GREMLIN Database
Q9HRN3 - Proteinase IV homolog
UniProt: Q9HRN3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 300 (245)
Sequences: 3807 (2860)
Seq/√Len: 182.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_V103_L4.6031.00
130_K222_E3.6561.00
133_V220_A3.3891.00
111_T128_T3.2991.00
68_R99_A2.8651.00
83_V125_I2.8511.00
199_D202_T2.8311.00
130_K232_D2.7221.00
215_V220_A2.6191.00
144_V180_F2.6191.00
174_R178_A2.4381.00
194_D200_R2.4241.00
104_A129_D2.4131.00
113_V117_A2.2981.00
153_G156_S2.2941.00
186_D190_N2.1881.00
44_N77_D2.1861.00
232_D236_R2.1801.00
71_R102_R2.1181.00
132_Y232_D2.0611.00
99_A102_R2.0391.00
213_K216_E2.0341.00
110_V236_R1.9901.00
67_L103_L1.9831.00
132_Y222_E1.9701.00
170_A173_A1.9701.00
225_G228_A1.9661.00
195_D199_D1.9321.00
76_I107_K1.9291.00
220_A223_I1.9011.00
233_A237_A1.8851.00
212_N216_E1.8821.00
196_L201_E1.8551.00
78_A233_A1.8471.00
67_L100_V1.8471.00
50_N82_R1.8331.00
93_S120_G1.8081.00
100_V109_V1.7681.00
101_K105_Q1.7621.00
113_V137_S1.7431.00
165_G171_D1.7131.00
49_V70_I1.7101.00
186_D196_L1.6931.00
135_P223_I1.6851.00
159_K165_G1.6691.00
52_E84_S1.6531.00
222_E232_D1.6521.00
101_K190_N1.6151.00
113_V139_V1.6071.00
51_I124_T1.6041.00
63_V96_Q1.6021.00
212_N215_V1.5811.00
123_Y187_V1.5641.00
81_L100_V1.5541.00
96_Q124_T1.5461.00
126_A191_E1.5251.00
47_A76_I1.5051.00
67_L79_V1.5051.00
152_N156_S1.4941.00
185_L196_L1.4901.00
232_D235_D1.4741.00
80_V226_L1.4721.00
97_Y123_Y1.4691.00
15_S19_I1.4521.00
64_A99_A1.4431.00
71_R106_E1.4191.00
46_V78_A1.4071.00
153_G157_R1.4011.00
203_I217_I1.3821.00
71_R103_L1.3791.00
60_G64_A1.3601.00
226_L230_I1.3571.00
94_E187_V1.3531.00
97_Y127_P1.3441.00
215_V222_E1.3271.00
252_L256_L1.3121.00
94_E183_S1.3051.00
189_M194_D1.3031.00
188_V200_R1.2911.00
101_K104_A1.2801.00
160_S164_K1.2711.00
84_S115_G1.2621.00
224_G229_A1.2621.00
253_G256_L1.2601.00
54_A86_P1.2351.00
119_S142_V1.2311.00
51_I63_V1.2221.00
14_T17_T1.2031.00
151_N155_P1.1841.00
178_A182_Q1.1801.00
161_A164_K1.1781.00
224_G228_A1.1721.00
89_A92_G1.1721.00
45_S76_I1.1701.00
57_G60_G1.1641.00
185_L201_E1.1641.00
101_K127_P1.1611.00
20_I24_A1.1561.00
83_V121_G1.1551.00
94_E98_R1.1471.00
97_Y191_E1.1441.00
151_N169_P1.1421.00
144_V177_A1.1391.00
229_A233_A1.1341.00
228_A232_D1.1121.00
203_I209_Y1.1041.00
97_Y126_A1.0981.00
183_S187_V1.0941.00
15_S18_F1.0941.00
117_A121_G1.0931.00
133_V223_I1.0821.00
97_Y101_K1.0661.00
132_Y224_G1.0651.00
24_A27_G1.0641.00
182_Q196_L1.0591.00
23_A27_G1.0431.00
68_R72_G1.0421.00
17_T20_I1.0381.00
46_V80_V1.0351.00
68_R102_R1.0351.00
254_G257_S1.0341.00
151_N154_V1.0331.00
199_D218_G1.0321.00
215_V223_I1.0221.00
85_S121_G1.0060.99
210_A213_K1.0030.99
153_G173_A0.9940.99
187_V191_E0.9910.99
116_P138_L0.9790.99
179_T213_K0.9750.99
222_E228_A0.9750.99
44_N75_S0.9720.99
213_K217_I0.9570.99
98_R102_R0.9540.99
103_L106_E0.9510.99
254_G258_I0.9450.99
48_V226_L0.9420.99
70_I103_L0.9400.99
185_L189_M0.9390.99
176_R180_F0.9370.99
110_V229_A0.9360.99
47_A70_I0.9300.99
27_G31_G0.9290.99
14_T18_F0.9250.99
21_V25_I0.9170.99
234_A242_Y0.9160.99
86_P121_G0.9080.99
110_V233_A0.9070.99
70_I79_V0.9050.99
192_R221_D0.9040.99
55_I88_G0.8970.99
252_L257_S0.8950.99
256_L259_I0.8930.99
252_L258_I0.8870.99
78_A234_A0.8850.99
182_Q201_E0.8780.98
45_S73_N0.8760.98
80_V112_S0.8740.98
201_E205_R0.8720.98
163_D166_T0.8670.98
133_V215_V0.8650.98
164_K167_T0.8600.98
194_D218_G0.8600.98
127_P191_E0.8590.98
250_G256_L0.8550.98
154_V158_W0.8540.98
151_N170_A0.8470.98
130_K236_R0.8470.98
108_P112_S0.8400.98
94_E134_T0.8330.98
102_R105_Q0.8300.98
97_Y187_V0.8240.98
24_A28_G0.8230.98
224_G232_D0.8200.98
159_K163_D0.8140.98
179_T212_N0.8080.97
45_S245_V0.8040.97
91_S95_V0.8030.97
70_I107_K0.8010.97
201_E204_G0.8000.97
100_V127_P0.7960.97
255_L259_I0.7860.97
43_E75_S0.7850.97
113_V133_V0.7850.97
98_R135_P0.7820.97
80_V233_A0.7790.97
18_F22_V0.7730.97
119_S140_G0.7720.97
249_P252_L0.7710.97
181_R185_L0.7660.96
64_A95_V0.7580.96
101_K191_E0.7540.96
144_V184_F0.7530.96
228_A231_A0.7490.96
242_Y246_Y0.7490.96
253_G257_S0.7480.96
119_S141_S0.7450.96
46_V237_A0.7430.96
22_V25_I0.7430.96
141_S184_F0.7360.96
49_V66_E0.7340.95
251_G254_G0.7340.95
80_V229_A0.7330.95
93_S124_T0.7330.95
203_I219_L0.7260.95
248_S251_G0.7250.95
78_A237_A0.7240.95
189_M200_R0.7210.95
256_L260_G0.7110.95
138_L208_I0.7100.95
16_W29_V0.7100.95
21_V28_G0.7080.94
164_K169_P0.7070.94
142_V188_V0.7020.94
251_G256_L0.7020.94
104_A127_P0.7010.94
90_V180_F0.7010.94
18_F21_V0.6960.94
150_E172_K0.6940.94
257_S260_G0.6930.94
71_R99_A0.6910.94
182_Q186_D0.6910.94
165_G168_G0.6890.94
111_T125_I0.6880.94
250_G254_G0.6860.94
161_A167_T0.6830.93
82_R112_S0.6810.93
249_P253_G0.6790.93
73_N76_I0.6760.93
23_A26_V0.6760.93
51_I81_L0.6730.93
194_D199_D0.6720.93
81_L111_T0.6720.93
29_V33_A0.6690.93
252_L260_G0.6650.92
91_S94_E0.6640.92
182_Q185_L0.6620.92
55_I96_Q0.6590.92
163_D167_T0.6590.92
20_I27_G0.6590.92
63_V81_L0.6520.92
253_G258_I0.6510.92
55_I60_G0.6500.92
14_T20_I0.6490.92
45_S75_S0.6490.92
28_G32_V0.6470.91
251_G258_I0.6390.91
119_S184_F0.6390.91
85_S184_F0.6370.91
49_V67_L0.6350.91
26_V30_G0.6330.91
155_P170_A0.6320.90
19_I22_V0.6320.90
243_G246_Y0.6310.90
179_T210_A0.6300.90
16_W20_I0.6260.90
168_G171_D0.6260.90
250_G257_S0.6260.90
160_S165_G0.6240.90
154_V157_R0.6240.90
239_V243_G0.6220.90
53_S211_G0.6210.90
190_N235_D0.6180.89
132_Y229_A0.6180.89
70_I76_I0.6170.89
108_P113_V0.6140.89
132_Y228_A0.6140.89
63_V66_E0.6130.89
113_V125_I0.6130.89
27_G30_G0.6110.89
249_P256_L0.6110.89
250_G253_G0.6080.89
230_I234_A0.6070.89
85_S206_A0.6060.89
202_T217_I0.6040.88
160_S167_T0.6030.88
185_L200_R0.6010.88
49_V79_V0.6000.88
88_G140_G0.5980.88
49_V100_V0.5950.88
129_D236_R0.5940.88
94_E123_Y0.5940.88
160_S163_D0.5920.87
61_D65_K0.5920.87
100_V128_T0.5920.87
184_F214_A0.5910.87
148_V167_T0.5910.87
78_A110_V0.5910.87
88_G141_S0.5910.87
189_M204_G0.5910.87
251_G260_G0.5890.87
230_I233_A0.5880.87
33_A36_S0.5880.87
159_K164_K0.5880.87
250_G258_I0.5870.87
99_A103_L0.5870.87
199_D203_I0.5870.87
136_S183_S0.5860.87
200_R203_I0.5860.87
88_G92_G0.5860.87
98_R101_K0.5840.87
215_V218_G0.5810.86
161_A165_G0.5800.86
110_V237_A0.5790.86
100_V126_A0.5780.86
106_E129_D0.5780.86
78_A109_V0.5750.86
126_A188_V0.5740.86
95_V99_A0.5730.86
155_P169_P0.5680.85
23_A30_G0.5680.85
55_I121_G0.5680.85
162_P165_G0.5670.85
80_V237_A0.5670.85
119_S144_V0.5660.85
87_G141_S0.5640.85
248_S253_G0.5630.85
241_N246_Y0.5620.85
248_S252_L0.5620.85
49_V63_V0.5610.84
31_G36_S0.5590.84
32_V35_Q0.5590.84
60_G92_G0.5580.84
155_P168_G0.5570.84
66_E70_I0.5570.84
184_F206_A0.5560.84
22_V26_V0.5560.84
15_S21_V0.5540.84
118_A138_L0.5520.83
175_A178_A0.5520.83
47_A73_N0.5510.83
122_Y192_R0.5480.83
161_A168_G0.5460.83
79_V109_V0.5450.83
252_L259_I0.5450.83
82_R114_R0.5450.83
205_R209_Y0.5430.82
145_I165_G0.5420.82
177_A180_F0.5420.82
211_G224_G0.5420.82
19_I23_A0.5400.82
88_G142_V0.5390.82
252_L255_L0.5380.82
110_V132_Y0.5370.82
189_M196_L0.5360.82
117_A137_S0.5310.81
16_W27_G0.5260.80
15_S30_G0.5250.80
168_G173_A0.5230.80
231_A241_N0.5220.80
85_S88_G0.5190.80
64_A68_R0.5170.79
231_A234_A0.5140.79
134_T225_G0.5140.79
248_S259_I0.5140.79
54_A58_G0.5120.79
20_I23_A0.5110.79
87_G184_F0.5110.79
22_V31_G0.5100.78
41_G45_S0.5090.78
110_V232_D0.5060.78
83_V117_A0.5050.78
19_I28_G0.5040.78
65_K69_S0.5030.77
197_T202_T0.5020.77
87_G119_S0.5010.77
142_V219_L0.5000.77
162_P167_T0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bf0A 3 0.79 100 0.47 Contact Map
3rstA 3 0.6867 100 0.512 Contact Map
4kwbA 5 0.73 100 0.522 Contact Map
3vivA 2 0.6733 100 0.63 Contact Map
4gm2A 3 0.5667 99.9 0.639 Contact Map
2f6iA 5 0.6 99.9 0.649 Contact Map
2cbyA 3 0.5567 99.9 0.649 Contact Map
3p2lA 4 0.6233 99.9 0.652 Contact Map
1yg6A 4 0.6333 99.9 0.657 Contact Map
4u0gA 4 0.6333 99.9 0.657 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.