.575	0.86
126_A	188_V	0.574	0.86
95_V	99_A	0.573	0.86
155_P	169_P	0.568	0.85
23_A	30_G	0.568	0.85
55_I	121_G	0.568	0.85
162_P	165_G	0.567	0.85
80_V	237_A	0.567	0.85
119_S	144_V	0.566	0.85
87_G	141_S	0.564	0.85
248_S	253_G	0.563	0.85
241_N	246_Y	0.562	0.85
248_S	252_L	0.562	0.85
49_V	63_V	0.561	0.84
31_G	36_S	0.559	0.84
32_V	35_Q	0.559	0.84
60_G	92_G	0.558	0.84
155_P	168_G	0.557	0.84
66_E	70_I	0.557	0.84
184_F	206_A	0.556	0.84
22_V	26_V	0.556	0.84
15_S	21_V	0.554	0.84
118_A	138_L	0.552	0.83
175_A	178_A	0.552	0.83
47_A	73_N	0.551	0.83
122_Y	192_R	0.548	0.83
161_A	168_G	0.546	0.83
79_V	109_V	0.545	0.83
252_L	259_I	0.545	0.83
82_R	114_R	0.545	0.83
205_R	209_Y	0.543	0.82
145_I	165_G	0.542	0.82
177_A	180_F	0.542	0.82
211_G	224_G	0.542	0.82
19_I	23_A	0.540	0.82
88_G	142_V	0.539	0.82
252_L	255_L	0.538	0.82
110_V	132_Y	0.537	0.82
189_M	196_L	0.536	0.82
117_A	137_S	0.531	0.81
16_W	27_G	0.526	0.80
15_S	30_G	0.525	0.80
168_G	173_A	0.523	0.80
231_A	241_N	0.522	0.80
85_S	88_G	0.519	0.80
64_A	68_R	0.517	0.79
231_A	234_A	0.514	0.79
134_T	225_G	0.514	0.79
248_S	259_I	0.514	0.79
54_A	58_G	0.512	0.79
20_I	23_A	0.511	0.79
87_G	184_F	0.511	0.79
22_V	31_G	0.510	0.78
41_G	45_S	0.509	0.78
110_V	232_D	0.506	0.78
83_V	117_A	0.505	0.78
19_I	28_G	0.504	0.78
65_K	69_S	0.503	0.77
197_T	202_T	0.502	0.77
87_G	119_S	0.501	0.77
142_V	219_L	0.500	0.77
162_P	167_T	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bf0A	3	0.79	100	0.47	Contact Map
3rstA	3	0.6867	100	0.512	Contact Map
4kwbA	5	0.73	100	0.522	Contact Map
3vivA	2	0.6733	100	0.63	Contact Map
4gm2A	3	0.5667	99.9	0.639	Contact Map
2f6iA	5	0.6	99.9	0.649	Contact Map
2cbyA	3	0.5567	99.9	0.649	Contact Map
3p2lA	4	0.6233	99.9	0.652	Contact Map
1yg6A	4	0.6333	99.9	0.657	Contact Map
4u0gA	4	0.6333	99.9	0.657	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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